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| 1 | Accuracy assessment of global historical cropland datasets based on regional reconstructed historical data——A case study in Northeast China显示文摘Historical cropland datasets are fundamental for quantifying the effects of human land use activities on climatic change and the carbon cycle. Two representative global land-use datasets, the Global Land Use Database (termed SAGE dataset) and the Historical Database of the Global Environment (termed HYDE dataset) have been established and used widely. Despite improvement of data quality and methodologies for extracting historical land use information, certain dataset limitations exist that need to be quantified and communicated to users so that they can make informed decisions on whether and how these land-use products should be used. The Cropland data of Northeast China (CNEC) is based on calibrated historical data and a multi-sourced data conversion model, and reconstructs cropland cover change in Northeast China over the last 300 years. Us- ing the CNEC as a reference, we evaluated the accuracy of cropland cover for SAGE and HYDE in Northeast China at spatial scales ranging from the entire Northeast China to provinces and even individual raster grid cells. Neither SAGE nor HYDE reflects real historical land reclamation. Cropland areas in SAGE are overestimated by 20.98 times in 1700 to 1.6 times in 1990. Although HYDE is better, there are significant disagreements in cropland area and distribution between HYDE and CNEC, especially in the 18th and 19th centuries. The proportion of total grid cells whose relative error was greater than 100% was 63.55% in 1700 and 53.27% in 1780. Global cropland dataset errors over Northeast China originate mainly from both the reverse calculation method for historical cropland data based on modern spatial patterns, and modern land-use outputs from satellite data. | Li BeiBei Fang XiuQi Ye Yu Zhang XueZhen | 2010 | Science China Earth Sciences2010，53，11： | 31 |
| 2 | Comparisons of cropland area from multiple datasets over the past 300 years in the traditional cultivated region of China显示文摘陆地使用 / 盖住变化是在气候和生态的模拟的一个重要参数。尽管他们广泛地在社区,半自动地面防空系统数据集和 HYDE 数据集被使用了,二代表性的全球历史的陆地使用数据集,很少在地区性的规模关于他们的精确性被估计。这里,我们为中国(TCRC ) 的传统的栽培区域执行了一些评价在上持续 300 年,由把 SAGE2010 和 HYDE (v3.1 ) 与中国历史的农田数据集(CHCD ) 作比较。比较在三空间规模被执行:由 60 km 格子房间的全部学习区域,省的区域和 60 km。结果证明(1 ) 从 SAGE2010 的农田区域从 CHCD 是多于那的大部分;而且,以在 1950 以后的从 1700 ~ 1950 和 0.34% 的 0.51% 的率的生长从 CHCD 与那也不一致。(2 ) HYDE 数据集(v3.1 ) 在全部学习区域上比半自动地面防空系统数据集接近了 CHCD 数据集。然而,大偏爱能被 60 km 格子房间规模在省的规模和 60 km 检测。有比70%大的偏爱的格子房间的百分比(<-70%或>70%)并且90%(<-90%或>90%)当那些有的偏爱为仅仅5%6%从10%~10%并且从30%~30%报道 时,分别地说明了全部的格子房间的56%63%和40%45%并且17%全部的格子房间分别地。(3 ) 用本地历史的档案,有高精确性的历史的数据集将是改进气候和生态的模拟的精确性的一个珍贵方法重建。 | HE Fanneng LI Shicheng ZHANG Xuezhen GE Quansheng DAI Junhu | 2013 | Journal of Geographical Sciences2013，23，6： | 21 |
| 3 | Cropland cover change in Northeast China during the past 300 years显示文摘Land use/cover change induced by human activities has emerged as a 'global' phenomenon with Earth system consequences. Northeast China is an area where the largest land cultivation activities by migrants have happened in China during the past 300 years. In this paper, methods including documentary data calibration and multi-sourced data conversion model are used to reconstruct historical cropland cover change in Northeast China during the past 300 years. It is concluded that human beings have remarkably changed the natural landscape of the region by land cultivation in the past 300 years. Cropland area has increased almost exponentially during the past 300 years, especially during the past 100 years when the ratio of cropland cover changed from 