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| 1 | The Tea Tree Genome Provides Insights into Tea Flavor and Independent Evolution of Caffeine Biosynthesis显示文摘茶是世界有巨大的经济、药用、文化的重要性的最旧、很流行的包含咖啡因的饮料。这里,我们在场第一个高质量的核苷酸序列充满重复(80.9%) ,栽培的茶树山茶 sinensis 的 3.02-Gb 染色体。我们证明茶树的一种非常地大的染色体尺寸从一些 LTR retrotransposon 家庭的慢、稳定、长期的扩大被结果。除了一个最近的整个染色体的复制事件,基因的系特定的扩大把新陈代谢的生合成与 flavonoid 联系了被发现,它提高 catechin 生产,萜烯酶激活,和应力公差,为茶风味和改编的重要特征。我们相对可可子和咖啡表明一个独立人士和茶咖啡因合成小径的快速的进化。在 25 山茶种类之中的比较研究表明那更高的表情大多数 flavonoid- 和咖啡因铺平 -- 然而并非 theanine 相关的基因贡献 catechins 和咖啡因的增加的生产并且因此提高处理茶的适用性和茶质量。这些新奇调查结果为进一步的 metabolomic 和典型生合成小径的功能的 genomic 精炼铺平道路并且将帮助开发将最后满足并且吸引世界范围的更多的茶喝酒者的茶风味的一个更多样化的集合。 | En-Hua Xia Hai-Bin Zhang Jun Sheng Kui Li Qun-Jie Zhang Changhoon Kim Yun Zhang Yuan Liu Ting Zhu Wei Li Hui Huang Yan Tong Hong Nan Cong Shi Chao Shi Jian-Jun Jiang Shu-Yan Mao Jun-Ying Jiao Dan Zhang Yuan Zhao You-Jie Zhao Li-Ping Zhang Yun-Long Liu Ben-Ying Liu Yue Yu Sheng-Fu Shao De-Jiang Ni Evan E. Eichler Li-Zhi Gao | 2017 | Molecular Plant2017，10，6： | 113 |
| 2 | GL3.3, a Novel QTL Encoding a GSK3/SHAGGY- like Kinase, Epistatically Interacts with GS3 to Produce Extra-long Grains in Rice显示文摘 | Duo Xia Nao Zhou Rongjia Liu Wenhan Dan Pingbo Li Bian Wu Junxiao Chen Lingqiang Wang Guanjun Gao Qinglu Zhang Yuqing He | 2018 | Molecular Plant2018，11，5： | 41 |
| 3 | Corrigendum to “Properties improvement of SPEEK based proton exchange membranes by doping of ionic liquids and Y_2O_3”[Prog. Nat. Sci.: Mater. Int. 22 (1) (2012) 26-30] | Jianbin Chen a, Qiang Guo a, Dan Li a, Juying Tong a,b, Xia Li a a School of Materials Science and Engineering, Shanghai University, Shanghai 201800, China b School of Wenling, Zhejiang TV University, Wenling 317500, China | 2012 | Progress in Natural Science:Materials International2012，22，3： | 33 |
| 4 | Effect of hepatocyte apoptosis induced by TNF-α on acute severe hepatitis in mouse models显示文摘AIM To study the effect of hepatocyteapoptosis and necrosis induced by TNF-α on thepathogenesis of acute severe hepatitis(ASH).METHODS The model of ASH was prepared inD-galactosamine(GAIN)sensitized BALB/c miceby injection of either endotoxin(ET)or tumornecrosis factor-α(TNF-α).Morphologicalchanges of apoptotic hepatocytes were studiedby both light and electron microscope and in siteend labeling method(ISEL).Molecular biologicalchanges of DNA ladder were observed byelectrophoresis of extract from liver tissues.Biochemical changes were measured by alanineaminotransferase(ALT),asparticaminotransferase(AST)and TNF-α.The relationbetween apoptosis and necrosis was evaluatedsimultaneously.RESULTS The sequence of hepatocyteapoptosis,necrosis,and final death from ASHwas observed both in GAIN/ET and GAIN/TNF-agroup.Apoptosis was prominent at 3.5 h and 5 hafter injection of inducer,while necrosis becamedominant at 9 h after challenge.The appearanceof apoptosis was earlier in GAIN/TNF-α groupthan that in GAIN/ ET group.Pretreatment ofmice with antiTNF IgG1 may completely preventthe liver injury induced by GalN/ET.CONCLUSION TNF-α can cause liver damageby inducing hepatic apoptosis and necrosis inmice with endotoxemia. | Guo Qing Zang Xia Qiu Zhou Hong Yu Qing Xie Guo Ming Zhao Bin Wang Qing Guo Yue Qin Xiang Dan Liao Department of Infectious Diseases,Rujin Hospital,Shanghai Second Medical University,Shanghai 200025,China | 2000 | World Journal of Gastroenterology2000，6，5： | 30 |
