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| 1 | Role of PERK/eIF2α/CHOP Endoplasmic Reticulum Stress Pathway in Oxidized Low-density Lipoprotein Mediated Induction of Endothelial Apoptosis显示文摘Objective PERK/eI F2α/CHOP is a major signaling pathway mediating endoplasmic reticulum(ER) stress related with atherosclerosis.Oxidized LDL(ox-LDL) also induces endothelial apoptosis and plays a vital role in the initiation and progression of atherosclerosis.The present study was conducted to explore the regulatory effect of ox-LDL on PERK/e IF2α/CHOP signaling pathway in vascular endothelial cells.Methods The effects of ox-LDL on PERK and p-e IF2α protein expression of primary human umbilical vein endothelial cells(HUVECs) were investigated by Western blot analysis.PERK gene silencing and selective eI F2α phosphatase inhibitor,salubrinal were used to inhibit the process of ox-LDL induced endothelial cell apoptosis,caspase-3 activity,and CHOP mR NA level.Results Ox-LDL treatment significantly increased the expression of PERK,PERK-mediated inactivation of e IF2α phosphorylation,and the expression of CHOP,as well as the caspase-3 activity and apoptosis.The effects of ox-LDL were markedly decreased by knocking down PERK with stable transduction of lentiviral sh RNA or by selective eI F2α phosphatase inhibitor,salubrinal.Conclusion This study provides the first evidence that ox-LDL induces apoptosis in vascular endothelial cells mediated largely via the PERK/eI F2α/CHOP ER-stress pathway.It adds new insights into the molecular mechanisms underlying the pathogenesis and progression of atherosclerosis. | TAO Yong Kang YU Pu Lin BAI Yong Ping YAN Sheng Tao ZHAO Shui Ping ZHANG Guo Qiang | 2016 | Biomedical and Environmental Sciences2016，29，12： | 21 |
| 2 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 3 | Effectiveness of Different Waist Circumference Cut-off Values in Predicting Metabolic Syndrome Prevalence and Risk Factors in Adults in China显示文摘Objective To study the effectiveness of waist circumference cut-off values in predicting the prevalence of metabolic syndrome(MetS) and risk factors in adults in China. Methods A cross-sectional survey was condcuted in 14 provinces(autonomous region, municipality) in China. A total of 47 325 adults aged ≥20 years were selected by multistage stratified sampling, and questionnaire survey and physical and clinical examination were conducted among them. MetS was defined according to the International Diabetes Federation(IDF) criteria and modified IDF criteria.Results The age-standardized prevalence of MetS was 24.2%(22.1% in men and 25.8% in women) and 19.5%(22.1% in men and 18.0% in women) according to the IDF criteria and modified IDF criteria respectively. The age-standardized prevalence of pre-MetS was 8.1%(8.6% in men and 7.8% in women) according to the modified IDF criteria. The prevalence of MetS was higher in urban residents than rural residents and in northern China residents than in southern China residents. The prevalence of central obesity was about 30% in both men and women according to the ethnicity-specific cut-off values of waist circumference for central obesity(90 cm for men and 85 cm for women). Multivariate regression analysis revealed no significant difference in risk factors between the two MetS definitions. Conclusion Using both the modified IDF criteria and ethnicity-specific cut-off values of waist circumference can provide more useful information about the prevalence of MetS in China. | ZHOU Hai Cheng LAI Ya Xin SHAN Zhong Yan JIA Wei Ping YANG Wen Ying LU Ju Ming WENG Jian Ping JI Li Nong LIU Jie TIAN Hao Ming JI Qiu He ZHU Da Long CHEN Li GUO Xiao Hui ZHAO Zhi Gang Li Qiang ZHOU Zhi Guang GE Jia Pu SHAN Guang Liang | 2014 | Biomedical and Environmental Sciences2014，27，5： | 17 |