10% to 20%. Until the middle of the 19th century, the agricultural area was still mainly restricted in Liaoning Province. From the late 19th century to the early 20th century, dramatic changes took place when the northern boundary of cultivation had extended to the middle of Heilongjiang Province. During the 20th century, three agricultural regions with high ratio of cropland cover were formed after the two phases of spatial expansion of cropland area in 1900s—1930s and 1950s—1980s. Since 1930s—1940s, the expansion of new cultivated area have invaded the forest lands especially in Jilin and Heilongjiang Provinces. | YE Yu FANG XiuQi REN YuYu ZHANG XueZhen CHEN Li | 2009 | Science China Earth Sciences2009，52，8： | 21 |
| 4 | Leaching ion adsorption rare earth by aluminum sulfate for increasing efficiency and lowering the environmental impact显示文摘The leaching efficiency(LE) of ion adsorption rare earth(IARE) by the sulfate and chloride of ammonium,magnesium and aluminum were comparatively determined using column leaching method. It is found that at equal equivalent concentration of cation, the LE of IARE by aluminum sulfate is the highest, and the zeta potential of clay mineral particles in the tailing is near to zero, which means a lower risk of landslide and pollutant emission. Furthermore, the optimum concentration of aluminum sulfate is determined to be0.02 mol/L, which is much lower than that of ammonium sulfate and magnesium sulfate. To reduce the production cost and environmental impact, we proposed a multi-stage leaching process, which was firstly leaching with ammonium sulfate and then with aluminum sulfate, following by water washing and lime neutralizing. With the ratio of ammonium sulfate to aluminum sulfate varying from 1:0 to 0.5:0.5, the residual ammonium in tailing decreases from 11.2% to 0.6%, however, the LE of RE shows an optimum value at 0.8:0.2. By neutralizing the pH of tailing with lime water to over 6, the ion concentration in water rinsing solution can meet the requirement for water discharge. At the same time, the zeta potential of clay particles is found to be around-5 mV, means a relatively lower risk of landslide. These facts indicate that the LE of IARE can be increased and the danger caused by tailings landslides and pollutant emissions can be reduced by replacing ammonium sulfate with aluminum sulfate as leaching reagent. | Lifen Yang Cuicui Li Dashan Wang Fengyang Li Yanzhu Liu Xuezhen Zhou Mingbiao Liu Xiufeng Wang Yongxiu Li | 2019 | Journal of Rare Earths2019，37，4： | 19 |
| 5 | Schisandra sphenanthera extract(Wuzhi Tablet)protects against chronic-binge and acute alcohol-induced liver injury by regulating the NRF2-ARE pathway in mice显示文摘Alcohol abuse leads to alcoholic liver disease and no effective therapy is currently available.Wuzhi Tablet(WZ), a preparation of extract from Schisandra sphenanthera that is a traditional hepatoprotective herb, exerted a significant protective effect against acetaminophen-induced liver injury in our recent studies, but whether WZ can alleviate alcohol-induced toxicity remains unclear. This study aimed to investigate the contribution of WZ to alcohol-induced liver injury by using chronic-binge and acute models of alcohol feeding. The activities of ALT and AST in serum were assessed as well as the level of GSH and the activity of SOD in the liver. The expression of CYP2E1 and proteins in the NRF2-ARE signaling pathway including NRF2, GCLC, GCLM, HO-1 were measured, and the effect of WZ on NRF2 transcriptional activity was determined. We found that both models resulted in liver steatosis accompanied by increased transaminase activities, but that liver injury was significantly attenuated by WZ. WZ administration also inhibited CYP2E1 expression induced by alcohol, and elevated the level of GSH and the activity of SOD in the liver. Moreover, the NRF2-ARE signaling pathway was activated by WZ andthe target genes were all upregulated. Furthermore, WZ significantly activated NRF2 transcriptional activity. Collectively, our study demonstrates that WZ protected against alcohol-induced liver injury by reducing oxidative stress and improving antioxidant defense, possibly by activating the NRF2-ARE pathway. | Xuezhen Zeng Xi Li Chenshu Xu Fulin Jiang Yufei Mo Xiaomei Fan Yaoting Li Yiming Jiang Dongshun Li Min Huang Huichang Bi | 2017 | Acta Pharmaceutica Sinica B2017，7，5： | 13 |
| 6 | Carbon emissions induced by cropland expansion in Northeast China during the past 300 years显示文摘Assessments of the impacts of land use and land cover changes(LUCC) on the terrestrial carbon budget, atmospheric CO2 concentration, and CO2-related climatic change are important to understand the environmental effects of LUCC and provide information about the effects of historical carbon emissions. Using regional land cover reconstructions from historical records, with a bookkeeping model, we estimated the carbon sink changes caused by historical cropland expansion in Northeast China during the past 300 years. The conclusions are as follows:(1) There was a dramatic land reclamation of cropland during the past 300 years in Northeast China. Approximately 26% of the natural land was cultivated, and 38% of the grassland and 20% of the forest and shrubland were converted to cropland.(2) The carbon emission induced by cropland expansion between 1683 and 1980 was 1.06–2.55 Pg C, and the estimation from the moderate scenario was 1.45 Pg C. The carbon emissions of the soil carbon pool was larger than that from the vegetation carbon pool and comprised more than 2/3 of the total carbon emissions.(3) The carbon emissions of the three provinces in Northeast China were different. Heilongjiang Province had the largest carbon emissions, and Jilin Province had the second largest emissions.(4) The primary source of carbon emissions was forest reclamation(taking 60% of the total emissions in the moderate scenario), the secondary source was grassland cultivation(taking 27%), and the tertiary sources were shrubland and wetland reclamation(taking 13%). Examination on the data accuracy revealed that the high-resolution regional land cover data allowed the carbon budget to be evaluated at the county level and improved the precision of the results. The carbon emission estimation in this study was lower than those in previous studies because of the improved land use data quality and various types of land use change considered. | LI BeiBei FANG XiuQi YE Yu ZHANG XueZhen | 2014 | Science China Earth Sciences2014，57，9： | 8 |
| 7 | How is mRNA expression predictive for protein expression? A correlation study on human circulating monocytes显示文摘在学习 mRNA 表示的一个关键假设是它在蛋白质表示的预言是增进知识的。然而,仅仅有限的研究在酵母探索了 mRNA 蛋白质表示关联或人的纸巾和结果是相对不一致的。我们从 30 个无关的女人在刚孤立的人的传播单核白血球在 mRNA 蛋白质表情上执行了关联分析。为 71 基因的表示蛋白质被确定并且由结合的 2-D 电气泳动识别了集体 spectrometry。相应 mRNA 表达式被 Affymetrix 基因芯片确定。重要关联(r=0.235, P < 0.0001 ) 包括所有学习基因和所有样品为整个数据集被观察。关联在基因本体论的不同生物范畴变化了。例如,最高的关联以细胞的部件为细胞外的区域的基因被完成(r=0.643, P < 0.0001 ) 并且最低关联为规定的基因被获得(r=0.099, P=0.213 ) 以生物过程。在染色体,样品的一半证明为 71 基因的重要积极关联和重要关联在所有样品在平均 mRNA 和平均蛋白质表示层次之间被发现(r=0.296, P < 0.01 ) 。在学习组水平,然而,仅仅五学习基因越过所有样品有重要积极关联。我们的结果显示出在 mRNA 和蛋白质表示层次之间的全面积极关联。然而,中等、变化的关联建议那 mRNA 表情可能有时是有用的,但是远非当然在预言蛋白质表示层次完善。 | Yanfang Guo Peng Xiao Shufeng Lei Feiyan Deng Gary Guishan Xiao Yaozhong Liu Xiangding Chen Liming Li Shan Wu Yuan Chen Hui Jiang Lijun Tan Jingyun Xie Xuezhen Zhu Songping Liang Hongwen Deng | 2008 | Acta Biochimica et Biophysica Sinica2008，40，5： | 7 |
