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| 1 | Classification of breast lesions based on a dual S-shaped logistic model in dynamic contrast enhanced magnetic resonance imaging显示文摘This study proposes a novel dual S-shaped logistic model for automatically quantifying the characteristic kinetic curves of breast lesions and for distinguishing malignant from benign breast tumors on dynamic contrast enhanced (DCE) magnetic resonance (MR) images.D(,) is the diagnostic parameter derived from the logistic model.Significant differences were found in D(,) between the malignant benign groups.Fisher's Linear Discriminant analysis correctly classified more than 90% of the benign and malignant kinetic breast data using the derived diagnostic parameter (D(,)).Receiver operating characteristic curve analysis of the derived diagnostic parameter (D(,)) indicated high sensitivity and specificity to differentiate malignancy from benignancy.The dual S-shaped logistic model was effectively used to fit the kinetic curves of breast lesions in DCE-MR.Separation between benign and malignant breast lesions was achieved with sufficient accuracy by using the derived diagnostic parameter D(,) as the lesion's feature.The proposed method therefore has the potential for computer-aided diagnosis in breast tumors. | DANG Yi GUO Li LV DongJiao WANG XiaoYing ZHANG Jue | 2011 | Science China(Life Sciences)2011，54，10： | 8 |
| 2 | A feedback latching controller for two-body wave energy converters under irregular wave conditions显示文摘Latching control is considered to be an effective way to improve the energy absorption of a wave energy converter(WEC).Recently, a latching control method was realized in a hydraulic power take-off(PTO) system and was demonstrated to be effective in one-body WECs. However, the effectiveness of latching control for two-body WECs still needs to be tested. In this paper, a feedback latching controller is proposed for a conceptual two-body WEC. In this conceptual design, a permanent-magnet linear generator(PMLG) is adopted as the PTO system, and a pure water hydraulic cylinder system is designed for performing the latching control. A feedback control strategy based on the measurement of latching force is established, formulated and tested numerically under realistic irregular wave conditions. The effects of the wave peak period and the PTO damping coefficient on the effectiveness of the latching control is also investigated. The results indicate that the proposed feedback latching control is effective for improving the annual power absorption of the two-body WEC. Furthermore, compared to another latching control,the proposed control is more practical because it does not require any knowledge of the wave conditions or the dynamics of the whole WEC system. | LIU Kun WANG DongJiao QIU ShouQiang YE JiaWei OU JinPing | 2018 | Science China(Technological Sciences)2018，61，8： | 2 |
| 3 | Nonlinear Dynamic Analysis of Flexible Marine-Risers显示文摘A nonlinear dynamic analysis model is estabilished on the basis of 'lumped mass' approach, which takes the influence of the fluid flow within the pipe into consideration. Numerical results are compared with the published works, and the effects of internal fluid flow, internal pressure, dyanmics as well as the nonlinear characteristics on the behavior of flexible risers are discussed. From this work, some useful conclusions are drawn. | Chen Jiajing and Wang Dongjiao Professor, South China University of Technology, Guangzhou PhD Student, Hong Kong Polytechnic Formerly, South China University of Technology, Guangzhou | 1991 | China Ocean Engineering1991，6，4： | 2 |
