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| 1 | Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress显示文摘在细胞的 ubiquitin (Ub ) 的改变动态平衡,作为 Ub 知道强调,展示并且影响处于多重条件的细胞的回答,然而,内在的机制不完全地被理解。这里,我们报导 autophagy 受体 p62/sequestosome-1 与结合酶, UBE2D2 和 UBE2D3 的 E2 Ub 交往。内长的 p62 在 Ub 动态平衡的 upregulation 期间经历 E2 依赖的 ubiquitylation,一个条件作为 Ub + 应力称为,那对由 bortezomib 的 Ub overexpression,热吃惊或延长 proteasomal 抑制内在,化学疗法的药。p62 的 Ubiquitylation 破坏 p62 的 UBA 领域的 dimerization,解放它的能力认出为选择 autophagy 的 polyubiquitylated 货物。我们进一步证明这机制可能为在 Ub + 压力条件之上的 autophagy 激活是批评的。机制的描述和在察觉到 Ub 应力并且控制选择 autophagy 的 p62 的规章的角色能帮助理解并且调制细胞的回答到许多内长、环境的挑战,潜在地对 autophagy 相关的病为治疗学的策略的发展打开一条新大街。 | Hong Peng Jiao Yang Guangyi Li Qing You Wen Han Tianrang Li Darning Gao Xiaoduo Xie Byung-Hoon Lee Juan Du Jian Hou Tao Zhang Hai Rao Ying Huang Qinrun Li Rong Zeng Lijian Hui Hongyan Wang Qin Xia Xuemin Zhang Yongning He Masaaki Komatsu Ivan Dikic Daniel Finley Ronggui Hu | 2017 | Cell Research2017，27，5： | 9 |
| 2 | Bacteria-host relationship: ubiquitin ligases as weapons of invasion显示文摘 | Timurs Maculins Evgenij Fiskin Sagar Bhogaraju Ivan Dikic | 2016 | Cell Research2016，26，4： | 2 |
| 3 | Autophagy in anti-microbial immunity显示文摘 | Ligia C. Gomes Ivan Dikic | 2014 | Molecular Cell2014，，： | 1 |
| 4 | A Role for Ubiquitin in Selective Autophagy显示文摘 | Vladimir Kirkin David G. McEwan Ivana Novak Ivan Dikic | 2009 | Molecular Cell2009，，3： | 1 |
| 5 | Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking显示文摘 | David Nonis Mirko H.H. Schmidt Simone van de Loo Florian Eich Ivan Dikic Joachim Nowock Georg Auburger | 2008 | Cellular Signalling2008，，10： | 1 |
| 6 | New EMBO Member's Review Ubiquitytation and cell signaling 显示文摘 | KAISA HAGLUND IVAN DIKIC | 2005 | The EMBO Journal2005，24，7： | 1 |
| 7 | RNA binding to p62 impacts selective autophagy显示文摘Role of RNA regulation in autophagy was rather unexplored until Horos et al. recently showed that vault RNA1-1 binds directly to p62/SQSTM1, a well-established autophagy receptor. This binding leads to inhibition of p62 oligomerization and negative regulation of selective autophagy pathways. | Mohit Misra Ivan Dikic | 2019 | Cell Research2019，29，7： | 1 |
| 8 | Synthesis and biological evaluation of a series of flavone derivatives as potential radioligands for imaging the multidrug resistance-associated protein 1 (ABCC1/MRP1)显示文摘 | Sylvie Mavel Branko Dikic Somchit Palakas Patrick Emond Ivan Greguric Adrienne Gomez de Gracia Filomena Mattner Manuel Garrigos Denis Guilloteau Andrew Katsifis | 2005 | Bioorganic & Medicinal Chemistry2005，，5： | 1 |
| 9 | Ubiquitin-induced phase separation of p62/SQSTM1显示文摘 | Lina Herhaus Ivan Dikic | 2018 | Cell Research2018，28，4： | 1 |
| 10 | Gasdermin B in the host–pathogen tug-of-war显示文摘The Shigella flexneri effector IpaH7.8 targets gasdermin B for degradation in infected host cells.This bacterial strategy counteracts a host defense mechanism in which the lymphoid cell compartment activates the bactericidal properties of gasdermin B. | Timurs Maculins Ivan Dikic | 2021 | Cell Research2021，31，10： | 0 |
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