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| 1 | Shortened Basal Internodes Encodes a Gibberellin 2-Oxidase and Contributes to Lodging Resistance in Rice显示文摘改进住宿抵抗的繁殖半矮子变化被证明了在自从绿 revolution.?However 的来临,增加谷物产量极其成功,在亚洲繁殖半矮子米饭变化的多数主要依赖于 SD1 的变异的等位基因的基因介绍,它编码赤霉素( GA ) 20-oxidase , OsGA20ox2 ,为催化 GA 生合成。这里,我们报导新米饭住宿抵抗基因,弄短的基础 Internodes (SBI ) ,它编码赤霉素 ? 2-oxidase 并且明确地控制灰煤杆的延伸通过撤销的基础 internodes GA 活动。SBI 主要在灰煤杆被表示基础 internodes。基因分析显示 SBI 是影响米饭高度和住宿抵抗的半主导的基因。SBI 突变而产生之遗传的变体显示不同活动并且与米饭变化的高度被联系。与 SBI 等位基因的更高的活动繁殖与改进住宿抵抗和增加的产量产生新米饭变化。SBI 的发现为生产半矮子米饭显型提供一个理想的基因资源并且为与提高的住宿抵抗和高产量引起米饭变化提供有效策略。 | Chang Liu Jinshan Gui Chenjian Fu Hasi Yu Dongliang Song Junhui Shen Peng Qin Xuanming Liu Bin Han Yuanzhu Yang Laigeng Li | 2018 | Molecular Plant2018，11，2： | 33 |
| 2 | Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicenter trial显示文摘Tocilizumab has been reported to attenuate the“cytokine storm”in COVID-19 patients.We attempted to verify the effectiveness and safety of tocilizumab therapy in COVID-19 and identify patients most likely to benefit from this treatment.We conducted a randomized,controlled,open-label multicenter trial among COVID-19 patients.The patients were randomly assigned in a 1:1 ratio to receive either tocilizumab in addition to standard care or standard care alone.The cure rate,changes of oxygen saturation and interference,and inflammation biomarkers were observed.Thirty-three patients were randomized to the tocilizumab group,and 32 patients to the control group.The cure rate in the tocilizumab group was higher than that in the control group,but the difference was not statistically significant(94.12%vs.87.10%,rate difference 95%CI−7.19%–21.23%,P=0.4133).The improvement in hypoxia for the tocilizumab group was higher from day 4 onward and statistically significant from day 12(P=0.0359).In moderate disease patients with bilateral pulmonary lesions,the hypoxia ameliorated earlier after tocilizumab treatment,and less patients(1/12,8.33%)needed an increase of inhaled oxygen concentration compared with the controls(4/6,66.67%;rate difference 95%CI−99.17%to−17.50%,P=0.0217).No severe adverse events occurred.More mild temporary adverse events were recorded in tocilizumab recipients(20/34,58.82%)than the controls(4/31,12.90%).Tocilizumab can improve hypoxia without unacceptable side effect profile and significant influences on the time virus load becomes negative.For patients with bilateral pulmonary lesions and elevated IL-6 levels,tocilizumab could be recommended to improve outcome. | Dongsheng Wang Binqing Fu Zhen Peng Dongliang Yang Mingfeng Han Min Li Yun Yang Tianjun Yang Liangye Sun Wei Li Wei Shi Xin Yao Yan Ma Fei Xu Xiaojing Wang Jun Chen Daqing Xia Yubei Sun Lin Dong Jumei Wang Xiaoyu Zhu Min Zhang Yonggang Zhou Aijun Pan Xiaowen Hu Xiaodong Mei Haiming Wei Xiaoling Xu | 2021 | Frontiers of Medicine2021，15，3： | 2 |
| 3 | Efficacy of rigosertib, a small molecular RAS signaling disrupter for the treatment of KRAS-mutant colorectal cancer显示文摘Objective:Mutant KRAS,the principal isoform of RAS,plays a pivotal role in the oncogenesis of colorectal cancer by constitutively activating the RAF/MEK/ERK and PI3K/AKT pathways.Effective targeted therapies are urgently needed.We investigated whether rigosertib,a benzyl styryl sulfone RAS signaling disruptor,could selectively kill KRAS-mutant colorectal cancer cells.Methods:CCK-8 was used to determine the cell viability.Patient-derived tumor and cancer cell xenograft models were used to detect the inhibitory efficacy of rigosertib.Flow cytometry was used to evaluate the apoptosis and cell cycle progression.Apoptosis and cell cycle arrest markers were detected by Western blot.DCFH-DA was used to determine the reactive oxygen species.Immunohistochemistry staining and Western blot were performed to