| 4 | IL-33 drives the antitumor effects of dendritic cells via the induction of Tc9 cells显示文摘Dendritic cell(DC)tumor vaccines exert their antitumor effects through the induction of effector T cells.We recently identified Tc9 cells as a new potent antitumor effector T cell subset.However,approaches to direct DCs to preferably prime antitumor Tc9 cells should be further exploited.Here,we demonstrate that the addition of interleukin(IL)-33 potently promotes the induction of Tc9 cells by DCs in vitro and in vivo.IL-33 treatment also drives the cytotoxic activities of DC-induced Tc9 cells.Notably,IL-33 treatment enhances cell survival and proliferation of DC-primed CD8+T cells.More importantly,the addition of IL-33 during in vitro priming of tumor-specific Tc9 cells by DCs increases the antitumor capability of Tc9 cells.Mechanistic studies demonstrated that IL-33 treatment inhibits exhaustive CD8+T cell differentiation by inhibiting PD-1 and 2B4 expression and increasing IL-2 and CD127(IL-7 receptor-α,IL-7Rα)expression in CD8+T cells.Finally,the addition of IL-33 further promotes the therapeutic efficacy of DC-based tumor vaccines in the OT-I mouse model.Our study demonstrates the important role of IL-33 in DC-induced Tc9 cell differentiation and antitumor immunity and may have important clinical implications. | Ning Liu Yuxue Jiang Jintong Chen He Nan Yinghua Zhao Xiao Chu Alison Wang Dongjiao Wang Tianxue Qin Sujun Gao Ying Yue Siqing Wang | 2019 | Cellular & Molecular Immunology2019，16，7： | 2 |
| 5 | Non-enzy- matic detection of hydrogen peroxide using a functionalized three- dimensional graphene electrode 显示文摘 | Xi Fengna Zhan Dongjiao Wang Xuewan | 2013 | Electrochem Com- mun2013，26，： | 1 |
| 6 | Cryo-copolymerization preparation of dextran-hyaluronate based supermacroporous cryogel scaffolds for tissue engineering applications显示文摘Dextran-hyaluronate (Dex -- 哈) 为软织物工程的基于的 supermacroporous cryogel 脚手架被在结冰条件下面在各种各样的 macromonomer 集中包含葡聚糖 methacrylate (Dex 麻省) 和 hyaluronate methacrylate (哈麻省) 的水的答案的免费激进的 cryo-copolymerization 准备。这被观察为 Dex 的准备的 macromonomers 的合适的全部的集中 -- 哈有满足的性质的 cryogel 支架是 5%(w/w ) 在 1% 的哈麻省集中(w/v ) ,它然后被用来生产测试支架。有 5% 的获得的 cryogel 支架(w/w ) macromonomer 答案有高水位线渗透(5.1 ? 桴 ? 潨灳瑩? | Dongjiao ZHOU Shaochuan SHEN Junxian YUN Kejian YAO Dong-Qiang LIN | 2012 | Frontiers of Chemical Science and Engineering2012，6，3： | 1 |
| 7 | The numerical prediction of draghead motion of trailing suction Hopper dredger in time domain显示文摘 | Chen Zhanglan Ye Jiawei Wang Dongjiao | 2014 | Ocean Engineering2014，91，： | 1 |
| 8 | Research Progress of Low Temperature Preservation Technology for Aquatic Products显示文摘Aquatic products are highly perishable because of the biological characteristics.So it is very important to study the preservation of aquatic products.Low temperature preservation technology is the earliest and most widely used technology.This paper introduced the research progress of low temperature preservation technology for aquatic products at home and abroad,and pointed out some problems and the future development trend of low temperature preservation.It provides a basis for the development of the aquatic product processing. | Suolian WU Huaibin KANG Dongjiao LI | 2019 | Agricultural Biotechnology2019，8，5： | 1 |
| 9 | The Design of the Hidden Curriculum and the Socialization of the Personality 显示文摘 | Zhang Dongjiao | 1991 | Education Research1991，8，： | 1 |
| 10 | Non-enzymatic detection of hydrogen peroxide using a functionalized three-dimensional graphene electrode显示文摘 | Fengna Xi Dongjiao Zhao Xuewan Wang Peng Chen | 2013 | Electrochemistry Communications2013，，： | 1 |
| 11 | Clonal Growth of Hum an Acute Leukem ia Cells in Serum -free Methylcellulose Medium显示文摘The clonal growth of human acute leukemia cell line (K562) and acute myeloid leukemia cells in the serum free culture (SFC) was studied in order to establish a SFC system which could replace the effects of serum by using semi solid methylcellulose culture technique. Our results showed that the clonal growth of K562 cells in semi solid culture was dependent on exogenous serum. The K562 could be grown in SFC supplemented with 4 major replacing substances. The multifactor and multilevel orthogonal experiment demonstrated that the colony formation was