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| 1 | FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathway显示文摘成纤维细胞生长因素 21 (FGF21 ) , FGF 总科的一个最近识别的成员,主要从肝和脂肪质的纸巾被分泌并且在改进新陈代谢的症候群和动态平衡起一个重要作用。这研究的目的是在含酒精的脂肪肝疾病(AFLD ) 评估 FGF21 的角色并且决定它是否在 AFLD 上有治疗学的效果。在这份报纸,我们在长期的乙醇 gavage 和对待白酒的 HepG2 房间的一个鼠科的模型在导致白酒的肝损害上测试了 FGF21 的效果。男千米;公里老鼠每天收到了 5 g/kg 乙醇 gavage 的单个剂量 6 个星期,它导致了重要脂肪肝和肝损害。导致白酒的脂肪肝房间模型被在 75 公里的最后的集中增加乙醇进 HepG2 房间文化的媒介 9 天完成。结果与 recombinant FGF21 显示出那个处理在长期的乙醇 gavage 和对待白酒的 HepG2 房间的一个鼠科的模型的改善含酒精的脂肪肝和肝损害。另外, FGF21 处理下面调整丰满的酸的肝的表示合成的关键酶,激活的肝的 AMPK-SIRT1 小径和显著地下面调整的肝的氧化压力蛋白质。一起拿, FGF21 由 AMPK-SIRT1 小径的激活在 vitro 并且在 vivo 改正 AFLD 的多重新陈代谢的参数。 | Shenglong Zhu Lei Ma Yunzhou Wu Xianlong Ye Tianyuan Zhang Qingyang Zhang Lubna Muhi Rasoul Yunye Liu MO Guo Bing Zhou Guiping Ren Deshan Li | 2014 | Acta Biochimica et Biophysica Sinica2014，46，12： | 11 |
| 2 | Vibration suppression of a large flexible spacecraft for on-orbit operation显示文摘Flexible appendages, such as solar panels, communication antennas and other large structures, are mounted on the base of a space robot and target satellite. The vibration of the flexible structure is excited by operations of a space manipulator. It is very challenging to control the vibration of large flexible appendages for on-orbit operation and, especially when the manipulator operates a non-cooperative target with unknown structural parameters and vibration information. In this study, a hybrid control method is proposed based on wave-based control and PD control methods to control the motion of a manipulator while suppressing the vibration of appendages. First, the rigid-flexible coupled dynamic model of a compounded system is established.This is followed by designing a hybrid control strategy combining wave-based control and PD control for restto-rest maneuvers based on the characteristics of the compounded system. Finally, the simulation of a 3D compounded system is provided to verify the effectiveness of the presented approach. The simulation results indicate that the space robot can successfully berth the target while suppressing the vibrations of the structure. | Deshan MENG Houde LIU Yanan LI Wenfu XU Bin LIANG | 2017 | Science China(Information Sciences)2017，60，5： | 6 |
| 3 | Activation of TLR7 increases CCND3 expression via the downregulation of miR-15b in B cells of systemic lupus erythematosus显示文摘全身的豺狼座 erythematosus (SLE ) 是 B 房间 hyperreactivity 描绘的自体免疫的疾病。像使用费的受体 7 (TLR7 ) 表明小径反常地在 SLE B 房间被激活。CyclinD3 (CCND3 ) 在 B 房间增长,开发,和区别起一个重要作用。尽管以前的研究为自发的幼芽的中心的发展集中了于 TLR7 的 B 房间内在的角色,在 SLE B 房间的 CCND3 上的 TLR7 的影响仍然不是清楚的。这里,我们使用了介绍薄片的 B 房间并且发现 CCND3 与 SLE 有关并且显著地在 SLE B 房间提高了。而且,我们决定 CCND3 的表示水平更高,当 miR-15b 与正常题目相比在从 SLE 病人和 B6.MRL-Faslpr/J 豺狼座老鼠的 B 房间是显著地更低的时。而且,我们证明 TLR7 的激活戏剧性地增加了 CCND3 表示,但是显著地减少了在在 vitro 的 B 房间的 miR-15b 并且我们鉴别 CCND3 是 miR-15b 的一个直接目标。为了推进,证实我们的结果,我们由谈论地对待 C57BL/6 (B6 ) 建立了另一个豺狼座模型有为 8 个星期的 TLR-7 收缩筋 imiquimod (IMQ ) 的老鼠根据以前描述的协议。Expectedly,有 IMQ 的热门治疗显著地也增加了 CCND3 并且减少在 B6 老鼠的 B 房间的 miR-15b。一起拿,我们的结果鉴别 TLR7 的激活在 B cells; 经由 miR-15b 的 downregulation 增加了 CCND3 表示;因此,这些调查结果建议那外来的导致因素的 CCND3 表情可以在 SLE 贡献 B 房间的反常。 | Deshan Ren Fei Liu Guanjun Dong Ming You Jianjian Ji Yahong Huang Yayi Hou Hongye Fan | 2016 | Cellular & Molecular Immunology2016，13，6： | 5 |
| 4 | Distribution and possible role of PDGF-AA and PDGFR-α in the gastrointestinal tract of adult guinea pigs显示文摘 | Fangxiao Chan Yong Liu Haimei Sun Xiaoshuang Li Hongwei Shang Dongying Fan Jing An Deshan Zhou | 2010 | Virchows Archiv2010，，3： | 1 |
| 5 | Compatibilization of PPO/LCP blends by semi-interpenetrating liquid crystalline polymer networks LCP/PS显示文摘 | Xinyu Du Deshan Liu | 2001 | Macromol Mater Eng2001，274，1： | 1 |
| 6 | Effect of kudzuvine roots in improving neuroelectrophysiological function of brain in patients with diabetes mellitus type 2显示文摘 | Liu Deshan Gao Wei Wang Shuli | 2004 | Chinese Journal Integrative Medicine2004，10，4： | 1 |
| 7 | Chimeric anti-IL-17 full-length monoclonal antibody is a novel potentialcandidate for the treatment of rheumatoid arthritis显示文摘 | Fuliang Bai Hui Tian Zeshan Niu Mingyao Liu Guiping Ren Yinhang Yu Tian Sun Siming Li Deshan Li | 2014 | International Journal of Molecular Medicine2014，，3： | 1 |
| 8 | Effect of kudzuvine roots in improving neuroelectrophysiological function of brain in patients with diabetes mellitus type 2显示文摘 | Liu Deshan Gao Wei Wang Shuli | 2004 | Chinese Journal Integrative Medicine2004，10，4： | 1 |
