|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Life and death at the mucosal-luminal interface: New perspectives on human intestinal ischemia-reperfusion显示文摘Intestinal ischemia is a frequently observed phenomenon. Morbidity and mortality rates are extraordinarily high and did not improve over the past decades. This is in part attributable to limited knowledge on the pathophysiology of intestinal ischemia-reperfusion(IR) in man, the paucity in preventive and/or therapeutic options and the lack of early diagnostic markers for intestinal ischemia. To improve our knowledge and solve clinically important questions regarding intestinal IR, we developed a human experimental intestinal IR model. With this model, we were able to gain insight into the mechanisms that allow the human gut to withstand short periods of IR without the development of severe inflammatory responses. The purpose of this review is to overview the most relevant recent advances in our understanding of the pathophysiology of human intestinal IR, as well as the(potential) future clinical implications. | Joep Grootjans Kaatje Lenaerts Wim A Buurman Cornelis HC Dejong Joep PM Derikx | 2016 | World Journal of Gastroenterology2016，22，9： | 11 |
| 2 | Human small intestine is capable of restoring barrier function after short ischemic periods显示文摘AIM To assess intestinal barrier function during human intestinal ischemia and reperfusion(IR).METHODS In a human experimental model,6 cm of jejunum was selectively exposed to 30 min of ischemia(I) followed by 30 and 120 min of reperfusion(R). A sham procedure was also performed. Blood and tissue was sampled at all-time points. Functional barrier function was assessed using dual-sugar absorption tests with lactulose(L) and rhamnose(R). Plasma concentrations of citrulline,an amino acid described as marker for enterocyte function were measured as marker of metabolic enterocytes restoration. Damage to the epithelial lining was assessed by immunohistochemistry for tight junctions( TJs),by plasma marker for enterocytes damage(I-FABP) and analyzed by electron microscopy(EM) using lanthanum nitrate as an electrondense marker.RESULTS Plasma L/R ratio's were significantly increased after 30 min of ischemia(30 I) followed by 30 min of reperfusion(30 R) compared to control(0.75 ± 0.10 vs 0.20 ± 0.09,P < 0.05). At 120 min of reperfusion(120 R),ratio's normalized(0.17 ± 0.06) and were not significantly different from control. Plasma levels of I-FABP correlated with plasma L/R ratios measured at the same time points(correlation: 0.467,P < 0.01). TJs staining shows distortion of staining at 30 I. An intact lining of TJs was again observed at 30 I120 R. Electron microscopy analysis revealed disrupted TJs after 30 I with paracellular leakage of lanthanum nitrate,which restored after 30 I120 R. Furthermore,citrulline concentrations closely paralleled the histological perturbations during intestinal IR.CONCLUSION This study directly correlates histological data with intestinal permeability tests,revealing that the human gut has the ability of to withstand short episodes of ischemia,with morphological and functional recovery of the intestinal barrier within 120 min of reperfusion. | Dirk HSM Schellekens Inca HR Hundscheid Claire AJI Leenarts Joep Grootjans Kaatje Lenaerts Wim A Buurman Cornelis HC Dejong Joep PM Derikx | 2017 | World Journal of Gastroenterology2017，23，48： | 4 |
| 3 | Genetic characterization of worldwide Prunus domestica(plum)germplasm using sequence-based genotyping显示文摘Prunus domestica commonly known as European plum is a hexaploid fruit tree species cultivated around the world.Locally it is used for fresh consumption,in jams or jellies,and the production of spirits while commercially the fruit is primarily sold dried(prunes).Despite its agricultural importance and long history of cultivation,many questions remain about the origin of this species,the relationships among its many pomological types,and its underlying genetics.Here,we used a sequence-based genotyping approach to characterize worldwide plum germplasm including the potential progenitor Eurasian plum species.Analysis of 405 DNA samples established a set of four clades consistent with the pomological groups Greengages,Mirabelles,European plums,and d’Agen(French)prune plums.A number of cultivars from each clade were identified as likely clonal selections,particularly among the“French”type prune germplasm that is widely cultivated today.Overall,there was relatively low genetic diversity across all cultivated plums suggesting they have been largely inbred and/or derived from a limited number of founders.The results agree with P.domestica having originated as an interspecific hybrid of a diploid P.cerasifera and a tetraploid P.spinosa that itself may have been an interspecific hybrid of P.cerasifera and an unknown Eurasian plum species.The low genetic diversity and lack of true wild-types coupled with the known cultivation history of Eurasian plums imply that P.domestica may have been a product of inter-specific cross breeding and artificial selection by early agrarian Eurasian societies. | Tetyana Zhebentyayeva Vijay Shankar Ralph Scorza Ann Callahan Michel Ravelonandro Sarah Castro Theodore DeJong Christopher A.Saski Chris Dardick | 2019 | Horticulture Research2019，6，1： | 4 |
