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5篇 您的检索式:作者名="Debbie Trinder"
    题名 作者 年代 出处 被引量
1Liver iron transport显示文摘肝在铁新陈代谢起一个中央作用。它是为铁的主要存储地点并且也表示涉及铁运输和铁动态平衡的规定的分子的一个复杂范围。与肝的铁运输或规定联系的越来越多的基因被识别了。这些包括转铁蛋白受体(TFR1 并且 2 ) , ferrireductase (STEAP3 ) ,运输 ers 二价的金属 transporter-1 (DMT1 ) 和象 haemochromatosis 蛋白质, HFE 和 haemojuvelin (HJV ) 一样的 ferroportin (FPN ) ,它正在表明分子。许多也这些基因参予铁集中于肝的肽 hepcidin 的规章的小径。然而,我们开始仍然仅仅正在理解在肝之间的复杂相互作用熨运输和铁动态平衡。这评论在铁运输和铁动态平衡的规定构画出我们铁新陈代谢和他们的角色的分子的当前的知识。Ross M Graham Anita CG Chua Carly E Herbison John K Olynyk Debbie Trinder 2007World Journal of Gastroenterology2007,13,35:12
2Iron:An emerging factor in colorectal carcinogenesis显示文摘The carcinogenic potential of iron in colorectal cancer(CRC) is not fully understood.Iron is able to undergo reduction and oxidation,making it important in many physiological processes.This inherent redox property of iron,however,also renders it toxic when it is present in excess.Iron-mediated generation of reactive oxygen species via the Fenton reaction,if uncontrolled,may lead to cell damage as a result of lipid peroxidation and oxidative DNA and protein damage.This may promote carcinogenesis through increased genomic instability,chromosomal rearrangements as well as mutations of proto-oncogenes and tumour suppressor genes. Carcinogenesis is also affected by inflammation which is exacerbated by iron.Population studies indicate an association between high dietary iron intake and CRC risk.In this editorial,we examine the link betweeniron-induced oxidative stress and inflammation on the pathogenesis of CRC.Anita CG Chua Borut Klopcic Ian C Lawrance John K Olynyk Debbie Trinder 2010World Journal of Gastroenterology2010,16,6:3
3Athletic induced iron deficiency: new insights into the role of inflammation, cytokines and hormones显示文摘Peter Peeling Brian Dawson Carmel Goodman Grant Landers Debbie Trinder 2008European Journal of Applied Physiology2008,,4:1
4Hepatic iron loading in mice increases cholesterol biosynthesis显示文摘Ross M. Graham Anita C. G. Chua Kim W. Carter Roheeth D. Delima Daniel Johnstone Carly E. Herbison Martin J. Firth Rebecca O’Leary Elizabeth A. Milward John K. Olynyk Debbie Trinder 2010Hepatology2010,,2:1
5The Regulation of Cellular Iron Metabolism显示文摘Anita C. G. Chua Ross M. Graham Debbie Trinder John K. Olynyk 2007Critical Reviews in Clinical Laboratory Sciences (-)2007,,5:1
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