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| 1 | Approaches to establish Q-markers for the quality standards of traditional Chinese medicines显示文摘Traditional Chinese medicine(TCM) has played a pivotal role in maintaining the health of Chinese people and is now gaining increasing acceptance around the global scope. However, TCM is confronting more and more concerns with respect to its quality. The intrinsic 'multicomponent and multitarget' feature of TCM necessitates the establishment of a unique quality and bioactivity evaluation system, which is different from that of the Western medicine. However, TCM is investigated essentially as'herbal medicine' or 'natural product', and the pharmacopoeia quality monographs are actually chemicalmarkers-based, which can ensure the consistency only in the assigned chemical markers, but, to some extent, have deviated from the basic TCM theory. A concept of 'quality marker'(Q-marker), following the 'property-effect-component' theory, is proposed. The establishment of Q-marker integrates multidisciplinary technologies like natural products chemistry, analytical chemistry, bionics, chemometrics,pharmacology, systems biology, and pharmacodynamics, etc. Q-marker-based fingerprint and multicomponent determination conduce to the construction of more scientific quality control system of TCM.This review delineates the background, definition, and properties of Q-marker, and the associated technologies applied for its establishment. Strategies and approaches for establishing Q-marker-based TCM quality control system are presented and highlighted with a few TCM examples. | Wenzhi Yang Yibei Zhang Wanying Wu Luqi Huang Dean Guo Changxiao Liu | 2017 | Acta Pharmaceutica Sinica B2017，7，4： | 51 |
| 2 | Chinese Overseas investment Calls for Perfection of Overseas Investment Insurance显示文摘Overseas investment insurance is a non-profitable insur- ance provided by the government of a state for her enterprises which have invested in the developing countries or areas against political risks.Such a gov- ernmental guarantee system was first established in the United States in the middle of last century.Nowadays most developed countries and some of the developing countries have followed American practices and set up similar systems to encourage their enterprises to make investment in developing areas which are often regarded to be more easily to have political risks.In | Liu Yajun,associateprofessor,tutor of postgraduate,vice dean of the School of International Law of Northwest University of Political Science and Law.His main research orientation includes international trade law and international investment law. | 2008 | China's Foreign Trade2008，，8： | 22 |
| 3 | Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is an aggressive malignancy with extremely skewed ethnic and geographic distributions.Increasing evidence indicates that targeting the tumor microenvironment(TME)represents a promising therapeutic approach in NPC,highlighting an urgent need to deepen the understanding of the complex NPC TME.Here,we generated single-cell transcriptome profiles for 7581 malignant cells and 40,285 immune cells from fifteen primary NPC tumors and one normal sample.We revealed malignant signatures capturing intratumoral transcriptional heterogeneity and predicting aggressiveness of malignant cells.Diverse immune cell subtypes were identified,including novel subtypes such as CLEC9A^+dendritic cells(DCs).We further revealed transcriptional regulators underlying immune cell diversity,and cell–cell interaction analyses highlighted promising immunotherapeutic targets in NPC.Moreover,we established the immune subtype-specific signatures,and demonstrated that the signatures of macrophages,plasmacytoid dendritic cells(pDCs),CLEC9A^+DCs,natural killer(NK)cells,and plasma cells were significantly associated with improved survival outcomes in NPC.Taken together,our findings represent a unique resource providing in-depth insights into the cellular heterogeneity of NPC TME and highlight potential biomarkers for anticancer treatment and risk stratification,laying a new foundation for precision therapies in NPC. | Yu-Pei Chen Jian-Hua Yin Wen-Fei Li Han-Jie Li Dong-Ping Chen Cui-Juan Zhang Jia-Wei Lv Ya-Qin Wang Xiao-Min Li Jun-Yan Li Pan-Pan Zhang Ying-Qin Li Qing-Mei He Xiao-Jing Yang Yuan Lei Ling-Long Tang Guan-Qun Zhou Yan-Ping Mao Chen Wei Ke-Xu Xiong Hong-Bo Zhang Shi-Da Zhu Yong Hou Ying Sun Michael Dean Ido Amit Kui Wu Dong-Ming Kuang Gui-Bo Li Na Liu Jun Ma | 2020 | Cell Research2020，30，11： | 19 |