| 4 | 考虑随机模型精化的精密GPS动态定位新方法(英文)显示文摘GPS动态定位要求建立函数模型和随机模型。函数模型描述的是观测值和待估参数之间的物理和几何关系,随机模型描述了GPS观测值的统计特征,并通过观测值的方差协方差给定了每个观测值对最后的定位结果的贡献。正确给定函数模型和随机模型对于GPS定位结果的估计和观测值的粗差探测均至关重要。由于有各种误差存在于伪距和载波相位观测值中,一般GPS动态定位模型均采用双差观测值来构建函数模型。有时候,仔细地使用单差观测值,较之双差观测值有更多的优点,给出了选用单差观测值的理由。但是单差观测值给函数模型带来了接收机钟差,如果直接使用单差观测方程,设计矩阵是奇异的。为了解决这个问题,将伪距观测值中接收机钟差项和接收机延迟项合并为一个新的未知参数。至于载波相位观测值,首先选定一个参考卫星,然后在观测方程的右端同时增加一正一负的参考卫星单差整周模糊度,将正项与接收机钟差项和接收机延迟项合并为一个新的未知参数,将负项和原观测方程中的单差整周模糊度项合并为双差整周模糊度,而参考卫星观测方程的模糊度项则为零,这样无须组建双差观测值,软件实现较容易,也可以直接使用LAMBDA法求整周模糊度,最终也解决了观测方程奇异的问题。准确理解观测值的统计特征是建立GPS随机模型的基础。 | 柳响林 DEJONG Cornelis Dick | 2003 | 测绘学报2003，32，4： | 4 |
| 5 | Enhanced recovery after surgery: A consensus review of clinical care for patients undergoing colonic resection显示文摘 | K.C.H. Fearon O. Ljungqvist M. Von Meyenfeldt A. Revhaug C.H.C. Dejong K. Lassen J. Nygren J. Hausel M. Soop J. Andersen H. Kehlet | 2005 | Clinical Nutrition2005，，3： | 3 |
| 6 | 当前围手术期处理模式:北欧五国结直肠外科医生调查显示文摘 | Kristoffer Lassen Pascal Hannemann Olle Ljungqvist Ken Fearon Cornelis H C Dejong Maarten F von Meyenfeldt Jonatan Hausel Jonas Nygren Jens Andersen Arthur Revhaug 王东 | 2005 | 英国医学杂志中文版2005，8，6： | 3 |
| 7 | Early Endoscopic Retrograde Cholangiopancreatography in Predicted Severe Acute Biliary Pancreatitis: A Prospective Multicenter Study显示文摘 | Hjalmar C. van Santvoort Marc G. Besselink Annemarie C. de Vries Marja A. Boermeester Kathelijn Fischer Thomas L. Bollen Geert A. Cirkel Alexander F. Schaapherder Vincent B. Nieuwenhuijs Harry van Goor Cees H. Dejong Casper H. van Eijck Ben J. Witteman Ba | 2009 | Annals of Surgery2009，，1： | 2 |
| 8 | The enhanced recovery after surgery (ERAS) pathway for patients undergoing major elective open colorectal surgery: A meta-analysis of randomized controlled trials显示文摘 | Krishna K. Varadhan Keith R. Neal Cornelius H.C. Dejong Kenneth C.H. Fearon Olle Ljungqvist Dileep N. Lobo | 2010 | Clinical Nutrition2010，，4： | 2 |
| 9 | Virtual Liver Resection and Volumetric Analysis of the Future Liver Remnant using Open Source Image Processing Software显示文摘 | Joost R. Vorst Ronald M. Dam Rogier S. A. Stiphout Maartje A. den Broek Ilona H. Hollander Alfons G. H. Kessels Cornelis H. C. Dejong | 2010 | World Journal of Surgery2010，，10： | 2 |
| 10 | Structured Synchronous Implementation of an Enhanced Recovery Program in Elective Colonic Surgery in 33 Hospitals in The Netherlands显示文摘 | Freek Gillissen Christiaan Hoff José M. C. Maessen Bjorn Winkens Jitske H. F. A. Teeuwen Maarten F. Meyenfeldt Cornelis H. C. Dejong | 2013 | World Journal of Surgery2013，，5： | 2 |
| 11 | ESPEN Guidelines on Enteral Nutrition: Gastroenterology显示文摘 | H. Lochs C. Dejong F. Hammarqvist X. Hebuterne M. Leon-Sanz T. Schütz W. van Gemert A. van Gossum L. Valentini H. Lübke S. Bischoff N. Engelmann P. Thul | 2006 | Clinical Nutrition2006，，2： | 2 |
| 12 | Topoisomerase Ⅱ as a target of VM-26 and 4'-(9-Acridinylamino) meth-anesulfonmaniside in atypical multidrug resistant human small cell lung carcinoma cells显示文摘 | Dejong S Kooistra AJ Deveries E | 1993 | Cancer Res1993，53，： | 1 |
| 13 | Use of labelled nitrogen to monitor transition In Nitrogen depondence from storage to current-year uptake in mature Walnut trees显示文摘 | Deng S Weinbaum S A DeJong T M | 1989 | Tree1989，3，： | 1 |
| 14 | Influence of temperature and pressure on asphaltene flocculation 显示文摘 | Hirsehberg A DeJong L N J Schipper B A | 1984 | SPE 112021984，，： | 1 |
| 15 | Computer simulation model for predicting soil water content profiles显示文摘 | Dejong R Cameron D R | 1979 | Soil Sci1979，128，： | 1 |
| 16 | Electron and hole transport in poly( pphenylene vinylene) device 显示文摘 | Blom P W M Dejong M J M Vleggaar J J M | 1996 | Appl Phys Lett1996，68，： | 1 |
| 17 | A comparison of performance of tetra-ploid progenies produced by diploid and their vegetativelydoubled(tetraploid) counterpart parents 显示文摘 | Tai G C C Dejong H | 1997 | Theor Appl Gen-et1997，94，： | 1 |
| 18 | Bio-mediated Soil Improve?ment显示文摘 | Dejong JT Brina MM Brian CM | 2010 | Ecological Engineering2010，36，： | 1 |
| 19 | Micro-RNA-155 in- hibits IFN-gamma signaling in CD4^+ T cells 显示文摘 | Banerjee A Sehambaeh F DeJong CS | 2010 | Eur J Immunol2010，40，1： | 1 |
| 20 | The enhanced recovery after surgery (ERAS) pathway for patients undergoing major elec- tive open coloreetal surgery: a recta-analysis of randomized con- trolled trials显示文摘 | Varadhan KK Neal KR Dejong CH | 2010 | Clin Nutr2010，29，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员