|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 阿尔茨海默病患者脑血流的动态调节显示文摘脑自动调节和压力反射敏感性是维持脑血流量的关键机制。该研究评估了这些调控机制在阿尔茨海默病导致的痴呆和轻度认知障碍患者中是否受到影响,因为这会增加降压治疗的风险。 | 刘青 叶鹏 de Heus RAA de Jong DLK Sanders ML van Spijker GJ Oudegeest-Sander MH Hopman MT Lawlor BA Olde Rikkert MGM Claassen JAHR | 2018 | 中华高血压杂志2018，26，8： | 4 |
| 2 | Efficacy and Safety of Anticoagulation on Patients With Cirrhosis and Portal Vein Thrombosis显示文摘 | María Gabriela Delgado Susana Seijo Ismael Yepes Linette Achécar Maria Vega Catalina ángeles García–Criado Juan G. Abraldes Joaquín de la Pe?a Rafael Ba?ares Agustín Albillos Jaume Bosch Juan Carlos García–Pagán | 2012 | Clinical Gastroenterology and Hepatology2012，，7： | 3 |
| 3 | Early Endoscopic Retrograde Cholangiopancreatography in Predicted Severe Acute Biliary Pancreatitis: A Prospective Multicenter Study显示文摘 | Hjalmar C. van Santvoort Marc G. Besselink Annemarie C. de Vries Marja A. Boermeester Kathelijn Fischer Thomas L. Bollen Geert A. Cirkel Alexander F. Schaapherder Vincent B. Nieuwenhuijs Harry van Goor Cees H. Dejong Casper H. van Eijck Ben J. Witteman Ba | 2009 | Annals of Surgery2009，，1： | 2 |
| 4 | Trans-catheter arterial chemoembolization as first-line treatment for hepatic metastases from endocrine tumors显示文摘 | Alain Roche Baragur V. Girish Thierry de Baère Eric Baudin Valérie Boige Dominique Elias Philippe Lasser Martin Schlumberger Michel Ducreux | 2003 | European Radiology2003，，1： | 2 |
| 5 | 改良FOLFIRINOX方案一线化疗中国转移性胰腺癌患者的疗效与安全性研究显示文摘背景与目的奥沙利铂(oxaliplatin)、伊立替康(irinotecan)、5-氟尿嘧啶(5-fluorouracil)和1-醛氢叶酸(l-leucovorin)联合用药(即FOLFIRINOX方案)已成为晚期胰腺癌(pancreatic cancer,PC)的一线治疗方案之一。然而,与FOLFIRINOX标准剂量相关的3级或4级不良事件的较高发生率限制了该方案在临床上的广泛应用。在本研究中,我们对改良FOLFIRINOX方案一线化疗中国转移性PC患者的疗效和安全性进行了评价。方法将组织学证实为原发转移性胰腺癌,且东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)体能状态评分为0-2的患者纳入本研究。所有患者均接受改良FOLFIRINOX方案治疗(静脉滴注奥沙利铂65 mg/m^2、伊立替康150 mg/m^2、l-醛氢叶酸200 mg/m^2、5-氟尿嘧啶2400 mg/m^2,每2周重复1次)。治疗持续12个周期,除非患者出现疾病进展(progressive disease,PD)、症状恶化的疾病稳定(stable disease,SD)、不可耐受的不良事件或要求提前终止治疗。主要终点为客观缓解率(objective response rate,ORR)。结果2012年7月至2017年4月期间,共有来自3个机构的65例患者被纳入本研究。所有患者均接受了至少1个周期化疗,化疗周期中位数为8个周期(范围:1-12个周期)。本研究中未观察到完全缓解。21(32.3%)例患者为部分缓解,27(41.5%)例表现为SD。总体人群的ORR和疾病控制率(diseasecontrol rate,DCR)分别为32.3%和73.8%。中位总生存期和无进展生存期分别为11.60[95%置信区间(confidence interval,CI):8.76-14.44]个月和5.77(95%CI:5.00-6.54)个月。主要的3级或4级不良事件包括中性粒细胞减少(12.3%)和腹泻(6.2%)。未观察到与治疗相关的死亡。结论改良FOLFIRINOX具有良好的耐受性,可作为中国转移性PC中国患者的一线治疗方案。 | Zhi‑Qiang Wang Fei Zhang Ting Deng Le Zhang Fen Feng Feng‑Hua Wang Wei Wang De‑Shen Wang Hui‑Yan Luo Rui‑Hua Xu Yi Ba Yu‑Hong Li | 2019 | 癌症2019，38，8： | 2 |
| 6 | Diffusion imaging for evaluation of tumor therapies in preclinical animal models显示文摘 | Moffat BA Hall DE Stojanovska J | 2004 | MAGMA2004，17，3： | 1 |