| 4 | Spin-decoupled metasurface for simultaneous detection of spin and orbital angular momenta via momentum transformation显示文摘With inherent orthogonality,both the spin angular momentum(SAM)and orbital angular momentum(OAM)of photons have been utilized to expand the dimensions of quantum information,optical communications,and information processing,wherein simultaneous detection of SAMs and OAMs with a single element and a single-shot measurement is highly anticipated.Here,a single azimuthal-quadratic phase metasurface-based photonic momentum transformation(PMT)is illustrated and utilized for vortex recognition.Since different vortices are converted into focusing patterns with distinct azimuthal coordinates on a transverse plane through PMT,OAMs within a large mode space can be determined through a single-shot measurement.Moreover,spin-controlled dual-functional PMTs are proposed for simultaneous SAM and OAM sorting,which is implemented by a single spin-decoupled metasurface that merges both the geometric phase and dynamic phase.Interestingly,our proposed method can detect vectorial vortices with both phase and polarization singularities,as well as superimposed vortices with a certain interval step.Experimental results obtained at several wavelengths in the visible band exhibit good agreement with the numerical modeling.With the merits of ultracompact device size,simple optical configuration,and prominent vortex recognition ability,our approach may underpin the development of integrated and high-dimensional optical and quantum systems. | Yinghui Guo Shicong Zhang Mingbo Pu Qiong He Jinjin Jin Mingfeng Xu Yaxin Zhang Ping Gao Xiangang Luo | 2021 | Light(Science & Applications)2021，10，4： | 14 |
| 5 | Geochemical Characteristics and Genesis of the Luxi-Xianrenzhang Diabase Dikes in Xiazhuang Uranium Orefield, Northern Guangdong Province显示文摘The Luxi-Xianrenzhang diabase dikes were emplaced into the eastern part of the Guidong composite granitoids in northern Guangdong Province at the end of the Early Cretaceous. They show tholeiitic features, enrichment in large ion lithophile elements, slight enrichment in light rare earth elements, depletion in Zr and Hf, and basically no depletion in Nb and Ta and no Eu anomaly. They are similar to intraplate basalt in terms of trace element characteristics. They have high εNd(t) values (3.6–4.9), initial 87Sr/86Sr ratios (0.70530–0.70641) and δ18O values and Dupal anomaly of Pb isotope compositions. Their Sr-Nd, Pb-Sr, Pb-Nd and Pb-Pb isotopes plot between DMM and EMII, with Pb similar to EMII, Nd relatively close to DMM and Sr in between. This profile suggests that the diabase dikes studied were derived from partial melting of a mantle source that had been subjected to metasomatism by fluids originated from a subduction zone under a tectonic environment of crustal extension and lithosphere thinning in the late Yanshanian. | LING Hongfei SHEN Weizhou DENG Ping JIANG Shaoyong JIANG Yaohui YE Haimin PU Wei TAN Zhengzhong | 2005 | Acta Geologica Sinica(English Edition)2005，79，4： | 13 |
| 6 | De novo mutation in ATP6V1B2 impairs lysosome acidification and causes dominant deafness-onychodystrophy syndrome显示文摘 | Yongyi Yuan Jianguo Zhang Qing Chang Jin Zeng Feng Xin Jianjun Wang Qingyan Zhu Jing Wu Jingqiao Lu Weiwei Guo Xukun Yan Hui Jiang Binfei Zhou Qi Li Xue Gao Huijun Yuan Shiming Yang Dongyi Han Zixu Mao Ping Chen Xi Lin Pu Dai | 2014 | Cell Research2014，24，11： | 13 |
| 7 | Angiomyolipoma with minimal fat: differentiation from renal cell carcinoma at helical CT显示文摘Renal cell carcinoma (RCC) accounts for 85%-90% of all kidney tumors.Although the majority of renal tumors in surgical series are malignant,a number of patients do undergo nephrectomy for benign lesions.1 Such minimal fat angiomyolipomas (AML) are visually indistinguishable from RCC and present particular diagnostic difficulties.2,3 In this study,CT number in region of whole mass (ROW) is advocated. | ZHAO Xiao-jun PU Jin-xian PING Ji-gen ZANG Jin LU Yong XI Qi-lin HOU Wen-jie | 2013 | Chinese Medical Journal2013，，5： | 12 |