| 5 | The Medicinal Herb Panax notoginseng Genome Provides Insights into Ginsenoside Biosynthesis and Genome Evolution显示文摘 | Dan Zhang Wei Li En-hua Xia Qun-jie Zhang Yuan Liu Yun Zhang Yan Tong Yuan Zhao Yong-chao Niu Jia-huan Xu Li-zhi Gao | 2017 | Molecular Plant2017，10，6： | 27 |
| 6 | Optimal performance of a generalized irreversible four-reservoir isothermal chemical potential transformer显示文摘A new cyclic model of a four-reservoir isothermal chemical potential transformer with irreversible mass transfer, mass leakage and internal dissipation is put forward in this paper. The optimal relation be-tween the coefficient of performance (COP) and the rate of energy pumping of the generalized irre-versible four-reservoir isothermal chemical potential transformer has been derived by using finite-time thermodynamics or thermodynamic optimization. The maximum COP and the corresponding rate of energy pumping, as well as the maximum rate of energy pumping and the corresponding COP, have been obtained. Moreover, the influences of the irreversibility on the optimal performance of the iso-thermal chemical potential transformer have been revealed. It was found that the mass leakage affects the optimal performance both qualitatively and quantitatively, while the internal dissipation affects the optimal performance quantitatively. The results obtained herein can provide some new theoretical guidelines for the optimal design and development of a class of isothermal chemical potential trans-formers, such as mass exchangers, electrochemical, photochemical and solid state devices, fuel pumps, etc. | XIA Dan CHEN LinGen SUN FengRui | 2008 | Science China Chemistry2008，51，10： | 20 |
| 7 | From concept to reality-A review to the primary test stand and its preliminary application in high energy density physics显示文摘Pulsed power technology,whereas the electrical energy stored in a relative long period is released in much shorter timescale,is an efficient method to create high energy density physics(HEDP)conditions in laboratory.Around the beginning of this century,China Academy of Engineering Physics(CAEP)began to build some experimental facilities for HEDP investigations,among which the Primary Test Stand(PTS),a multi-module pulsed power facility with a nominal current of 10 MA and a current rising time~90 ns,is an important achievement on the roadmap of the electro-magnetically driven inertial confinement fusion(ICF)researches.PTS is the first pulsed power facility beyond 10 TW in China.Therefore,all the technologies have to be demonstrated,and all the engineering issues have to be overcome.In this article,the research outline,key technologies and the preliminary HEDP experiments are reviewed.Prospects on HEDP research on PTS and pulsed power development for the next step are also discussed. | Jianjun Deng Weiping Xie Shuping Feng Meng Wang Hongtao Li Shengyi Song Minghe Xia Ji Ce An He Qing Tian Yuanchao Gu Yongchao Guan Bin Wei Xianbin Huang Xiaodong Ren Jiakun Dan Jing Li Shaotong Zhou Hongchun Cai Siqun Zhang Kunlun Wang Qiang Xu Yujuan Wang Zhaohui Zhang Guilin Wang Shuai Guo Yi He Yiwei Zhou Zhanji Zhang Libing Yang Wenkang Zou | 2016 | Matter and Radiation at Extremes2016，1，1： | 19 |