| 7 | Burn scar revision on the face显示文摘 | De Souza BA Adlard R Shibu M | 2002 | Dermatol Surg2002，28，8： | 1 |
| 8 | Treatment with intravitreal steroid reduces blood-retinal bar-rier breakdown due to retinal photocoagulation显示文摘 | Wilson CA Berkowitz BA Sato Y Ando N Handa JT de Juan EJr | 1992 | Arch Oph-Mmol1992，110，8： | 1 |
| 9 | An official ATS/IDSA statement:diagnosis,treatment,and prevention of nontuberculous mycobacterial diseases显示文摘 | Griffith DE Aksamit T Brown-Elliott BA | | 0，，04： | 1 |
| 10 | Perioperative statin thera- py in patients at high risk for cardiovascular morbidity undergoing surgery: a review 显示文摘 | de Waal BA Buise MP van Zundert AA | 2015 | Br J Anaesth2015，114，1： | 1 |
| 11 | The utility of capsule endoscopy and its role for diagnosing pathology in the gastrointestinal tract显示文摘 | Carlo JT De Marco D Smith BA | 2005 | Am J Surg2005，190，6： | 1 |
| 12 | Theprognostic value of anti-cyclic citrullinated peptide antibody inpatients with recent-onset rheuma toid arthritis显示文摘 | Kroot EJ De Jong BA Van leeuwen MA | 2000 | Arthritis Rheum2000，43，10： | 1 |
| 13 | Intraoral salivary duct carcinoma:case report with immunohistochemical observations显示文摘 | Lopes MA de Abreu Alves F Levy BA | 2001 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2001，91，6： | 1 |
| 14 | Polymorphisms in or near tumour necrosis factor (TNF)-gene do not determine levels of endotoxin-induced TNF production 显示文摘 | de Jong BA Westendorp RG Bakker AM | 2002 | Genes Immun2002，3，1： | 1 |
| 15 | Endothelin-1 synthesis,receptors,and signal transduction in alveolar epithelium:evidence for an autocrine role显示文摘 | Markewitz BA Kohan DE Michael JR | 1995 | Am J Physiol1995，268，： | 1 |
| 16 | The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide显示文摘 | Schellekens GA Visser H de Jong BA | | 0，，1： | 1 |
| 17 | Adverse events during radiofrequency treatment of 582hepatic tumors显示文摘 | de Baère T Risse O Kuoch V | 2003 | AJR Am J Roentgenol2003，181，3： | 1 |
| 18 | Sensory gating of auditory evoked potentials in rats:effects of repetitive stimulation and the interstimulus interval显示文摘 | De Bruin NM Ellenbroek BA Van Schaijk WJ | 2001 | Biological Psychology2001，55，： | 1 |
| 19 | Antioxidant and free radical scavenging activity of isoflavone metabolites显示文摘 | Rimbach G De Pascual-Teresa S Ewins BA | 2003 | Xeno-biotica2003，33，： | 1 |
| 20 | Chronic reduction of cerebral blood flow in the adult rat: late- emerging CA1 cell loss and memory dysfunction 显示文摘 | BA Pappas JC De La Torre CM Davidson | 1996 | Brain research1996，708，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员