| 8 | The therapeutic effects of recombinant adenovirus RA538 on human gastric carcinoma cells in vitro and in vivo显示文摘AIM To evaluate the potential of RA-538 genetherapy for gastric carcinoma.METHODS Human gastric carcinoma cell lineSGC7901 treated with Ad-RA538 or Ad-LacZ wereanalysed by X-gal stain,MTT,DNA ladder,Tunel,flow cytometric analysis,PCR,andWestern Blot in vitro.The tumorigenicity andexperimental therapy in nude mice model wereassessed in vivo.RESULTS Ad-LacZ could efficiently transferthe LacZ gene into SGC7901 cells.X-gal-positivecells at MOI 25,50,100,and 200 were 90%,100%,100%,and 100% respectively.Ad-RA538could strongly inhibit cell growth and inducedapoptosis in SGC7901 cells.The proliferation ofthe Ad-RA538-infected SGC7901 cells wasreduced by 76.3%.The mechanism of killing ofgastric carcinoma cells by Ad-RA538 was foundto be apoptosis by DNA ladder,Tunel and flowcytometric analysis.The tumorigenicity in nudemice using Ad-RA538 showed that all three micefailed to form tumor from 7 to 30 days comparedwith Ad-LacZ and parent SGC7901 cells.Experimental therapy on the nude mice modelbearing subcutaneous tumor of SGC790| cells showed that intratumor instillation of Ad-RA538inhibited the growth of the tumors.Ad-RA538-treated tumors were inhibited by 60.66 %,compared with that of the tumor injected withAd-LacZ and mock.CONCLUSION The expression of Ad-RA538 can inhibit growth and induce apoptosis of gastric cancer cell in vitro and in vivo. Ad-RA538 can be used potentially in gene therapy for gastric carcinoma. | Jie Ping Chen Chen Lin Cai Pu Xu Xue Yan Zhang Ming Wu | 2000 | World Journal of Gastroenterology2000，6，6： | 12 |
| 9 | Hydrodynamics of a Newly China-Made Jiuling Bileaflet Heart Valve Prostheses显示文摘Jiuling bileaflet prosthetic heart valve is manufactured in compliance with the national standard of P.R.C. GB12279 90. This mechanical heart valve substitute is constructed entirely of solid low temperature pyrolytic carbon. There is no graphite substrate within the leaflets or orifice. This prosthesis presents with satisfactory histocompatibility and induces little hemocoagulation around it. Objective: This study aimed to assess the hydrodynamic function of the newly China made Jiuling bileaflet heart valve prostheses. Methods: Jiuling valve has been tested in a pulsatile flow simulator in the aortic position. The testing condition was set at the pulsatile frequency of 55, 75, and 100 beats/min and a constant cardiac output of 4 L/min. The mean pressure differences, leakage volumes and closing volumes across each valve, and the effective orifice areas have been analyzed. Results: The Jiuling heart valves prosthesis had the lowest pressure difference at any given tissue annulus diameter. The mean pressure difference of all the Jiuling valves decreases with increasing the tissue annulus diameter or pulse frequency, and is in the range of below 10 mmHg. CarboMedics (CarboMedics, Inc., Austin, Tex.) is similar to that of the 21 mm and 23 mm Jiuling heart valves at the given pulse rate under 4 L/min. C L tilting disc valve (Lanzhou CarboMedics Inc., China) is similar to that of the 23 mm Jiuling heart valve. The effective orifice area of the Jiuling mechanical valve increases with increasing the tissue annulus diameter or pulse frequency. CarboMedics and C L tilting disc valve is similar to that of the 21 mm and 23 mm Jiuling heart valves. The Closing volume of the Jiuling prosthetic cardiac valves increases with increasing the tissue annulus diameter, but decreases with increasing the pulse frequency, and is in the range of below 11% (normalized by stroke volume). CarboMedics is below 16.5% of stroke volume; and C L tilting disc valve is below 7.5%. The leakage volume of the Jiuling prosthetic cardiac valves increases with increasing the tissue annulus diameter, but decreases with increasing the pulse frequency, and are in the range of below 28.9% (normalized by stroke volume). The leakage volume of CarboMedics is higher than that of the same sized 25 mm Jiuling