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| 1 | A human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification显示文摘MLL-AF4 熔化基因是在在婴儿的高风险的尖锐成淋巴细胞的白血病的一个特点 genomic 错误。尽管 MLL-AF4 在人的开发期间出生前地产生,这很好被建立,它在在 utero 的造血的开发的效果仍然保持未经勘探。我们创造了一个人特定的细胞的系统在 MLL-AF4-expressing 人的胚胎的干细胞(hESCs ) 学习早 hemato-endothelial 开发。介绍的功能的研究,同种细胞的分析和基因表示表明在 hESCs 的 MLL-AF4 的那表情有 phenotypic,功能并且基因表示影响。MLL-AF4 在 hESCs 充当全球 transcriptional 使活跃之物和 homeobox 基因表示的一个积极管理者。机能上地, MLL-AF4 从 hESCs 提高 hemogenic 先锋的说明,但是强烈损害进一步造血的承诺赞成 endothelial 房间命运。MLL-AF4 hESCs transcriptionally 被告知向对 endothelial 成熟敏感的 hemogenic 先锋区分,由联系到 vascular-endothelial 功能和早造血作用的主人基因的显著 upregulation 思考了。而且,我们报导那 MLL-AF4 表情不是足够的转变导出 hESC 的造血的房间。这个工作说明 hESCs 怎么可以提供唯一的卓见进人的开发并且推进我们理解白血病的熔化基因,知道出生前地产生,调整人的胚胎的造血的说明。 | Clara Bueno Rosa Montes Gustavo J Melen Verdnica Ramos-Mejia Pedro J Real Ver6nica Ayllo'n Laura Sanchez Gertmdis Ligero Inmaculada Gutierrez-Aranda Agustin F Femfindez Mario F Fraga Inmaculada Moreno-Gimeno Deborah Btlrks Maria del Carmen Plaza-Calonge Juan C Rodriguez-Manzaneque Pablo Menendez | 2012 | Cell Research2012，22，6： | 2 |
| 2 | Adipocyte iron regulates adiponectin and insulin sensitivity显示文摘 | Gabrielsen J Scott Gao Yan Simcox Judith A Huang Jingyu Thorup David Jones Deborah Cooksey Robert C Gabrielsen David Adams Ted D Hunt Steven C Hopkins Paul N Cefalu William T McClain Donald A | 2012 | EN2012，，10： | 2 |
| 3 | Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson’s disease: an open-label, phase I trial显示文摘 | William J Marks Jill L Ostrem Leonard Verhagen Philip A Starr Paul S Larson Roy AE Bakay Robin Taylor Deborah A Cahn-Weiner A Jon Stoessl C Warren Olanow Raymond T Bartus | 2008 | Lancet Neurology2008，，5： | 1 |
| 4 | The Relation between Systematic Reviews and Practice Guidelines显示文摘 | Nancy L G Gray Ellrodt | 1997 | Annal of Internal Medicine1997，127，3： | 1 |
| 5 | Polyoxometalates in Medicine显示文摘 | Rhule J T Hill C L Deborah A Judd | 1998 | Chem Rev1998，98，： | 1 |
| 6 | The Differential Role of Characteristics of Music on High- and Low-Involvement Consumers' Processing of Ads 显示文摘 | Deborah J Macinnis C Whan Park | 1991 | Journal of Consumer Research1991，15，2： | 1 |
| 7 | 显示文摘 | Robert C T Slade Jamer A Knowles Deborah J Jones | 1997 | Solid State Ionics1997，96，： | 1 |
| 8 | Early assessments of dysphagia and aspiration risk in acute stroke patients显示文摘 | Deborah J C David G Kalra L | | 0，，05： | 1 |
| 9 | Strategic brand concept-image management显示文摘 | Park C Whan Bernard J Jaworski and Deborah J MacInnis | 1986 | Journal of Marketing1986，50，4： | 1 |
| 10 | Early assessments of dysphagia and aspiration risk in acute stroke patients显示文摘 | Deborah J C David G Kalra L | 2003 | Stroke2003，34，5： | 1 |
| 11 | What to Say When: AdvertisingAppeals in Evolving Markets 显示文摘 | Rajesh K C Gerard J T Deborah J M | 2003 | Journal of Marketing Research2003，38，4： | 1 |
| 12 | Inhibition of Plasmodium clagy gene function by antisense RNA显示文摘 | Donald G J Deborah C H Elizaberh A T | 2000 | Mol Bioehem Parasitol2000，，110： | 1 |
| 13 | Understanding the factors influencing safe and unsafe motorcycle rider intentions显示文摘 | Deborah J Tunnicliff Barry C | 2012 | Accident Analysis & Prevention2012，49，： | 1 |
| 14 | The Ties That Bind: Measuring the Strength of Consumers' Emotional Attachments to Brands显示文摘 | Thomson Matthew Deborah J Maclnnis C Whan Park | 2005 | Journal of Consumer Psychology2005，15，1： | 1 |
| 15 | Physical model testing ofcompaction grouting in cohesionless soil显示文摘 | Silas C Nicholas Deborah J Goodings | 2000 | Journal of Geotechni-cal and Geo environmental Engineering ASCE2000，126，9： | 1 |
| 16 | Ef ect of massage therapy on pain,anxiety,and tension in cardiac surgical patients:A pilot study显示文摘 | Susanne M C Laura J W Deborah E | | 0，，02： | 1 |
| 17 | The Differential Role of Characteristics of Musicon High- and Low- Involvement Consumers' Processing of Ads显示文摘 | MaeInnis Deborah J C Whan Park | 1991 | Journal of Consumer Research1991，，18： | 1 |
| 18 | Beyond attitudes:Attachment and consumer behavior显示文摘 | PARK C WHAN DEBORAH J MACINNIS JOSEPH PRIESTER | 2006 | Seoul Journal Business2006，12，2： | 1 |
| 19 | Strategic Brand Concept Image Management显示文摘 | Park C Whan Bernand J Janorski Deborah J MacInnis | 1986 | Journal of Marketing1986，，50： | 1 |
| 20 | Identification of Structural and Spatial Features that Influence Storm-Related Dune Erosion along a Barrier-Island Ecosystem in the Gulf of Mexico显示文摘 | Pries Alexander J Miller Deborah L Branch Lyn C | 2008 | Journal of Coastal Research (C)2008，，4： | 1 |
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