statistically influenced by the 4 replacing substances at various concentrations ( P <0.01). Among them, bovine serum albumin had greatest effect on clonal growth of K562 cells with the optimal concentration being 15 mg/L, followed by transferring, cholesterol and insulin with their optimal concentrations being of 150 mg/L, 7.8 mg/L and 7.0 mg/L respectively. SFC system was formed with the 4 substances at their optimal concentrations. Colony formation of the blast cells in 10 patients with acute myeloid leukemia was observed in this SFC system. There was a heterogeneity of acute myeloid leukemia cells among the 10 patients in response to the growth substances. In SFC system, there was a linear relationship between the number of the clonal formation and the count of the added cells, indicating the colony growth of the cells. Primary acute leukemia cells maintained in SFC system in 10 cases could completely form clones. The colony formation number in some cases in SFC system was more than that of the serum containing culture. The SFC system could partially replace the serum for study of the clonal formation of human leukemia cells. | CHEN Zhichao , ZOU Ping , YOU Yong , LIU Zhongping , XIANG Jianping , YU Dongjiao Institute of Hematology, Tongji Medical University, Wuhan 430030 | 1999 | Journal of Huazhong University of Science and Technology(Medical Sciences)1999，19，3： | 0 |
| 12 | The Com prehensive Evaluation on Four Indices of Drug Re-sistance in Acute Myeloid Leukem ia显示文摘To study sensitivity of drug resistance indexes and resistance manner in acute myeloid leukemia (AML), MTT drug sensitivity, growth types of CFU L in vitro , Bcl 2 antigen and Bcl 2/Bax ratio and intracellular fluorescence intensity of daunorubicin (DNR) were determined. In 62 cases of AML, the positive coincidence rate was 73 % with MTT test and the negative coincidence rate was 70 %. In 3 commonly used drugs, if one drug showed sensitivity, the coincidence remission rate reached 71 %. In 51 cases of AML, there were 31 patients in the group of complete remission (CR), in which CFU L of 29 patients showed independent growth. CFU L of 2 patients showed no growth. However, there were 20 patients in the group of non remission (NR), in which CFU L of 14 patients showed independent growth. CFU L of 6 patients showed non growth pattern. Statistical analysis showed significant difference ( P <0.05). In 32 cases of AML, the expression rate of Bcl 2 was 59.55 %±19.56 % in drug sensitive group, and one was 77.36 %±11.91 % in drug resistant group, respectively ( P <0.05). At the same time, the ratio of Bcl 2/Bax was 7.50±5.04 in drug sensitive group and one was 14.32±8.99 in drug resistant group, respectively ( P <0.05). In 15 case of clinically drug resistant AML, the fluorescence histogram of DNR showed left shift of main peak (LSMP) in 12 patients. They were diagnosed as classical drug resistance. Meanwhile, 1 patient showed right shift of main peak (RSMP) in 3 patients. They were diagnosed as re growth drug resistance. It is concluded that MTT and CFU L might be used for prediction of drug sensitivity or resistance when patients were on treatment. Bcl 2 and ratio of Bcl 2/Bax might be associated with the prognosis. DNR histogram could be employed for identify the pattern drug resistance. The strength and weakness of these techniques were discussed. | CHEN Yan , HE Mingsheng , XIANG Zhifu , WU Yudan, YUE Beibei , YU Dongjiao, LI Huiyu Institute of Hematology, Xiehe Hospital, Tongji Medical University, Wuhan, 430022 | 1999 | Journal of Huazhong University of Science and Technology(Medical Sciences)1999，19，3： | 0 |
| 13 | The detrimental effects of social capital on the balanced development of compulsory education and their governance显示文摘以追求教育公平为主旨的义务教育均衡发展既是一种政策取向,也是一种教育实践。目前,人们更关注义务教育的非均衡发展状态、成因及其治理问题。不同时期不同的生产方式、政策选择和制度安排是形成义务教育区域之间、城乡之间和校际之间差异的历史原因和现实原因。义务教育非均衡发展的直接后果是导致非规范性择校行为的发生。在择校过程中,家庭和学校社会资本的力量日益突出,其负向功能被诱发,破坏了就近入学政策,加剧了家庭与家庭之间、学校与学校之间社会资本的分化,损害了教育公平价值。由此,我们提出政府对于消除社会资本障碍的方向性建议:通过合理的政策选择和制度安排,在义务教育学校资源配置均衡的基础上,降低家庭社会资本在教育选择中的作用,建设学校社会资本发挥作用的良性竞争环境,从而治理目前部分家庭及学校社会资本参与择校所引发的社会问题。 | ZHANG Dongjiao | 2009 | Frontiers of Education in China2009，4，3： | 0 |
