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| 1 | Air pollutants contribution and control strategies of energy-use related sources in Beijing显示文摘Based on the statistical analysis of emission inventory and ISCST3 model simulation, the emission and ambient concentration contributions of energy-use related sources to the major pollutants of SO2, NOx and PM10 in urban areas of Beijing were analyzed. The SO2 emission contributions of coal burning in power plants, industrial and heating sectors were 49%, 26% and 24% respectively. The vehicle exhaust contributed 74% of the NOx concentration. As to PM10, the industrial sector was the largest emission (28%) and concentration (21%) contributor despite of the fugitive sources. The source emission contributions of VOC and NH3, which greatly influence the generation of secondary pollutants, were discussed as well. This paper also analyzed the control strategies of energy consumption and vehicle sources, based on which the control scenario in 2008 was established and the change of emission and concentration contribution were estimated. The results show that the cleaner energy use, industrial structure improvement, transportation mode modification and single vehicle emission control will greatly improve air quality. The industrial sector will change to the largest contributor of SO2 and as to NOx, vehicle emission control is still important. | HAO Jiming WANG Litao LI Lin HU Jingnan YU Xuechun | 2005 | Science China Earth Sciences2005，48，z2： | 24 |
| 2 | Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Treatment of severe Coronavirus Disease 2019(COVID-19)is challenging.We performed a phase 2 trial to assess the efficacy andsafety of human umbilical cord-mesenchymal stem cells(UC-MScs)to treat severe coViD-19 patients with lung damage,based onour phase 1 data.In this randomized,double-blind,and placebo-controlled trial,we recruited 101 severe coVID-19 patients withlung damage.They were randomly assigned at a 2:1 ratio to receive either UC-MSCs(4×10^(7)cells per infusion)or placebo on day 0,3,and 6.The primary endpoint was an altered proportion of whole lung lesion volumes from baseline to day 28.Other imagingoutcomes,6-minute walk test(6-MWT),maximum vital capacity,diffusing capacity,and adverse events were recorded and analyzed.In all,100 COVID-19 patients were finally received either UC-MSCs in=65)or placebo(n=35).UC-MSCs administrationexerted numerical improvement in whole lung lesion volume from baseline to day 28 compared with the placebo(the mediandifference was-13.31%,95%Cl-29.14%,2.13%,P=0.08).UC-MSCs significanty reduced the proportions of solid componentlesion volume compared with the placebo(median difference:-15.45%;95%CI-30.82%,-0.39%;P=0.043).The 6-MWT showedan increased distance in patients treated with UC-MSCs(difference:27.00 m;95%CI 0.00,57.00;P=0.057).The incidence of adverseevents was similar in the two groups.These results suggest that UC-MSCs treatment is a safe and potentially effective therapeuticapproach for COVID-19 patients with lung damage.A phase 3 trial is required to evaluate effects on reducing mortality andpreventing long-term pulmonary disability. | Lei Shi Hai Huang Xuechun Lu Xiaoyan Yan Xiaojing Jiang Ruonan Xu Siyu Wang Chao Zhang Xin Yuan Zhe Xu Lei Huang Jun-Liang Fu Yuanyuan Li Yu Zhang Wei-Qi Yao Tianyi Liu Jinwen Song Liangliang Sun Fan Yang Xin Zhang Bo Zhang Ming Shi Fanping Meng Yanning Song Yongpei Yu Jiqiu Wen Qi Li Qing Mao Markus Maeurer Alimuddin Zumla Chen Yao Wei-Fen Xie Fu-Sheng Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 13 |
| 3 | Status and development of high-power laser facilities at the NLHPLP显示文摘In this paper, we review the status of the multifunctional experimental platform at the National Laboratory of High Power Laser and Physics(NLHPLP). The platform, including the SG-II laser facility, SG-II 9th beam, SG-II upgrade(SG-II UP) facility, and SG-II 5 PW facility, is operational and available for interested scientists studying inertial confinement fusion(ICF) and a broad range of high-energy-density physics. These facilities can provide important experimental capabilities by combining different pulse widths of nanosecond, picosecond, and femtosecond scales. In addition, the SG-II UP facility, consisting of a single petawatt system and an eight-beam nanosecond system, is introduced including several laser technologies that have been developed to ensure the performance of the facility. Recent developments of the SG-II 5 PW facility are also presented. | Jianqiang Zhu Jian Zhu Xuechun Li Baoqiang Zhu Weixin Ma Xingqiang Lu Wei Fan Zhigang Liu Shenlei Zhou Guang Xu Guowen Zhang Xinglong Xie Lin Yang Jiangfeng Wang Xiaoping Ouyang Li Wang Dawei Li Pengqian Yang Quantang Fan Mingying Sun Chong Liu Dean Liu Yanli Zhang Hua Tao Meizhi Sun Ping Zhu Bingyan Wang Zhaoyang Jiao Lei Ren Daizhong Liu Xiang Jiao Hongbiao Huang Zunqi Lin | 2018 | High Power Laser Science and Engineering2018，6，4： | 8 |
