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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | CDC2/CDK1 Expression in Esophageal Adenocarcinoma and Precursor Lesions Serves as a Diagnostic and Cancer Progression Marker and Potential Novel Drug Target显示文摘 | Donna E Hansel Surajit Dhara RuChih C Huang Raheela Ashfaq Mari Deasel Yutaka Shimada Harold S Bernstein John Harmon Malcolm Brock Arlene Forastiere M Kay Washington Anirban Maitra Elizabeth Montgomery | 2005 | The American Journal of Surgical Pathology2005，，3： | 1 |
| 3 | Safety of adenoviral vectors: results of clinical investigations in 445 cancer patients treated with advexin? (Adenoviral p53) gene therapy显示文摘 | Louis AZ Donna C James M | 2004 | Mol ther2004，9，1： | 1 |
| 4 | The prevalence and management of asthma in primary-aged schoolchildren in the south of England显示文摘 | DONNA M C JENNY M W HELEN C | 2002 | Health Educ Res2002，97，2： | 1 |
| 5 | HIV Testing Frequency Among Men Who Have Sex With Men Attending Sexually Transmitted Disease Clinics: Implications for HIV Prevention and Surveillance显示文摘 | Donna J Helms Hillard S Weinstock Kristen C Mahle Kyle T Bernstein Bruce W Furness Charlotte K Kent Cornelis A Rietmeijer Akbar M Shahkolahi James P Hughes Matthew R Golden | 2009 | JAIDS Journal of Acquired Immune Deficiency Syndromes2009，，3： | 1 |
| 6 | Contrast in stream-channel response to major storms in two mountainous areas of California显示文摘 | Michael N K Donna C M | 1985 | Ge- ology1985，13，： | 1 |
| 7 | Production of α-1,3-galactosyltransferase knockout Pigs by nuclear transfer cloning显示文摘 | Donna K S Kwang W P Hee T C Julia L G Gi S I Melissa S Aaron B August R Billy N D Clifton N M David B C Robert J H Randall S P | 2002 | Science2002，295，5557： | 1 |
| 8 | Designing a reverse logistics operation for short cycle time repair services显示文摘 | M Mehdi Aminia Donna Retzlaff Roberts Carol c Bienstock | 2005 | Journal of Production economics2005，7，： | 1 |
| 9 | Sudden unexpected death in epilepsy显示文摘 | Shields BE Donna M John C | 2002 | Am J Forensic Med Pathol2002，23，4： | 1 |
| 10 | Toxicogenomics: a New Revolution in Drug Safety显示文摘 | ARTHUR L C MICHAEL P C DONNA L M | 2002 | Drug Discovery Today2002，7，13： | 1 |
| 11 | Safety of adenoviral vectors:results of clinical investigations in 445 cancer patients treated with advexin? (Adenoviral p53) gene therapy显示文摘 | Louis AZ Donna C James M | 2004 | Molecular therapy2004，9，1： | 1 |
| 12 | Technical ef- ficiency in the use of health care resources: a comparison of OECD countries 显示文摘 | Donna Retzlaff-Roberts Chang C F Rubin R M | 2004 | Health Policy2004，69，1： | 1 |
| 13 | compound specific isotope analysis of fatty acids and poycyclic aromatic hydrocarbons in aerosols:implication for biomass burning 显示文摘 | Donna C B Stephen M A Vaughan C T | 1996 | Organic Geochemistry1996，25，： | 1 |
| 14 | A psychological approach to occupational safety显示文摘 | Gemma C Donna M B Helen D C | | 0，，01： | 1 |
| 15 | Isoflavones and cognitive function in older women: the soy and postmenopausal health in agong (SOPHIA) study显示文摘 | DONNA K A DENISE V M ELIZABETH B C | 2003 | Menopause2003，10，： | 1 |
| 16 | Limited resection for non–small cell lung cancer: observed local control with implantation of I-125 brachytherapy seeds显示文摘 | Winnie Lee Benedict D.T Daly Thomas A DiPetrillo Donna M Morelli Andrew C Neuschatz Jody Morr Mark J Rivard | 2003 | The Annals of Thoracic Surgery2003，，1： | 1 |
| 17 | ^68Ga-DOTANOC: biodistribution and dosimetry in patients affected by neuroendocrine tumors 显示文摘 | Pettinato C Samelli A Di Donna M | 2008 | Eur J Nucl Med Mol Imaging2008，35，1： | 1 |
| 18 | Evaluation of zinc complexes on the replication of rhinovirus 2 in vitro显示文摘 | Vincent JM Donna C Daneil M | 1989 | Res Commun Chem Pathol Pharmacol1989，3，： | 1 |
| 19 | How can accelerated development of bioenergy contribute to the future UK energy mix? insights from a MARKAL modelling exercise 显示文摘 | DONNA C SOPHIE J BRIGHID M | 2009 | Biotechnology for Biofuels2009，13，2： | 1 |
| 20 | Adjuvant immunotherapy treatment of renal carcinoma patients with autologous tumor cells and Bacillus Calmette-Guerin: Five-year results of a prospective randomized study 显示文摘 | Galligioni E Quaia M Merlo A Carbone A Spada A Favaro D Santarosa M Sacco C Talamini R Francmi M Crivellari D Di Donna D Mazza G Viggiano G Galassi P Panizzo R Carmignani G Fiaccavento G | 1996 | Cancer1996，77，12： | 1 |
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