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| 1 | Deletion of IFT20 in early stage T lymphocyte differentiation inhibits the development of col agen-induced arthritis显示文摘IFT20 is the smallest member of the intraflagellar transport protein(IFT) complex B. It is involved in cilia formation. Studies of IFT20 have been confined to ciliated cells. Recently, IFT20 was found to be also expressed in non-ciliated T cells and have functions in immune synapse formation and signaling in vitro. However, how IFT20 regulates T-cell development and activation in vivo is still unknown. We deleted the IFT20 gene in early and later stages of T-cell development by crossing IFT20flox/flox(IFT20f/f) mice with Lck-Cre and CD4-Cre transgenic mice, and investigated the role of IFT20 in T-cell maturation and in the development of T cell-mediated collagen-induced arthritis(CIA). We found that both Lck-Cre/IFT20f/f and CD4-Cre/IFT20f/f mice were indistinguishable from their wild-type littermates in body size, as well as in the morphology and weight of the spleen and thymus. However, the number of CD4- and CD8-positive cells was significantly lower in thymus and spleen in Lck-Cre/IFT20f/f mice. Meanwhile, the incidence and severity of CIA symptoms were significantly decreased, and inflammation in the paw was significantly inhibited in Lck-Cre/IFT20f/f mice compared to Lck-Cre/IFT201/1littermates. Deletion IFT20 in more mature T cells of CD4-Cre/IFT20f/f mice had only mild effects on the development of T cells and CIA. The expression of IL-1b, IL-6 and TGF-b1 were significantly downregulated in the paw of Lck-Cre/IFT20f/f mice, but just slight decreased in CD4-Cre/IFT20f/f mice. These results demonstrate that deletion of IFT20 in the early stage of T-cell development inhibited CIA development through regulating T-cell development and the expression of critical cytokines. | Xue Yuan Lee Ann Garrett-Sinha Debanjan Sarkar Shuying Yang | 2014 | Bone Research2014，2，4： | 4 |
| 2 | Correlating mode-I fracture toughness and mechanical properties of heat-treated crystalline rocks显示文摘For the effect of thermal treatment on the mode-I fracture toughness(FT), three crystalline rocks(two basalts and one tonalite) were experimentally investigated. Semi-circular bend specimens of the rocks were prepared following the method suggested by the International Society for Rock Mechanics(ISRM)and were treated at various temperatures ranging from room temperature(25 ℃) to 600 ℃. Mode-I FT was correlated with tensile strength(TS), ultrasonic velocities, and Young's modulus(YM). Additionally,petrographic and X-ray diffraction analyses were carried out to find the chemical changes resulting from the heat treatment. Further, scanning electron microscopy(SEM) was conducted to observe the micro structural changes when subjected to high temperatures. These experiments demonstrate that heat treatment has a strong negative impact on the FT and mechanical properties of the rocks. From room temperature to 600 ℃, mode-I FT values of massive basalt, giant plagioclase basalt, and tonalite were reduced by nearly 52%, 68%, and 64%, respectively. Also, at all temperature levels, FT and mechanical properties are found to be exponentially correlated. However, the exact nature of the relationship mainly depends on rock type. Besides, TS was found to be a better indicator of degradation degree than the mode-I FT. SEM images show that micro crack density and structural disintegration of the mineral grains increase with temperature. These physical changes confirm the observed reduction in the stiffness of heat-treated crystalline rocks. | Mayukh Talukdar Debanjan Guha Roy T.N.Singh | 2018 | Journal of Rock Mechanics and Geotechnical Engineering2018，10，1： | 3 |
| 3 | Observation of Resistive Switching Memory by Reducing Device Size in a New Cr/CrO_x/TiO_x/TiN Structure显示文摘The resistive switching memory characteristics of 100 randomly measured devices were observed by reducing device size in a Cr/Cr Ox/Ti Ox/Ti N structure for the first time.Transmission electron microscope image confirmed a viahole size of 0.4 lm.A 3-nm-thick amorphous Ti Oxwith 4-nm-thick polycrystalline Cr Oxlayer was observed.A small 0.4-lm device shows reversible resistive switching at a current compliance of 300 l A as compared to other larger size devices(1–8 lm)owing to reduction of leakage current through the Ti Oxlayer.Good device-to-device uniformity with a yield of[85%has been clarified by weibull distribution owing to higher slope/shape factor.The switching mechanism is based on oxygen vacancy migration from the Cr Oxlayer and filament formation/rupture in the Ti Oxlayer.Long read pulse endurance of[105cycles,good data retention of 6 h,and a program/erase speed of 1 ls pulse width have been obtained. | Debanjan Jana Subhranu Samanta Sourav Roy Yu Feng Lin Siddheswar Maikap | 2015 | Nano-Micro Letters2015，7，4： | 2 |
