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| 1 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 2 | Inhibition of lipogenesis and induction of apoptosis by valproic acid in prostate cancer cells via the C/EBPα/SREBP-1 pathway显示文摘Lipid metabolism reprogramming is now accepted as a new hallmark of cancer.Hence,targeting the lipogenesis pathway may be a potential avenue for cancer treatment.Valproic acid(VPA)emerges as a promising drug for cancer therapy;however,the underlying mechanisms are not yet fully understood.In this study,we aimed to investigate the effects and mechanisms of VPA on cell viability,lipogenesis,and apoptosis in human prostate cancer PC-3 and LNCaP cells.The results showed that VPA significantly reduced lipid accumulation and induced apoptosis of PC-3 and LNCaP cells.Moreover,the expression of CCAAT/enhancer-binding proteinα(C/EBPα),as well as sterol regulatory element-binding protein 1(SREBP-1)and its downstream effectors,including fatty acid synthase(FASN),acetyl CoA carboxylase 1(ACC1),and anti-apoptotic B-cell lymphoma 2(Bcl-2),was markedly decreased in PC-3 and LNCaP cells after VPA administration.Mechanistically,the overexpression of C/EBPαrescued the levels of SREBP-1,FASN,ACC1,and Bcl-2,enhanced lipid accumulation,and attenuated apoptosis of VPA-treated PC-3 cells.Conversely,knockdown of C/EBPαby siRNA further decreased lipid accumulation,enhanced apoptosis,and reduced the levels of SREBP-1,FASN,ACC1,and Bcl-2.In addition,SREBP-1a and 1c enhanced the expressions of FASN and ACC1,but only SREBP-1a had a significant effect on Bcl-2 expression in VPA-treated PC-3 cells.Based on the results,we concluded that VPA significantly inhibits cell viability via decreasing lipogenesis and inducing apoptosis via the C/EBPα/SREBP-1 pathway in prostate cancer cells.Therefore,VPA that targets lipid metabolism and apoptosis is a promising candidate for PCa chemotherapy. | Bo Pang Juanjuan Zhang Xi Zhang Jihong Yuan Yanan Shi Ling Qiao | 2021 | Acta Biochimica et Biophysica Sinica2021，53，3： | 2 |
| 3 | A method to predict cooling load of large commercial buildings based on weather forecast and internal occupancy显示文摘就大商业大楼的顾客有更高的密度和随意的特征的事实而言,这份报纸论述了基于天气预报和内部占有密度使负担预言方法凉下来的 airconditioning。多重线性反馈回归模型被使用预言,与精确,冷却的空调负担。盒子分析证明最大的吝啬的相对错误时时并且预言冷却负担最大值的日报分别地是 18.1% 和 5.14% 。 | Junbao JIA Jincheng XING Jihong LING Ren PENG | 2016 | Frontiers in Energy2016，10，4： | 2 |
| 4 | Carbon Dots-in-Zeolite via In-Situ Solvent-Free Thermal Crystallization:Achieving High-Efficiency and Ultralong Afterglow Dual Emission显示文摘Organic afterglow materials are highly desirable for optoelectronic applications,but they usually suffer from complex preparation process,low quantum efficiency,and short lifetime due to the ultrafast deactivation of the highly active excited states involved.Here,we succeeded in achieving solventfree thermal syntheses of high-efficiency afterglow CDs@zeolite composite materials by simply grinding the solid raw materials of zeolite and precursor CDs at room temperature,followed by thermal crystallization.This method afforded maximum embedding of CDs into growing zeolite crystals,as well as strong host–guest interaction to surpass the nonradiative transition of CDs,thus producing composite materials with ultralong dual emission of thermally activated delayed fluorescence and room temperature phosphorescence with a record high lifetime of 1.7 and 2.1 s,respectively,and the quantum yield of 90.7%.Furthermore,in a preliminary experiment,we applied the composite materials in alternatingcurrent light-emitting diode supplementary lighting,which exhibited a promising potential in optoelectronic applications. | Hongyue Zhang Kaikai Liu Jiancong Liu Bolun Wang Chengyu Li Wei Song Jiyang Li Ling Huang Jihong Yu | 2020 | CCS Chemistry2020，2，3： | 1 |