| 9 | The catalytic behavior of crosslinked polystyrene bound platinum complex in the hydrosilyla- tion of olefins显示文摘 | Kan Chengyou Du Chimin Liu Deshan | 2002 | Polym J2002，34，3： | 1 |
| 10 | Core-shell morphology prediction via interfacial energy estimation and its application to polyacrylate - polysiloxane latex particles显示文摘 | KAN CHENG-YOU KONG XIANG-ZHENG LIU DESHAN | 2000 | Polymer Preprints2000，41，2： | 1 |
| 11 | Effects of ligustrazine on somatosensory evoked potential in normal rabbits and rabbits with cerebral ischemia-reperfusion injury显示文摘BACKGROUND: Somatosensory evoked potential (SEP) has become a method with higher sensitivity and specificity than electroencephalogram in detecting the brain function and the region, range and degree of ischemia. However, the effects of ligustrazine on SEP is still not clear. OBJECTIVE: To study the protective effects of ligustrazini injection on cerebral ischemiareperfusion injury. DESIGN: Auto-control study, random grouping. SETTING: Qilu Hospital of Shandong University. MATERIALS: The experiment was completed in the Cerebral Functional Room of Qilu Hospital Affiliated to Shandong University from March 2002 to June 2004. A totally of 24 healthy Harbin rabbits were randomly divided into blank control group (n=8), model control group (n=8) and ligustrazine treatment group (n=8). Hydrochloric ligustrazine injection, 40 mg/2 mL each ampoule, was provided by the Third Pharmaceutical Factory of Beijing (certification: 93035236273). The main component was hydrochloric ligustrazine and the chemical name was 2, 3, 5, 6-tetramethyl pyrazine hydrochloride. METHODS: ① Modeling method: The bilateral common carotid artery ligation was adopted to make the model. ② Index of cerebral functional lesion evaluated with SEP during ischemia-reperfusion: DISA 2000C neuromyoeletrometer provided by Dantec Electronics Ltd, Denmark was used to detect SEP. ③ Interventional process: Blank control group: The latencies and amplitudes of SEP were measured before injection with 1.5 mg/kg ligustrazine and at the points of 15 minutes, 20 minutes, 30 minutes, 60 minutes, 90 minutes and 120 minutes after injection. Ligustrazine treatment group: Rabbits were injected with 1.5 mg/kg ligustrazine, and those of model control group were injected the same volume of saline. Thirty minutes later, the bilateral common carotid artery of the rabbits all had been ligated for 30 minutes, and then reperfused for 120 minutes. The latencies and amplitudes of SEP were measured before injection, before ligation, at the points of 1 minute, 5 minutes, 10 minutes, 15 minutes, 20 minutes, 25 minutes and 30 minutes after ligation, and at the points of 5 minutes, 10 minutes, 15 minutes, 20 minutes, 30 minutes, 60 minutes, 90 minutes and 120 minutes after reperfusion. ④ Evaluating criteria: Normal values of P-wave latencies and amplitudes were (19.34±3.18) ms and (4.55±1.43) μV. Average value before injection in blank control group and average values before injection, after injection and before ligation in ischemia-reperfusion group were regarded as control criteria to evaluate changes of Pwave latencies and amplitudes after experiment. MAIN OUTCOME MEASURES: P-wave latencies and amplitudes of SEP in the three groups. RESULTS: A total of 24 rabbits were involved in the final analysis without any loss. ① Blank control group: The P-wave latencies delayed markedly at each time point after injection. Compared with that before injection, there was a significant difference (P < 0.05-0.01). The P-wave amplitudes did not fluctuate noticeably all the time after injection, but significantly decreased when compared with those before injection (P < 0.05-0.01). ② Ischemia-reperfusion group: The P-wave latencies delayed and amplitudes decreased in the rabbits with cerebral ischemiareperfusion at all points of time during cerebral ischemia-reperfusion, and there was significant difference when compared with the levels before ischemia (P < 0.05). When ligustrazine was injected, the latencies and amplitudes changed less, and as compared with the levels before ischemia, the difference was not significant (P > 0.05). CONCLUSION: ① Ligustrazine can inhibit P-wave latencies and amplitudes of SEP of normal rabbits. ② Ligustrazine can improve P-wave latencies and amplitudes of SEP of rabbits with cerebral ischemia-reperfusion injury. | Deshan Liu Shuli Wang Yuanyuan Hao | 2006 | Neural Regeneration Research2006，1，1： | 1 |
