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| 1 | Detection and characterization of murine colitis and carcinogenesis by molecularly targeted contrast-enhanced ultrasound显示文摘AIM To study mucosal addressin cellular adhesion molecule-1(MAd CAM-1) and vascular endothelial growth factor(VEGF)-targeted contrast enhanced ultrasound(CEUS) for the assessment of murine colitis and carcinogenesis. METHODS C57BL/6 mice were challenged with 3% dextran sodium-sulfate(DSS) for three, six or nine days to study the development of acute colitis. Ultrasound was performed with and without the addition of unspecific contrast agents. MAd CAM-1-targeted contrast agent was used to detect and quantify MAd CAM-1 expression. Inflammatory driven colorectal azoxymethane(AOM)/DSS-induced carcinogenesis was examined on day 42 and 84 using VEGF-targeted contrast agent. Highly specific tissue echogenicity was quantified using specialized software. Sonographic findings were correlated to tissue staining, western blot analysis and immunohistochemistry to quantify the degree of inflammation and stage of carcinogenesis. RESULTS Native ultrasound detected increased general bowel wall thickening that correlated with more progressed and more severe DSS-colitis(healthy mice: 0.3 mm ± 0.03 vs six days DSS: 0.5 mm ± 0.2 vs nine days DSS: 0.6 mm ± 0.2, P < 0.05). Moreover, these sonographic findings correlated well with clinical parameters such as weight loss(r2 = 0.74) and histological damage(r2 = 0.86)(P < 0.01). In acute DSS-induced murine colitis, CEUS targeted against MAd CAM-1 detected and differentiated stages of mild, moderate and severe colitis via calculation of mean pixel contrast intensity in decibel(9.6 d B ± 1.6 vs 12.9 d B ± 1.4 vs 18 d B ± 3.33, P < 0.05). Employing the AOM/DSSinduced carcinogenesis model, tumor development was monitored by CEUS targeted against VEGF and detected a significantly increased echogenicity in tumors as compared to adjacent healthy mucosa(healthy mucosa, 1.6 d B ± 1.4 vs 42 d, 18.2 d B ± 3.3 vs 84 d, 18.6 d B ± 4.9, P < 0.01). Tissue echogenicity strongly correlated with histological analysis and immunohistochemistry findings(VEGF-positive cells in 10 high power fields of healthy mucosa: 1 ± 1.2 vs 42 d after DSS start: 2.4 ± 1.6 vs 84 d after DSS start: 3.5 ± 1.3, P < 0.01). CONCLUSION Molecularly targeted CEUS is a highly specific and noninvasive imaging modality, which characterizes murine intestinal inflammation and carcinogenesis in vivo. | Markus Brückner Jan Heidemann Tobias M Nowacki Friederike Cordes Jorg Stypmann Philipp Lenz Faekah Gohar Andreas Lügering Dominik Bettenworth | 2017 | World Journal of Gastroenterology2017，23，16： | 4 |
| 2 | 应用组织追踪技术分析健康人左心室心肌力学参数显示文摘目的:分析健康成年人左心室整体和局部心肌力学参数及性别差异。方法:连续选取2015年10月至2016年8月于乌尔姆大学医院进行1.5 T心脏磁共振检查的健康成年男、女性各50名。进行稳态自由进动序列成像并半自动地勾画出左心室心内、外膜位置后,使用组织追踪技术测量左心室整体和局部(基底段、中间段和心尖段)心肌在径向、周向和纵向的应变、应变率、位移、位移速度、扭转和扭转率峰值,采用t检验或非参数检验比较性别差异。结果:(1)女性整体和局部心肌应变、应变率的峰值水平均高于男性;(2)女性中间段心肌纵向位移的峰值水平高于男性;(3)女性整体和中间段心肌纵向位移速度的峰值水平高于男性;(4)扭转和扭转率均未见显著性别差异。结论:女性左心室整体和局部的部分力学参数水平高于男性。 | 瞿洋洋 PAUL Jan BUCKERT Dominik 朱建 马根山 RASCHE Volker | 2017 | 东南大学学报(医学版)2017，36，3： | 2 |
| 3 | 'Click' chemistry by microcontact printing显示文摘 | Dorota I Rozkiewicz Dominik Jan'czewski Willem Verboom | 2006 | Angewandte Chemie International Edition2006，45，32： | 1 |
| 4 | Holocene ITCZ and Indian monsoon dynamics recorded in stalagmites from Oman and Yemen (Socotra)显示文摘 | Dominik Fleitmann Stephen J. Burns Augusto Mangini Manfred Mudelsee Jan Kramers Igor Villa Ulrich Neff Abdulkarim A. Al-Subbary Annett Buettner Dorothea Hippler Albert Matter | 2006 | Quaternary Science Reviews2006，，1： | 1 |
| 5 | LOH at 6q and 10q in fractionated circulat- ing DNA of ovarian cancer patients is predictive for tumor cell spread and overall survival显示文摘 | Jan Dominik Kuhlmann Heidi Sehwarzenbach Pauline Wim- berger | 2012 | BMC cancer2012，31，12： | 1 |
| 6 | Reduction of Elevated Cytokine Levels in A cute/ A cute‐on‐Chronic Liver Failure Using Super‐Large Pore Albumin Dialysis Treatment: An In Vitro Study显示文摘 | Adrian Dominik Jan Stange Claudia Pfensig Luise Borufka Helga Weiss‐Reining Martin Eggert | 2014 | Ther Apher Dial2014，，4： | 1 |