| 8 | Acupuncture at the Taixi(KI3) acupoint activates cerebral neurons in elderly patients with mild cognitive impairment显示文摘Our previous findings have demonstrated that acupuncture at the Taixi(KI3) acupoint in healthy youths can activate neurons in cognitive-related cerebral cortex. Here, we investigated whether acupuncture at this acupoint in elderly patients with mild cognitive impairment can also activate neurons in these regions. Resting state and task-related functional magnetic resonance imaging showed that the pinprick senstation of acupuncture at the Taixi acupoint differed significantly between elderly patients with mild cognitive impairment and healthy elderly controls. Results showed that 20 brain regions were activated in both groups of participants, including the bilateral anterior cingulate gyrus(Brodmann areas [BA] 32, 24), left medial frontal cortex(BA 9, 10, 11), left cuneus(BA 19), left middle frontal gyrus(BA 11), left lingual gyrus(BA 18), right medial frontal gyrus(BA 11), bilateral inferior frontal gyrus(BA 47), left superior frontal gyrus(BA11), right cuneus(BA 19, 18), right superior temporal gyrus(BA 38), left subcallosal gyrus(BA 47), bilateral precuneus(BA 19), right medial frontal gyrus(BA 10), right superior frontal(BA 11), left cingulate gyrus(BA 32), left precentral gyrus(BA 6), and right fusiform gyrus(BA 19). These results suggest that acupuncture at the Taixi acupoint in elderly patients with mild cognitive impairment can also activate some brain regions. | Shangjie Chen Maosheng Xu Hong Li Jiuping Liang Liang Yin Xia Liu Xinyan Jia Fen Zhu Dan Wang Xuemin Shi Lihua Zhao | 2014 | Neural Regeneration Research2014，9，11： | 18 |
| 9 | Growth-inhibiting effects of taxol on human liver cancer in vitro and in nude mice显示文摘AIM To investigate the effects of taxol onSMMC-7721 human hepatoma and itsmechanisms.METHODS In vitro cell growth was assessedby trypan blue exclusion method.Experimentalhepatoma model was established by seedingSMMC-7721 cells subcutaneously into Balb/c(nu/nu)nude mice.In vivo tumor growth wasdetermined by measurement of tumor diameterwith Vernier calipers.The syntheses of DNA,RNA and protein were analyzed by incorporationof ~3H-thymidine,~3H-uridine and ~3H-leucinerespectively.Using light and electronmicroscopes to observe the morphologicalchanges of cells including mitosis andapoptosis.RESULTS Taxol was effective against SMMC-7721 human hepatoma cell growth in the rangesof 2.5 nmol/L-10 nmol/L with mitotic arrestand apoptosis in vitro.DNA,RNA and proteinsyntheses in cells were also obviouslysuppressed by in vitro treatment of taxol for72 h.Taxol at 2.5 nmol/L reduced ~3H-thymidineuptake to about 34% of the control value(P<0.05).Increasing the dose of taxol to20 nmol/L resulted in a greater decrease in ~3H-thymidine incorporation to 60% of the controlvalue(P<0.01).At a concentration of 20 nmol/L,the ~3H-uridine and ~3H-leucine uptakeswere reduced to 52%(P<0.05)and 63%(P<0.01),respectively.In vivo,taxolsignificantly inhibited SMMC-7721 tumor growthat 10 mg/kg,i.p.,once daily for 10 d.A morethan 90% decrease in tumor volume wasobserved by day 11(P<0.01)similarly withmitotic arrest and cell apoptosis.CONCLUSION Taxol has a marked anticanceractivity in SMMC-7721 human hepatoma both invitro and in nude mice.Its mechanisms might beassociated with mitotic arrest,subsequently,apoptosis of the hepatoma cells.No obvioustoxicity was observed with in vivoadministration of taxoi. | Jin Hui Yuan Ru Ping Zhang Ru Gang Zhang Li Xia Guo Xing Wang Wang Dan Luo Yong Xie Hong Xie | 2000 | World Journal of Gastroenterology2000，6，2： | 18 |
