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| 1 | China National Medical Products Administration approval summary:anlotinib for the treatment of advanced non-small cell lung cancer after two lines of chemotherapy显示文摘Background:On May 8,2018,the China National Medical Products Administration(NMPA)approved anlotinib,an orally administered anti-angiogenesis inhibitor,for the treatment of patients with advanced non-small cell lung can-cer(NSCLC)who have progressed after treatment with two or more lines of prior systemic chemotherapy.Main body of the abstract:China NMPA reviewed and inspected a regional double-blinded,placebo-controlled,Phase III trial comparing the overall survival(OS)of NSCLC patients between the anlotinib and placebo arms.A total of 437 patients were randomized(2:1)to receive either anlotinib(n=294)or placebo(n=143)once daily on a 2-week on and 1-week off schedule.Patients with epidermal growth factor receptor(EGFR)or activating anaplastic lymphoma kinase(ALK)genomic tumor aberrations should have disease progression on NMPA-approved therapy.Anlotinib is the first NMPA-approved drug for patients with advanced NSCLC who have progressed on at least two lines of prior systemic chemotherapies in China.The approval was based on a statistically and clinically significant improvement in median OS with anlotinib(9.46 months)compared with placebo[6.37 months;hazard ratio(HR])=0.70,95%confidence interval(CI)=0.55-0.89;two-sided log-rank P=0.002].The confirmed objective response rate(ORR)was 9.2%in the anlotinib arm and 0.7%in the placebo arm.The median duration of response(DoR)was 4.83 months,with a 95%CI of 3.31-6.97 months.The toxicity profile of anlotinib was consistent with that of known anti-angiogenesis inhibitors.Common adverse drug reactions(ADRs)in anlotinib-treated patients included hypertension(67.4%),hand-foot syndrome(43.9%),hemoptysis(14.0%),thyroid stimulating hormone(TSH)elevation(46.6%),and corrected QT interval(QTc)prolongation(26.2%).Short conclusion:Anlotinib demonstrated a clinically significant OS prolongation as a novel therapeutic option for advanced or metastatic NSCLC following at least two lines of chemotherapy. | Ming Zhou Xiaoyuan Chen Hong Zhang Lin Xia Xin Tong Limin Zou Ruimin Hao Jianhong Pan Xiao Zhao Dongmei Chen Yuanyuan Song Yueli Qi Ling Tang Zhifang Liu Rong Gao Yuankai Shi Zhimin Yang | 2019 | Cancer Communications2019，39，1： | 35 |
| 2 | The antitumor effect of tanshinone IIA on antiproliferation and decreasing VEGF/VEGFR2 expression on the human non-small cell lung cancer A549 cell line显示文摘The effects of tanshinone IIA on the proliferation of the human non-small cell lung cancer cell line A549 and its possible mechanism on the VEGF/VEGFR signal pathway were investigated.The exploration of the interaction between tanshinone IIA and its target proteins provides a feasible platform for studying the anticancer mechanism of active components of herbs.The CCK-8 assay was used to evaluate the proliferative activity of A549 cells treated with tanshinone IIA(2.5 80 μmol/L) for 24,48 and 72 h,respectively.Flow cytometry was used for the detection of cell apoptosis and cell cycle perturbation.VEGF and VEGFR2 expression were studied by Western blotting.The binding mode of tanshinone IIA within thecrystal structure of the VEGFR2 protein was evaluated with molecular docking analysis by use of the CDOCKER algorithm in Discovery Studio 2.1.The CCK-8 results showed that tanshinone IIA can significantly inhibit A549 cell