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| 1 | The enhanced protective effects of salvianic acid A: A functionalized nanoparticles against ischemic stroke through increasing the permeability of the blood-brain barrier显示文摘Ischemic stroke is the leading cause of disability and death worldwide. Currently, the only proven treatment for ischemic stroke is restoring the cerebral blood supply. In addition, some of the tissue is damaged during the subsequent reperfusion because of the overproduction of reactive oxygen species (ROS). Furthermore, antioxidant therapies have shown promise in preclinical studies for the treatment of ischemia-reperfusion injury. However, their therapeutic efficacy has been limited because of their low bioavailability in brain. To resolve this issue, we synthesized ROS-responsive, fan-shaped dendrimer nanoparticles (NPs) and conjugated them with a blood-brain barrier (BBB)-targeting peptide, COG1410, and salvianic acid A (SA), which is an effective antioxidant in ischemic stroke. The BBB targeting peptide acts as a ligand of the nanocarrier system and penetrates the BBB through the endocytosis of the ligand receptor. The results showed that T-SA-NPs not only target and accumulate in the infarct area, they also reduce over 2 times of the infarct area and reverse the behavioral deficits in MCAO mice, which illustrates that these NPs have an effective therapeutic effect on the ischemic stroke. In addition, these NPs had no toxicity in any organs of the body. Importantly, the present study provides an alternative strategy for delivering antioxidants to the brain and achieving targeted therapy of ischemic stroke. | Yaru Li Xiaojie Zhang Zhifeng Qi Xueling Guo Xiaopeng Liu Wenjuan Shi Yang Liu Libo Du | 2020 | Nano Research2020，13，10： | 4 |
| 2 | Resveratrol suppresses P-selectin, PSGL-1, and VWF through SIRT1 signaling pathway显示文摘 | Zhenkai Lou Kaili Du Tingting Wang Xueling Zhao Xingguo Li Bing Wang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，9： | 2 |
| 3 | Equilibrium, thermodynam- ics and breakthrough studies for adsorption of solanesol ontomacroporous resins显示文摘 | Du Xueling Yuan Qipeng Li Ye | 2008 | Chem Eng Processing2008，47，8： | 1 |
| 4 | Biochip as a potential platform of serological interferon a2b antibody assay 显示文摘 | Du Weidong Xu Zhenshan Ma Xueling | 2003 | Journal of Biotechnology2003，106，： | 1 |
| 5 | Biochip as a potential interferon a2b antibody assay 显示文摘 | Weidong Du Zhenshan Xu Xueling Ma | 2003 | J Biotechnol2003，106，1： | 1 |
| 6 | Enhancement of dendritic cell-tumor fusion vaccine potency by indoleamine-pyrrole 2,3-dioxygenase inhibitor, 1-MT显示文摘 | Xueling Ou Shaohui Cai Peng Liu Jun Zeng Yuwen He Xinyao Wu Jun Du | 2008 | Journal of Cancer Research and Clinical Oncology2008，，5： | 1 |
| 7 | Equilibrium, thermodynamics and breakthrough studies for adsorption of solanesol onto macroporous resins 显示文摘 | DU Xueling YUAN Qipeng LI Ye | 2008 | Chemical Engineering and Processing2008，47，8： | 1 |
| 8 | Optimisation of enzyme assisted extraction of silybin from the seeds of Silybum marianum by Box-Behnken experimental design显示文摘 | LIU Hong DU Xueling YUAN Qipeng | 2009 | Phytochem Anal2009，20，6： | 1 |
| 9 | Optimisation of enzyme assisted extraction of silybin from the seeds of silybum marianum by box-behnken显示文摘 | Liu Hong Du Xueling Yuan Qipeng | 2009 | Exper Design Phytochem Anal2009，20，3： | 1 |
| 10 | Development and validation of a new PCR optimization method by combining experimental design and artificial neural network显示文摘 | LI Ye DU Xueling YUAN Qipeng | 2010 | Appl Biocbem Biotechnol2010，160，1： | 1 |
| 11 | Podophyllotoxin-loaded solid lipid nanoparticles for epidermal targeting显示文摘 | Huabing Chen Xueling Chang Danrong Du Wei Liu Jie Liu Ting Weng Yajiang Yang Huibi Xu Xiangliang Yang | 2005 | Journal of Controlled Release2005，，2： | 1 |