| 8 | Reconstruction of cropland area and spatial distribution in the mid-Northern Song Dynasty (AD1004-1085)显示文摘为了理解历史的导致人的土地,盖住变化和它的气候的效果,与明确的空间信息创造历史的陆地使用数据集是必要的。用税农田区域和从历史的文件编的家庭的数字,我们在每陆(在北歌王朝的一个省级的政治区域) 以内估计了真实农田区域和人口在中间 -- 北歌王朝(AD1004-1085 ) 。评价通过分析税,人口和农业开发的当代的政策被完成。然后,我们把政治基于区域的农田区域变换成地理上明确的格子在由 60 km 的 60 km 的房间尺寸的基于房间的部分农田。变换作为独立变量用地志的斜坡,高度和人口密度基于每个格子房间的精明的耕作适用性。作为结果,在在 1070 年代的北歌领土以内的农田的全部的区域被估计是大约 7.2 亿亩(中国区域单位, 1 亩 = 666.7 m2 ) ,哪个 40.1% 和 59.9% 分别地发生在北方和南方。人口被估计是大约 8720 万,哪个 38.7% 和 61.3% 分别地在北方和南方,并且人均的农田区域是大约 8.2 亩。国家吝啬的开垦比率(即到全部的土地的农田区域的比率区域;RRA 此后为短) 是一回 16.6% 。平凡区域例如诺思中国平原,中间和长江的更低的活动范围, Guanzhong 平原,包围东廷·莱克和波伊昂·莱克和四川盆的平原,有更高的 RRA,主要是超过 40% ;当时多山、多山的区域例如 Nanling 山的南方,西南区域(排除 Chengdu 平原) ,黄土高原和东南沿海的区域,有更低的 RRA,是不到 20% 。而且, RRA 与地志的斜坡和高度变化了。在低高度(250 m ) 的区域,中间的高度(250100 m ) 和高高度(10003500 m ) ,有 4.43 亿, 2.15 亿并且 6400 万亩农田分别地并且他们的地区性的吝啬的 RRA 分别地是 27.5% , 12.6% 和 7.2% 。在扁平的斜坡,轻轻的斜坡,中等斜坡和陡峭的斜坡的区域,有 1.16 亿, 4.56 亿, 1.44 亿并且 200 万亩农田分别地并且他们的地区性的吝啬的 RRA 分别地是 34.6% , 20.7% , 8.5% 和 2.3% 。 | HE Fanneng LI Shicheng ZHANG Xuezhen | 2012 | Journal of Geographical Sciences2012，22，2： | 7 |
| 9 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 10 | Evaluating the fractionation of ion-adsorption rare earths for in-situ leaching and metallogenic mechanism显示文摘The fractionation of ion adsorption rare earths(IAREs) along the depth in a shaft of a deposit at Dajishan,Jiangxi, China was comparatively evaluated using the partition values(PVs) and relative fractionation values(RFVs) of the leached rare earths(REs). It is found that both PVs and RFVs can objectively reflect the migration and fractionation of REs, but RE content and abrasion pH could not. However, the RFVs can provide more information to quantitatively evaluating the migration and fractionation characteristics of REs along the selected direction and region than PVs could, which is of significance for designing the optimal procedures of in-situ leaching based on the determined flow direction of injecting solution. It is demonstrated that the migration of Ce, Pr, and Nd along the depth direction is inert, and that of REs post Sm and Y is active. Meanwhile, the migration of La shows region characteristics which is active in the upper and inert in lower region. More interesting, the dependence of RFVs on atomic number of REs displays a tetrad group variation trend. However, the fractionation of REs among clay minerals with different particle sizes is not evident, especially for the clay in the bottom region. These results indicate that the migration and fractionation of REs not only are dominated by the adsorption of their hydrated ions, but also rely on their hydrolysis tendency, which provide information for understanding the metallogenic mechanism of IAREs. | Qiuhua Xu Lifeng Yang Dashan Wang Xiao Hou Yuanyuan Sun Xuezhen Zhou Xinmu Zhou Yongxiu Li | 2018 | Journal of Rare Earths2018，36，12： | 4 |
| 11 | Progress of Jinping Underground laboratory for Nuclear Astrophysics(JUNA)显示文摘Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given. | WeiPing Liu ZhiHong Li JiangJun He XiaoDong Tang Gang Lian Zhu An JianJun Chang Han Chen QingHao Chen XiongJun Chen ZhiJun Chen BaoQun Cui XianChao Du ChangBo Fu Lin Gan Bing Guo GuoZhu He Alexander Heger SuQing Hou HanXiong Huang Ning Huang BaoLu Jia LiYang Jiang Shigeru Kubono JianMin Li KuoAng Li Tao Li YunJu Li Maria Lugaro XiaoBing Luo HongYi Ma ShaoBo Ma DongMing Mei YongZhong Qian JiuChang Qin Jie Ren YangPing Shen Jun Su LiangTing Sun WanPeng Tan Isao Tanihata Shuo Wang Peng Wang YouBao Wang Qi Wu ShiWei Xu ShengQuan Yan LiTao Yang Yao Yang XiangQing Yu Qian Yue Sheng Zeng HuanYu Zhang Hui Zhang LiYong Zhang NingTao Zhang QiWei Zhang Tao Zhang XiaoPeng Zhang XueZhen Zhang ZiMing Zhang Wei Zhao Zuo Zhao Chao Zhou | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，4： | 3 |