proliferation in a dose-and time-dependent manner.Flow cytometry results showed that the apoptosis rate of tested group was higher than the vehicle control,and tanshinone IIAtreated cells accumulated at the S phase,which was higher than the vehicle control.Furthermore,the expression of VEGF and VEGFR2 was decreased in Western blot.Finally,molecular docking analysis revealed that tanshinone IIA could be stably docked into the kinase domain of VEGFR2 protein with its unique modes to form H-bonds with Cys917 and π–π stacking interactions with Val848.In conclusion,tanshinone IIA may suppress A549 proliferation,induce apoptosis and cell cycle arrest at the S phase.This drug may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2. | Jun Xie Jiahui Liu Heng Liu Shihui Liang Meigui Lin Yueyu Gu Taoli Liu Dongmei Wang Hui Gee Sui-lin Mo | 2015 | Acta Pharmaceutica Sinica B2015，5，6： | 26 |
| 3 | Indirect mineral carbonation of titanium-bearing blast furnace slag coupled with recovery of TiO_2 and Al_2O_3显示文摘Large quantities of CO_2 and blast furnace slag are discharged in the iron and steel industry. Mineral carbonation of blast furnace slag can offer substantial CO_2 emission reduction and comprehensive utilization of the solid waste.This paper describes a novel route for indirect mineral carbonation of titanium-bearing blast furnace(TBBF) slag,in which the TBBF slag is roasted with recyclable(NH_4)_2SO_4(AS) at low temperatures and converted into the sulphates of various valuable metals, including calcium, magnesium, aluminium and titanium. High value added Ti-and Al-rich products can be obtained through stepwise precipitation of the leaching solution from the roasted slag. The NH_3 produced during the roasting is used to capture CO_2 from flue gases. The NH_4HCO_3 and(NH_4)_2CO_3 thus obtained are used to carbonate the CaSO_4-containing leaching residue and MgSO_4-rich leaching solution, respectively. In this study, the process parameters and efficiency for the roasting, carbonation and Ti and Al recovery were investigated in detail. The results showed that the sulfation ratios of calcium,magnesium, titanium and aluminium reached 92.6%, 87% and 84.4%, respectively, after roasting at an AS-to-TBBF slag mass ratio of 2:1 and 350 °C for 2 h. The leaching solution was subjected to hydrolysis at 102 °C for 4 h with a Ti hydrolysis ratio of 95.7% and the purity of TiO_2 in the calcined hydrolysate reached 98 wt%.99.7% of aluminium in the Ti-depleted leaching solution was precipitated by using NH_3. The carbonation products of Ca and Mg were CaCO_3 and(NH_4)_2 Mg(CO_3)_2·4H_2O, respectively. The latter can be decomposed into MgCO_3 at 100–200 °C with simultaneous recovery of the NH_3 for reuse. In this process, approximately 82.1% of Ca and 84.2%of Mg in the TBBF slag were transformed into stable carbonates and the total CO_2 sequestration capacity per ton of TBBF slag reached up to 239.7 kg. The TiO_2 obtained can be used directly as an end product, while the Al-rich precipitate and the two carbonation products can act, respectively, as raw materials for electrolytic aluminium,cement and light magnesium carbonate production for the replacement of natural resources. | Lin Wang Weizao Liu Jingpeng Hu Qiang Liu Hairong Yue Bin Liang Guoquan Zhang Dongmei Luo Heping Xie Chun Li | 2018 | Chinese Journal of Chemical Engineering2018，26，3： | 14 |