| 10 | A comprehensive review of integrative pharmacology-based investigation:A paradigm shift in traditional Chinese medicine显示文摘Over the past decade,traditional Chinese medicine(TCM) has widely embraced systems biology and its various data integration approaches to promote its modernization.Thus,integrative pharmacology-based traditional Chinese medicine(TCMIP) was proposed as a paradigm shift in TCM.This review focuses on the presentation of this novel concept and the main research contents,methodologies and applications of TCMIP.First,TCMIP is an interdisciplinary science that can establish qualitative and quantitative pharmacokinetics-pharmacodynamics(PK-PD) correlations through the integration of knowledge from multiple disciplines and techniques and from different PK-PD processes in vivo.Then,the main research contents of TCMIP are introduced as follows:chemical and ADME/PK profiles of TCM formulas;confirming the three forms of active substances and the three action modes;establishing the qualitative PK-PD correlation;and building the quantitative PK-PD correlations,etc.After that,we summarize the existing data resources,computational models and experimental methods of TCMIP and highlight the urgent establishment of mathematical modeling and experimental methods.Finally,we further discuss the applications of TCMIP for the improvement of TCM quality control,clarification of the molecular mechanisms underlying the actions of TCMs and discovery of potential new drugs,especially TCM-related combination drug disco very. | Haiyu Xu Yanqiong Zhang Ping Wang Junhong Zhang Hong Chen Luoqi Zhang Xia Du Chunhui Zhao Dan Wu Feng Liu Hongjun Yang Changxiao Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 18 |
| 11 | USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy显示文摘Macrophage polarization to proinflammatory M1-like or anti-inflammatory M2-like cells is critical to mount a host defense or repair tissue.The exact molecular mechanisms controlling this process are still elusive.Here,we report that ubiquitin-specific protease 19(USP19)acts as an anti-inflammatory switch that inhibits inflammatory responses and promotes M2-like macrophage polarization.USP19 inhibited NLRP3 inflammasome activation by increasing autophagy flux and decreasing the generation of mitochondrial reactive oxygen species.In addition,USP19 inhibited the proteasomal degradation of inflammasome-independent NLRP3 by cleaving its polyubiquitin chains.USP19-stabilized NLRP3 promoted M2-like macrophage polarization by direct association with interferon regulatory factor 4,thereby preventing its p62-mediated selective autophagic degradation.Consistent with these observations,compared to wild-type mice,Usp19−/−mice had decreased M2-like macrophage polarization and increased interleukin-1βsecretion,in response to alum and chitin injections.Thus,we have uncovered an unexpected mechanism by which USP19 switches the proinflammatory function of NLRP3 into an anti-inflammatory function,and suggest that USP19 is a potential therapeutic target for inflammatory interventions. | Tao Liu Liqiu Wang Puping Liang Xiaojuan Wang Yukun Liu Jing Cai Yuanchu She Dan Wang Zhi Wang Zhiyong Guo Samuel Bates Xiaojun Xia Junjiu Huang Jun Cui | 2021 | Cellular & Molecular Immunology2021，18，10： | 15 |