| 12 | 普通玉米、糯玉米和蒸汽压片玉米对生长猪能量和营养物质消化率的影响显示文摘研究的目的是通过饲喂生长猪普通玉米、糯玉米和蒸汽压片玉米来测定其消化能、代谢能和营养物质的表观消化率。 | 朱秋凤 张永静 温春雨 徐作鹏 Dongli Ma Juntao Li Chengfei Huang Fengjuan Yang Yi Wu Ling Liu Wei Jiang Zhicheng Jia Peijun Zhang Xuezhen Liu Shuai Zhang | 2021 | 猪业科学2021，38，3： | 3 |
| 13 | Abnormal regulation of chemokine TECK and its receptor CCR9 in the endometriotic milieu is involved in pathogenesis of endometriosis by way of enhancing invasiveness of endometrial stromal cells显示文摘The chemokine thymus-expressed chemokine(TECK),which regulates T-cell development and tissue-specific homing,has been identified as a potential contributor to the pathogenesis and progression of endometriosis.Dioxin(2,3,7,8-tetrachlorodibenzo-p-dioxin,TCDD),an air pollutant,and estrogen also appear to be involved in endometriosis.Both endometrial stromal cells(ESCs)and the combination of 17b-estradiol and TCDD increase the secretion of TECK in the endometriosis-associated cells and promote the invasiveness of ESCs by increasing expression of matrix metalloproteinase(MMP)-2 and MMP-9.Anti-TECK neutralizing antibodies can effectively inhibit the invasiveness of ESCs and the expression of MMP-2 and MMP-9 in the cells.Interestingly,the expression of chemokine C receptor 9(CCR9)and its ligand TECK increases significantly in the endometriotic milieu of patients with endometriosis.Therefore,the over-expressed TECK interacts with CCR9 on the ESCs in the endometriotic milieu,which may contribute to the onset and progression of endometriosis. | Yun Wang Jing Yu Xuezhen Luo Xiaoqiu Wang Mingqing Li Ling Wang Dajin Li | 2010 | Cellular & Molecular Immunology2010，7，1： | 3 |
| 14 | Discrete element simulations and experiments of soil-winged subsoiler interaction显示文摘Understanding soil disturbance behaviors under the impact of the winged subsoiler is critical for designing or optimizing the winged subsoiler(a primary subsoiling tool).In this study,a soil-winged subsoiler interaction model was developed and the effects of winged subsoiler on soil disturbance behaviors were investigated using the discrete element method(DEM)simulations and lab soil-bin tests.The results showed that wings mainly affected the disturbance range and fragmentation degree of soil above them.The draught forces of share section(SS),arc section in the hardpan(ASHP),arc section in the top layer(ASTL)and line section(LS)were accounted for 69.53%,25.22%,4.73%and 0.52%of the total draught force of winged subsoiler;the lateral disturbance range from high to low of the soil at different depths followed the ranking:top layer(TL),hardpan disturbed by arc section(HDAS)and hardpan disturbed by share section(HDSS).Wings had the greatest influence on the draught force of ASHP.Adding wings to an arc-shaped subsoiler increased the disturbance areas of HDAS,TL and HDSS by 47.52%,7.74%and 4.59%,respectively,but meanwhile increased the total draught force by 36%.Compared with a non-winged subsoiler,winged subsoiler had higher soil looseness(15.83%),soil disturbance coefficient(58.59%),furrow width(448.65 mm)and soil disturbance area ratio(0.3835),but poorer soil surface flatness(19.79 mm)and lower soil loosening efficiency(39.35 mm²/N).This study provided critical information for optimizing winged subsoilers on aspects of improving soil loosening effectiveness and reducing draught force. | Xuezhen Wang Peng Li Jinpu He Wuquan Wei Yuxiang Huang | 2021 | International Journal of Agricultural and Biological Engineering2021，14，1： | 3 |