| 4 | Study of altitudinal lapse rates of δ^(18)O in precipitation/river water with seasons on the southeast Tibetan Plateau显示文摘Seasonal δ 18O variation in water on the southeast Tibetan Plateau has been studied, showing the consistent variation pattern of δ 18O with altitude indicative of relevant atmospheric circulation processes. Study shows a similar variation pattern of fixed-site river water δ 18O with that of the precipitation δ 18O in southeast Tibet. δ 18O in regional rivers in southeast Tibet demonstrates a gradual depletion with increasing altitude, though the rates vary seasonally. The most depleted river 18O occurs during the monsoon period, with the lowest δ 18O/altitude lapse rate. The river 18O during the westerly period is also depleted, together with low δ 18O/altitude lapse rate. The pre-monsoon rivers witness the most enriched 18O with least significant correlation coefficient with the linear regression, whilst the postmonsoon rivers witness the largest δ 18O/altitude lapse rate. Different coherence of seasonal δ 18O variation with the altitude effect is attributed to different moisture supplies. Though sampling numbers vary with seasons, the δ 18O-H linear correlation coefficients all reach the 0.05 confidence level, thus witnessing the variation features of δ 18O in seasonal river water due to the influence of atmospheric general circulation and land surface processes revealed from the altitudinal lapse rates. | YANG XiaoXin XU BaiQing YANG Wei QU DongMei LIN Ping-Nan | 2009 | Chinese Science Bulletin2009，54，16： | 13 |
| 5 | A circular zone partition method for identifying Duffing oscillator state transition and its application to BPSK signal demodulation显示文摘When a Duffing oscillator is applied to signal detection, identifying its state transition is indispensable. Due to lack of an effective method for automatically distinguishing the state transition, phase analysis is extensively used. However, it needs ocular estimation to identify phase pattern corresponding to transition of Duffing oscillator. Hence it is not fit for communication signal demodulation. To solve the problem, this paper proposes a method, called circular zone partition (CZP), for partitioning trajectory on the phase plane of Duffing oscillator. First, a computing model for Duffing oscillator is described. Then, the fundamental principle and algorithm for the CZP method are discussed. Meanwhile the equation of a circular zone divider and its realization are presented. Thus, by way of the divider, the two-dimensional phase trajectory pattern of Duffing oscillator driven by an external signal can be transformed into the one-dimensional time signal, whose envelop after being filtered is able to indicate the state transition, i.e. the presence or the absence of external signal. Finally, to verify the effect of the CZP method on binary phase shifted keying (BPSK) signal demodulation, two examples are presented and simulation results show that this CZP method is accurate and valid for BPSK signal demodulation. | FU YongQing WU DongMei ZHANG Lin & LI XingYuan | 2011 | Science China(Information Sciences)2011，54，6： | 9 |
| 6 | Efficacy and safety of vitamin D3 in patients with diabetic nephropathy: a meta-analysis of randomized controlled trials显示文摘 | Zhao Junyu Dong Jianjun Wang Haipeng Shang Hongxia Zhang Dongmei Liao Lin | 2014 | Chinese Medical Journal2014，，15： | 9 |
