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| 1 | Alcoholic liver disease: A current molecular and clinical perspective显示文摘Heavy alcohol use is the cause of alcoholic liver disease(ALD).The ALD spectrum ranges from alcoholic steatosis to steatohepatitis,fibrosis,and cirrhosis.In Western countries,approximately 50%of cirrhosis-related deaths are due to alcohol use.While alcoholic cirrhosis is no longer considered a completely irreversible condition,no effective anti-fibrotic therapies are currently available.Another significant clinical aspect of ALD is alcoholic hepatitis(AH).AH is an acute inflammatory condition that is often comorbid with cirrhosis,and severe AH has a high mortality rate.Therapeutic options for ALD are limited.The established treatment for AH is corticosteroids,which improve short-term survival but do not affect long-term survival.Liver transplantation is a curative treatment option for alcoholic cirrhosis and AH,but patients must abstain from alcohol use for 6 months to qualify.Additional effective therapies are needed.The molecular mechanisms underlying ALD are complex and have not been fully elucidated.Various molecules,signaling pathways,and crosstalk between multiple hepatic and extrahepatic cells contribute to ALD progression.This review highlights established and emerging concepts in ALD clin-icopathology,their underlying molecular mechanisms,and current and future ALD treatment options. | Koichiro Ohashi Michael Pimienta Ekihiro Seki | 2018 | Liver Research2018，2，4： | 15 |
| 2 | Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice显示文摘 | Kouichi Miura Yuzo Kodama Sayaka Inokuchi Bernd Schnabl Tomonori Aoyama Hirohide Ohnishi Jerrold M. Olefsky David A. Brenner Ekihiro Seki | 2010 | Gastroenterology2010，，1： | 3 |
| 3 | Role of Toll-Like Receptors and Their Downstream Molecules in the Development of Nonalcoholic Fatty Liver Disease显示文摘 | Kouichi Miura Ekihiro Seki Hirohide Ohnishi David A. Brenner Ian Nicholas Crispe | 2011 | Gastroenterology Research and Practice2011，，： | 3 |
| 4 | Hepatic Stellate Cells Secrete Angiopoietin 1 That Induces Angiogenesis in Liver Fibrosis显示文摘 | Kojiro Taura Samuele De Minicis Ekihiro Seki Etsuro Hatano Keiko Iwaisako Christoph H. Osterreicher Yuzo Kodama Kouichi Miura Iwao Ikai Shinji Uemoto David A. Brenner | 2008 | Gastroenterology2008，，5： | 3 |
| 5 | Current Views of Toll-Like Receptor Signaling Pathways显示文摘 | Masahiro Yamamoto Kiyoshi Takeda Ekihiro Seki | 2010 | Gastroenterology Research and Practice2010，，： | 3 |
| 6 | Recent advancement of molecular mechanisms of liver fibrosis显示文摘 | Ekihiro Seki David A. Brenner | 2015 | J Hepatobiliary Pancreat Sci2015，，： | 2 |
| 7 | Toll‐like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice显示文摘 | Kouichi Miura Ling Yang Nico van Rooijen David A. Brenner Hirohide Ohnishi Ekihiro Seki | 2013 | Hepatology2013，，2： | 2 |
| 8 | Toll-Like Receptor Signaling and Liver Fibrosis显示文摘 | Tomonori Aoyama Yong-Han Paik Ekihiro Seki Ian Nicholas Crispe | 2010 | Gastroenterology Research and Practice2010，，： | 2 |
| 9 | Role and cellu- lar source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis 显示文摘 | Samuele DM Ekihiro S Paik YH | 2010 | Hepatology2010，52，4： | 1 |
| 10 | Nrf2 Activation Protects the Liver From Ischemia/Reperfusion Injury in Mice显示文摘 | Kazuhiro Kudoh Hiroshi Uchinami Masato Yoshioka Ekihiro Seki Yuzo Yamamoto | 2014 | Annals of Surgery2014，，1： | 1 |
| 11 | Selective inacti- vation of NF-KB in the liver using NF-KB decoy suppresses CC14-induced liver injury and fibrosis 显示文摘 | GAKUHEI S YUJI I EKIHIRO S | 2007 | Am J Physiol Gastrointest Liver Physiol2007，293，3： | 1 |
| 12 | The TLR4/TRIF-Mediated Activation of NLRP3 Inflammasome Underlies Endotoxin-Induced Liver Injury in Mice显示文摘 | Hiroko Tsutsui Michiko Imamura Jiro Fujimoto Kenji Nakanishi Ekihiro Seki | 2010 | Gastroenterology Research and Practice2010，，： | 1 |
| 13 | CX3CL1‐CX3CR1 interaction prevents carbon tetrachloride‐induced liver inflammation and fibrosis in mice显示文摘 | Tomonori Aoyama Sayaka Inokuchi David A. Brenner Ekihiro Seki | 2010 | Hepatology2010，，4： | 1 |
| 14 | Toll-like receptor signaling in liver regeneration,fibrosis and carcinogenesis显示文摘 | EKIHIRO S EEK JP JIRO F | 2011 | Hepatol Res2011，41，： | 1 |
| 15 | Toll-Like Receptor Signaling in the Liver显示文摘 | Robert F. Schwabe Ekihiro Seki David A. Brenner | 2006 | Gastroenterology2006，，6： | 1 |
| 16 | Toll-Like Receptor 3 in Liver Diseases显示文摘 | Shi Yin Bin Gao Ekihiro Seki | 2010 | Gastroenterology Research and Practice2010，，： | 1 |
| 17 | Lipepelysaccharide-in-duced IL-18 secretion from murine Kuppffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-β显示文摘 | Ekihiro S Hiroko T Hiroki N | 2001 | J Immunol2001，166，： | 1 |
| 18 | Gastric Bypass Surgery Improves Metabolic and Hepatic Abnormalities Associated With Nonalcoholic Fatty Liver Disease显示文摘 | Samuel Klein Bettina Mittendorfer J. Christopher Eagon Bruce Patterson LaFaine Grant Nikki Feirt Ekihiro Seki David Brenner Kevin Korenblat Jennifer McCrea | 2006 | Gastroenterology2006，，6： | 1 |
| 19 | Transforming Growth Factor–β Signaling in Hepatocytes Promotes Hepatic Fibrosis and Carcinogenesis in Mice With Hepatocyte-Specific Deletion of TAK1显示文摘 | Ling Yang Sayaka Inokuchi Yoon Seok Roh Jingyi Song Rohit Loomba Eek Joong Park Ekihiro Seki | 2013 | Gastroenterology2013，，5： | 1 |
| 20 | Selective inactivation of NF-KB in the liver using NF-KB decoy suppresses CCl4-induced liver injury and fibrosis显示文摘 | Gakuhei Son Yuji Iimuro Ekihiro Seki | 2007 | Am J Physiol Gastrointest Liver Physiol2007，293，： | 1 |
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