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147篇 您的检索式:作者名="Dikic"
    题名 作者 年代 出处 被引量
1Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress显示文摘在细胞的 ubiquitin (Ub ) 的改变动态平衡,作为 Ub 知道强调,展示并且影响处于多重条件的细胞的回答,然而,内在的机制不完全地被理解。这里,我们报导 autophagy 受体 p62/sequestosome-1 与结合酶, UBE2D2 和 UBE2D3 的 E2 Ub 交往。内长的 p62 在 Ub 动态平衡的 upregulation 期间经历 E2 依赖的 ubiquitylation,一个条件作为 Ub + 应力称为,那对由 bortezomib 的 Ub overexpression,热吃惊或延长 proteasomal 抑制内在,化学疗法的药。p62 的 Ubiquitylation 破坏 p62 的 UBA 领域的 dimerization,解放它的能力认出为选择 autophagy 的 polyubiquitylated 货物。我们进一步证明这机制可能为在 Ub + 压力条件之上的 autophagy 激活是批评的。机制的描述和在察觉到 Ub 应力并且控制选择 autophagy 的 p62 的规章的角色能帮助理解并且调制细胞的回答到许多内长、环境的挑战,潜在地对 autophagy 相关的病为治疗学的策略的发展打开一条新大街。Hong Peng Jiao Yang Guangyi Li Qing You Wen Han Tianrang Li Darning Gao Xiaoduo Xie Byung-Hoon Lee Juan Du Jian Hou Tao Zhang Hai Rao Ying Huang Qinrun Li Rong Zeng Lijian Hui Hongyan Wang Qin Xia Xuemin Zhang Yongning He Masaaki Komatsu Ivan Dikic Daniel Finley Ronggui Hu 2017Cell Research2017,27,5:9
2Bacteria-host relationship: ubiquitin ligases as weapons of invasion显示文摘Timurs Maculins Evgenij Fiskin Sagar Bhogaraju Ivan Dikic 2016Cell Research2016,26,4:2
3Targeting the ubiquitin system in cancer therapy显示文摘Hoeller D Dikic I 2009Nature2009,458,7237:1
4CIN85/CMS family of adaptor molecules显示文摘DIKIC I 2002FEBS Lett2002,529,1:1
5The role of ubiquitylation in receptor endocytosis and endosomal sorting显示文摘Haglund K Dikic I 2012J Cell Sci2012,125,2:1
6Targeting the ubiquitin system in cancer therapy显示文摘Hoeller D Dikic I 2009Nature2009,458,43:1
7PLEKHM1 :adapting to life at the ly- sosome 显示文摘MCEWAN D G DIKIC I 2015Autophagy2015,11,4:1
8Stenting a myocardial bridge:a wrong decision in STEMI?显示文摘Tomasevic M Dikic M Ostojic M 2011Acta Cardiologica2011,66,1:1
9CIN85/CMS family of adaptor molecules显示文摘Dikic I 2002FEBS Lett2002,529,1:1
10Ubiquitination in disease pathogenesis and treatment显示文摘Popovic D Vucic D Dikic I 2014NatMed2014,20,11:1
11Ubiquitin and ubiquitin-like proteins in cancer pathogenesis显示文摘Hoeller D Hecker CM Dikic I 2006Nat Rev Cancer2006,6,10:1
12Carbendazim impends hepatic necrosis when combined with imazalil or cypermethrin 显示文摘DIKIC D LANDEKA I KNEZEVIC F 2012Basic and Clinical Pharmacology and Toxicol- ogy2012,110,5:1
13Autophagy in anti-microbial immunity显示文摘Ligia C. Gomes Ivan Dikic 2014Molecular Cell2014,,:1
14Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization,activation,and cell proliferation显示文摘Spivak-Kroizman T Lemmon M A Dikic I 1994Cell1994,79,:1
15The Cbl interactome and its funetions显示文摘Sehmidt MHH Dikic i 2005Nat Rev Mol Cell Biol2005,6,:1
16Ubiquitin and ubiquitin like proteins in cancer pathogenesis 显示文摘HOELLER D HECKER C M DIKIC I 2006Nat Rev Can2006,6,10:1
17A Role for Ubiquitin in Selective Autophagy显示文摘Vladimir Kirkin David G. McEwan Ivana Novak Ivan Dikic 2009Molecular Cell2009,,3:1
18CIN85/CMS family of adaptor molecules显示文摘Dikic I 2002FEBS Lett2002,529,1:1
19Correla-tion analysis of predictive factors of successful implantation in fertiliza-tion in vitro显示文摘Papic - Obradovic M Dragojevic - Dikic S Mitrovic A 2003Srp Arh Celok Lek2003,131,78:1
20The Cbl interaetome and its functions 显示文摘Schmidt MH Dikic I 2005Nat Rev Mol Cell Biol2005,6,12:1
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