| 7 | Ultrathin AgPt alloy nanowires as a high-performance electrocatalyst for formic acid oxidation显示文摘探讨不够的 electrocatalytic 活动和蚁的酸氧化反应(FAOR ) 的稳定性 electrocatalysts,以及他们的高度花费了,我们此处表明 ultrathin AgPt 合金 nanowires 的灵巧的热水的合成用终止胺 poly (N-isopropylacrylamide )(PNIPAM-NH 2) 作为一个指导结构的代理人。AgCl 的起始的产生猛抛, AgPt nanoparticles 的随后的形成,和他们的面向的附件说明 ultrathin AgPt 合金 nanowires 的形成。得益于他们的唯一的 1D anisotropy 和 alloyed 作文,准备 ultrathin AgPt nanowires 展览为 FAOR 的一项优异 electrocatalytic 活动和更好的公司忍耐,到达 1.6 褶层和 3.7 褶层更高特定的当前的密度比 AgPt nanoparticles 和商业磅黑人催化剂分别地。另外, ultrathin AgPt 合金 nanowires 在 electrocatalysis 期间表明优异电气化学的稳定性和结构的坚韧性,使他们成为有希望的 FAOR electrocatalyst。这个工作不仅为高贵基于金属的 ultrathin nanowires 的合成提供可靠策略,而且在新窗户中为燃料房间 systems.Open 图象向有效 electrocatalysts | Xian Jiang Gengtao Fu Xia Wu Yang Liu Mingyi Zhang Dongmei Sun Lin Xu Yawen Tang | 2018 | Nano Research2018，11，1： | 9 |
| 8 | Spinel MnCo2O4 nanoparticles cross-linked with two-dimensional porous carbon nanosheets as a high-efficiency oxygen reduction electrocatalyst显示文摘为氧减小反应(ORR ) 的催化剂在燃料房间起一个重要作用。有到基于磅的催化剂的可比较的 ORR 活动的其他的非宝贵的金属催化剂为燃料房间的发展是高度合乎需要的。在这个工作,我们第一次报导尖晶石 MnCo 2 O 4/C ORR 催化剂由一致 MnCo 2 O 4 nanoparticles cross-linked 与二维( 2D )多孔的碳 nanosheets (缩短的同样多孔的 MnCo 2 O 4/C nanosheets ),在哪个葡萄糖作为模板被用作碳来源和 NaCl 。获得的多孔的 MnCo 2 在场的 O 4/C nanosheets 互连的多孔的体系结构和一个大表面区域的联合性质(175.3 m 2( | Gengtao Fu Zhenyuan Liu Jingfei Zhang Jiayan Wu Lin Xu Dongmei Sun Jubing Zhang Yawen Tang Pei Chen | 2016 | Nano Research2016，9，7： | 7 |
| 9 | 中国国家药品监督管理局批准安罗替尼用于经两种系统化疗后疾病进展的晚期非小细胞肺癌的治疗显示文摘背景2018年5月8日,中国国家药品监督管理局(National Medical Products Administration,NMPA)批准了小分子多靶点抗血管抑制剂盐酸安罗替尼,用于既往经过至少两种系统化疗后疾病进展的晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的治疗。概要中国NMPA审查了一项随机双盲、安慰剂对照的III期临床试验,该临床试验的主要终点为总生存期(overall survival,OS)。试验共纳入437例患者随机分组(2∶1)接受安罗替尼(n=294)或安慰剂(n=143)治疗,每日1次,连服2周,停药1周。表皮生长因子受体(epidermal growth factor receptor,EGFR)基因敏感突变或间变性淋巴瘤激酶(activating anaplasticlymphomakinase,ALK)阳性的患者须经过NMPA已批准的药物治疗后出现疾病进展。安罗替尼为中国NMPA批准的用于治疗既往经过两种及以上系统化疗后疾病进展的晚期NSCLC患者的首个药物。安罗替尼组的中位OS(9.46个月)较安慰剂组[6.37个月;风险比(hazard ratio,HR)=0.70,95%置信区间(confidence Interval,CI):0.55–0.89;双侧log-rank P=0.002]显著延长。安罗替尼组的客观缓解率(objective responserate,ORR)为9.2%,安慰剂组为0.7%。安罗替尼组的中位缓解持续时间(durationofresponse,DoR)为4.83个月,95%CI为3.31–6.97个月。安罗替尼的常见不良反应(adverse drug reactions,ADRs)包括高血压(67.4%)、手足综合征(43.9%)、咳血(14.0%)、促甲状腺激素(thyroid stimulating hormone,TSH)升高(46.6%)、心电图QT间期(corrected QT Interval,QTc)延长(26.2%)。结论安罗替尼显著延长了患者的OS,可作为经二线及以上化疗后晚期或转移性非小细胞肺癌的一种新的治疗方案。 | Ming Zhou Xiaoyuan Chen Hong Zhang Lin Xia Xin Tong Limin Zou Ruimin Hao Jianhong Pan Xiao Zhao Dongmei Chen Yuanyuan Song Yueli Qi Ling Tang Zhifang Liu Rong Gao Yuankai Shi Zhimin Yang | 2019 | 癌症2019，38，12： | 7 |
| 10 | Facile synthesis based on novel carbon-supported cyanogel of structurally ordered Pd3Fe/C as electrocatalyst for formic acid oxidation显示文摘 | Zhenyuan Liu Gengtao Fu Jiahui Li Zhenqi Liu Lin Xu Dongmei Sun Yawen Tang | 2018 | Nano Research2018，11，9： | 6 |
| 11 | Dendritic platinum-copper bimetallic nanoassemblies with tunable composition and structure: Arginine-driven self-assembly and enhanced electrocatalytic activity显示文摘 | Gengtao Fu Huimin Liu Nika You Jiayan Wu Dongmei Sun Lin Xu Yawen Tang Yu Chen | 2016 | Nano Research2016，9，3： | 6 |
| 12 | Genome-wide DNA methylation profiles in Tibetan and Yorkshire pigs under highaltitude hypoxia显示文摘Background: Tibetan pigs, which inhabit the Tibetan Plateau, exhibit distinct phenotypic and physiological characteristics from those of lowland pigs and have adapted well to the extreme conditions at high altitude.However, the genetic and epigenetic mechanisms of hypoxic adaptation in animals remain unclear.Methods: Whole-genome DNA methylation data were generated for heart tissues of Tibetan pigs grown in the highland(TH, n = 4) and