| 12 | Safflower Extract and Aceglutamide Injection Promoting Recovery of Peripheral Innervations via Vascular Endothelial Growth Factor-B Signaling in Diabetic Mice显示文摘 | Dan Li You-Gang Chen Cui-Juan Zhang Jing Tian Xia Li | 2017 | Chinese Medical Journal2017，，23： | 13 |
| 13 | Chinese herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019: a retrospective cohort study显示文摘This study aimed to evaluate the efficacy of Chinese herbal medicine(CHM)in patients with severe/critical coronavirus disease 2019(COVID-19).In this retrospective study,data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVID-19 in Wuhan before March 20,2020.All patients were divided into an exposed group(CHM users)and a control group(non-users).After propensity score matching in a 1:1 ratio,156 CHM users were matched by propensity score to 156 non-users.No significant differences in seven baseline clinical variables were found between the two groups of patients.All-cause mortality was reported in 13 CHM users who died and 36 non-users who died.After multivariate adjustment,the mortality risk of CHM users was reduced by 82.2%(odds ratio 0.178,95%CI 0.076–0.418;P<0.001)compared with the non-users.Secondly,age(odds ratio 1.053,95%CI 1.023–1.084;P<0.001)and the proportion of severe/critical patients(odds ratio 0.063,95%CI 0.028–0.143;P<0.001)were the risk factors of mortality.These results show that the use of CHM may reduce the mortality of patients with severe/critical COVID-19. | Guohua Chen Wen Su Jiayao Yang Dan Luo Ping Xia Wen Jia Xiuyang Li Chuan Wang Suping Lang Qingbin Meng Ying Zhang Yuhe Ke An Fan Shuo Yang Yujiao Zheng Xuepeng Fan Jie Qiao Fengmei Lian Li Wei Xiaolin Tong | 2020 | Frontiers of Medicine2020，14，6： | 10 |
| 14 | A new iridoid glycoside from Gardenia jasminoides显示文摘新 iridoid glycoside, 6 ′ - O-sinapoylgeniposide,从栀子 jasminoides 埃利斯被孤立,它的结构根据 1D 和 2D NMR 被阐明, HR-ESI-MS 技术。 | Xiao Qin Zhou Zhi Ming Bi Ping Li Dan Tang Hal Xia Cai | 2007 | Chinese Chemical Letters2007，18，10： | 10 |
| 15 | Fluoxetine ameliorates symptoms of refractory chronic prostatitis/chronic pelvic pain syndrome显示文摘背景范畴长期的 prostatitis/chronic 骨盆的疼痛症候群(CP/CPPS ) 是有生活的质量上的重要影响的不清楚的病原学的普通症候群。因为为 CP/CPPS 的多重治疗的结果远离同意,可能的心理因素被认为在这上在 CP/CPPS.Based 起一个重要作用,我们在这研究与倔强的 CP/CPPS.Methods 在人调查了抗抑郁剂药( fluoxetine )的角色,没有对标准治疗的反应,与倔强的 CP/CPPS 诊断的 42 个人(包括多重抗菌素功课和 a-blockers )为 fluoxetine 被提交治疗。所有病人收到了 fluoxetine (20 mg/d ) 三个月并且以前临床上被评估(基线) ,并且在治疗的 4, 8 和 12 个星期以后。评估包括了健康长期的前列腺炎症状索引(NIH-CPSI ) 和贝克萧条的研究所盘点的一个公民(BDI ) 问询表。而且,主观全球评价( SGA )在 therapy.Results 的 第4 , 第8 和 第12 星期被估计重要减少为全部的 NIH-CPSI ( 28.55~9.29 )被观察, NIH-CPSI 疼痛( 14.69~5.19 ), NIH-CPSI 尿( 4.95~1.88 ),生活( 8.83~2.20 )的 NIH-CPSI 质量,和 BDI ( 34.67~13.95 )与基线相比得分,所有 P 珍视 0.05 。(69.05%) 29 在主观全球评价以后报导了显著改进,(78.57%) 33 有一比在在治疗(第 12 星期) 的结束的 NIH-CPSI 的 50% 减少大。同时,皮尔森关联系数分析表明了在 BDI 分数和每个 CPSI 分数之间的积极关联。没有不利事件在这 study.Conclusions Fluoxetine 被报导看起来是在改善的安全、有效的治疗症状在,和生活的质量,有困难的 CP/CPPS 的人。而且,困难的 CP/CPPS-related 症状的改善能与在压抑的症状的减少有关。 | XIA Dan WANG Ping CHEN Jun WANG Shuo JIANG Hai | 2011 | Chinese Medical Journal2011，，14： | 10 |