| 4 | Effect of selected signals of interest on ultrasonic backscattering measurement in cancellous bones显示文摘This study examined how the signals of interest (SOI) effect on the backscattering measurement numerically based on 3-D finite-difference time-domain (FDTD) method. High resolution microstructure mappings of bovine cancellous bones provided by micro-CT were used as the input geometry for simulations. Backscatter coefficient (BSC), integrated backscatter coefficient (IBC) and apparent integrated backscatter (AIB) were calculated with changing the start (L1) and duration (L2) of the SOI. The results demonstrated that BSC and IBC decrease as L1 increases, and AIB decreases more rapidly as L1 increases. The backscattering parameters increase with fluctuations as a function of L2 when L2 is less than 6 mm. However, BSC and IBC change little as L2 continues to increase, while AIB slowly decreases as L2 continues to increase. The results showed how the selections of the SOI effect on the backscattering measurement. An explicit standard for SOI selection was proposed in this study and short L1 (about 1.5 mm) and appropriate L2 (6 mm-12 mm) were recommended for the calculations of backscattering parameters. | LIU ChengCheng HAN HaiJie TA DeAn WANG WeiQi | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，7： | 10 |
| 5 | Status and development of high-power laser facilities at the NLHPLP显示文摘In this paper, we review the status of the multifunctional experimental platform at the National Laboratory of High Power Laser and Physics(NLHPLP). The platform, including the SG-II laser facility, SG-II 9th beam, SG-II upgrade(SG-II UP) facility, and SG-II 5 PW facility, is operational and available for interested scientists studying inertial confinement fusion(ICF) and a broad range of high-energy-density physics. These facilities can provide important experimental capabilities by combining different pulse widths of nanosecond, picosecond, and femtosecond scales. In addition, the SG-II UP facility, consisting of a single petawatt system and an eight-beam nanosecond system, is introduced including several laser technologies that have been developed to ensure the performance of the facility. Recent developments of the SG-II 5 PW facility are also presented. | Jianqiang Zhu Jian Zhu Xuechun Li Baoqiang Zhu Weixin Ma Xingqiang Lu Wei Fan Zhigang Liu Shenlei Zhou Guang Xu Guowen Zhang Xinglong Xie Lin Yang Jiangfeng Wang Xiaoping Ouyang Li Wang Dawei Li Pengqian Yang Quantang Fan Mingying Sun Chong Liu Dean Liu Yanli Zhang Hua Tao Meizhi Sun Ping Zhu Bingyan Wang Zhaoyang Jiao Lei Ren Daizhong Liu Xiang Jiao Hongbiao Huang Zunqi Lin | 2018 | High Power Laser Science and Engineering2018，6，4： | 8 |
| 6 | MicroRNA Expression Signature and Antisense-Mediated Depletion Reveal an Essential Role of MicroRNA in Vascular Neointimal Lesion Formation显示文摘 | Ruirui Ji Yunhui Cheng Junming Yue Jian Yang Xiaojun Liu He Chen David B. Dean Chunxiang Zhang | 2007 | Circulation Research2007，，11： | 4 |
| 7 | Novel C-17 spirost protostane-type triterpenoids from Alisma plantago-aquatica with antiinflammatory activity in Caco-2 cells显示文摘Twenty-one protostane-type triterpenoids with diverse structures, including nine new compounds(1 e9), were isolated from the of Alisma plantago-aquatica Linn. Structurally, alisolides A-F(1 e6), composed of an oxole group coupled to a five-membered ring, represent unusual C-17 spirost protostane-type triterpenoids. Alisolide H(8) is a novel triterpenoid with an unreported endoperoxide bridge. Alisolide I(9) represents the first example of 23,24-acetal triterpenoid. Their structures were elucidated based on spectroscopic analysis, wherein the absolute configurations of 4-6, 8 were further confirmed by the Mo2(OAc)4-induced ECD method. Furthermore, all isolates were evaluated for their inhibitory effects on LPS-induced NO production in Caco-2 cells, and all the compounds showed remarkable inhibitory activities, with IC50 values in the range of 0.76 e38.20 mmol/L. | Qinghao Jin Jianqing Zhang Jinjun Hou Min Lei Chen Liu Xia Wang Yong Huang Shuai Yao Bang Yeon Hwang Wanying Wu Dean Guo | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 3 |
| 8 | Outline of Urban Development in China 2005显示文摘The year of 2005 is important for China, in terms of both completing the accom- plishments of the 10th Five-Year Plan and laying a solid foundation for the further growth during the 11th Five-Year Plan period. Both the central and local govern- | MAO Qizhi, Doctor, Professor, Associate Dean, School of Architecture, Tsinghua University, Beijing, P. R. China. YU Taofang, Doctor, Lecturer, School of Architecture, Tsinghua University, Beijing, P. R. China. LIU Jian | 2007 | China City Planning Review2007，16，1： | 3 |