| 4 | 152 W high-power blue diode laser operated at 447 nm显示文摘We demonstrate a high-power blue diode laser operated at 447 nm combining laser diodes using an optical fiber bundle. As many as 127 diode lasers at 447 nm were coupled into 400 μm/0.22 NA fibers using an aspherical lens group with different focus lengths. The bare fibers were mechanically bundled through high temperature ultraviolet adhesive after the coatings of the 127 fibers were stripped. The diameter of the fiber bundle was 6 mm. The total output power of such a bundle was 152 W with electro-optical conversion efficiency of 27.56%and the RMS power instability was less than ±1% within 3 h. | Peng Wu Ling Zhang Haijuan Yu Xiandan Yuan Zhiyan Zhang Pengfei Zhao Shuzhen Zou Chaojian He Yaoyao Qi Yingying Yang Gang Li Xubao Wang Xuechun Lin | 2017 | Journal of Semiconductors2017，38，7： | 4 |
| 5 | The next detectors for gravitational wave astronomy显示文摘This paper focuses on the next detectors for gravitational wave astronomy which will be required after the current ground based detectors have completed their initial observations, and probably achieved the first direct detection of gravitational waves. The next detectors will need to have greater sensitivity, while also enabling the world array of detectors to have improved angular resolution to allow localisation of signal sources. Sect. 1 of this paper begins by reviewing proposals for the next ground based detectors,and presents an analysis of the sensitivity of an 8 km armlength detector, which is proposed as a safe and cost-effective means to attain a 4-fold improvement in sensitivity. The scientific benefits of creating a pair of such detectors in China and Australia is emphasised. Sect. 2 of this paper discusses the high performance suspension systems for test masses that will be an essential component for future detectors, while sect. 3 discusses solutions to the problem of Newtonian noise which arise from fluctuations in gravity gradient forces acting on test masses. Such gravitational perturbations cannot be shielded, and set limits to low frequency sensitivity unless measured and suppressed. Sects. 4 and 5 address critical operational technologies that will be ongoing issues in future detectors. Sect. 4 addresses the design of thermal compensation systems needed in all high optical power interferometers operating at room temperature. Parametric instability control is addressed in sect. 5. Only recently proven to occur in Advanced LIGO, parametric instability phenomenon brings both risks and opportunities for future detectors. The path to future enhancements of detectors will come from quantum measurement technologies. Sect. 6 focuses on the use of optomechanical devices for obtaining enhanced sensitivity, while sect. 7 reviews a range of quantum measurement options. | BLAIR David JU Li ZHAO ChunNong WEN LinQing MIAO HaiXing CAI RongGen GAO JiangRui LIN XueChun LIU Dong WU Ling-An ZHU ZongHong HAMMOND Giles PAIK Ho Jung FAFONE Viviana ROCCHI Alessio BLAIR Carl MA YiQiu QIN JiaYi PAGE Michael | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，12： | 3 |
| 6 | Progress of the injection laser system of SG-Ⅱ显示文摘A high power laser system was used to drive the ignition of inertial confinement fusion(ICF), of which the high energy,the uniform focal spot, the accurate laser waveform, and the synchronization between the laser beams are key parameters.To accomplish this, global laser characteristics control should be assured, which was the main purpose of the injection laser system. In this paper, the key technological progress involved in the improvement of the performance of the injection laser of SG-II is reported, including frequency domain control, time domain control, near-field spatial shaping, preamplifier technology, and the optical parametric chirped pulse amplification pump source. | Wei Fan Youen Jiang Jiangfeng Wang Xiaochao Wang Dajie Huang Xinghua Lu Hui Wei Guoyang Li Xue Pan Zhi Qiao Chao Wang He Cheng Peng Zhang Wenfa Huang Zhuli Xiao Shengjia Zhang Xuechun Li Jianqiang Zhu Zunqi Lin | 2018 | High Power Laser Science and Engineering2018，6，2： | 3 |