characterize RAS signaling markers in colorectal cancer tissues and cells.Results:Rigosertib(RGS)exhibited a cytotoxic effect against colorectal cancer cells,which was greater in KRAS-mutant cells.Furthermore,RGS induced mitotic arrest and oxidative stress-dependent apoptosis in KRAS-mutant DLD1 and HCT116 cells.Besides,RGS disrupted RAS signaling,and the inhibition of RAS/MEK/ERK was independent of cellular oxidative stress.Using patient-derived xenograft models,the response and tumor inhibition of RGS were significantly higher in the KRAS-mutant subgroup,while p-MEK,p-ERK,and p-AKT levels of RGS-treated tumors were significantly decreased.Finally,in a KRAS-mutant,chemotherapy-resistant patient-derived xenograft model,RGS showed a stronger therapeutic effect than the combination standard therapy involving fluoropyrimidine+oxaliplatin/irinotecan+bevacizumab.Conclusions:These data showed that targeting RAS signaling using RGS could be a therapeutic treatment for KRAS-mutant colorectal cancer patients. | Xinyi Zhou Qian Xiao Dongliang Fu Haochen Zhang Yang Tang Jinjie He Yeting Hu Xiangxing Kong Fei Teng Xiangrui Liu Ying Yuan Kefeng Ding | 2022 | Cancer Biology & Medicine2022，19，2： | 2 |
| 4 | Anatomic Retroperitoneoscopic Adrenalectomy for Selected Adrenal Tumors >5 cm: Our Technique and Experience显示文摘 | Baojun Wang Xin Ma Hongzhao Li Taoping Shi Dongliang Hu Bin Fu Bin Lang Guangfu Chen Xu Zhang | 2011 | Urology2011，，2： | 2 |
| 5 | 消化道神经内分泌肿瘤临床病理特征及预后因素分析(英文)显示文摘Objective: The aim of the study was to analyze the clinicopathologic characteristics of gastroenteropancreatic neuroendocrine neoplasm(GEP-NEN) and to explore the prognostic factors for patients and differences of immunohistochemical markers between neuroendocrine tumor(NET) and neuroendocrine carcinoma(NEC). Methods: Retrospective reviews were conducted for the charts of 119 patients with GEP-NEN at the Affiliated Hospital of Qingdao University(China) from August 2003 to December 2013. Kaplan-Meier method was used to do the overall survivals analysis for the patients at different levels of predictive factors. Meanwhile, Cox proportional hazard model was used to select independent risk factors of survival. Analysis of variance was used to compare the expression of immunohistochemical markers among different pathological grades. Results: Among 119 patients, pancreas(45/119, 37.82%) and rectum(33/119, 27.73%) were mostly involved. The onset age of GEP-NEN in female group was younger than that of the male group. There were 13 deaths(10.92%) during 18.9(0.1–133.4) months follow-up period. Multivariate analysis indicated that neural invasion, gender and pathological grades of NET and NEC were independent risk factors. In neuroendocrine neoplasm(NEN), Syn expression in G2 was higher than G1 and G3, while Cg A showed no significant difference. All markers showed no significant differences between NET and NEC. Conclusion: GEP-NEN may occur at multiple sites of digestive system and lack specific clinical manifestations. Syn expression detected for the prognosis of G1, G2 and G3 tumors have clinical significance. Neural invasion, sex and pathological grades were independent prognostic factors for GEP-NEN patients. No significant difference was found in different pathological grades of NET and NEC. | Ping Yang Jie Liu Dongliang Lin Haiyang Fu Jing Chu Feng Li Guiyan Han Yujun Li Weiwei Fu | 2014 | The Chinese-German Journal of Clinical Oncology2014，13，12： | 1 |
| 6 | Anatomic Retroperitoneoscopic Adrenalectomy for Selected Adrenal Tumors >5 cm: Our Technique and Experience显示文摘 | Baojun Wang Xin Ma Hongzhao Li Taoping Shi Dongliang Hu Bin Fu Bin Lang Guangfu Chen Xu Zhang | 2011 | Urology2011，，2： | 1 |