| 5 | A new pyrolysis technology and equipment for treatment of municipal household garbage and hospital waste显示文摘 | Zhang Yufeng Deng Na Ling Jihong | 2003 | Renew Energy2003，28，15： | 1 |
| 6 | Facile active control of a pulsed erbium-doped fiber laser using modulation depth tunable carbon nanotubes显示文摘Short pulsed fiber lasers have been widely made using single-walled carbon nanotubes as a saturable absorber(SA). However, most of the currently used devices can only operate in one determined operation state with an unchangeable modulation SA depth in the cavity, which significantly limits their application in photonic devices.In this paper, well-aligned carbon nanotube arrays are synthesized using zeolite AlPO_4-5 as a template, which features anisotropic optical absorption. The linear optical absorption of the as-synthesized carbon nanotube arrays can easily be tuned by adjusting a polarization controller, thus providing a tunable modulation depth for the carbon nanotube SA. By exploiting this SA in an erbium-doped fiber laser cavity, both Q-switched and modelocked pulsed lasers are achieved by simply adjusting a polarization controller under a fixed pump power of 330 mW. In addition, the repetition rate of the Q-switching and pulse duration of the mode-locking can be tuned according to the variation of modulation depth. Moreover, soliton molecules can be obtained when the modulation depth of the SA is 4.5%. | XINTONG XU SHUANGCHEN RUAN JIANPANG ZHAI LING LI JIHONG PEI ZIKANG TANG | 2018 | Photonics Research2018，，11： | 1 |
| 7 | A new pyrolysis technology and equipment for treatment of municipal household garbage and hospital waste 显示文摘 | Zhang Yufeng Deng Na Ling Jihong | 2003 | Renewable Energy2003，28，15： | 1 |
| 8 | Study on biological contaminant control strategies under different ventilation models in hospital operating room显示文摘 | ZHANG RUI TU GUANGBEI LING JIHONG | 2007 | Building and Environment2007，，1： | 1 |
| 9 | A new pyrolysis technology and equipment for treatment of municipal household garbage and hospital waste 显示文摘 | ZHANG Yufeng DENG Na LING Jihong | 2003 | Renew Energy2003，28，15： | 1 |
| 10 | Energy consumption of 270 schools in Tianjin, China显示文摘与教育原因的快速的发展,学校大楼的增加的精力消费逐渐地在中国在最近的年里正在引起普遍担心。这份报纸论述了位于天津的城市的 270 所学校的精力消费的分析,中国。分析明确地集中了于计算空格热能消费索引和学校的不同类型的非加热的精力消费索引,瞄准提供为详细描述政策和措施的政府的可靠、精确的数据。采用区域加热和煤气的锅炉的学校的空间热能消费是 92.04 kWh/(m 2 | Jincheng XING Junjie CHEN Jihong LING | 2015 | Frontiers in Energy2015，9，2： | 0 |