lowland(TL, n = 4), as well as Yorkshire pigs grown in the highland(YH, n = 4) and lowland(YL, n = 4), using methylated DNA immunoprecipitation sequencing.Results: We obtained 480 million reads and detected 280679, 287224, 259066, and 332078 methylation enrichment peaks in TH, YH, TL, and YL, respectively. Pairwise TH vs. YH, TL vs. YL, TH vs. TL, and YH vs. YL comparisons revealed6829, 11997, 2828, and 1286 differentially methylated regions(DMRs), respectively. These DMRs contained 384, 619,192, and 92 differentially methylated genes(DMGs), respectively. DMGs that were enriched in the hypoxia-inducible factor 1 signaling pathway and pathways involved in cancer and hypoxia-related processes were considered to be important candidate genes for high-altitude adaptation in Tibetan pigs.Conclusions: This study elucidates the molecular and epigenetic mechanisms involved in hypoxic adaptation in pigs and may help further understand human hypoxia-related diseases. | Bo Zhang Dongmei Ban Xiao Gou Yawen Zhang Lin Yang Yangzom Chamba Hao Zhang | 2019 | Journal of Animal Science and Biotechnology2019，10，2： | 6 |
| 13 | Effect of Bacillus amyloliquefaciens and Bacillus subtilis on fermentation, dynamics of bacterial community and their functional shifts of whole-plant corn silage显示文摘Background:Bacillus amyloliquefaciens(BA)and Bacillus subtilis(BS)are usually used as feed supplements directly or bacterial inoculants in biological feeds for animals.However,few research have reported the effects of BA and BS on fermentation characteristics and bacterial community successions of whole-plant corn silage during ensiling.If the BA and BS inoculants have positive effects on silages,then they could not only improve fermentation characteristics,but also deliver BA or BS viable cells to ruminants,which would play its probiotic effect.Therefore,the objectives of this study were to investigate the effects of BA and BS on the fermentation,chemical characteristics,bacterial community and their metabolic pathway of whole-plant corn silage.Results:Freshly chopped whole-plant corn was inoculated without or with BA and BS,respectively,and ensiled for1,3,7,14 and 60 d.Results showed that BA and BS inoculations increased lactic acid concentrations of whole-plant corn silages compared with control,and BA inoculation decreased acetic acid concentrations,whereas BS inoculation decreased fiber contents and increased crude protein(CP)content.Higher water-soluble carbohydrate contents and lower starch contents were observed in BA-and BS-inoculated silages compared with that in control.The decreased CP content and increased non-protein nitrogen content were observed in BA-inoculated silage,which was consistent with the higher amino acid metabolism abundances observed in BA-inoculated silage.In addition,it was noteworthy that BA and BS inoculations increased the metabolism of cofactors and vitamins,and decreased the relative abundances of drug resistance:antimicrobial pathways.We also found that the bacterial metabolism pathways were clearly separated into three clusters based on the ensiling times of whole-plant corn silage in the present study.There were no significant differences in bacterial community compositions among the three groups during ensiling.However,BA and BS inoculations decreased the relative abundances of undesirable bacteria such as Acetobacter and Acinetobacter.Conclusion:Our findings suggested that the BS strain was more suitable as silage inoculants than the BA strain in whole-plant corn silage in this study. | Jie Bai Marcia Franco Zitong Ding Lin Hao Wencan Ke Musen Wang Dongmei Xie Ziqian Li Yixin Zhang Lin Ai Xusheng Guo | 2022 | Journal of Animal Science and Biotechnology2022，13，3： | 5 |
