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| 1 | Cancer metabolism and tumor microenvironment:fostering each other?显示文摘The changes associated with malignancy are not only in cancer cells but also in environment in which cancer cells live.Metabolic reprogramming supports tumor cells’high demand of biogenesis for their rapid proliferation,and helps tumor cells to survive under certain genetic or environmental stresses.Emerging evidence suggests that metabolic alteration is ultimately and tightly associated with genetic changes,in particular the dysregulation of key oncogenic and tumor suppressive signaling pathways.Cancer cells activate HIF signaling even in the presence of oxygen and in the absence of growth factor stimulation.This cancer metabolic phenotype,described firstly by German physiologist Otto Warburg,ensures enhanced glycolytic metabolism for the biosynthesis of macromolecules.The conception of metabolite signaling,i.e.,metabolites are regulators of cell signaling,provides novel insights into how reactive oxygen species(ROS)and other metabolites deregulation may regulate redox homeostasis,epigenetics,and proliferation of cancer cells.Moreover,the unveiling of noncanonical functions of metabolic enzymes,such as the moonlighting functions of phosphoglycerate kinase 1(PGK1),reassures the importance of metabolism in cancer development.The metabolic,microRNAs,and ncRNAs alterations in cancer cells can be sorted and delivered either to intercellular matrix or to cancer adjacent cells to shape cancer microenvironment via media such as exosome.Among them,cancer microenvironmental cells are immune cells which exert profound effects on cancer cells.Understanding of all these processes is a prerequisite for the development of a more effective strategy to contain cancers. | Yiyuan Yuan Huimin Li Wang Pu Leilei Chen Dong Guo Hongfei Jiang Bo He Siyuan Qin Kui Wang Na Li Jingwei Feng Jing Wen Shipeng Cheng Yaguang Zhang Weiwei Yang Dan Ye Zhimin Lu Canhua Huang Jun Mei Hua-Feng Zhang Ping Gao Peng Jiang Shicheng Su Bing Sun Shi-Min Zhao | 2022 | Science China(Life Sciences)2022，65，2： | 5 |
| 2 | Uptake of graphene enhanced the photophosphorylation performed by chloroplasts in rice plants显示文摘New and enhanced functions were potentially imparted to the plant organelles after interaction with nanoparticles.In this study,we found that∼44%and∼29%of the accumulated graphene in the rice leaves passively transported to the chloroplasts and thylakoid,respectively,significantly enhanced the fluorescence intensity of chloroplasts,and promoted about 2.4 times higher adenosine triphosphate production than that of controls.The enhancement of graphene on the photophosphorylation was ascribed to two reasons:One is that graphene facilitates the electron transfer process of photosystem II in thylakoid,and the other is that graphene protects the photosystem II against photo-bleaching by acting as a scavenger of reactive oxygen species.Overall,our work here confirmed that graphene translocating in the thylakoid promoted the photosynthetic activity of chloroplast in vivo and in vitro,providing new opportunities for designing biomimetic materials to enhance the solar energy conversion systems,especially for repairing or increasing the photosynthesis activity of the plants grown under stress environment. | Kun Lu Danlei Shen Shipeng Dong Chunying Chen Sijie Lin Shan Lu Baoshan Xing Liang Mao | 2020 | Nano Research2020，13，12： | 4 |
| 3 | A Field Investigation on the Effects of Background Erosion on the Free Span Development of a Submarine Pipeline显示文摘The safety of submarine pipelines is largely influenced by free spans and corrosions. Previous studies on free spans caused by seabed scours are mainly based on the stable environment, where the background seabed scour is in equilibrium and the soil is homogeneous. To study the effects of background erosion on the free span development of subsea pipelines, a submarine pipeline located at the abandoned Yellow River subaqueous delta lobe was investigated with an integrated surveying system which included a Multibeam bathymetric system, a dual-frequency side-scan sonar, a high resolution sub-bottom profiler, and a Magnetic Flux Leakage(MFL) sensor. We found that seabed homogeneity has a great influence on the free span development of the pipeline. More specifically, for homogeneous background scours, the morphology of scour hole below the pipeline is quite similar to that without the background scour, whereas for inhomogeneous background scour, the nature of spanning is mainly dependent on the evolution of seabed morphology near the pipeline. Magnetic Flux Leakage(MFL) detection results also reveal the possible connection between long free spans and accelerated corrosion of the pipeline. | WEN Shipeng XU Jishang HU Guanghai DONG Ping SHEN Hong | 2015 | Journal of Ocean University of China2015，14，4： | 4 |