| 11 | Stacking monolayers at will:A scalable device optimization strategy for two-dimensional semiconductors显示文摘In comparison to monolayer(1L),multilayer(ML)two-dimensional(2D)semiconducting transition metal dichalcogenides(TMDs)exhibit more application potential for electronic and optoelectronic devices due to their improved current carrying capability,higher mobility,and broader spectral response.However,the investigation of devices based on wafer-scale ML-TMDs is still restricted by the synthesis of uniform and high-quality ML films.In this work,we propose a strategy of stacking MoS_(2) monolayers via a vacuum transfer method,by which one could obtain wafer-scale high-quality MoS_(2) films with the desired number of layers at will.The optical characteristics of these stacked ML-MoS_(2) films(>2L)indicate a weak interlayer coupling.The stacked MLMoS_(2) phototransistors show improved optoelectrical performances and a broader spectral response(approximately 300-1,000 nm)than that of 1L-MoS_(2).Additionally,the dual-gate ML-MoS_(2) transistors enable enhanced electrostatic control over the stacked ML-MoS_(2) channel,and the 3L and 4L thicknesses exhibit the optimal device performances according to the turning point of the current on/off ratio and the subthreshold swing. | Xiaojiao Guo Honglei Chen Jihong Bian Fuyou Liao Jingyi Ma Simeng Zhang Xinzhi Zhang Junqiang Zhu Chen Luo Zijian Zhang Lingyi Zong Yin Xia Chuming Sheng Zihan Xu Saifei Gou Xinyu Wang Peng Gong Liwei Liu Xixi Jiang Zhenghua An Chunxiao Cong Zhijun Qiu Xing Wu Peng Zhou Xinyu Chen Ling Tong Wenzhong Bao | 2022 | Nano Research2022，15，7： | 0 |
| 12 | Effects of the incorporation amounts of CdS and Cd(SCN_(2)H_(4))_(2)Cl_(2)on the performance of perovskite solar cells显示文摘An excellent organolead halide perovskite film is important for the good performance of perovskite solar cells(PSCs).However,defects in perovskite crystals can affect the photovoltaic properties and stability of solar cells.To solve this problem,this study incorporated a complex of Cd S and Cd(SCN_(2)H_(4))_(2)Cl_(2)into the CH_(3)NH_(3)Pb I_(3)active layer.The effects of different doping concentrations of Cd S and Cd(SCN_(2)H_(4))_(2)Cl_(2)on the performance and stability of PSCs were analyzed.Results showed that doping appropriate incorporation concentrations of Cd S and Cd(SCN_(2)H_(4))_(2)Cl_(2)in CH_(3)NH_(3)Pb I_(3)can improve the performance of the prepared solar cells.In specific,Cd S and Cd(SCN_(2)H_(4))_(2)Cl_(2)can effectively passivate the defects in perovskite crystals,thereby suppressing the charge recombination in PSCs and promoting the charge extraction at the TiO_(2)/perovskite interface.Due to the reduction of perovskite crystal defects and the enhancement of compactness of the Cd S:Cd(SCN_(2)H4)_(2)Cl_(2):CH_(3)NH_(3)Pb I_(3)composite film,the stability of PSCs is significantly improved. | Jihong Zheng Liangxin Zhu Zhitao Shen Fumin Li Lanyu Ling Huilin Li Chong Chen | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，2： | 0 |
| 13 | Method for rating energy performance of public buildings显示文摘这份报纸为决定大楼精力消费基准讨论了几个 state-of-art 方法的比较研究。一条新途径,联合了在它的评价系统造基准和运作的基准的想法,被建议。案例研究被进行它把建议途径用于 benchmarking 在天津的一座存在办公大楼。而且,用在 eQUEST 的评价方法的参考书大楼模型和真实大楼模型的基准的计算也被考虑。而且,引用大楼模型的模拟结果作为基线被拿把真实办公大楼划分成不同精力性能等级。 | Jincheng XING Youli LI Jihong LING Huiyang YU Liwen WANG | 2014 | Frontiers in Energy2014，8，3： | 0 |
