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| 1 | RAB31 marks and controls an ESCRT-independent exosome pathway显示文摘Exosomes are generated within the multivesicular endosomes(MVEs)as intraluminal vesicles(ILVs)and secreted during the fusion of MVEs with the cell membrane.The mechanisms of exosome biogenesis remain poorly explored.Here we identify that RAB31 marks and controls an ESCRT-independent exosome pathway.Active RAB31,phosphorylated by epidermal growth factor receptor(EGFR),engages flotillin proteins in lipid raft microdomains to drive EGFR entry into MVEs to form ILVs,which is independent of the ESCRT(endosomal sorting complex required for transport)machinery.Active RAB31 interacts with the SPFH domain and drives ILV formation via the Flotillin domain of flotillin proteins.Meanwhile,RAB31 recruits GTPase-activating protein TBC1D2B to inactivate RAB7,thereby preventing the fusion of MVEs with lysosomes and enabling the secretion of ILVs as exosomes.These findings establish that RAB31 has dual functions in the biogenesis of exosomes:driving ILVs formation and suppressing MVEs degradation,providing an exquisite framework to better understand exosome biogenesis. | Denghui Wei Weixiang Zhan Ying Gao Liyan Huang Run Gong Wen Wang Ruhua Zhang Yuanzhong Wu Song Gao Tiebang Kang | 2021 | Cell Research2021，31，2： | 12 |
| 2 | Isosteric design of friction-reduction and anti-wear lubricant additives with less sulfur content显示文摘To reduce harmful sulfur content in lubricant additives, making use of isosterism has been shown to be an effective strategy. When thiobenzothiazole compounds were used as templates, the exchange of sulfur atoms in the thiazole ring with oxygen atoms and NH groups produced twelve isosteres. Similarly, 2-benzothiazole- S-carboxylic acid esters were used as template molecules to produce six isosteres. About 30% of the isosteres exhibited a satisfactory deviation of ±5% relative to the template, ignoring the specific changes in the base oils, the differences in molecular structure, and the friction or wear properties. The template molecules and isosteres in triisodecyl trimellitate exhibited better tribological properties than in trimethylolpropane trioleate or bis(2- ethylhexyl) adipate. Comparative molecular field analysis(CoM FA)- and comparative molecular similarity index analysis(CoMSIA)-quantitative structure tribo-ability relationship(QSTR) models were employed to study the correlation of molecular structures between the base oils and additives. The models indicate that the higher the structural similarities of the base oils and additives are, the more synergetic the molecular force fields of the lubricating system are; the molecular force fields creating synergistic effects will improve tribological performance. | Xinlei GAO Denghui LIU Ze SONG Kang DAI | 2018 | Friction2018，6，2： | 7 |
| 3 | Electro-mechanical coupling wave propagating in a locally resonant piezoelectric/elastic phononic crystal nanobeam with surface effects显示文摘The model of a 'spring-mass' resonator periodically attached to a piezoelectric/elastic phononic crystal(PC) nanobeam with surface effects is proposed, and the corresponding calculation method of the band structures is formulized and displayed by introducing the Euler beam theory and the surface piezoelectricity theory to the plane wave expansion(PWE) method. In order to reveal the unique wave propagation characteristics of such a model, the band structures of locally resonant(LR) elastic PC Euler nanobeams with and without resonators, the band structures of LR piezoelectric PC Euler nanobeams with and without resonators, as well as the band structures of LR elastic/piezoelectric PC Euler nanobeams with resonators attached on PZT-4, with resonators attached on epoxy, and without resonators are compared. The results demonstrate that adding resonators indeed plays an active role in opening and widening band gaps. Moreover, the influence rules of different parameters on the band gaps of LR elastic/piezoelectric PC Euler nanobeams with resonators attached on epoxy are discussed, which will play an active role in the further realization of active control of wave propagations. | Denghui QIAN | 2020 | Applied Mathematics and Mechanics(English Edition)2020，41，3： | 5 |