| 14 | Sugarcane transcription factor ScWRKY4 negatively regulates resistance to pathogen infection through the JA signaling pathway显示文摘WRKY transcription factors,transcriptional regulators unique to plants,play an important role in defense response to pathogen infection.However,the resistance mechanisms of WRKY genes in sugarcane remain unclear.In the present study,gene ontology(GO)enrichment analysis revealed that WRKY gene family in sugarcane was extensively involved in the response to biotic stress and in defense response.We identified gene ScWRKY4,a classⅡc member of the WRKY gene family,in sugarcane cultivar ROC22.This gene was induced by salicylic acid(SA)and methyl jasmonate(MeJA)stress.Interestingly,expression of ScWRKY4 was down-regulated in smut-resistant sugarcane cultivars but up-regulated in smutsusceptible sugarcane cultivars infected with Sporisorium scitamineum.Moreover,stable overexpression of the ScWRKY4 gene in Nicotiana benthamiana enhanced susceptibility to Fusarium solani var.coeruleum and caused down-regulated expression of immune marker-related genes.Transcriptome analysis indicated suppressed expression of most JAZ genes in the signal transduction pathway.ScWRKY4 interacted with ScJAZ13 to repress its expression.We thus hypothesized that the ScWRKY4 gene was involved in the regulatory network of plant disease resistance,most likely through the JA signaling pathway.The present study depicting the molecular involvement of ScWRKY4 in sugarcane disease resistance lays a foundation for future investigation. | Dongjiao Wang Wei Wang Shoujian Zang Liqian Qin Yanlan Liang Peixia Lin Yachun Su Youxiong Que | 2024 | The Crop Journal2024，12，1： | 0 |
| 15 | Zinc finger protein 831 promotes apoptosis and enhances chemosensitivity in breast cancer by acting as a novel transcriptional repressor targeting the STAT3/Bcl2 signaling pathway显示文摘Emerging evidence suggested that zinc finger protein 831(ZNF831)was associated with immune activity and stem cell regulation in breast cancer.Whereas,the roles and molec-ular mechanisms of ZNF831 in oncogenesis remain unclear.ZNF831 expression was significantly diminished in breast cancer which was associated with promoter CpG methylation but not mu-tation.Ectopic over-expression of ZNF831 suppressed breast cancer cell proliferation and col-ony formation and promoted apoptosis in vitro,while knockdown of ZNF831 resulted in an opposite phenotype.Anti-proliferation effect of ZNF831 was verified in vivo.Bioinformatic analysis of public databases and transcriptome sequencing both showed that ZNF831 could enhance apoptosis through transcriptional regulation of the JAK/STAT pathway.ChiP and luciferase report assays demonstrated that ZNF831 could directly bind to one specific region of STAT3 promoter and induce the transcriptional inhibition of STAT3.As a result,the attenuation of STAT3 led to a restraint of the transcription of Bcl2 and thus accelerated the apoptotic progression.Augmentation of STAT3 diminished the apoptosis-promoting effect of ZNF831 in breast cancer cell lines.Furthermore,ZNF831 could ameliorate the anti-proliferation effect of capecitabine and gemcitabine in breast cancer cell lines.Our findings demonstrate for the first time that ZNF831 is a novel transcriptional suppressor through inhibiting the expression of STAT3/Bcl2 and promoting the apoptosis process in breast cancer,suggesting ZNF831 as a novel biomarker and potential therapeutic target for breast cancer patients. | Jun Fan Zhe Zhang Hongqiang Chen Dongjiao Chen Wenbo Yuan Jingzhi Li Yong Zeng Shimeng Zhou Shu Zhang Gang Zhang Jiashen Xiong Lu Zhou Jing Xu Wenbin Liu Yan Xu | 2024 | Genes & Diseases2024，11，1： | 0 |
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