| 14 | DanHong Injection inhibits the development of primary abdominal aortic aneurysms in apoE knockout mice显示文摘Clinical observations indicate that DanHong Injection(DHI)can increase blood flow and reduce various syndromes in patients with cardiovascular disease.However,it still needs to define the function of DHI and the involved mechanisms in details,such as the protective effect on the development of primary abdominal aortic aneurysms(AAAs).In this study,we determined whether DHI is able to inhibit AAA in apoE knockout(apoE-/-)mice.Thirty apoE-/-male mice on high-fat diet(0.5%cholesterol,21%fat)were randomly divided into two groups and received i.p.injection of saline(100 lL/day)and DHI(100 lL/day),respectively,for 16 weeks.At the end of experiment,we determined the development of atherosclerosis in en face aorta and aneurysms,pathological morphology of arterial wall,and serum lipid levels.We also determined the expression of monocyte chemoattractant protein-1(MCP-1),MMP-2,and MMP-9mRNA in aortic wall using real-time RT-PCR.Our results indicated that high-fat diet induced the development of AAAs in apoE-/-mice,but the induction was totally blocked by DHI(P\0.01).The result of staining of abdominal aortic cross sections showed that DHI maintained the collagen content in arterial wall,thereby preventing the animals from the development of AAA.Although DHI had little effect on serum total-and LDLcholesterol levels,it reduced the expression of MCP-1,MMP-2,and MMP-9 mRNA in aortic wall(P\0.01).Taken together,our study suggests that DHI can inhibit the high-fat diet-induced AAA formation.The inhibitory effects may be related to the maintenance of the collagen content and inhibition of expression of AAA-related genes.Our study may suggest a new application of DHI in clinics. | Mengyang Liu Yuanli Chen Xiaoxiao Yang Ling Zhang Tao Zhao Buchang Zhao Lifu Jia Yan Zhu Xiumei Gao Boli Zhang Xiaoju Li Rong Xiang Jihong Han Yajun Duan | 2014 | Chinese Science Bulletin2014，59，13： | 0 |
| 15 | Impacts of opening baffle of city road tunnels on natural ventilation performance显示文摘Based on the opening baffle mode for natural ventilation of city road tunnels,this paper studies the impacts of opening baffle on natural ventilation performance by verifying numerical simulation through model tests.By analyzing the impacts of installation angle,dimension,location,and quantity of opening baffle on ventilation performance,the paper reached the conclusions as follows:1)When installation angle is larger than 45°and tunnel ventilation is well operated,the baffle exhaust could increase by at least 30%compared to when there is no baffle.2)The baffle reaches its optimal performance when the length of the baffle is equal to the width of the city road tunnels.3)Baffle exhaust could increase by 30%when it is installed in the downstream of openings.4)The performance of a single baffle is better than that of multiple baffles. | Weixiao YANG Jincheng XING Jianxing LI Jihong LING Haixian HAO Zhiqiang YAN | 2013 | Frontiers of Structural and Civil Engineering2013，7，1： | 0 |
| 16 | Quantitative research of incentive effects of heat-metering policy on energy-saving behavior in Tianjin显示文摘支持精力效率和排放减小,中国政府在过去的十年在热米改革投资了大量资源。然而,热米,能至少在发达国家在 15% 减少精力消费,仍然不在中国是众所周知的。这论文份量上分析了在占有行为考虑精力节省在天津从 2008 ~ 2012 基于约 20000 个用户的热能消费的测量数据利用统计方法上的热米政策的唤起效果。统计数据基于 metering 并且基于区域在在用户之间的精力消费上显示出重要差别。在加热季节的节省精力的率作为热米政策的工具在 20112012 在 20082009 ~ 10.27% 从 4.11% 显著地增加了。差别在根据显示出的各种各样的室外的温度节省精力占有行为节省精力比在一个冷季节在一个温暖的季节是更重要的。它也证明热米政策的影响将比以更好绝缘的单位(6.45%) 在通常绝缘的大楼(15.55%) 里是更显著的。而且,这份报纸在中国的北加热区域为热米政策的明确的表达和实现建议了一些可行建议。 | Jihong LING Haitao MA Huizhu YU Jincheng XING | 2014 | Frontiers in Energy2014，8，4： | 0 |