| 16 | Inhibition of Bcl-2 enhances the efficacy of epirubicin chemotherapy in PC-3 prostate cancer cells显示文摘在癌症房间的 Bcl-2 蛋白质的背景 Overexpression 能禁止规划房间死亡并且产生 chemoresistance.Bcl-2 antisense oligonucleotide ( G3139 )看了它在现出症状之前的潜的模型提高的 antitumor 效果什么时候与学习试图调查在雄激素无关的前列腺 cancer.Methods PC3 前列腺与 epirubicin 相结合的 G3139 的功效的 基于taxol 的 chemotherapy.This 结合了癌症房间线与 epirubicin 和 Bcl-2 antisense oligonucleotide alon 有教养。 | JIANG Hai XIA Dan WU Ling-jiao CHEN Zhao-dian | 2011 | Chinese Medical Journal2011，，23： | 9 |
| 17 | SnSb@carbon nanocable anchored on graphene sheets for sodium ion batteries显示文摘有唯一的 nanostructures 的材料的开发是为在钠离子电池的钠存储的改进的有效策略完成稳定的骑车的性能和好率能力。在这个工作, SnSbcore/carbon-shell nanocables 直接在 graphene 表(GS ) 上抛锚了被热水的技术和化学蒸汽免职综合。同时的碳涂层和 SnSb 合金的封装为在钠离子电池减轻卷变化问题是有效的。在在钠离子电池为 SnSb 优化电解质以后,优化同轴的 SnSb/carbon nanocable/GS (SnSb/CNT@GS ) nanostructure 在 1 M NaClO 表明了稳定的骑车的能力和率性能 < 潜水艇 class= “ a-plus-plus ” > 有丙烯碳酸盐(PC ) 的 4 +5% fluoroethylene 碳酸盐(FEC ) 。SnSb/CNT@GS 电极能为多达 100 个周期保留 360 mAh/g 的一个能力,它是 71% 理论能力。这比在测试的另外的三电解质高( 1 M NaClO <潜水艇class=“ a-plus-plus ”> 4 在 PC , 1 M NaClO <潜水艇class=“ a-plus-plus ”>在 PC/FEC ( 1:1 v/v )和 1 M NaPF 的 4 <潜水艇class=“ a-plus-plus ”> 6 + PC ),并且比没有 graphene 的增加的样品的高。好电气化学的性能能被归因于禁止 SnSb 粒子,以及它的高传导性的凝块的外部碳 nanocable 层和 graphene 提供的有效缓冲。 | Li Li Kuok Hau Seng Dan Li Yongyao Xia Hua Kun Liu Zaiping Guo | 2014 | Nano Research2014，7，10： | 9 |
| 18 | Liquid biopsy for non-invasive assessment of liver injury in hepatitis B patients显示文摘BACKGROUND Hepatitis B is a major public health problem in China. Accurate liver injury assessment is essential for clinical evidence-based treatment. Liver biopsy is considered the gold standard method to stage liver disease, but it is not widely used in resource-limited settings. Therefore, non-invasive liquid biopsy tests are needed. AIM To assess liver injury in hepatitis B patients using quantified cell free DNA combined with other serum biomarker as a liquid biopsy-based method. METHODS A cohort of 663 subjects including 313 hepatitis B patients and 350 healthy controls were enrolled. Ultrasound-guided liver biopsies followed by histopathological assessments were performed for the 263 chronic hepatitis B patients to determine the degree of liver injury. Cell-free DNA was quantified using a novel duplex real-time polymerase chain reaction assay. RESULTS Compared with healthy controls, patients with hepatitis B virus (HBV) infection had significantly higher plasma DNA, serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin, and HBV DNA levels (P<0.01). Serum ALT, AST, bilirubin, and plasma DNA levels of patients with markedsevere inflammation were significantly higher than those with mild-moderate inflammation (P<0.01). There was a statistically significant correlation between hepatocyte inflammation severity and serum bilirubin (R^2=0.673, P<0.01) or plasma DNA (R^2=0.597, P<0.01) levels. The areas under the curves of serum ALT, bilirubin, plasma DNA, and their combination to distinguish between patients with mild–moderate and marked-severe inflammation were 0.8059, 0.7910, 0.7921, and 0.9564, respectively. CONCLUSION The combination of plasma DNA, serum ALT, and bilirubin could be a candidate liquid biopsy for non-invasive assessment of liver injury in hepatitis B patients. | Wen-Ying Xia Li Gao Er-Hei Dai Dan Chen Er-Fu Xie Li Yang Shi-Chang Zhang Bing-Feng Zhang Jian Xu Shi-Yang Pan | 2019 | World Journal of Gastroenterology2019，25，29： | 9 |