| 9 | Bleaching effect and nonvolatile holographic storage in doubly doped LiNbO_3:Fe:Cu crystals显示文摘The bleaching effect, i.e. the crystal shows that decoloration after it is illuminated by ultraviolet light, has been observed in congruent LiNbO3:Fe:Cu crystals. Based on this bleaching effect, a new technique including the recording phase by two interfering red beams and fixing phase by both UV light and a coherent red beam has been experimentally investigated to realize nonvolatile holographic storage in LiNbO3:Fe:Cu. The results of proof-of-concept experiments confirm that bleaching effect becomes an alternative physical mechanism for nonvolatile holographic storage with high recording sensitivity and weak light-induced scattering noise. | LIU Dean, LIU Liren, ZHOU Changhe, REN Liyong & LI GuangaoShanghai Institute of Optics and Fine Mechanics, Chinese Academy ofSciences, Shanghai 201800, ChinaDepartment of Physics, Nankai University, Tianjin 300071, China | 2002 | Chinese Science Bulletin2002，47，20： | 3 |
| 10 | Deep reinforcement with spectrum series learning control for a mode-locked fiber laser显示文摘A spectrum series learning-based model is presented for mode-locked fiber laser state searching and switching.The mode-locked operation search policy is obtained by our proposed algorithm that combines deep reinforcement learning and long short-term memory networks.Numerical simulations show that the dynamic features of the laser cavity can be obtained from spectrum series.Compared with the traditional evolutionary search algorithm that only uses the current state,this model greatly improves the efficiency of the mode-locked search.The switch of the mode-locked state is realized by a predictive neural network that controls the pump power.In the experiments,the proposed algorithm uses an average of only 690 ms to obtain a stable mode-locked state,which is one order of magnitude less than that of the traditional method.The maximum number of search steps in the algorithm is 47 in the 16°C–30°C temperature environment.The pump power prediction error is less than 2 mW,which ensures precise laser locking on multiple operating states.This proposed technique paves the way for a variety of optical systems that require fast and robust control. | ZHAN LI SHUAISHUAI YANG QI XIAO TIANYU ZHANG YONG LI LU HAN DEAN LIU XIAOPING OUYANG JIANQIANG ZHU | 2022 | Photonics Research2022，10，6： | 2 |
| 11 | Practice on Urban Regeneration Planning for Traditional Industrial City of Wuhan | LIU Qizhi,PhD,Senior Urban Planner,Registered Urban Planner,Deputy Director of Land Resources and Urban Planning Bureau of Wuhan,Vice Chairman of Academic Committee of Urban Planning Society of China,Wuhan,P.R.China.HE Mei,Senior Urban Planner,Registered Urban Planner,Associate Dean of Wuhan Planning and Design Institute,Wuhan,P.R.China.WANG Yun,Senior Urban Planner,Registered Urban Planner,Associate Chief Planner of Wuhan Planning and Design Institute,Wuhan,P.R.China.ZHU Zhibing,Urban Planner,Registered Urban Planner,Wuhan Planning and Design Institute,Wuhan,P.R.China. | 2011 | China City Planning Review2011，20，3： | 2 |
| 12 | Evolution of low-frequency noise passing through a spatial filter in a high power laser system显示文摘The theoretical model of spatial noise passing through a spatial filter is established in high power laser system under the small signal approximation. The transmission characteristic for a noise signal passing through spatial filters with different magnifications is analyzed by numerical simulation, according to the actual structure of the high power laser system. The results show that the spatial modulation period of low-frequency noise getting through the pinhole will be proportional to the magnification of the spatial filter. When the magnification is less than 1, the safe low-frequency noise will be extruded into the high-frequency region, which is the fast increasing part, and finally develops into the most dangerous part which can damage the optical devices. The conclusion of this research improves the relay imaging theory of a spatial filter and provides an important theoretical basis for a general design of high power laser systems. | SUN PingPing LIU DeAn ZHANG YanLi LI XiaoYan ZHANG Yan ZHU JianQiang | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，3： | 2 |
