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| 1 | Failure of hepatocyte marker-expressing hematopoietic progenitor cells to efficiently convert into hepatocytes in vitro显示文摘 | Lian G Wang C Teng C Zhang C Du L Zhong Q Miao C Ding M Deng H | 2006 | 中国生物学文摘2006，20，5： | 11 |
| 2 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 3 | 笋芽顶端分生组织在竹秆横切面形态形成中的作用与机制研究显示文摘竹秆的横切面主要由表皮、皮层、维管组织、基本组织及髓腔(早期为髓组织)组成。这些组织均由笋芽茎顶端分生组织分化发育而来,且其在生长发育过程中促使了竹秆横切面形态(本文特指:竹秆横切面外轮廓形状、围度及壁-腔结构)的形成。然而,人们对于这一生长发育过程的生物学机制知之甚少。本研究利用解剖学、数学模拟等方法,对 20 种具不同秆径竹种的笋芽顶端分生组织进行了分析。研究结果发现,笋芽顶端分生组织指状形态的维持是竹子产生圆柱形竹秆的基础;在顶端分生组织细胞数目增加的同时,线性增加原体细胞数目应是竹子在演化过程中产生大径竹秆且保持规则壁-腔结构的方式。进一步通过研究一个竹壁增厚且壁-腔架构紊乱的稳定变异体———实肚竹( Phyllostachys nidularia f. farcta)发现,其笋芽顶端分生组织细胞数目减少且原体/原套细胞数比值降低使其产生了高比例的壁组分组织(指基本分生组织与肋状分生组织)与低比例的髓组织。上述 2 种组织的比例失衡,使得实肚竹笋芽在后续发育中壁组分组织随机挤入到了髓组织中,最终形成了实肚竹异常的竹秆横切面形态(竹壁多样化增厚且壁-腔结构紊乱)。此外,相对较小的顶端分生组织,使得实肚竹笋芽产生了较少的内源激素,如其生长素含量仅约为其原种篌竹的 67. 5%,各细胞分裂素含量也显著低于篌竹笋芽。转录组分析进一步发现,在实肚竹笋芽中与激素及代谢相关的功能基因呈显著下调表达。这些生理与分子变化最终导致了实肚竹竹秆矮化、秆径减小且生物量降低。本论文的研究结果为研究竹秆横切面发育提供了一个重要的视角,同时也为实肚竹厚壁茎秆的形成提出了一个合理的机制。 | Wang Y Sun X Ding Y Fei Z Jiao C Fan M Yao B Xin P Chu J Wei Q 王雨珺 魏强 | 2019 | 世界竹藤通讯2019，17，3： | 5 |
| 4 | A concise survey of scheduling with time-dependent processing times显示文摘 | Cheng T C E Ding Q Lin B M T | 2004 | European Journal of Operational Research2004，152，： | 1 |
| 5 | Atmospheric hexachloroeyclohexartes in the North Pacific Ocean and the adjacent arctic region: spatial patterns, chiral signatures, and sea - air exchanges 显示文摘 | DING X WANG X M XIE Z Q | 2007 | Environ Sci Technol2007，41，： | 1 |
| 6 | Re verse signaling using an inducible costimulator to enhance im munogenic function of dendritic cells显示文摘 | Tang G Qin Q Zhang P Wang G Liu M Ding Q | 2009 | Ceil Mol Life Sci2009，66，： | 1 |
| 7 | Regulatory cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice 显示文摘 | Ding Q Yeung M Camirand G | 2011 | J Clin Invest2011，121，9： | 1 |
| 8 | Expression pattern genomic struc- ture, and promoter analysis of the gene encoding stilbene synthase from Chinese wild Vitis pseudoreticulata显示文摘 | XU W R YU Y H ZHOU Q DING J H DAI L M XIE X Q XU Y ZHANG C H WANG Y J | 2011 | Journal of Experimen- tal Botany2011，62，8： | 1 |
| 9 | Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice 显示文摘 | Ding Q Yeung M Camirand G | 2011 | J Clin Invest2011，121，9： | 1 |
| 10 | A concise survey of scheduling with time-dependent processing times显示文摘 | Cheng T C E Ding Q Lin B M T | 2004 | European Journal of Operational Research2004，152，： | 1 |
| 11 | Optimal cutter selection for complex mould machining显示文摘 | DING X M LU Y Q LIU P L | 2005 | SIM Technical Reports2005，6，1： | 1 |
| 12 | Shrimp zircon geochronological and geochemical evidence for Neo - Proterozoic arc - related magmatism along the western of the Yangtze Block, South China 显示文摘 | Zhou M F Yah D P Kennedy A K Li Q I and Ding J | 2002 | Earth Planet Sci Lett2002，196，： | 1 |
| 13 | A concise survey of scheduling with time-dependent processing times显示文摘 | Cheng T C E Ding Q Lin B M T | 2004 | European Journal of Operational Research2004，152，1： | 1 |
| 14 | 查看详情显示文摘 | Yan L W Duan X R Ding X T Dong J Q Yang Q W Liu Y Zou X L Liu D Q Xuan W M Chen L Y Rao J Song X M Huang Y Mao W C Wang Q M Li Q Cao Z Li B Cao J Y Lei G J Zhang J H Li X D Chen W Cheng J Cui C H Cui Z Y Deng Z C Dong Y B Feng B B Gao Q D Han X Y Hong W Y | | 0，，： | 1 |
| 15 | Electron Field Emission for Uhrananocrystalline Diamond Films 显示文摘 | Krauss A T Auciello O Ding M Q | 2001 | Journal of Applied Physics2001，89，5： | 1 |
| 16 | Effect of rare earth ele- ments on the consolidation behavior and microstructure of tung- sten alloys 显示文摘 | ZHAO M ZHOU Z DING Q M | 2015 | International Journal of Refractory Metals and Hard Materials2015，48，： | 1 |
| 17 | Weighted finite difference methods for a class of space fractional partial differential equations with variable coefficients显示文摘 | DING Z Q XIAO A G LI M | 2010 | J Comput Appl Math2010，233，： | 1 |
| 18 | Selective transformation of cellulose into sorbitol by using a bifunc-tional nickel phosphide catalyst显示文摘 | DING L N WANG A Q ZHENG M Y ZHANG T | 2010 | ChemSusChem2010，3，7： | 1 |
| 19 | Water-assisted solventextraction of bitumen from oil sands显示文摘 | Yang H Q Wang Y H Ding M S | 2012 | Industrial & EngineeringChemistry Research2012，51，7： | 1 |
| 20 | Establishment of a highly migratory sub- clone reveals that CD133 contributes to migration and invasion- through epithelial - mesenchymal transition in pancreatic cancer 显示文摘 | Ding Q Yoshimitsu M | 2012 | Hum Cell2012，25，： | 1 |
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