| 7 | A New Ductile Fracture Criterion and Its Application to the Prediction of Forming Limit in Deep Drawing显示文摘With considering the influence of equivalent plastic strain on void-damage and taking Lemaitre damage equivalent stress as plastic potential, based on continuous damage mechanics theory, a new criterion for ductile fracture is derived. The two key material constants in the criterion are determined by the combination of tension tests with FE (finite element) simulation. On the basis of the values of stress and strain calculated from commercial finite element software, the forming limit in cylindrical deep drawing of annealed aluminum alloy LY12(M) is predicted by means of the new ductile fracture criterion. Experiments verify that the predicted results are in agreement with the experimental ones. Hence, it is reliable to predict the forming limit in deep drawing by means of the new ductile fracture criterion. | Yuying YANG Zhongqi YU Xuechun LI Zhenzhong SUN | 2003 | Journal of Materials Science & Technology2003，19，z1： | 3 |
| 8 | p53 deficiency-induced Smad1 upregulation suppresses tumorigenesis and causes chemoresistance in colorectal cancers显示文摘The DNA damage response helps to maintain genome integrity,suppress tumorigenesis,and mediate the effects of radiotherapy and chemotherapy.Our previous studies have shown that Smad1 is upregulated and activated by Atm in DNA damage response,which can further bind to p53 and promote p53 stabilization.Herewe report another aspect of the interplay between p53 and Smad1.Comparison of rectal tumor against paired paraneoplastic specimens and analysis of>500 colorectal tumors revealed that Smad1 was upregulated in tumor samples,which was attributable to p53 defects.Using MEFs as a model,we found that knockdown of the elevated Smad1 in p532/2 MEFs promoted cell proliferation,E1A/Ras-induced cell transformation,and tumorigenesis.Mechanistic studies suggest that elevated Smad1 and momentary activation inhibit cell proliferation by upregulating p57Kip2 and enhancing Atm–Chk2 activation.Surprisingly,elevated Smad1 appears to have a negative effect on chemotherapy,as colorectal tumors,primary cancer cells,and cell lines with Smad1 knockdown all showed an increase in chemosensitivity,which could be attributable to elevated p57Kip2.These findings underscore the significance of Smad1–p53 interaction in tumor suppression and reveal an unexpected role for Smad1 in chemoresistance of colorectal cancers. | Xinsen Ruan Qiao Zuo Hao Jia Jenny Chau Jinlin Lin Junping Ao Xuechun Xia Huijuan Liu Samy LHabib Chuangang Fu Baojie Li | 2015 | Journal of Molecular Cell Biology2015，7，2： | 2 |
| 9 | The circFASN/miR-33a pathway participates in tacrolimusinduced dysregulation of hepatic triglyceride homeostasis显示文摘Dyslipidemia exhibits a high incidence after liver transplantation,in which tacrolimus,a widely used immunosuppressant,plays a fundamental role.MicroRNAs and related circRNAs represent a class of noncoding RNAs that have been recognized as important regulators of genes associated with lipid metabolism.However,their transcriptional activities and functional mechanisms in tacrolimus-related dyslipidemia remain unclear.In this study,we observed that tacrolimus could induce triglyceride accumulation in hepatocytes by stimulating sterol response element-binding proteins(SREBPs)and miR-33a.Our in silico and experimental analyses identified miR-33a as a direct target of circFASN.Tacrolimus could downregulate circFASN and result in elevated miR-33a in vivo and in vitro.Overexpression of circFASN or silencing of miR-33a decreased the promoting effects of tacrolimus on triglyceride accumulation.Clinically,the incidence of dyslipidemia in liver transplant recipients with elevated serum miR-33a after liver transplantation was higher than that in patients without elevated serum miR-33a(46.3%vs.18.8%p=0.012,n=73).Our results showed that the circFASN/miR-33a regulatory system plays a distinct role in tacrolimus-induced disruption of lipid homeostasis.MiR-33a is likely a risk factor for tacrolimus-related dyslipidemia,providing a potential therapeutic target to combat tacrolimus-induced dyslipidemia after liver transplantation. | Chenzhi Zhang Kangchen Chen Rongli Wei Guanghan Fan Xuechun Cai Li Xu Beini Cen Jianguo Wang Haiyang Xie Shusen Zheng Xiao Xu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 10 | Wavefront control of laser beam using optically addressed liquid crystal