| 13 | An Ultrasonic Backscatter Instrument for Cancellous Bone Evaluation in Neonates显示文摘Ultrasonic backscatter technique has shown promise as a noninvasive cancellous bone assessment tool. A novel ultrasonic backscatter bone diagnostic(UBBD) instrument and an in vivo application for neonatal bone evaluation are introduced in this study. The UBBD provides several advantages, including noninvasiveness, nonionizing radiation, portability, and simplicity. In this study, the backscatter signal could be measured within 5 s using the UBBD. Ultrasonic backscatter measurements were performed on 467 neonates(268 males and 199 females) at the left calcaneus. The backscatter signal was measured at a central frequency of 3.5 MHz. The delay(T_1) and duration(T_2) of the backscatter signal of interest(SOI) were varied, and the apparent integrated backscatter(AIB), frequency slope of apparent backscatter(FSAB), zero frequency intercept of apparent backscatter(FIAB), and spectral centroid shift(SCS) were calculated. The results showed that the SOI selection had a direct influence on cancellous bone evaluation. The AIB and FIAB were positively correlated with the gestational age(|R| up to 0.45, P < 0.001) when T_1 was short(< 8 μs), while negative correlations(|R| up to 0.56, P < 0.001) were commonly observed for T_1 > 10 μs. Moderate positive correlations(|R| up to 0.45, P < 0.001) were observed for FSAB and SCS with gestational age when T_1 was long(> 10 μs). The T_2 mainly introduced fluctuations in the observed correlation coefflcients. The moderate correlations observed with UBBD demonstrate the feasibility of using the backscatter signal to evaluate neonatal bone status. This study also proposes an explicit standard for in vivo SOI selection and neonatal cancellous bone assessment. | Chengcheng Liu Rong Zhang Ying Li Feng Xu Dean Ta Weiqi Wang | 2015 | Engineering2015，1，3： | 2 |
| 14 | G Protein α Subunit Genes Control Growth, Development, and Pathogenicity of Magnaporthe grisea显示文摘 | LIU S H DEAN R A | 1997 | Mol Plant-Microbe Interact1997，10，9： | 1 |
| 15 | Beach nourishment in China:status and prospects显示文摘 | Cai F Dean R G Liu J | | 0，，32： | 1 |
| 16 | Starch gelatinization under pressure studied by high pressure DSC显示文摘 | Liu H Yu L Dean K | 2009 | Carbohydrate polymers2009，75，3： | 1 |
| 17 | Control of pore geometry,on influencing the mechanical property of porous Hydroxyapatite bioceramic显示文摘 | Liu Dean M O | 1996 | J Mater Sci Lett1996，15，： | 1 |
| 18 | Regioselective oxidation of tetracycline by permanganate through alternating susceptible moiety and increasing electron donating ability显示文摘Permanganate has attracted much attention in wide range of chemistry and particularly in degradation of environmental pollutants.However,few studies have discussed the feature of regioselective reactivity of permanganate with specific moiety of the target compound.Herein,we studied the reaction between permanganate and tetracycline that is an emerging micropollutant with different species containing several electron-rich groups.The second-order rate constants increased from 6.0 to 9.0 and could be quantitatively modeled by considering the speciation of both reactants,yielding kTC0=11.7(mol/L)^-1 sec^-1,kTC-=35.7(mol/L)^-1 sec^-1,kTC2-=43.1(mol/L)^-1 sec^-1 for individual reaction channels.Degradation products were then identified as the hydroxylated and demethylated compounds.The result suggested a rate-limiting step of simple hydroxylation at the phenolic and/or alkene moieties,while the demethylation should be caused by the unavoidably formed manganese oxide via single electron oxidation.This is supported by the DFT calculation,indicating the primary oxidation of phenolic group of TC0 with activation barrier of 44.5 kcal/mol and of alkene group of TC-and TC2-with activation barriers of 44.0 and 43.4 kcal/mol,respectively.This is in agreement with the experimental results,implying the alternation of regioselectivity associated with the deprotonation process.The result was further supported by performing the Fukui function and electrostatic potential analysis,reflecting the more probable site and better electron donating tendency beneficial to the permanganate oxidation. | Xiaohua Jiang William AJefferson Dean Song Hanyang Cheng Fengmin Li Zhimin Qiang Aiqian Zhang Huijuan Liu Jiuhui Qu | 2020 | Journal of Environmental Sciences2020，32，1： | 1 |
| 19 | The effect of ultra-high molecular weight polyethylene wear debris on MG63 osteosarcoma cells in vitro显示文摘 | Dean DD Schwartz Z Liu Y | 1999 | J Bone Joint Surg(Am)1999，81，4： | 1 |
| 20 | Immediate and late outcomes of subclavian artery stenting 显示文摘 | AL-MUBARAK N LIU M W DEAN L S | 1999 | Catheter Cardi- ovasc Interv1999，46，2： | 1 |
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