valve, and the C L tilting disc valve is also higher than that of Jiuling valve at 4 L/min. Conclusion: For a given tissue diameter, the Jiuling valve showed significantly better hemodynamic characteristics. The material used in the construction is biocompatible, durable, and thromboresistant. The design permits light weight, low profile, and high ratio of flow area to tissue annulus diameter. | CHU Yin ping 1,CHEN Ru kun 2,FAN Yu bo 3 , PU Fang 31 Department of Thoracic & Cardiovascular Surgery Second Hospital Affiliated Shanxi Medical University, Taiyuan 030001,China 2 Second Affiliated Hospital of Zhejiang University Medical | 2000 | Chinese Journal of Biomedical Engineering(English Edition)2000，9，4： | 8 |
| 10 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 11 | Seasonal variability of the zooplankton community in the southwest of the Huanghai Sea (Yellow Sea) Cold Water Mass显示文摘Samples were collected with a plankton net in the four seasonal cruises during 2006-2007 to study the seasonal variability of the zooplankton community in the southwest part of Huanghai Sea Cold Water Mass (HSCWM, Yellow Sea Cold Water Mass). The spatial and temporal variations of zooplankton species composition, biomass, abundance and biodiversity were examined. A total of 122 zooplankton species and 30 pelagic larvae were identified in the four cruises. Calanus sinicus and Aidanosagitta crassa were the most dominant species, and Themisto gaudichaudi and Euphausia pacifica were widely distributed in the HSCWM area. The spatial patterns of non-gelatinous zooplankton (removing the high water content groups) were similar to those of the total zooplankton biomass in autumn, but different significantly in the other three seasons. The seasonal means of zooplankton biomass in spring and summer were much higher than that in autumn and winter. The total zooplankton abundance averaged 283.5 ind./m^3 in spring (highest), 192.5 ind./m^3 in summer, 165.5 ind./m^3 in autumn and 65.9 ind./m^3 in winter (lowest), and the non-gelatinous groups contributed the most total abundance. Correlation analysis suggests that the non-gelatinous zooplankton biomass and abundance had a significant positive correlation in the whole year, but the relationship was insignificant between the total zooplankton biomass and abundance in spring and summer. The diversity index H of zooplankton community averaged 1.88 in this study, which was somewhat higher than historical results. Relatively low diversity in summer was related to the high dominance of Calanus sinicus, probably due to the strongest effect of the HSCWM in this season. | LIU Ping SONG Hongjun WANG Xiao WANG Zongling PU Xinming ZHU Mingyuan | 2012 | Acta Oceanologica Sinica2012，31，4： | 8 |
| 12 | Metabolic Disorders Increase the Risk to Incident Cardiovascular Disease in Middle-aged and Elderly Chinese显示文摘Objective The association of metabolic syndrome (MetS) with cardiovascular diseases (CVD) has not been adequately explored in middle-aged and elderly Chinese.This study aimed to investigate MetS' prevalence and its impact on the CVD incidence in this specific population group.Methods A data set of a community-based prospective cohort study was analyzed.A total of 2300 subjects aged 40-94 years were followed up for the CVD events.MetS defined according to the JCDCG criteria was assessed at baseline,and the middle-aged and elderly groups were classified by the WHO definition.Results As compared with the middle-aged group,the prevalence of MetS increased by 0.6 times (34.6% vs.21.3%) and the incidence density of CVD increased by 4.9 times in the elderly group (52.3/1000 person-year vs.8.9/1000 person-year).Furthermore,the multivariate Cox regression revealed that the risk to CVD incidence was independently related to increased waist circumference in the middle-aged group (HR=2.23,P<0.01) and to elevated blood glucose in the elderly group (HR=1.39,P<0.01).Conclusion MetS was highly prevalent in middle-aged and elderly Chinese.MetS significantly increased the risk to CVD incidence in the elderly.All individuals with metabolic disorders should receive active clinical care to reduce the incidence of CVD. | ZHANG Ming Liang HOU Xu Hong ZHU Yun Xia LU Jun Xi PENG Liang Pu GU Hui Lin JIA Wei Ping | 2012 | Biomedical and Environmental Sciences2012，25，1： | 7 |