| 4 | Dynamic cell transition and immune response landscapes of axolotl limb regeneration revealed by single-cell analysis显示文摘Dear Editor,The axolotl,Ambystoma mexicanum,has extraordinary capability to fully recover multiple tissues after lost,whereas such capability has disappeared in mammals.Thus,deci-phering detailed mechanisms underlying axolotl regenera-tion could provide valuable lessons for regenerative medicine.However,many questions,such as the origin of essential progenitor cells and key responses of individual types of cells for regeneration remain elusive(Haas and Whited,2017).Newly developed single-cell RNA sequenc-ing(scRNA-seq)method enables researchers to observe cellular and molecular dynamics in axolotl regeneration at the single-cell resolution(Gerber et al.,2018;Leigh et al.,2018),but the reported transcriptome landscapes are only for certain cell types or in certain regenerative stages.A complete overview of the regeneration process for all cell types is still lacking. | Hanbo Li Xiaoyu Wei Li Zhou Weiqi Zhang Chen Wang Yang Guo Denghui Li Jjianyang Chen Tianbin Liu Yingying Zhang Shuai Ma Congyan Wang Fujian Tan Jiangshan Xu Yang Liu Yue Yuan Liang Chen Qiaoran Wang Jing Qu Yue Shen Shanshan Liu Guangyi Fan Longqi Liu Xin Liu Yong Hou Guang-Hui Liu Ying Gu Xun Xu | 2021 | Protein & Cell2021，12，1： | 3 |
| 5 | Exosome-loaded extracellular matrix-mimic hydrogel with anti-inflammatory property Facilitates/promotes growth plate injury repair显示文摘Growth plate cartilage has limited self-repair ability,leading to poor bone bridge formation post-injury and ultimately limb growth defects in children.The current corrective surgeries are highly invasive,and outcomes can be unpredictable.Following growth plate injury,the direct loss of extracellular matrix(ECM)coupled with further ECM depletion due to the inhibitory effects of inflammation on the cartilage matrix protein greatly hinder chondrocyte regeneration.We designed an exosome(Exo)derived from bone marrow mesenchymal stem cells(BMSCs)loaded ECM-mimic hydrogel to promote cartilage repair by directly supplementing ECM and anti-inflammatory properties.Aldehyde-functionalized chondroitin sulfate(OCS)was introduced into gelatin methacryloyl(GM)to form GMOCS hydrogel.Our results uncovered that GMOCS hydrogel could significantly promote the synthesis of ECM due to the doping of OCS.In addition,the GMOCS-Exos hydrogel could further promote the anabolism of chondrocytes by inhibiting inflammation and ultimately promote growth plate injury repair through ECM remodeling. | Pengfei Guan Can Liu Denghui Xie Shichao Mao Yuelun Ji Yongchang Lin Zheng Chen Qiyou Wang Lei Fan Yongjian Sun | 2022 | Bioactive Materials2022，7，4： | 3 |
| 6 | The LYZ centroid conjecture for star bodies显示文摘Lutwak et al.(2010) established the Orlicz centroid inequality for convex bodies and conjectured that their Orlicz centroid inequality could be extended to star bodies. Zhu(2012) confirmed the conjectured Lutwak, Yang and Zhang(LYZ) Orlicz centroid inequality and solved the equality condition for the case that φis strictly convex. Without the condition that φ is strictly convex, this paper studies the equality condition of the conjectured LYZ Orlicz centroid inequality for star bodies. | Denghui Wu Jiazu Zhou | 2018 | Science China Mathematics2018，61，7： | 2 |
| 7 | Deriving Temporal and Vertical Distributions of Methane in Xianghe Using Ground-based Fourier Transform Infrared and Gas-analyzer Measurements显示文摘Methane(CH4)is one of the most important greenhouse gases in the atmosphere,making it worthwhile to study its temporal and vertical distributions in source areas,e.g.,North China.For this purpose,a ground-based high-resolution Fourier transform infrared spectrometer(FTIR),the Bruker IFS 125 HR,along with an in-situ instrument,the Picarro G2301,were deployed in Xianghe County(39.8°N,117.0°E),Hebei Province,China.Data have been recorded since June2018.For the FTIR measurements,we used two observation modes to retrieve the mole fraction of CH4:the Total Carbon Column Observing Network(TCCON)method(retrieval algorithm:GGG2014),and the Network for the Detection of Atmospheric Composition Change(NDACC)method(retrieval algorithm:SFIT4).Combining FTIR with in-situ measurements,we found the temporal and vertical distributions of atmospheric CH4 within three vertical layers(near the ground,in the troposphere,and in the stratosphere),and throughout the whole atmosphere.Regarding the diurnal variation of CH4 near the ground,the concentration at night was higher than during the daytime.Regarding the seasonal variation,CH4 was low in spring and high in summer,for all three vertical layers.In addition,there was a peak of CH4 in winter near the ground,both in the troposphere and the whole atmosphere.We found that variation of CH4 in the tropospheric column was close to that of the in-situ measurements near the ground.Furthermore,the variations of CH4 in the stratospheric column could be influenced by vertical motions,since it was higher in summer and lower in winter. | Denghui JI Minqiang ZHOU Pucai WANG Yang YANG Ting WANG Xiaoyu SUN Christian HERMANS Bo YAO Gengchen WANG | 2020 | Advances in Atmospheric Sciences2020，37，6： | 2 |
| 8 | Free-space realization of tunable pin-like optical vortex beams显示文摘We demonstrate,both analytically and experimentally,free-space pin-like optical vortex beams (POVBs). Such angular-momentum-carrying beams feature tunable peak intensity and undergo robust antidiffracting propagation,realized by judiciously modulating both the amplitude and the phase profile of a standard laser beam.Specifically,they are generated by superimposing a radially symmetric power-law phase on a helical phase structure,which allows the inclusion of an orbital angular momentum term to the POVBs. During propagation in free space,these POVBs initially exhibit autofocusing dynamics,and subsequently their amplitude patterns morph into a high-order Bessel-like profile characterized by a hollow core and an annular main lobe with a constant or tunable width during propagation. In contrast with numerous previous endeavors on Bessel beams,our work represents the first demonstration of long-distance free-space generation of optical vortex 'pins' with their peak intensity evolution controlled by the impressed amplitude structure. Both the Poynting vectors and the optical radiation forces associated with these beams are also numerically analyzed,revealing novel properties that may be useful for a wide range of applications. | DOMENICO BONGIOVANNI DENGHUI LI MIHALIS GOUTSOULAS HAO WU YI HU DAOHONG SONG ROBERTO MORANDOTTI NIKOLAOS KEFREMIDIS ZHIGANG CHEN | 2021 | Photonics Research2021，9，7： | 2 |
| 9 | Roles of Te and Mn in the two phases of manganite with nominal composition La_(0.6)Sr_(0.1)Te_xMnO_3显示文摘Powder samples with nominal composition La0.6Sr0.1TexMnO3 (x = 0.00, 0.05, 0.10, 0.15, 0.20) were prepared using the sol-gel method with thermal treatment up to 1473 K. On the basis of powder X-ray diffraction (XRD), thermogravimetric and magnetic measurements, it was found that almost all of the Te and a few of the Mn ions were lost from the samples when they were calcined at 1473 K. The reason for the Te loss and a quantitative phase analysis for the samples calcined at 1473 K are discussed in detail. | LI Yanfeng JI Denghui ZHAO Zhiwei TANG Guide LIU Shaopeng ZHANG Yuge LI Zhuangzhi HOU Denglu ZHU Minggang | 2011 | Rare Metals2011，30，3： | 2 |
| 10 | Intrusions of Kuroshio and Shelf Waters on Northern Slope of South China Sea in Summer 2015显示文摘The northern slope region of the South China Sea(SCS) is a biological hot spot characterized by high primary productivity and biomasses transported by cross-shelf currents, which support the spawning and growth of commercially and ecologically important fish species. To understand the physical and biogeochemical processes that promote the high primary production of this region, we conducted a cruise from June 10 and July 2, 2015. In this study, we used fuzzy cluster analysis and optimum multiparameter analysis methods to analyze the hydrographic data collected during the cruise to determine the compositions of the upper 55-m water masses on the SCS northern slope and thereby elucidate the cross-slope transport of shelf water(SHW) and the intrusions of Kuroshio water(KW). We also analyzed the geostrophic currents derived from acoustic Doppler current profiler measurements and satellite data. The results reveal the surface waters on the northern slope of the SCS to be primarily composed of waters originating from South China Sea water(SCSW), KW, and SHW. The SCSW dominated a majority of the study region at percentages ranging between 60% and 100%. We found a strong cross-slope current with speeds greater than 50 cms^(-1) to have carried SHW into and through the surveyed slope area, and KW to have intruded onto the slope via mesoscale eddies, thereby dominating the southwestern section of the study area. | LI Denghui ZHOU Meng ZHANG Zhaoru ZHONG Yisen ZHU Yiwu YANG Chenghao XU Mingquan XU Dongfeng HU Ziyuan | 2018 | Journal of Ocean University of China2018，17，3： | 2 |