| 4 | Homo-PROTAC mediated suicide of MDM2 to treat non-small cell lung cancer显示文摘The dose-related adverse effects of MDM2-P5 3 inhibitors have caused significant concern in the development of clinical safe anticancer agents.Herein we report an unprecedented homo-PROTAC strategy for more effective disruption of MDM2-P53 interaction.The design concept is inspired by the capacity of sub-stoichiometric catalytic PROTACs enabling to degrade an unwanted protein and the dual functions of MDM2 as an E3 ubiquitin ligase and a binding protein with tumor suppressor P53.The new homo-PROTACs are designed to induce self-degradation of MDM2.The results of the investigation have shown that PROTAC 11 a efficiently dimerizes MDM2 with highly competitive binding activity and induces proteasome-dependent self-degradation of MDM2 in A549 non-small cell lung cancer cells.Furthermore,markedly,enantiomer 11 a-1 exhibits potent in vivo antitumor activity in A549 xenograft nude mouse model,which is the first example of homo-PROTAC with in vivo therapeutic potency.This study demonstrates the potential of the homo-PROTAC as an alternative chemical tool for tumorigenic MDM2 knockdown,which could be developed into a safe therapy for cancer treatment. | Shipeng He Junhui Ma Yuxin Fang Ying Liu Shanchao Wu Guoqiang Dong Wei Wang Chunquan Sheng | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 4 |
| 5 | The Genetic Mechanism of Inertinite in the Middle Jurassic Inertinite- Rich Coal Seams of the Southern Ordos Basin显示文摘also an important geological information carrier of coal forming environments.In the southern section of the Ordos Basin,the No.4 inertinite-rich coal seam of the Middle Jurassic Yan’an Formation in the Binchang Coal field was selected as an example to study the genetic mechanism of the inertinite.In this study,the results obtained from experimental tests of coal rock,including principal and trace elements,stable carbon isotopes,scanning electron microscopy,inertinite reflectance,sporopollen and free radical retorting methods,were analyzed.Then,the findings were combined with the previous understanding of the oxygen content in the atmosphere and ground fire characteristics,in order to discuss the genesis mechanism of inertinite in the No.4 coal seam.The obtained research results were as follows:(1)During the coal forming period of the No.4 coal seam,the overall climate had been relatively dry.There were four relatively dry-wet climate cycles in the No.4 coal seam,which were controlled by the eccentricity astronomical period.The inertinite content were relatively high during the dry periods;(2)The temperature range suitable for microorganism activities during the oxidation processes was between 0 and 80℃.The simulation results of the free radical concentrations showed that the maximum temperature of fusain in the No.4 coal seam during the process of coalification had not exceeded 300℃,which was significantly higher than the temperature range of microorganism activities.Therefore,these were not conducive to the activities of microorganism and formation of inertinite during the coal-forming period;(3)The genesis temperature of the inertinite in the No.4 coal seam was calculated according to the reflectance of the inertinite,which was lower than 400℃.This result supported the cause of wildfire of the inertinite and reflected that the type of wildfire was mainly ground fire,along with partially surface fire.Moreover,the paleogeographic location,climatic conditions,atmospheric oxygen concentration,etc.of the study area showed that the conditions for wildfire events were in fact available;(4)There were dense and scattered fusinite observed in the No.4 coal seam,and the thickness of cell walls were found to differ.It was speculated that this was related to the type of wildfire,combustion temperatures,combustion timeframes,and different initial conditions of the burned objects during the coal forming periods. | Dongdong Wang Qiang Mao Guoqi Dong Shipeng Yang Dawei Lv Lusheng Yin | 2019 | Journal of Geological Research2019，1，3： | 3 |
| 6 | Protective humoral immunity in SARS-CoV-2 infected pediatric patients显示文摘After the rapid spread of SARS-CoV-2 in Wuhan,China,at the beginning of 2020,about 1.5 million confirmed cases and over 80,000 deaths have been reported around 200 countries and territories all over the world and the number continues to increase.However,we still have limited knowledge of this new coronavirus,especially the interaction between SARS-CoV-2 and our immune system. | Yaguang Zhang Jin Xu Ran Jia Chunyan Yi Wangpeng Gu Pengcheng Liu Xinran Dong Hao Zhou Bo Shang Shipeng Cheng Xiaoyu Sun Jing Ye Xuezhen Li Jia Zhang Zhiyang Ling Liyan Ma Bingbing Wu Mei Zeng Wenhao Zhou Bing Sun | 2020 | Cellular & Molecular Immunology2020，17，7： | 2 |
| 7 | An analytical solution of wave exciting loads on CALM buoy with skirt显示文摘 | WANG Dong~iao SUN Shipeng | 2014 | Applied Mechanics and Materials2014，，： | 1 |
| 8 | Image Compression With Edge-Based Inpainting显示文摘 | Dong Liu Xiaoyan Sun Feng Wu Shipeng Li Ya-Qin Zhang | 2007 | IEEE Transaction on Circuits and Systems for Video Technology2007，17，10： | 1 |
| 9 | Potential contribution of increased soluble IL-2R to lymphopenia in COVID-19 patients显示文摘Since the outbreak of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),more than 6 million cases are confirmed and over 300,000 cases are dead after infection.Dysfunction of immunity in COVID-19 patients has been considered as one of the fatal factors for patients,especially cytokine release syndrome and lymphopenia.1,2,3 The reduced number and increased exhaustion level of lymphocyte are associated with elevated inflammatory cytokines in COVID-19 patients.4,5 However,the mechanism of cytokine-induced lymphopenia in COVID-19 is very unclear.IL-2 is critical for the proliferation,differentiation,and function of T cells,including Tregs,CD4+,and CD8+effector cells.6 Here,we reported the negative relationship between the concentration of soluble IL-2 receptor(sIL-2R)and T-cell number in blood from COVID-19 patients.In vitro addition of recombinant CD25 could inhibit the proliferation and function of T cells from PBMC after stimulated with TCR signaling,which could be rescued by strong IL-2 signaling.Our data suggested the importance of IL-2 signaling in lymphopenia of COVID-19 patients. | Yaguang Zhang Xiaojing Wang Xuezhen Li Dong Xi Ruizhi Mao Xiaohui Wu Shipeng Cheng Xiaoyu Sun Chunyan Yi Zhiyang Ling Liyan Ma Qin Ning Yiru Fang Bing Sun Di Wu | 2020 | Cellular & Molecular Immunology2020，17，8： | 0 |
| 10 | Assessing comparable bioconcentration potentials for nanoparticles in aquatic organisms via combined utilization of machine learning and toxicokinetic models显示文摘The toxicokinetic(TK)model‐derived kinetic bioconcentration factor(BCFk)provides a quantitatively comparable index to estimate the bioaccumulation potential of nanoparticles(NPs)that barely reach thermodynamic equilibrium in aquatic organisms,but experimental data are limited for various NPs.In the present study,a machine learning model was applied to offer reliable in silico predictions for the dynamic body burden of diverse NPs to derive corresponding parameters for the TK model.The developed eXtreme Gradient Boosting‐derived TK(XGB‐TK)model was applied to predict BCFk results for a broad range of metallic or carbonaceous NPs,with an appreciable prediction R2 of 0.96.The BCFk values were predicted based on a random combination of selected variable features,revealing that their bioaccumulation potential showed an overall negative correlation with NP density or organism size.By applying importance analysis and partial dependence plots,NP density and organism size were revealed to be the top essential features that impact the bioaccumulation potential.The conjunctively used XGB‐TK model enabled a prior comparison for diverse NPs and straightforward derivation on the dependency of features,which could also guide the bioaccumulation mechanism exploration and experimental condition formulation. | Shipeng Dong Zihao Wu Mingjie Wang Xiaoyan Sun Liang Mao | 2023 | SmartMat2023，4，3： | 0 |
| 11 | Rodent Fauna in Southeast Forest Region of Heilongjiang Province of China and Its Damage on Agriculture and Forestry显示文摘[Objective]The paper was to understand the rodent fauna in southeast forest region of Heilongjiang Province and its harm to agriculture and forests.[Methods]The southeast forest region of Heilongjiang Province was surveyed from March2008 to December2013 using night trap method combined with integrated collation of literature. [Result]There were totally 21 species of rodents in southeast forest region of Heilongjiang Province,belonging to 16 genera,8 families,3orders,and the fauna was mainly consisted of palaearctic realm; in terms of captured number,Clethrionomys rufocanus was the dominant species in forest region,while Apodemus agrarius was the dominant species in fields. The number of rodents was closely related to stand age,and the density of rodents was lower in the forest land with longer stand age and greater density. Rodents caused greater harm to timber forest and middle-aged forest than economic forest and young forest,and their damage on newly planted seedlings was particularly greater. The number of rodent population was the highest in summer,but the smallest in spring,while its interannual changes were stable. [Conclusion]The study provided a scientific basis for forestry management and rodent control,which also offered the basic biological data for the study of rodents. | Jin Zhimin Dong Shipeng Liu Wenyang Fu Dahang Zhu Xianbing | 2014 | Animal Husbandry and Feed Science2014，6，4： | 0 |
| 12 | Perioperative treatment of liver transplantation显示文摘A case of liver transplantation in the department of general surgery of the third affiliated hospital of Inner Mongolia medical school was collected and analyzed on the basis of diagnosis,physical examination and treatment.Liver transplantation was very complicated,accompanied by various postoperative complications.So this paper aims to share experience of perioperative management of liver transplantation among physicians. | Shengbin Zhang Rui Liu Shipeng Song Weiqing Wang Jin Zhao Xiaoshi Dong | 2014 | Discussion of Clinical Cases2014，1，1： | 0 |
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