| 13 | Effects of High Temperature on Antioxidant Enzymes and Lipid Peroxidation in Flag Leaves of Wheat During Grain Filling Period显示文摘On the basis of the phytotron, the effects of high temperature (daily average temperature 25, 30, 35 and 40°C, respectively) on antioxidant enzymes and lipid peroxidation in flag leaves of wheat at 50% relative air moisture during grain fastest filling stage [19-21 days after anthesis (DAA)] were studied. The wheat cultivars tested were Yangmai 9 with weak-gluten and Yangmai 12 with medium-gluten. Compared with 25°C, the higher the temperature was, the higher was the MDA content in flag leaves, while lower were the SOD, POD, and CAT activities. SOD and CAT activities in Yangmai 12 appeared to be more sensitive to high temperature than that in Yangmai 9. But POD activity in Yangmai 12 was less sensitive to high temperature. MDA content in Yangmai 12 was higher than that in Yangmai 9. The 1 000-grain weight declined with increase in temperature. | LIU Ping GUO Wen-shan PU Han-chun FENG Chao-nian ZHU Xin-kai PENG Yong-xin | 2006 | Agricultural Sciences in China2006，5，6： | 7 |
| 14 | Clinical Predictors of Outcome in Patients with Anti-neutrophil Cytoplasmic Autoantibody-related Renal Vasculitis: Experiences from a Single-center显示文摘 | Lei Pu Gui-Sen Li Yu-Rong Zou Ping Zhang Li Wang | 2017 | Chinese Medical Journal2017，，8： | 6 |
| 15 | Prevalence of Overweight and Obesity among Students Aged 7-22 Years in Jiangsu Province,China显示文摘Objective To report the prevalence and trend of overweight and obesity among students aged 7-22 years in Jiangsu,2010 to 2013.Methods This cross-sectional study was carried out as part of students physical fitness and health survey in Jiangsu province.A total of 255,581 subjects(50.03% males and 49.97% females) enrolled in 82 school and 10 universities in Jiangsu.Weights and heights were obtained for each subject and its body mass index(BMI) was calculated using the Chinese Working Group on Obesity in China(CWGO).Results Anthropometric measurement including bodyweight,height,BMI and bust were significantly different between males in urban compared to females living rural areas(P<0.001).The total prevalence of overweight and obesity was 12.4% and 5.7%.Males had a significantly higher rate than in female's student.The prevalence of overweight and obesity by age groups was(14.5%,10.3%) at age 7-11 years,(11.2%,6.8%) at age 12-14 years,(11.7%,3.1%) at age 15-17 years,and(11.4%,2.3%) at age 18-22 years.By regions;the highest prevalence of overweight obesity reported in Taizhou(10.0%,14.2%),Xuzhou(9.4%,12.5%),and Nanjing(9.2%,15.6%),respectively.Conclusion The finding declares that overweight and obesity are important health problems among students in Jiangsu Province.Early intervention programme are needed to address this problems. | Taha Hussein Musa WEI Li LI Xiao Shan PU Yue Pu WEI Ping Min | 2016 | Biomedical and Environmental Sciences2016，29，10： | 5 |
| 16 | Assessment on the Effects of Hepatitis B Prevention and Control Measures in Western China:A Comparison of Three Population-based Serosurveys显示文摘Objective Despite the remarkable progress in efforts to control disease spread,the nationwide elimination of hepatitis B in China is still hindered by the persistently high rate of hepatitis B virus(HBV)infection in Western China.This study aimed to evaluate the strategy of hepatitis B prevention and control in Western China and identify potential areas and strategies for improvement.Methods Susceptible population vaccination,health education,professional training of doctors,and other prevention and control measures