| 15 | Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver显示文摘Obesity is a major risk factor for cancers including hepatocellular carcinoma(HCC)that develops from a background of non-alcoholic fatty liver disease(NAFLD).Hypercholesterolemia is a common comorbidity of obesity.Although cholesterol biosynthesis mainly occurs in the liver,its role in HCC development of obese people remains obscure.Using high-fat high-carbohydrate diet-associated orthotopic and spontaneous NAFLD-HCC mouse models,we found that hepatic cholesterol accumulation in obesity selectively suppressed natural killer T(NKT)cell-mediated antitumor immunosurveillance.Transcriptome analysis of human liver revealed aberrant cholesterol metabolism and NKT cell dysfunction in NAFLD patients.Notably,cholesterol-lowering rosuvastatin restored NKT expansion and cytotoxicity to prevent obesogenic diet-promoted HCC development.Moreover,suppression of hepatic cholesterol biosynthesis by a mammalian target of rapamycin(mTOR)inhibitor vistusertib preceded tumor regression,which was abolished by NKT inactivation but not CD8^(+)T cell depletion.Mechanistically,sterol regulatory element-binding protein 2(SREBP2)-driven excessive cholesterol production from hepatocytes induced lipid peroxide accumulation and deficient cytotoxicity in NKT cells,which were supported by findings in people with obesity,NAFLD and NAFLD-HCC.This study highlights mTORC1/SREBP2/cholesterol-mediated NKT dysfunction in the tumor-promoting NAFLD liver microenvironment,providing intervention strategies that invigorating NKT cells to control HCC in the obesity epidemic. | Wenshu Tang Jingying Zhou Weiqin Yang Yu Feng Haoran Wu Myth T.S.Mok Lingyun Zhang Zhixian Liang Xiaoyu Liu Zhewen Xiong Xuezhen Zeng Jing Wang Jiahuan Lu Jingqing Li Hanyong Sun Xiaoyu Tian Philip Chun Yeung Yong Hou Heung Man Lee Candice C.H.Lam Howard H.W.Leung Anthony W.H.Chan Ka Fai To John Wong Paul B.S.Lai Kelvin K.C.Ng Simon K.H.Wong Vincent W.S.Wong Alice P.S.Kong Joseph J.Y.Sung Alfred S.L.Cheng | 2022 | Cellular & Molecular Immunology2022，19，7： | 3 |
| 16 | An approach to spatially explicit reconstruction of historical forest in Northeast China显示文摘历史的陆地封面数据集的空间地明确的重建在学习陆地使用和陆地封面变化(LUCC ) 的气候、生态的效果起一个重要作用。用潜在的自然植被(PNV ) 和基于卫星的陆地使用数据,我们当人的骚乱不在时决定了森林盖子的可能的最大的分发程度。随后,地形学和气候因素被选择为耕作估计土地的适用性。最后,一个历史的森林区域分配模型为耕作根据土地的适用性被设计。作为案例研究,我们使用了历史的森林区域分配模型重建在有一个 10-km 决定的东北中国的为 1780 和 1940 的森林盖子。验证模型,我们为 2000 把基于卫星的森林盖子数据与我们的重建作比较。绝对偏爱的一个样品 t 测试证明二尾巴的意义是 0.12,比重要水平大 0.05,建议模型有强壮的能力捕获森林的空间分发。另外,我们在东北中国为 1780 在县规模计算了我们的重建的相对差别。差别其亲戚从 30% ~ 30%的县的数字是 99,为 74.44% 所有县的财务。这些调查结果证明省的森林区域能用模型被转变成森林盖子地图很好。 | LI Shicheng HE Fanneng ZHANG Xuezhen | 2014 | Journal of Geographical Sciences2014，24，6： | 2 |
| 17 | Protective humoral immunity in SARS-CoV-2 infected pediatric patients显示文摘After the rapid spread of SARS-CoV-2 in Wuhan,China,at the beginning of 2020,about 1.5 million confirmed cases and over 80,000 deaths have been reported around 200 countries and territories all over the world and the number continues to increase.However,we still have limited knowledge of this new coronavirus,especially the interaction between SARS-CoV-2 and our immune system. | Yaguang Zhang Jin Xu Ran Jia Chunyan Yi Wangpeng Gu Pengcheng Liu Xinran Dong Hao Zhou Bo Shang Shipeng Cheng Xiaoyu Sun Jing Ye Xuezhen Li Jia Zhang Zhiyang Ling Liyan Ma Bingbing Wu Mei Zeng Wenhao Zhou Bing Sun | 2020 | Cellular & Molecular Immunology2020，17，7： | 2 |