modulator显示文摘An optically addressed liquid crystal modulator for wavefront control of 1053 nm laser beam is reported in this paper.Its working principle, control method and spatial phase modulation capability are mainly introduced. A new method of measuring the relationship between gray level and phase retardation is proposed. The rationality of the curve is further confirmed by designing special experiments. According to the curve, several spatial phase distributions have been realized by this home-made device. The results show that, not only the maximum phase retardation is larger than2π for 1053 nm wavelength, but also the control accuracy is high. Compared with the liquid crystal on silicon type spatial light modulator, this kind of modulator has the advantages of generating smooth phase distribution and avoiding the black-matrix effect. | Dajie Huang Wei Fan He Cheng Gang Xia Lili Pei Xuechun Li Zunqi Lin | 2018 | High Power Laser Science and Engineering2018，6，2： | 2 |
| 11 | PKC inhibition is involved in trichosanthin -induced apoptosis in human chronic myeloid leukemia cell line K562 显示文摘 | Jie Li Xuechun Xia Huiling Nie | 2007 | Biochimica et Biophysica Acta2007，1770，： | 1 |
| 12 | Trichosanthin induced apoptosis in HE - 60 ceils via mitochondrial and endoplasmic reticulum stress signaling pathway 显示文摘 | Jie Li Xuechun Xia Huiling Nie | 2007 | Biochimica et Biophysiea Acta2007，1770，： | 1 |
| 13 | A novel blue light generation by frequency doubling of a diode-pumped Nd:YAG thin disk laser显示文摘 | Lin Xuechun Li Ruining | 2004 | Optics Communications2004，237，： | 1 |
| 14 | IEEE T Plasma SCI显示文摘 | Li XueChun Wang You-Nian | 2007 | 35(5) : 1489 - 14952007，35，5： | 1 |
| 15 | Compensation method for performance degradation of optically addressed spatial light modulator induced by CW laser显示文摘In this paper,we propose an effective method to compensate for the performance degradation of optically addressed spatial light modulators(OASLMs).The thermal deposition problem usually leads to the on-off ratio reduction of amplitude OASLM,so it is difficult to achieve better results in high-power laser systems.Through the analysis of the laser-induced temperature rise model and the liquid crystal layer voltage model,it is found that reducing the driving voltage of the liquid crystal light valve and increasing the driving current of the optical writing module can compensate for the decrease of on-off ratio caused by temperature rise.This is the result of effectively utilizing the photoconductive effect of Bi_(12)SiO_(20)(BSO)crystal.The experimental results verify the feasibility of the proposed method and increase the laser withstand power of amplitude-only OASLM by about a factor of 2.5. | Tongyao Du Dajie Huang He Cheng Wei Fan Zhibo Xing Xuechun Li Jianqiang Zhu | 2022 | High Power Laser Science and Engineering2022，10，1： | 1 |
| 16 | Improvements in long-term output energy performance of Nd:glass regenerative amplifiers显示文摘Optical damages, which severely degrade the output energy performance of Nd:glass regenerative amplifiers, are discussed in detail in this paper. By a series of experiments, it has been confirmed that these damages result from laser-induced contamination. Based on this work, several improvements are made to boost output energy performance of the regenerative amplifier. The output energy of the regenerative amplifier after improvements declines 4% after 1000 h of operation, much less than it used to, 60% after 560 h of operation. | Peng Zhang Youen Jiang Jiangfeng Wang Wei Fan Xuechun Li Jianqiang Zhu | 2017 | High Power Laser Science and Engineering2017，5，4： | 1 |
| 17 | Effect of the material-hardening mode on the springback simulation accuracy of V-free bending 显示文摘 | Li Xuechun Yang Yuying Yongzhi Wang | 2002 | Journal of Materials Processing Technology2002，123，： | 1 |
| 18 | Pathogenesis of premature coronary artery disease:Focus on risk factors and genetic variants显示文摘The development of premature coronary artery disease(PCAD)is dependent on both genetic predisposition and traditional risk factors.Strategies for unraveling the genetic basis of PCAD have evolved with the advent of modern technologies.Genome-wide association studies(GWASs)have identified a considerable number of common genetic variants that are associated with PCAD.Most of these genetic variants are attributable to lipid and blood pressure-related single-nucleotide polymorphisms(SNPs).The genetic variants that predispose individuals to developing PCAD may depend on race and