have been implemented in Wuwei city since 2010.Data were obtained from three representative cross-sectional serosurveys conducted in 2010,2013,and 2015.The serum samples were subjected to enzyme-linked immunosorbent assays to detect the following seromarkers:HBV surface antigen(HBsAg),antibody against hepatitis B surface antigen(anti-HBs),and antibody against hepatitis B core antigen(anti-HBc).Estimates of variance were determined using Taylor series linearization methods.Results The three serosurveys revealed decreases in the prevalence of HBsAg(7.19% in 2010 vs.6.51% in 2013 vs.5.87% in 2015)and anti-HBc positivity(43.89%vs.32.87%vs.28.46%)and an increase in the prevalence of anti-HBs positivity(49.07%vs.53.66%vs.53.72%)over time.From 2010 to 2015,the legally reported incidence of hepatitis B in Wuwei city decreased from 686.53/100,000 to 53.72/100,000.Notably,persistently high HBsAg-positive rates(above 5.40%)were observed among subjects aged 20–69 years old in the three serosurveys;the prevalence of HBsAg was above 1% among children younger than 10 years old.Furthermore,rural subjects had higher rates of HBsAg and anti-HBc positivity than their urban counterparts(6.04%vs.4.83% and 30.26%vs.20.35%,respectively)in 2015 but had a lower rate of anti-HBs positivity(49.68 vs.55.18%).Multivariate regression analysis showed that age,urban and rural areas,and education level were the main factors affecting HBV infection.Conclusion Although vaccine-based prevention and control measures reduced the rate of HBV infection in Wuwei City over time,the hepatitis B infection rate in children younger than 10 years was still higher than the national average level.Therefore,the prevention and control of mother-to-child transmission and the management of the infected should be the focus of future prevention and control work. | CHEN Hui LIU Nan JI Zhao Hua PU Zhong Shu GUO Zhi Wen GAO Jie SHAO Zhong Jun LIU Yi Wen YAN Yong Ping | 2020 | Biomedical and Environmental Sciences2020，33，10： | 5 |
| 17 | Elevated Platelet Activating Factor Level in Ischemia-Related Arrhythmia and Its Electrophysiological Effect on Myocardium显示文摘Objective The mechanism through which platelet activating factor (PAF) induces cardiac electrical activity and arrhythmia is not well understood and previous studies have suggested a potential involvement of ion channels in its action. The present study was aimed to clarify the role of PAF in fatal arrhythmias following acute myocardia infarction (AMI) and the underlying mechanism. Methods (1) Blood PAF levels were measured among 72 AMI patients at the time of diagnosis with AMI and 48 h later, and their electrocardiogram (ECG) was recorded continuously. (2) Ischemia simulation and surface electrocardiogram were conducted in 20 pigs and their PAF levels were measured. (3) PAF perfusion and standard microelectrode recording were performed on guinea pig papillarymuscles. Results In both humans and pigs, elevated PAF levels were detected in AMI and simulated ischemia, respectively, and even higher PAF levels were found when fatal arrhythmias occurred. In guinea pig myocardium, PAF induced a shortening of action potential duration at 90% level of repolarization (APD 90 )under non-ischemic conditions and a more pronounced shortening under early simulated ischemic conditions. Conclusion AMI and ischemia are associated with increased PAF levels in humans and pigs, which are further raised when fatal arrhythmia follows. The effects of PAF on the myocardium may be mediated by multiple ion channels. | TAO Yong Kang ZHAO Shui Ping YU Pu Lin SHI Jing GU Cheng Dong SUN Hong Tao ZHANG Guo Qiang | 2013 | Biomedical and Environmental Sciences2013，26，5： | 5 |