| 4 | Stud- ies on structural insight of 2 amino-6-arylsulfonylben- zonitrile derivatives as anti HIV agents显示文摘 | Utpal Chandra De Sudhan Debnath Debanjan Sen | 2014 | International Journal of Research in Pharmacy and Chemistry2014，4，3： | 1 |
| 5 | Engineered cell homing显示文摘 | Debanjan S JoelA S Joseph AP | 2011 | Blood2011，118，25： | 1 |
| 6 | Innovations' origins: When, by whom, and how are radical innovations de- veloped? 显示文摘 | Peter N G Rachel S Debanjan M | 2009 | Marketing Science2009，28，1： | 1 |
| 7 | A simple chemical synthesis of nanocrystalline AFe2O4 (A=Fe, Ni, Zn): An efficient catalyst for selective oxidation of styrene显示文摘 | DEBANJAN G BABITA B SUNKARA V | 2005 | Journal of Molecular Catalysis A: Chemical2005，242，1： | 1 |
| 8 | The Optical Network Control Plane: State of the Standards and Deployment 显示文摘 | Debanjan Saha IBM Research Bala Rajagopalan | 2003 | Communications Magazine IEEE2003，41，8： | 1 |
| 9 | Golder,Whose Culture Matters?Near-Market Knowledge and Its Impact on Foreign Market Entry Timing显示文摘 | Mitra Debanjan and Peter N | 2002 | Journal of Marketing Research2002，，： | 1 |
| 10 | Protection, Restoration, and Disaster recovery显示文摘 | James M Debanjan S Satish T K | 2004 | IEEE Network2004，18，2： | 1 |
| 11 | IP-optical integration 显示文摘 | DEBANJAN S NASIR G | 2001 | IEEE Network2001，15，4： | 1 |
| 12 | ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development显示文摘 | Hayato Nakagawa Atsushi Umemura Koji Taniguchi Joan Font-Burgada Debanjan Dhar Hisanobu Ogata Zhenyu Zhong Mark A. Valasek Ekihiro Seki Juan Hidalgo Kazuhiko Koike Randal J. Kaufman Michael Karin | 2014 | Cancer Cell2014，，3： | 1 |
| 13 | Protection,restoration,and disaster recovery显示文摘 | JAMES M DeBANJAN S SATISH T K | 2004 | IEEE Network2004，18，2： | 1 |
| 14 | A microfluidic device for continuous manipulation of biological cells using dielectrophoresis显示文摘 | Debanjan Das Karabi Biswas Soumen Das | 2013 | Medical Engineering and Physics2013，，： | 1 |
| 15 | Protection,restoration, and disaster recovery 显示文摘 | Manchester James Saha Debanjan Tripathi Satish K | 2004 | IEEE Network2004，18，2： | 1 |
| 16 | IP over optical networks: architectural aspects显示文摘 | BALA RAJAGOPALAN DIMITRIOS PENDARAKIS DEBANJAN SAHA | 2000 | IEEE Communications Magazine2000，38，9： | 1 |
| 17 | Protection,restoration,and disaster recovery显示文摘 | Manchester James Saha Debanjan Tripathi Satish K | 2004 | IEEE Network2004，18，2： | 1 |
| 18 | Cold adaptation strategy of psychrophilic bacteria:an in-silico analysis of isocitrate dehydrogenase显示文摘Non-specific electrostatics is crucial for structure and stability;recently,it has been argued that psychrophilic proteins may also utilize specific electrostatic interactions.Do psychrophilic proteins increase the number of salt bridges for cold adaptation?Are there any changes that occur in their sequence,which helps them to adapt in an extreme environment?Do intra-protein interactions affect their stability?Is there any special type of intra-protein interaction present in psychrophilic protein structure?This study will give all those answers.Sequences(n~100)and structures of psychrophilic isocitrate dehydrogenase and mesophilic isocitrate dehydrogenase extracted from databases.Sequences had been analyzed in BLOCK and non-BLOCK format.The sequences of psychrophiles and mesophiles create two separate clades.The number of charged and uncharged polar residues is very much high in psychrophilic proteins.The formation of long network aromatic-aromatic interactions and network aromatic-sulfur interactions are very crucial for psychrophilic protein stability.Identification of these types of interactions is also a novelty of this study.Favorable mutation of charged residues with high-energy contributions affects the protein stability.This study will help in protein engineering. | Debanjan Mitra Pradeep Kr.Das Mohapatra | 2021 | Systems Microbiology and Biomanufacturing2021，1，4： | 1 |
| 19 | Pd on amine-terminated ferrite nanoparticles:A complete magnetically recoverable facile catalyst for hydrogenation reactions显示文摘 | Debanjan Guin Babita Baruwati Sunkara V Manorama | 2007 | Organic Letters2007，9，7： | 1 |
| 20 | Identification of Liver Cancer Progenitors Whose Malignant Progression Depends on Autocrine IL-6 Signaling显示文摘 | Guobin He Debanjan Dhar Hayato Nakagawa Joan Font-Burgada Hisanobu Ogata Yuhong Jiang Shabnam Shalapour Ekihiro Seki Shawn E. Yost Kristen Jepsen Kelly A. Frazer Olivier Harismendy Maria Hatziapostolou Dimitrios Iliopoulos Atsushi Suetsugu Robert M. Hoffm | 2013 | Cell2013，，： | 1 |
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