| 17 | Statistical analysis of residential building energy consumption in Tianjin显示文摘为了分析在居住大楼,精力消费的特征和室内的热舒适的精力消费上的精力保存政策的效果,在天津详细被调查,中国,基于官员,统计年鉴和地调查数据。305 个家庭的全面调查显示吝啬的电消费每家庭是 3215 kWh/a,年度冷却电消费在是 344 kWh/a,和吝啬的天然气消费因为煮是 103.2 m < 啜 class= “ a-plus-plus ” > 3 /a。3966 家庭数据的分析显示出加热在 1996 是 133.7 kWh/ 以前,设计的居住大楼的平均紧张的那个空格(m < 啜 class= “ a-plus-plus ” > 2 象 paclitaxel 那样的恐水病的药的 lubilization 和封装,而 alginate hydrogel 小岛包含了象 gemcitabine 那样的吸水的药。Alginate 胶化核心 LNC 关于粒子尺寸被描绘,多分散性索引(PDI ) ,形态学,封装效率,并且在 vitro 版本。双装载药的 alginate 胶化核心 LNC 有 171.8 的一种粒子尺寸 ? erance 到有毒的环境和更大的生物资源。与 9.02 ? g/L CA,成年芦苇积累了 0.51ral 特点或在为自治 selfing 罐头 substantiall 的选择?? | Jihong LING Luhui ZHAO Jincheng XING Zhiqiang LU | 2014 | Frontiers in Energy2014，8，4： | 0 |
| 18 | Heat transfer and temperature evolution in underground mininginduced overburden fracture and ground fissures: Optimal time window of UAV infrared monitoring显示文摘Heat transfer and temperature evolution in overburden fracture and ground fissures are one of the essential topics for the identification of ground fissures via unmanned aerial vehicle(UAV) infrared imager. In this study, discrete element software UDEC was employed to investigate the overburden fracture field under different mining conditions. Multiphysics software COMSOL were employed to investigate heat transfer and temperature evolution of overburden fracture and ground fissures under the influence of mining condition, fissure depth, fissure width, and month alternation. The UAV infrared field measurements also provided a calibration for numerical simulation. The results showed that for ground fissures connected to underground goaf(Fissure Ⅰ), the temperature difference increased with larger mining height and shallow buried depth. In addition, Fissure Ⅰ located in the boundary of the goaf have a greater temperature difference and is easier to be identified than fissures located above the mining goaf. For ground fissures having no connection to underground goaf(Fissure Ⅱ), the heat transfer is affected by the internal resistance of the overlying strata fracture when the depth of Fissure Ⅱ is greater than10 m, the temperature of Fissure Ⅱ gradually equals to the ground temperature as the fissures’ depth increases, and the fissures are difficult to be identified. The identification effect is most obvious for fissures larger than 16 cm under the same depth. In spring and summer, UAV infrared identification of mining fissures should be carried out during nighttime. This study provides the basis for the optimal time and season for the UAV infrared identification of different types of mining ground fissures. | Yixin Zhao Kangning Zhang Bo Sun Chunwei Ling Jihong Guo | 2024 | International Journal of Mining Science and Technology2024，34，1： | 0 |
| 19 | SEMA4D acts as a novel oligogenic pathogenic gene of idiopathic hypogonadotropic hypogonadism through thePlexinB1/MET/RND1/RHOA/RAF1/MAPK signaling axis显示文摘Idiopathic hypogonadotropic hypogonadism(IHH)is a rare genetic disease with clinical and genetic heterogeneity.This study aimed to investigate a novel causal gene of IHH and a homozygous mutation(p.Ala515Val)in SEMA4D,and sought to determine the mechanism of SEMA4D promoting GnRH neurons migration. | Daoqi Wang Yonghua Niu Jiahong Tan Jiaxin Wang Le Ling Yinwei Chen Jjianan Gong Hao Xu Qing Ling Jianhe Liu Jihong Liu | 2023 | Genes & Diseases2023，10，1： | 0 |
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