|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Spatial bandwidth extended reconstruction for digital color Fresnel holograms显示文摘 | PASCAL P PATRICE T DENIS M | | 0，，11： | 1 |
| 3 | Copolymerization and degradation of poly (lactic acidco-lysine) 显示文摘 | Denise A Barrera Eric Zylstra Peter T Lansbury | 1995 | Macromolecules1995，28，2： | 1 |
| 4 | Gallbladder emptying in normal volunteers com- parative study between cholescintigraphy and ultasonography 显示文摘 | Carlos A Buchpiguel Marcelo T Sapien-Za Denise P Vez- zozzo | 1996 | Clinical Nuclear Medicine1996，21，： | 1 |
| 5 | Inverse correlation between promoter strength and excision activity in class 1 integrons显示文摘 | Jové T Da Re S Denis F | | 0，，： | 1 |
| 6 | Synthesis and RGD peptide modification of a new biodegradable copolymer: Poly(lactic acid-co-lysine) 显示文摘 | Denise A Barrera Eric Zylstra Peter T Lansbury | 1993 | J Am Chem Soc1993，115，11： | 1 |
| 7 | Xenografts faithfully recapitulate breast cancer-specific gene expression patterns of parent primary breast tumors显示文摘 | Laura Petrillo Denise Wolf Ann Kapoun Nicholas Wang Andrea Barczak Yuanyuan Xiao Hasan Korkaya Frederick Baehner John Lewicki Max Wicha John Park Paul Spellman Joe Gray Laura van’t Veer Laura Esserman | 2012 | Breast Cancer Research and Treatment2012，，3： | 1 |
| 8 | Molecular characterization and spatial expression of the sunflower ABP1 Gene显示文摘 | CLEMENT T Denise M Michel W | 2003 | Plant Molecular Biology2003，52，： | 1 |
| 9 | In the QTL region surrounding porcine MHC, gene order is conserved with human genome显示文摘 | Carine Genêt Christine Renard Cédric Cabau Claire Rogel-Gaillard Jo?l Gellin Denis Milan | 2001 | Mammalian Genome2001，，3： | 1 |
| 10 | IgY: a promising antibody for use in immunodiagnostic and in immunotherapy显示文摘 | WILMAR D S DENISE V T | 2010 | Veterinary Immunology and Immunopathology2010，135，34： | 1 |
| 11 | Microstructure and fracture in three dimensions显示文摘 | Eric N Landis Edwin N Nagy Denis T Keane | 2002 | Engineering Fracture Mechanics2002，，7： | 1 |
| 12 | The choice among bank debt, non-bank private debt, and public debt: evidence from new corporate borrowings显示文摘 | David J Denis Vassil T Mihov | 2003 | Journal of Financial Economics2003，，1： | 1 |
| 13 | UCP2 protects hypothalamic cells from TNF-alpha-induced damage显示文摘 | Degasperi GR Romanatto T Denis RG | | 0，，20： | 1 |
| 14 | Anti-inflammatory potential of the probiotic dietary supplement Lactibiane Tolérance: In vitro and in vivo considerations显示文摘 | Sophie Drouault-Holowacz Beno?t Foligné Véronique Dennin Denise Goudercourt Kathleen Terpend André Burckel Bruno Pot | 2006 | Clinical Nutrition2006，，6： | 1 |
| 15 | Genetic challenges of flavor im- provement in tomato 显示文摘 | Harry J K Denise M T | 2013 | Trends in Genetics2013，29，4： | 1 |
| 16 | Homozygous Mutations in NEUROD1 Are Responsible for a Novel Syndrome of Permanent Neonatal Diabetes and Neurological Abnormalities显示文摘 | Rubio-Cabezas Oscar Minton Jayne A L Kantor Iren Williams Denise Ellard Sian Hattersley Andrew T | 2010 | Diabetes2010，，9： | 1 |
| 17 | Localization and cell surface anchoring of the Saccharomyces cerevisiae floceulation protein flol p显示文摘 | Bony M Denise T Barre P | 1997 | Journal of bacteriology1997，179，15： | 1 |
| 18 | Localization and cell surface anchoring of the Saccharomyces cerevisiae flocculation protein Flol p显示文摘 | Muriel B Denise T S Pierre B | 1997 | Bacteriology1997，179，15： | 1 |
| 19 | The Works Hard for the Money:Household Responsibilities and the Allocation of Work Effort显示文摘 | Bielby Denise D William T Bielby | 1988 | American Journal of Sociology1988，93，5： | 1 |
| 20 | Gallbladder Emptying in Normal Volunteers Comparative Study Between Cholescintigraphy and Ultasonography显示文摘 | CARLOS A BUCHPIGUEL MD MARCELO T SAPIENZA MD DENISE P VEZZOZZO MD | 1996 | Clinical Nuclear Medicine1996，21，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员