| 19 | Paired associated magnetic stimulation promotes neural repair in the rat middle cerebral artery occlusion model of stroke显示文摘Paired associative stimulation has been used in stroke patients as an innovative recovery treatment.However,the mechanisms underlying the therapeutic effectiveness of paired associative stimulation on neurological function remain unclear.In this study,rats were randomly divided into middle cerebral occlusion model(MCAO)and paired associated magnetic stimulation(PAMS)groups.The MCAO rat model was produced by middle cerebral artery embolization.The PAMS group received PAMS on days 3 to 20 post MCAO.The MCAO group received sham stimulation,three times every week.Within 18 days after ischemia,rats were subjected to behavioral experiments—the foot-fault test,the balance beam walking test,and the ladder walking test.Balance ability was improved on days 15 and 17,and the footfault rate was less in their affected limb on day 15 in the PAMS group compared with the MCAO group.Western blot assay showed that the expression levels of brain derived neurotrophic factor,glutamate receptor 2/3,postsynaptic density protein 95 and synapsin-1 were significantly increased in the PAMS group compared with the MCAO group in the ipsilateral sensorimotor cortex on day 21.Resting-state functional magnetic resonance imaging revealed that regional brain activities in the sensorimotor cortex were increased in the ipsilateral hemisphere,but decreased in the contralateral hemisphere on day 20.By finite element simulation,the electric field distribution showed a higher intensity,of approximately 0.4 A/m^2,in the ischemic cortex compared with the contralateral cortex in the template.Together,our findings show that PAMS upregulates neuroplasticity-related proteins,increases regional brain activity,and promotes functional recovery in the affected sensorimotor cortex in the rat MCAO model.The experiments were approved by the Institutional Animal Care and Use Committee of Fudan University,China(approval No.201802173 S)on March 3,2018. | Bei-Yao Gao Cheng-Cheng Sun Guo-Hua Xia Shao-Ting Zhou Ye Zhang Ye-Ran Mao Pei-Le Liu Ya Zheng Dan Zhao Xu-Tong Li Janie Xu Dong-Sheng Xu Yu-Long Bai | 2020 | Neural Regeneration Research2020，15，11： | 8 |
| 20 | Images for diagnosis Sarcomatoid carcinoma of the renal pelvis in duplex kidney显示文摘肾的骨盆的 Sarcomatoid 过渡房间癌是一个稀罕的瘤,仅仅 14 个插图丰富的例子以前报导了。双肾是尿道的最普通的先天的反常,与约 2% 的发生。在双肾的肾的骨盆的瘤形成是稀罕的。我们报导了癌其 sarcomatoid 与两个肾的单位的膀胱手铐切除外科与肾盂积水膨出,和全部的 nephroureterectomy 从复制肾的骨盆的上面的部分发源的一个案例被执行。因为肾的骨盆的 sarcomatoid 癌的稀罕性质和它对辅助治疗的反应的明显的缺乏,做早诊断和早激进的外科改进幸存是必要的。为经常、勤奋的监视或对待的建筑群强调需要是重要的有在有瘤形成的风险的情况下的任何一个一半的肾盂积水膨出的双肾。 | CHEN Ge-ming CHEN Shan-wen XIA Dan LI Jun YAN Sheng JIN Bai-ye | 2011 | Chinese Medical Journal2011，，13： | 8 |
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