| 7 | Research Progress on Improving the Production Capacity of Brassica napus显示文摘During the past 30 years,Brassica napus L.has grown rapidly worldwide,and the emergence of a large number of innovative rape varieties has provided tremendous support for the food,feed,biofuel and ornamental markets.This paper summarized the research on B.napus variety screening,supporting cultivation techniques and breeding and utilization of fine varieties,and discussed the great potential of screening,planting and cultivating B.napus according to production goals in improving production efficiency,providing a basis for better development and utilization of B.napus. | Zhenxian GAO Dongliang TIAN Qiao CAO Lipeng LIANG Yali FU | 2022 | Agricultural Biotechnology2022，11，3： | 0 |
| 8 | Targeting RAS mutants in malignancies:successes,failures,and reasons for hope显示文摘RAS genes are the most frequently mutated oncogenes and play critical roles in the development and progression of malignancies.The mutation,isoform(KRAS,HRAS,and NRAS),position,and type of substitution vary depending on the tissue types.Despite decades of developing RAS-targeted therapies,only small subsets of these inhibitors are clinically effective,such as the allelespecific inhibitors against KRASG12C.Targeting the remaining RAS mutants would require further experimental elucidation ofRAS signal transduction,RASaltered metabolism,and the associated immune microenvironment.This study reviews the mechanisms and efficacy of novel targeted therapies for different RAS mutants,including KRAS allele-specific inhibitors,combination therapies,immunotherapies,and metabolism-associated therapies. | Hang Yang Xinyi Zhou Dongliang Fu Chenqin Le Jiafeng Wang Quan Zhou Xiangrui Liu Ying Yuan Kefeng Ding Qian Xiao | 2023 | Cancer Communications2023，43，1： | 0 |
| 9 | Orthogonal Aza-BODIPY–BODIPY dyad as heavy-atom free photosensitizer for photo-initiated antibacterial therapy显示文摘Photodynamic antibacterial therapy shows great potential in bacterial infection and the reactive oxygen species(ROS)production of the photosensitizers is crucial for the therapeutic e®ect.Introducing heavy atoms is a common strategy to enhance photodynamic performance,while dark toxicity can be induced to impede further clinical application.Herein,a novel halogen-free photosensitizer Aza-BODIPY-BODIPY dyad NDB with an orthogonal molecular conguration was synthesized for photodynamic antibacterial therapy.The absorption and emission peaks of NDB photosensitizer in toluene were observed at 703 nm and 744 nm,respectively.The°uorescence(FL)lifetime was measured to be 2.8 ns in toluene.Under 730 nm laser illumination,the ROS generation capability of NDB was 3-fold higher than that of the commercial ICG.After nanoprecipitation,NDB NPs presented the advantages of high photothermal conversion e±ciency(39.1%),good photostability,and excellent biocompatibility.More importantly,in vitro antibacterial assay conrmed that the ROS and the heat generated by NDB NPs could extirpate methicillin-resistant S.aureus e®ectively upon exposure to 730 nm laser,suggesting the potential application of NDB NPs in photo-initiated antibacterial therapy. | Dongliang Yang Liguo Sun Lei Xue Xiaorui Wang Yanling Hu Jinjun Shao Ling Fu Xiaochen Dong | 2022 | Journal of Innovative Optical Health Sciences2022，15，1： | 0 |
| 10 | THERMODYNAMIC PROPERTIES OF HOLE TRAPS A AND B IN GaAs显示文摘Equilibrium constant KT and free energy of formation △G°of the reaction(GaAsAsGa+(VGa)(2|-)+(e|-)=AsGaV(G|-)a+GaAsV(G|-)awere deduced as:KT=(1.088×108-1.09×1011·1/T)2△G°=-2RTln(1.088×108-1.09×1011·1/T)These seem to be applicable into practice under certain conditions. | FU ZHiping LU Dongliang ZHAN Qianbao ZHOU Jicheng Shanghai lnstitute of Metallurgy,Academia,Sinica,Shanghai,China | 1992 | Acta Metallurgica Sinica(English Letters)1992，5，12： | 0 |
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