| 14 | TCP7 functions redundantly with several Class Ⅰ TCPs and regulates endoreplication in Arabidopsis显示文摘TCP(TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR) proteins, a family of plantspecific transcription factors, play important roles in many developmental processes. However, genetic and functional redundancy among class I TCP limits the analysis of their biological roles. Here, we identified a dominantnegative mutant of Arabidopsis thaliana TCP7 named leaf curling-upward(lcu), which exhibits smaller leaf cells and shorter hypocotyls than the wild type, due to defective endoreplication. A septuple loss-of-function mutant of TCP7, TCP8, TCP14, TCP15, TCP21, TCP22, and TCP23 displayed similar developmental defects to those of lcu.Genome-wide RNA-sequencing showed that lcu and the septuple mutant share many misexpressed genes.Intriguingly, TCP7 directly targets the CYCLIN D1;1 (CYCD1;1) locus and activates its transcription. We determined that the C-terminus of TCP7 accounts for its transcriptional activation activity. Furthermore, the mutant protein LCU exhibited reduced transcriptional activation activity due to the introduction of an EAR-like repressive domain at its C-terminus. Together, these observations indicate that TCP7 plays important roles during leaf and hypocotyl development, redundantly, with at least six class I TCPs, and regulates the expression of CYCD1;1 to affect endoreplication in Arabidopsis. | Guofang Zhang Hongtao Zhao Chunguang Zhang Xiaoyun Li Yuanyuan Lyu Dongmei Qi Yanwei Cui Lin Hu Zhenjie Wang Zheng Liang Sujuan Cui | 2019 | Journal of Integrative Plant Biology2019，61，11： | 5 |
| 15 | The correlation and overlaps between PD-L1 expression and classical genomic aberrations in Chinese lung adenocarcinoma patients: a single center case series显示文摘Objective:To investigate the correlation and overlaps between PD-L1 expression and classical genomic aberrations in Chinese lung adenocarcinoma(LADC)patients.Methods:We reviewed 428 consecutive,surgically resected cases of LADC from October 2015 to December 2016 from our center.PD-L1 expression was evaluated based on tumor proportion score(TPS).Correlation and co-occurrence of PD-L1 expression level with those of classical driver genes,such as EGFR,ALK,ROS-1,and KRAS and with clinical variables and disease-free survival(DFS)were analyzed.Results:Seventy of the 428 cases(16.4%)showed TPS≥1%,and 21 cases(4.9%)showed TPS≥50%.PD-L1 positive expression was significantly associated with male gender,smoking,advanced TNM stage,and solid histologic subtype.Both TPS≥1% and ≥50%were correlated with the absence of an EGFR mutation(P<0.001)and the presence of ALK rearrangement(P=0.024).KRAS mutation was associated with TPS≥50%(P=0.035).PD-L1 positivity commonly overlapped with the alterations of classical driver oncogenes(58.5%with TPS≥1% and 42.9% with TPS≥50%).Approximately three-quarters of PD-L1 positive cases co-occurred with classical therapeutic-gene aberrations in cases with stage III/IV cancer or cancer progression.LADC could be divided into four subgroups based on the expression profile of current routine biomarkers for potential therapeutic strategies.Conclusions:PD-L1 expression is not only closely correlated with classic gene alterations but also commonly overlaps with the aberrations of classical driver oncogenes in Chinese LADC patients.These findings provide a useful overview of clinical strategies that rely on the profile of routinely used molecular biomarkers. | Jianghua Wu Wei Sun Haiyue Wang Xiaozheng Huang Xinyu Wang Weiyang Jiang Ling Jia Ping Wang Qin Feng Dongmei Lin | 2019 | Cancer Biology & Medicine2019，16，4： | 5 |