| 12 | Effect of Yiqi Bushen prescription on hippocampal neuronal apoptosis in diabetic rats显示文摘This study investigated the neuroprotective effect of Yiqi Bushen prescription (YQBS, supplementing qi and tonifying kidney) on neuronal cell apoptosis. Following YQBS treatment, the number of surviving hippocampal neurons increased, anti-apoptotic Bcl-2 expression increased and pro-apoptotic Bax expression decreased. In addition, diabetic rats exhibited improved learning and memory. YQBS treatment also increased Bcl-2 mRNA expression and the ratio of Bcl-2/Bax, but decreased levels of hypoxia-inducible factor-1α mRNA and Bax mRNA expression after high-glucose/hypoxia-induced injury. Results demonstrated that YQBS inhibited hippocampal neuronal apoptosis by decreasing hypoxia-inducible factor-1α expression and increasing Bcl-2 expression, thereby improving cognitive impairment in diabetic rats. | Deshan Liu Weiwei Lin Wei Gao Ping Chang Wei Li | 2011 | Neural Regeneration Research2011，6，21： | 1 |
| 13 | Cooperative planning ofmulti-agent systems based on task-oriented knowledge fusion with graph neural networks显示文摘Cooperative planning is one of the critical problems in the field of multi-agent system gaming.This work focuses on cooperative planning when each agent has only a local observation range and local communication.We propose a novel cooperative planning architecture that combines a graph neural network with a task-oriented knowledge fusion sampling method.Two main contributions of this paper are based on the comparisons with previous work:(1)we realize feasible and dynamic adjacent information fusion using GraphSAGE(i.e.,Graph SAmple and aggreGatE),which is the first time this method has been used to deal with the cooperative planning problem,and(2)a task-oriented sampling method is proposed to aggregate the available knowledge from a particular orientation,to obtain an effective and stable training process in our model.Experimental results demonstrate the good performance of our proposed method. | Hanqi DAI Weining LU Xianglong LI Jun YANG Deshan MENG Yanze LIU Bin LIANG | 2022 | Frontiers of Information Technology & Electronic Engineering2022，23，7： | 0 |
| 14 | Sulfonate-containing Copolymers Prepared by Semi-Continuous Emulsion Copolymerizaiton of Styrene and Sodium Styrene Sulfonate显示文摘 | Shiming HUANG Wei XIE Chengyou KAN Yajie LI Deshan LIU | 2005 | 复旦学报(自然科学版)2005，44，5： | 0 |
| 15 | Influences of Electrolytes on Soap-Free P(ST-MMA-AA) Emulsion Polymerization显示文摘 | Zeping LI Ronglong LI Yi DU Chengyou KAN Deshan LIU | 2005 | 复旦学报(自然科学版)2005，44，5： | 0 |
| 16 | Controlled synthesis of hierarchically-structured MnCo_2O_4 and its potential as a high performance anode material显示文摘To satisfy the upsurging demand for energy storage in modern society,anode materials which can deliver high capacity have been intensively researched for the next generation lithium ion batteries.Typically,the binary MnCo_2O_4 with a characteristic coupled metal cations showed promising potential due to its high theoretical capacity and low cost.Here,by means of a well-designed synthesis control,we demonstrated a scalable process to achieve a hierarchical structure of MnCo_2O_4,which existed as uniform microspheres with embedded mesopores,showing favorable structural characters for high performance during a fast charge/discharge process.Our synthesis highlighted the importance of sodium salicylate as an essential additive to control the precipitation of the two involved metal cations.It was proved that a dual role was played sodium salicylate which cannot only facilitate the formation of microspheric shape,but also act as an effective precursor for the creation of inner mesopores.We confirmed that the hierarchically-structured MnCo_2O_4 showed outstanding performance when it was tested as an anode material in lithium ion batteries as revealed by its extraordinary cycling stability and high rate capability. | Zixiao Wu Fuhai Li Yonggang Sun Deshan Bin Junyu Piao Xijie Lin Xiaochan Liu Anmin Cao Li-Jun Wan | 2017 | Science China Chemistry2017，60，9： | 0 |
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