| 11 | Comparison of catalytic pyrolysis of biomass with MCM-41 and CaO catalysts by using TGA–FTIR analysis显示文摘 | Denghui Wang Rui Xiao Huiyan Zhang Guangying He | 2010 | Journal of Analytical and Applied Pyrolysis2010，，2： | 1 |
| 12 | Pigeon Robot for Navigation Guided by Remote Control:System Construction and Functional Verification显示文摘Animal robots have outstanding advantages over traditional robots in their own energy supplies,orientation,and natural concealment,delivering significant value in the theories and applications of neural science,national security,and other fields.Presently,many animal robots have been fabricated,but researches about the applications of avian robots are still lacking.In this study,we constructed a Pigeon Robot System(PRS),optimized the electric stimulation parameters,assessed the electric stimulus of navigation,and evaluated the navigation efficiency in the field.Biphasic pulse constant current pattern was adapted,and the optimal stimulus parameters of 4 nuclei tested were of amplitude 0.3 mA,5 pulse trains,frequency 25 Hz,5 pulses,and a 25%duty cycle.Effective ratio of left and right steering behavior response to electric stimulus dorsointermedius ventralis anterior nuclei was 67%and 83%,respectively(mean value 75%).Electrical stimulation efficiency was 0.34-0.68 and path efficiency was 0.72-0.85 among pigeon robot individuals in the open field.Neither electrical stimulation efficiency nor path efficiency differed significantly(P>0.05),suggesting that the navigational PRS performance was not biased in either direction.PRS can achieve continuous navigation along simple pathways and provide the necessary application infrastructure and technical reference for the development of animal robot navigation technology. | Zhengyue Zhou Denghui Liu Hong Sun Wenbo Xu Xinmao Tian Xiaoyuan Li Han Cheng Zhenlong Wang | 2021 | Journal of Bionic Engineering2021，18，1： | 1 |
| 13 | Numerical investigation of wet gas flow in Venturi meter显示文摘 | Denghui He Bofeng Bai | 2012 | Flow Measurement and Instrumentation2012，28，11： | 1 |
| 14 | A new correlation for wet gas flow rate measurement with Venturi meter based on two-phase mass flow coefficient显示文摘 | Denghui He Bofeng Bai | 2014 | Measurement2014，58，2： | 1 |
| 15 | Enhanced brightness of organic light-emitting diodes based on Mg:Ag cathode using alkali metal chlorides as an electron injection layer显示文摘 | Ye Zou Zhenbo Deng Denghui Xu Zhaoyue Lü Yuehong Yin Hailiang Du Zheng Chen Yongsheng Wang | 2011 | Journal of Luminescence2011，，2： | 1 |
| 16 | Improved performance of organic light-emitting diodes with cesium chloride inside tris (8-hydroxyquinoline) aluminum显示文摘 | Zhaoyue Lü Zhenbo Deng Zheng Chen Hailiang Du Ye Zou Denghui Xu Yongsheng Wang | 2010 | Current Applied Physics2010，，3： | 1 |
| 17 | A fuzzy multi-criteria decision making approach for solving a biobjective personnel assignment problem 显示文摘 | Huang Denghui Chiu H N Yeh R H | 2009 | Computers Industrial Engineering2009，56，1： | 1 |
| 18 | Influence of mixing, oxygen and residence time on the SNCR process显示文摘 | Ling Liang Shien Hui Su Pan Tong Shang Changchun Liu Denghui Wang | 2014 | Fuel2014，，： | 1 |
| 19 | Expert System of the Parameter Optimization in the Heavy-Duty Cutting Processing 显示文摘 | Yuquan Chen Zhenjia Li Denghui Zhu | 2007 | Materials Science Forum2007，，： | 1 |
| 20 | Synthesis, formation mechanism and photocatalytic property of nanoplate-based copper sulfide hierarchical hollow spheres显示文摘 | Denghui Jiang Wenbin Hu Haoran Wang Bin Shen Yida Deng | 2012 | Chemical Engineering Journal2012，，： | 1 |
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