| 16 | Seasonal changes in the water-use strategies of three herbaceous species in a native desert steppe of Ningxia,China显示文摘Frequent periods of drought conditions are known to limit plant performance,primary production,and ecosystem stability in arid and semi-arid desert steppe environments.Plants often avoid competition by shifting their water use seasonally,which affects the water-use patterns of dominant species as well as the composition and structure of plant communities.However,the water-use strategies of dominant herbaceous species,which grow under natural field conditions in the desert steppe region of Ningxia Hui Autonomous Region,China,are poorly known.Here,we explored the possible sources of water uptake and water-use efficiency(WUE)of three dominant herbaceous plant species(Stipa breviflora,Agropyron mongolicum,and Glycyrrhiza uralensis)in a native desert steppe in the semi-arid area of Ningxia through an analysis of multiple parameters,including(1)the stable isotopic oxygen and hydrogen(δ18O andδ2H)compositions of precipitation,soil water,and stem water,(2)the carbon isotope(13C)composition of leaves,and(3)the soil water contents,based on field sampling across varying water conditions from June to September,2017.Frequent small precipitation events replenished shallow soil water,whereas large events only percolated down to the deep soil layers.Changes in soil water availability affected the water-use patterns of plants.Generally,during light precipitation periods,the deep root system of G.uralensis accessed deeper(>80 cm)soil water,whereas S.breviflora and A.mongolicum,which only have shallow roots,primarily absorbed water from the shallow and middle soil layers.As precipitation increased,all three plant species primarily obtained water from the shallow soil layers.Variation in soil water uptake between the dry and wet seasons enabled plants to make better use of existing satoil water.In addition,theδ13C values of G.uralensis and S.breviflora were higher than those of A.mongolicum.Theδ13C values of the three plant species were significantly negatively correlated with soil water content.Therefore,G.uralensis and S.breviflora maintained a higher WUE through their conservative and water-saving strategies across the entire growing season.In contrast,A.mongolicum,with a relatively low WUE in the wet season but a high WUE in the dry season,exhibited a more flexible water-use strategy.The different water-use strategies of these dominant plant species demonstrated the mechanisms by which plant communities can respond to drought. | HU Haiying ZHU Lin LI Huixia XU Dongmei XIE Yingzhong | 2021 | Journal of Arid Land2021，13，2： | 4 |
| 17 | Arginine-mediated synthesis of cube-like platinum nanoassemblies as efficient electrocatalysts显示文摘可控制高贵金属 nanocrystals 自己组装具有为高度活跃的 electrocatalysts 的发展的宽广兴趣。这里,我们与多孔的洞和不平的表面为像立方体的磅 nanoassemblies (Pt-CNAs ) 的产量很高的合成报导一条有效调停精氨酸的热水的途径基于零维的磅 nanocrystals 自己组装。在这进程,精氨酸充当在邻近的 nanocrystals 之间的 reductant,结构指导代理人,和连接器。有趣地, Pt-CNAs 展览单个水晶的结构与主导 { 100 } 方面由 X 光检查衍射证实了。把研究基于 electrocatalytic,同样综合的 Pt-CNAs 展览在甲醇氧化反应改进了 electrocatalytic 活动以及好稳定性和公司忍耐。Pt-CNAs 好表演被归因于他们的唯一的形态学和表面结构。我们相信这里构画出的合成策略能被递讲道理地设计的其它为在高效燃料房间的使用的一金属或二金属的 nanoassemblies。 | Gengtao Fu Qian Zhang Jiayan Wu Dongmei Sun Lin Xu Yawen Tang Yu Chen | 2015 | Nano Research2015，8，12： | 4 |