| 18 | Cancer metabolism and tumor microenvironment:fostering each other?显示文摘The changes associated with malignancy are not only in cancer cells but also in environment in which cancer cells live.Metabolic reprogramming supports tumor cells’high demand of biogenesis for their rapid proliferation,and helps tumor cells to survive under certain genetic or environmental stresses.Emerging evidence suggests that metabolic alteration is ultimately and tightly associated with genetic changes,in particular the dysregulation of key oncogenic and tumor suppressive signaling pathways.Cancer cells activate HIF signaling even in the presence of oxygen and in the absence of growth factor stimulation.This cancer metabolic phenotype,described firstly by German physiologist Otto Warburg,ensures enhanced glycolytic metabolism for the biosynthesis of macromolecules.The conception of metabolite signaling,i.e.,metabolites are regulators of cell signaling,provides novel insights into how reactive oxygen species(ROS)and other metabolites deregulation may regulate redox homeostasis,epigenetics,and proliferation of cancer cells.Moreover,the unveiling of noncanonical functions of metabolic enzymes,such as the moonlighting functions of phosphoglycerate kinase 1(PGK1),reassures the importance of metabolism in cancer development.The metabolic,microRNAs,and ncRNAs alterations in cancer cells can be sorted and delivered either to intercellular matrix or to cancer adjacent cells to shape cancer microenvironment via media such as exosome.Among them,cancer microenvironmental cells are immune cells which exert profound effects on cancer cells.Understanding of all these processes is a prerequisite for the development of a more effective strategy to contain cancers. | Yiyuan Yuan Huimin Li Wang Pu Leilei Chen Dong Guo Hongfei Jiang Bo He Siyuan Qin Kui Wang Na Li Jingwei Feng Jing Wen Shipeng Cheng Yaguang Zhang Weiwei Yang Dan Ye Zhimin Lu Canhua Huang Jun Mei Hua-Feng Zhang Ping Gao Peng Jiang Shicheng Su Bing Sun Shi-Min Zhao | 2022 | Science China(Life Sciences)2022，65，2： | 5 |
| 19 | Downregulation of mi R ‐101 in gastric cancer correlates with cyclooxygenase‐2 overexpression and tumor growth显示文摘 | Xiao‐Pu He Yun Shao Xiao‐Lin Li Wei Xu Guo‐Sheng Chen Huan‐Huan Sun Hai‐Chen Xu Xian Xu Dan Tang Xi‐Feng Zheng Yi‐Ping Xue Guo‐Chang Huang Wei‐Hao Sun | 2012 | FEBS J2012，，22： | 4 |
| 20 | Continuous glucose monitoring defined time-in-range is associated with sudomotor dysfunction in type 2 diabetes显示文摘BACKGROUND Time in range(TIR),as a novel metric for glycemic control,has robust relevance with diabetic complications.Diabetic peripheral neuropathy(DPN)is characterized by sudomotor dysfunction.AIM To explore the relationship between TIR obtained from continuous glucose monitoring(CGM)and sudomotor function detected by SUDOSCAN in subjects with type 2 diabetes.METHODS The research enrolled 466 inpatients with type 2 diabetes.All subjects underwent 3-d CGM and SUDOSCAN.SUDOSCAN was assessed with electrochemical skin conductance in hands(HESC)and feet(FESC).Average feet ESC<60μS was defined as sudomotor dysfunction(+),otherwise it was sudomotor dysfunction(-).TIR refers to the percentage of time when blood glucose is between 3.9-10 mmol/L during 1 d period.RESULTS Among the enrolled subjects,135(28.97%)presented with sudomotor dysfunction.Patients with sudomotor dysfunction(+)showed a decreased level of TIR(P<0.001).Compared to the lowest tertile of TIR,the middle and the highest tertiles of TIR was associated with an obviously lower prevalence of sudomotor dysfunction(20.51%and 21.94%vs 44.52%)(P<0.001).In addition,with the increase of TIR,HESC and FESC increased(P<0.001).Regression analysis demonstrated that TIR was inversely and independently linked with the prevalence of sudomotor dysfunction after adjusting for confounding values(odds ratio=0.979,95%CI:0.971-0.987,P<0.001).CONCLUSION The tight glycemic control assessed by TIR is of vitally protective value for sudomotor dysfunction in type 2 diabetes mellitus. | Qing-Yu Guo Bin Lu Zhan-Hong Guo Zhou-Qin Feng Yan-Yu Yuan Xu-Guang Jin Pu Zang Ping Gu Jia-Qing Shao | 2020 | World Journal of Diabetes2020，11，11： | 4 |
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