| 7 | Convective drying in combination with microwave and ir drying for biological materials 显示文摘 | Stefan Jan Kowalski Dominik Mierzwa | 2009 | Drying Technology2009，27，12： | 1 |
| 8 | Surface Geophysical Methods used to Verify the Karst Geological Structure in the Built-up Area:A Case Study of Specific Engineering-Geological Conditions显示文摘This article presents a research study of complex limestone karst engineering-geological conditions in the municipality Valaskanear Banska Bystrica in Slovakia.The aim of the study is to demonstrate the impossibility of spatial identification of cave spaces using surface geophysical methods due to the specific engineering-geological conditions of a thick surface layer of anthropogenic fill containing highly heterogeneous anthropogenic material.Its maximum thickness is 3 m.Another specificific condition of the study area is its location in the built-up area,due to which the applicability of geophysical methods was limited.The article contains methodological recommendations to be used in analogous geological conditions with karst structures topped with anthropogenic fill,which complicates the identification of cave spaces.The recommended solution herein is the identification of the cave system using underground mapping of the karst and its projection onto the surface for which surface geophysical methods have been combined. | Rene PUTISKA Marian MARSCHALKO Isik YILMAZ Dominik NIEMIEC CHENG Xianfeng Ivan DOSTAL Jan KUBAC | 2021 | Acta Geologica Sinica(English Edition)2021，95，5： | 1 |
| 9 | Prorenin and Renin-Induced Extracellular Signal–Regulated Kinase 1/2 Activation in Monocytes Is Not Blocked by Aliskiren or the Handle-Region Peptide显示文摘 | Sandra Feldt Wendy W. Batenburg Istvan Mazak Ulrike Maschke Maren Wellner Heda Kvakan Ralf Dechend Anette Fiebeler Celine Burckle Aurelie Contrepas A H. Jan Danser Michael Bader Genevieve Nguyen Friedrich C. Luft Dominik N. Muller | 2008 | Hypertension2008，，3： | 1 |
| 10 | PF-MPC: particle filter-model predictive control 显示文摘 | Dominik Stahl Jan Hauth | 2011 | Systems Control Letters2011，60，8： | 1 |
| 11 | Medical students teaching basic life support to school children as a required element of medical education:A randomised controlled study com- paring three different approaches to fifth year medical training in emergency medicine显示文摘 | Jan Breckwoldta Dominik Beetza Luise Schnitzerb | 2007 | Resuscitation2007，74，7： | 1 |
| 12 | Corrigendum to“Alternative feedstock for the production of activated carbon with ZnCl2:Forestry residue biomass and waste wood”[Carbon Resour.Convers.5(2022)299-309]显示文摘The authors regret that there was a mix-up in the illustrations during the approval process.Here is the correct image for Fig.4:The authors would like to apologise for any inconvenience caused. | Dominik Bosch Jan O.Back David Gurtner Sara Giberti Angela Hofmann Anke Bockreis | 2023 | Carbon Resources Conversion2023，6，1： | 0 |
| 13 | Cell:新分子或可有效清除肝脏和血液中的脂肪显示文摘肥胖和糖尿病持续上升代表着我们的社会所面临的一个重大的负担。脂肪肝和动脉粥样硬化是这些代谢疾病常见的后果,但是开发一种高效且又安全的能够逆转肥胖、胰岛素抵抗性、脂肪肝和动脉粥样硬化的药物仍然是全球头等的一项重大的科学挑战。 | Brian Finan Christoffer Clemmensen Zhimeng Zhu Kerstin Stemmer Karine Gauthier Luisa M uuml ller Meri De Angelis Kristin Moreth Frauke Neff Diego Perez-Tilve Katrin Fischer Dominik Lutter Miguel A. S aacute nchez-Garrido Peng Liu Jan Tuckermann Mohsen Malehmir Marc E. Healy Achim Weber Mathias Heikenwalder Martin Jastroch Maximilian Kleinert Sigrid Jall Sara Brandt Fr eacute d eacute ric Flamant Karl-Werner Schramm Heike Biebermann Yvonne D ouml ring Christian Weber Kirk M. Habegger Michaela Keuper Vasily Gelfanov Fa Liu Josef K ouml hrle Jan Rozman Helmut Fuchs Valerie Gailus-Durner Martin Hrabě de Angelis Susanna M. Hofmann Bin Yang Matthias H. Tsch ouml p Richard DiMarchi Timo D. M uuml ller | 2017 | 现代生物医学进展2017，17，4： | 0 |