| 18 | Bio-remediation of acephate–Pb(Ⅱ) compound contaminants by Bacillus subtilis FZUL-33显示文摘Removal of Pb^(2+)and biodegradation of organophosphorus have been both widely investigated respectively. However, bio-remediation of both Pb^(2+)and organophosphorus still remains largely unexplored. Bacillus subtilis FZUL-33, which was isolated from the sediment of a lake, possesses the capability for both biomineralization of Pb^(2+)and biodegradation of acephate. In the present study, both Pb^(2+)and acephate were simultaneously removed via biodegradation and biomineralization in aqueous solutions.Batch experiments were conducted to study the influence of p H, interaction time and Pb^(2+)concentration on the process of removal of Pb2+. At the temperature of 25°C, the maximum removal of Pb^(2+)by B. subtilis FZUL-33 was 381.31 ± 11.46 mg/g under the conditions of p H 5.5, initial Pb^(2+)concentration of 1300 mg/L, and contact time of 10 min. Batch experiments were conducted to study the influence of acephate on removal of Pb^(2+)and the influence of Pb2+on biodegradation of acephate by B. subtilis FZUL-33. In the mixed system of acephate–Pb2+, the results show that biodegradation of acephate by B. subtilis FZUL-33 released PO43+, which promotes mineralization of Pb2+. The process of biodegradation of acephate was affected slightly when the concentration of Pb2+was below 100 mg/L. Based on the results, it can be inferred that the B. subtilis FZUL-33 plays a significant role in bio-remediation of organophosphorus-heavy metal compound contamination. | Wenting Lin Zhen Huang Xuezhen Li Minghua Liu Yangjian Cheng | 2016 | Journal of Environmental Sciences2016，28，7： | 2 |
| 19 | Tuning thermal decomposition of ammonium perchlorate by nanoporous Gd2O3 for improved safety and enhanced propellant efficiency显示文摘Nanoporous Gd2O3 powders(NGPs) with different specific surface areas were prepared by a nonaqueous sol-gel method and utilized to tune the exothermal decomposition of ammonium perchlorate(AP) for enhanced propellant efficiency and improved safety.It is found that with the increasing dosage of NGPs into AP,the two exothermal peaks of AP merge into one intense exothermal peak,indicating that an 'energy stacking' has been achieved.Meanwhile,the unique delay of the first exothermal peak of AP is conducive to the safety of AP in application process.Furthermore,the dependence of decomposition heat of AP on dosage and calcination temperature is more evident than on the surface areas of NGPs,suggesting that the promotion effect of NGPs on the thermal decomposition of AP does not only rely on the surface interaction.Therefore,an electron transfer mechanism is proposed to illustrate the decomposition process of AP tuned by NGPs. | Xuezhen Zhou Chunyan Hu Xiaojun Liu Weifan Chen Qun Tang Yongxiu Li | 2020 | Journal of Rare Earths2020，38，1： | 2 |
| 20 | Comparative Study on Functional Properties of Mulberry Black Tea Fermented by Phellinus igniarius and Eurotium cristatum显示文摘[Objectives]To compare functional properties of mulberry black tea fermented by Phellinus igniarius and Eurotium cristatum.[Methods]The functional components of mulberry black tea fermented by P.igniarius and E.cristatum,the deep processing and health care effects of two probiotic fungi were explored.[Results]The polysaccharide content in the tea fermented by P.igniarius was the highest at 0.410 mg/mL,and the hydroxyl radical scavenging rate was the strongest,reaching 60.31%;the content of flavonoids in the tea fermented by E.cristatum was the highest,reaching 60.65μg/mL,and the content of polysaccharides was 83.17%higher than that of mulberry black tea,reaching 0.279 mg/mL.[Conclusions]The mulberry black tea fermented by P.igniarius and E.cristatum has improved in different functional components,and has its own advantages in aroma and mouthfeel,so it has certain research value and market prospect. | Yanrui MA Xuezhen LI Xuemei YANG Guangpeng LIU Le CHU Yan ZHAO Fatao HE | 2022 | Medicinal Plant2022，13，3： | 2 |
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