ethnicity.Some characteristic genetic variants have been identified in Chinese populations.Although translating this genetic knowledge into clinical applications is still challenging,these genetic variants can be used for CAD phenotype identification,genetic prediction and therapy.In this article we will provide a comprehensive review of genetic variants detected by GWASs that are predicted to contribute to the development of PCAD.We will highlight recent findings regarding CAD-related genetic variants in Chinese populations and discuss the potential clinical utility of genetic variants for preventing and managing PCAD. | Haiming Wang Zifan Liu Junjie Shao Min Jiang Xuechun Lu Lejian Lin Lin Wang Qiang Xu Haomin Zhang Xin Li Jingjing Zhou Yundai Chen Ran Zhang | 2022 | Genes & Diseases2022，9，2： | 1 |
| 19 | Maternal genetic history of southern East Asians over the past 12,000 years显示文摘Southern East Asia,including Guangxi and Fujian provinces in China,is home to diverse ethnic groups,languages,and cultures.Previous studies suggest a high complexity regarding population dynamics and the history of southern East Asians.However,large-scale genetic studies on ancient populations in this region are hindered by limited sample preservation.Here,using highly efficient DNA capture techniques,we obtain 48 complete mitochondrial genomes of individuals from Guangxi and Fujian in China and reconstruct their maternal genetic history over the past 12,000 years.We find a strong connection between southern East Asians dating to~12,000-6000 years ago and present-day Southeast Asians.In addition,stronger genetic affinities to northern East Asians are observed in historical southern East Asians than Neolithic southern East Asians,suggesting increased interactions between northern and southern East Asians over time.Overall,we reveal dynamic connections between ancient southern East Asians and populations located in surrounding regions,as well as a shift in maternal genetic structure within the populations over time. | Yalin Liu Tianyi Wang Xichao Wu Xuechun Fan Wei Wang Guangmao Xie Zhen Li Qingping Yang Peng Cao Ruowei Yang Feng Liu Qingyan Dai Xiaotian Feng Wanjing Ping Bo Miao Yun Wu Yichen Liu Qiaomei Fu | 2021 | Journal of Genetics and Genomics2021，48，10： | 1 |
| 20 | Nitrogen vacancies enriched Ce-doped Ni_(3)N hierarchical nanosheets triggering highly-efficient urea oxidation reaction in urea-assisted energy-saving electrolysis显示文摘Urea oxidation reaction (UOR),which has favorable thermodynamic energy barriers compared with oxygen evolution reaction (OER),can provide more cost-effective electrons for the renewable energy systems,but is trapped by its sluggish UOR kinetics and intricate reaction intermediates formation/desorption process.Herein,we report a novel and effective electrocatalyst consisting of carbon cloth supported nitrogen vacancies-enriched Ce-doped Ni_(3)N hierarchical nanosheets (Ce-Ni_(3)N @CC) to optimize the flat-footed UOR kinetics,especially the stiff rate-determine CO_(2)desorption step of UOR.Upon the introduction of valance state variable Ce,the resultant nitrogen vacancies enriched Ce-Ni_(3)N @CC exhibits an enhanced UOR performance where the operation voltage requires only 1.31 V to deliver the current density of 10 mA cm^(-2),which is superior to that of Ni_(3)N @CC catalyst (1.36 V) and other counterparts.Density functional theory (DFT) results demonstrate that the incorporation of Ce in Ni_(3)N lowers the formation energy of nitrogen vacancies,resulting in rich nitrogen vacancies in Ce-Ni_(3)N @CC.Moreover,the nitrogen vacancies together with Ce doping optimize the local charge distribution around Ni sites,and balance the adsorption energy of CO_(2)in the rate-determining step (RDS),as well as affect the initial adsorption structure of urea,leading to the superior UOR catalytic performance of Ce-Ni_(3)N @CC.When integrating the Ce-Ni_(3)N catalyst in UOR//HER and UOR//CO_(2)R flow electrolyzer,both of them perform well with low operation voltage and robust long-term stability,proofing that the thermodynamically favorable UOR can act as a suitable substitute anodic reaction compared with that of OER.Our findings here not only provide a novel UOR catalyst but also offer a promising design strategy for the future development of energy-related devices. | Meng Li Xiaodong Wu Kun Liu Yifan Zhang Xuechun Jiang Dongmei Sun Yawen Tang Kai Huang Gengtao Fu | 2022 | Journal of Energy Chemistry2022，31，6： | 1 |
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