| 14 | Alternative feedstock for the production of activated carbon with ZnCl_(2):Forestry residue biomass and waste wood显示文摘In order to substitute fossil resources in activated carbon(AC)production,recent efforts have focused on the utilization of renewable raw materials.Regions with important wood industries offer two potentially underestimated resource types:forestry residue biomass(FRB)and waste wood(WW).Although these materials are widely available(approx.130 mio.m3a-1 FRB,approx.50 mio.ta^(-1) WW in the EU),they are mostly valorised through energy production,as they are high in ashes and may be contaminated with organics and heavy metals.In this study,both FRB and WW were treated via one-step pyrolysis for AC production.ZnCl_(2) was applied as activating agent at pyrolysis temperatures varying from 400 to 600℃ and residence times between 1 and 3 h.Overall,76 samples were prepared and characterized thoroughly via elemental analysis,N_(2)/CO_(2) ad/-desorption,thermogravimetric analysis(TGA),scanning electron microscopy(SEM),and infrared spectroscopy(FTIR).The produced carbons showed specific surface areas of up to 1430 m2g��1 and a pore size distribution with a micropore share of up to 80%.The presence of oxygen-containing functional groups was confirmed via FTIR.Potential feedstock contamination can be mitigated,as minerals and heavy metals could be leached out(up to-99.15%)by an additional wash step and organic contamination undergoes thermal cracking during pyrolysis.The presented study could be a next step in upcycling considerable waste streams from the wood sector through localised and non-fossil-based AC production. | Dominik Bosch Jan OBack David Gurtner Sara Giberti Angela Hofmann Anke Bockreis | 2022 | Carbon Resources Conversion2022，5，4： | 0 |
| 15 | Crohn's disease complicated by intestinal infection with methicillin-resistant Staphylococcus aureus显示文摘We report on a 24-year-old male patient with history of bloody diarrhea, abdominal pain and vomiting. Endoscopy revealed massive ulcerative discontinuous proctosigmoiditis with deep, sharply demarcated epithelial denudations and enterotoxigenic methicillin-resistant Staphylococcus aureus (MRSA) was detected in mucosal biopsies. After treatment with linezolide and steroids, a significant amelioration of colitis was detected and testing for MRSA became negative. In face of the case presented here, we suggest that in patients with refractory inflammatory bowel disease (IBD), microbiological assessment should be performed to detect a possible Staphylococcus aureus infection in order to initiate an antimicrobial treatment in addition to IBDspecific treatment. | Dominik Bettenworth Tobias M Nowacki Alexander Friedrich Karsten Becker Johannes Wessling Jan Heidemann | 2013 | World Journal of Gastroenterology2013，19，27： | 0 |
| 16 | An Artificial Heart System for Testing and Evaluation of Cardiac Pacemakers显示文摘The usability assessment of a pacemaker is a complex task where the dedicated programmer for testing programmed algorithms is necessary.This paper provides the outcomes of development and complex testing of the artificial cardiac system to evaluate the pacemaker’s functionality.In this work,we used the modular laboratory platform ELVIS II and created graphical user interface in LabVIEW programming environment.The electrical model of the heart allows signals generation(right atrium,right ventricle)and the monitoring of the stimulation pulses.The LabVIEW user interface allows to set the parameters of the generated signals and the simulation of the cardiac rhythm disorders as well as the monitoring and visualization of the pacemaker behavior in real-time.The results demonstrate the capability of proposed system to evaluate the paced and sensed pulses.The proposed solution allows the scientists to test the behavior of any cardiac pacemaker for its pre-programmed settings and pacing mode.In addition,the proposed system can simulate various disorders and test cardiac pacemakers in different working modes. | Martin Augustynek Jan Kubicek Jaroslav Thomas Marek Penhaker Dominik Vilimek Michal Strycek Ondrej Sojka Antonino Proto | 2022 | Computers, Materials & Continua2022，，12： | 0 |
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