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| 1 | Evaluation of biodegradable electric conductive tube-guides and mesenchymal stem cells显示文摘AIM: To study the therapeutic effect of three tubeguides with electrical conductivity associated to mesenchymal stem cells(MSCs) on neuro-muscular regeneration after neurotmesis.METHODS: Rats with 10-mm gap nerve injury were tested using polyvinyl alcohol(PVA), PVA-carbon nanotubes(CNTs) and MSCs, and PVA-polypyrrole(PPy). The regenerated nerves and tibialis anterior muscles were processed for stereological studies after 20 wk. The functional recovery was assessed serially for gait biomechanical analysis, by extensor postural thrust, sciatic functional index and static sciatic functionalindex(SSI), and by withdrawal reflex latency(WRL). In vitro studies included cytocompatibility, flow cytometry, reverse transcriptase polymerase chain reaction and karyotype analysis of the MSCs. Histopathology of lung, liver, kidneys, and regional lymph nodes ensured the biomaterials biocompatibility. RESULTS: SSI remained negative throughout and independently from treatment. Differences between treted groups in the severity of changes in WRL existed, showing a faster regeneration for PVA-CNTs-MSCs(P < 0.05). At toe-off, less acute ankle joint angles were seen for PVA-CNTs-MSCs group(P = 0.051) suggesting improved ankle muscles function during the push off phase of the gait cycle. In PVA-PPy and PVA-CNTs groups, there was a 25% and 42% increase of average fiber area and a 13% and 21% increase of the 'minimal Feret's diameter' respectively. Stereological analysis disclosed a significantly(P < 0.05) increased myelin thickness(M), ratio myelin thickness/axon diameter(M/d) and ratio axon diameter/fiber diameter(d/D; g-ratio) in PVA-CNT-MSCs group(P < 0.05). CONCLUSION: Results revealed that treatment with MSCs and PVA-CNTs tube-guides induced better nerve fiber regeneration. Functional and kinematics analysis revealed positive synergistic effects brought by MSCs and PVA-CNTs. The PVA-CNTs and PVA-PPy are promising scaffolds with electric conductive properties, bio- and cytocompatible that might prevent the secondary neurogenic muscular atrophy by improving the reestablishment of the neuro-muscular junction. | Jorge Ribeiro Tiago Pereira Ana Rita Caseiro Paulo Armada-da-Silva Isabel Pires Justina Prada Irina Amorim Sandra Amado Miguel Franca Carolina Goncalves Maria Ascensao Lopes Jose Domingos Santos Dina Morais Silva Stefano Geuna Ana Lúcia Luís Ana Colette Maurício | 2015 | World Journal of Stem Cells2015，7，6： | 2 |
| 2 | Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03) 显示文摘 | Le Clerc S Limou S Coulonges C Carpentier W Dina C Taing L Delaneau O Labib T Sladek R ANRS Genomic Group Deveau C Guillemain H Ratsimandresy R Montes M Spadoni JL Therwath A Schichter F Matsuda F Gut I Leli6vre JD L6vy Y Froguel P Delfraissy JF Hercberg S Zagury JF | 2009 | Infect Dis2009，200，8： | 1 |
| 3 | Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups显示文摘 | Scherag A Dina C Hinney A Vatin V Scherag S Vogel C I Muller T D Grallert H Wichmann H E Balkau B Heude B Jarvelin M R Hartikainen A L Levy-Marchal C Weill J Delplanque J Korner A Kiess W Kovacs P Rayner N W Prokopenko I McCarthy M I Schafer H Jarick I Bo | | 0，，04： | 1 |
| 4 | Complementary and alternative medications in hepatitis C infection显示文摘Chronic hepatitis C(CHC) infection affects almost 3% of the global population and can lead to cirrhosis, liver failure, and hepatocellular carcinoma in a significant number of those infected. Until recently, the only treatments available were pegylated interferon and ribavirin, which traditionally were not very effective and have considerable side effects. For this reason, interest in complementary and alternative medications(CAM) in the management of hepatitis C has been investigated. Some CAM has demonstrated therapeutic potential in chronic hepatitis C treatment. Unfortunately, some CAM has been shown to have the potential to cause drug-induced liver injury. This article will review and evaluate many of the natural molecules that interact with the hepatitis C virus(HCV) life cycle and discuss their potential use and safety in HCV therapy, as well as highlight some important interactions between medical and complementary treatments. | Dina L Halegoua-De Marzio Jonathan M Fenkel | 2014 | World Journal of Hepatology2014，6，1： | 1 |