| 18 | Mechanical Behavior of a Glass-fiber Reinforced Composite to Steel Joint for Ships显示文摘在海洋的结构合成的增强的眼镜纤维的使用正在变得更普通,特别地由于潜在的重量积蓄。在增强的聚合物(GRP ) 上层建筑和钢壳形成了的眼镜纤维之间的关节的机械反应被检验并且随后修改了通过当模特儿并且测试的一个联合程序改进性能。一个有限元素的模型被开发预言关节的反应。模型在在不同材料,进步损坏,大变丑理论,和一种非线性的压力紧张关系之间的接口考虑接触。预言进步失败,分析联合 Hashin 失败标准和最大的压力失败标准。结果表演压力反应在力量上有大影响并且关节适用。Balsawood 钢接口被证明对关节的机械行为批评。在试验性的结果和数字预言之间的好同意被观察。 | Xiaowen Li Ping Li Zhuang Lin Dongmei Yang | 2015 | Journal of Marine Science and Application2015，14，1： | 3 |
| 19 | Chidamide combined with cyclophosphamide,doxorubicin,vincristine and prednisone in previously untreated patients with peripheral T-cell lymphoma显示文摘Objective:Chidamide is an oral histone deacetylase subtype-selective inhibitor approved for relapsed or refractory peripheral T-cell lymphoma(PTCL).This phase 1 b study evaluated the safety,pharmacokinetics,and preliminary efficacy of chidamide in combination with cyclophosphamide,doxorubicin,vincristine and prednisone(CHOP)for treatment-na?ve PTCL patients.Methods:This study was an open-label,multicenter trial composed of dose escalation and dose expansion.Patients received CHOP for six 21-d cycles and chidamide on d 1,4,8 and 11 in each cycle.Four dose levels of chidamide(20,25,30 and 35 mg)were evaluated.The primary objective was to evaluate the safety and tolerability of the combination regimen.Results:A total of 30 patients were evaluated in this study:15 in the dose-escalation part and 15 in the doseexpansion part.In the dose-escalation study,three patients were enrolled in the 35 mg chidamide cohort.One had dose-limiting toxicity with grade 3 vascular access complications,and one had grade 2 neutropenia with a sustained temperature>38°C.Dose escalation was stopped at this chidamide dose level.The most common(≥10%)grade 3 or 4 adverse events(AEs)were leukopenia(90.0%),neutropenia(83.3%),vomiting(13.3%),thrombocytopenia(10.0%)and febrile neutropenia(10.0%).No significant changes in chidamide pharmacokinetic properties were observed before and after combination treatment.The objective response rate for the 28 patients evaluable for preliminary efficacy was 89.3%(25/28),with 16(57.1%)achieving complete response or unconfirmed complete response.The estimated median progression-free survival was 14.0 months.In summary,we chose chidamide 30 mg as the recommended dose for phase 2.Conclusions:The addition of chidamide to standard CHOP chemotherapy was tolerable with promising preliminary efficacy in previously untreated PTCL patients,which supports further clinical studies with this combination regimen for the frontline treatment of PTCL. | Lin Gui Junning Cao Dongmei Ji Huilai Zhang Qian Fan Jun Zhu Yuqin Song Shiyu Jiang Zhiqiang Ning Jia Yu Yuankai Shi | 2021 | Chinese Journal of Cancer Research2021，33，5： | 3 |
| 20 | 以胶原-海藻酸钠纤维凝胶为原料的具有潜在组织工程应用的仿生支架材料的制备与评价显示文摘三维支架的孔结构和在细胞培养时稳定的性能在组织工程应用中非常重要。在这次研究中,将不同比例的海藻酸钠与胶原复合,在体外形成胶原原纤维分别得到复合凝胶,冻干,再化学交联,制备胶原-海藻酸钠复合支架。系统研究了海藻酸钠含量和交联处理对复合支架的孔结构、溶胀行为、酶降解和拉伸性能的影响。相关结果表明,现用的方法简单但能有效地制备高连通性的强韧的具有纳米纤维表层的仿生三维支架材料。NIH3T3细胞作为模型细胞,通过在交联支架材料内细胞增殖和浸润来评估细胞相容性、纳米纤维表层的依附性和多孔结构的稳定性。与机械性能最弱的交联的胶原海绵对比,该细胞培养的复合支架呈现出良好的多孔结构,因此,细胞可以在三维复合支架最表层增殖,也可以浸润到其内部。这些复合支架材料的孔径为150~300μm,孔隙率大于90%,拥有可调的良好生物降解能力和吸水性能,在组织工程学应用中很有前景。 | Lin Sang Dongmei Luo Songmei Xu 刘郁倩(编译) | 2014 | 西部皮革2014，36，6： | 2 |
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