| 5 | Hypomelanosis of Ito: neurological complica- tions in 34 cases 显示文摘 | Pascual-Castroviejo I Lopez-Rodriguez L de la Cruz Me- dina M | 1988 | Can J Neurol Sci1988，5，： | 1 |
| 6 | Clinical measurement of sit-to-stand performance in people with balance disorders: Validity of data for the five-times-sit-to-stand test 显示文摘 | Susan L W Dina M W Gregory F M | 2005 | Physical Therapy2005，85，11： | 1 |
| 7 | Mixed lymphohaemopoietic chimerism and graft-ver suslymphoma effects after non-myeloablative therapy and HLA-mismatched bone-marrow transplantation显示文摘 | Megan Sykes Frederic Preffer Steven McAfee Susan L Saidman Dina Weymouth David M Andrews Christine Colby Robert Sackstein David H Sachs Thomas R Spitzer | 1999 | The Lancet1999，，9166： | 1 |
| 8 | Sandra streukens comfort your online customer: quality, trust and loyalty on the internet 显示文摘 | DINA R ALLARD C V VERONICA L | 2004 | Managing Service Quality2004，14，6： | 1 |
| 9 | Squamous Cell Carcinoma of the Cervix: A Cytology-Histology-Human Papillomavirus Correlation in Clinical Practice显示文摘 | Miller Ross A Waters Lindsay L Mody Dina R Tams Kimberlee C | 2015 | Archives of Pathology & Laboratory Medicine2015，，6： | 1 |
| 10 | ,Improvement of dissolution properties of Carbamazepine through application of the liquisolid tablet technique显示文摘 | Saadia Tayel A Iman Soliman I Dina L | 2008 | Eur J Pharm Biopharm2008，69，1： | 1 |
| 11 | A genome-wide association study identifies novel risk loci for type 2 diabetes 显示文摘 | Sladek R Rocheleau G Rung J Dina C Shen L Serre D Boutin P Vincent D Belisle A Hadjadj S 2007 | 2007 | Nature2007，445，7130： | 1 |
| 12 | A refined Hilbert-Huang transform applications to interarea os- cillation monitoring 显示文摘 | Dina S L Arturo R M Bikash C P | 2009 | IEEE Transactions on Power System2009，24，2： | 1 |
| 13 | Alcohol intake modulates the effect of a polymorphism of cholesteryl ester transfer protein gene on plasma high density lipoprotein and the risk of myocardiol infarction 显示文摘 | Frederic F Dina B Gerald L | 1995 | J Clin Invest1995，96，： | 1 |
| 14 | A refined Hilbert-Huang transform with applications to interarea oscillation monitoring 显示文摘 | Dina S L Arturo R M Bikash C P | 2008 | IEEE Transaction on Power Systems2008，23，3： | 1 |
| 15 | Cli-ni- cal and ultrasound diagnostics of acute venous thrombosis 显示文摘 | Lemenev V L Kungurtsev E V Gol~dina I M | 2008 | Khirurgiia(Mosk)2008，，5： | 1 |
| 16 | Natural organic matter and sunlight accelerate the degradation of 1713-estradiol in water 显示文摘 | Dina M L Matthew T S Robert G W | 2009 | Science of the total Environment2009，407，： | 1 |
| 17 | One century of arsenic exposure in Latin America: A review of history and occurrence from 14 countries显示文摘 | Jochen Bundschuh Marta I. Litter Faruque Parvez Gabriela Román-Ross Hugo B. Nicolli Jiin-Shuh Jean Chen-Wuing Liu Dina López María A. Armienta Luiz R.G. Guilherme Alina Gomez Cuevas Lorena Cornejo Luis Cumbal Regla Toujaguez | 2011 | Science of the Total Environment2011，，： | 1 |
| 18 | A refinedHilbert-Huang transform with applications to inter-areaoscillation monitoring显示文摘 | DINA S L MESSINA A R BIKASH C P | 2009 | IEEE Transactions on PowerSystems2009，24，2： | 1 |
| 19 | Thermal stability of nanocomposites based on PP and bentonite 显示文摘 | Florencio G F Tomas J A M Marcelo S R Sue- dina M L S | 2005 | Polym Degrad Stab2005，89，： | 1 |
| 20 | Alzheimer’s disease and brain infarcts in the elderly显示文摘 | Dina Zekry Charles Duyckaerts Jo?l Belmin Caroline Geoffre Robert Moulias Jean-Jacques Hauw | 2002 | Journal of Neurology2002，，11： | 1 |
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