| 12 | Altered white matter microarchitecture in Parkinson’s disease:a voxel-based meta-analysis of diffusion tensor imaging studies显示文摘This study aimed to define the most consistent white matter microarchitecture pattern in Parkinson’s disease(PD)reflected by fractional anisotropy(FA),addressing clinical profiles and methodology-related heterogeneity.Web-based publication databases were searched to conduct a meta-analysis of whole-brain diffusion tensor imaging studies comparing PD with healthy controls(HC)using the anisotropic effect size–signed differential mapping.A total of 808 patients with PD and 760 HC coming from 27 databases were finally included.Subgroup analyses were conducted considering heterogeneity with respect to medication status,disease stage,analysis methods,and the number of diffusion directions in acquisition.Compared with HC,patients with PD had decreased FA in the left middle cerebellar peduncle,corpus callosum(CC),left inferior fronto-occipital fasciculus,and right inferior longitudinal fasciculus.Most of the main results remained unchanged in subgroup metaanalyses of medicated patients,early stage patients,voxel-based analysis,and acquisition with˂30 diffusion directions.The subgroup meta-analysis of medication-free patients showed FA decrease in the right olfactory cortex.The cerebellum and CC,associated with typical motor impairment,showed the most consistent FA decreases in PD.Medication status,analysis approaches,and the number of diffusion directions have an important impact on the findings,needing careful evaluation in future meta-analyses. | Xueling Suo Du Lei Wenbin Li Lei Li Jing Dai Song Wang Nannan Li Lan Cheng Rong Peng Graham J Kemp Qiyong Gong | 2021 | Frontiers of Medicine2021，15，1： | 0 |
| 13 | An Early Cretaceous gold mineralization event in the Triassic West Qinling orogen revealed from U-Pb titanite dating of the Ma'anqiao gold deposit显示文摘The West Qinling orogen in central China,formed from continental collision between the North China and Yangtze cratons in the Late Triassic,hosts numerous gold deposits with a total Au endowment of about 2000 t.Most deposits were emplaced at ca.250-195 Ma and are genetically associated with the Triassic orogenesis.Here in situ U-Pb titanite dating with laser ablation inductively coupled plasma mass spectrometry indicates the Ma’anqiao gold deposit in the northern portion of this orogen has a distinctive age and under a contrasting tectonic regime.This structurally controlled gold deposit is hosted in Late Ordovician to Early Silurian sub-greenschist facies metasedimentary rocks.The gold mineralization is hosted in quartz-pyritepyrrhotite veins and pyrite-pyrrhotite disseminations in hydrothermally altered rocks,which are crosscut by K-feldspar-calcitechlorite±pyrite veins.Titanite,present both in the disseminated sulfide ores and later veins,was used for in situ U-Pb dating.Titanite from three disseminated sulfide ore samples with Th and U averaging 27.46 and 39.31 ppm(1 ppm=1μg g^(-1)),respectively,yielded lower-intercept ages of 121.1±3.1 to 120.7±3.5 Ma(2σ)in the Tera-Wasserburg diagram.Titanite from three later vein samples with much lower Th and U concentrations averaging 2.74 and 16.21 ppm,respectively,yielded overlapping ages of 120.8±3.2 to 120.3±5.8 Ma(2σ).These new titanite U-Pb ages tightly constrain the formation of the Ma’anqiao gold deposit at ca.121-120 Ma and,when combined with independent geological data,indicate it is not related to the Triassic Qinling orogeny.Rather,its formation is attributed to lithospheric thinning and destruction of the North China craton during the Late Jurassic to Early Cretaceous which has generated numerous gold deposits along the southern margin of this craton.This catastrophic event caused extensive magmatism in large areas of the North Qinling terrane and northern edge of the West Qinling orogen immediately to the south of the North China craton.The heat flux and elevated geothermal gradients associated with this magmatism could have induced prograde metamorphism of the Paleozoic sedimentary infrastructure in and beneath these areas with the derived fluids ascending along pre-existing crustal-scale regional structures to form the Ma’anqiao gold deposit.We suggest that areas in the North Qinling terrane that have been affected by the Late Mesozoic magmatism are potential targets for future exploration of the decratonization-related gold deposits.Additionally,this study highlights the use of titanite U-Pb dating as a robust geochronometer for metasedimentary rock-hosted gold deposits in Phanerozoic orogens,which has previously not been utilized. | Chongguo HE Jianwei LI Daniel J.KONTAK Xiaoye JIN Yafei WU Hao HU Bo ZU Xueling YU Shaorui ZHAO Shiguang DU Yunlong ZHU Huan TAO | 2023 | Science China Earth Sciences2023，66，2： | 0 |
| 14 | Decidualization-derived cAMP regulates phenotypic and functional conversion of decidual NK cells from CD56dimCD16− NK cells显示文摘In early pregnancy,the decidua is populated by a large number of natural killer cells(NKs),most of which are CD56bright with a strong capacity to secrete cytokines,differing from peripheral and cord blood NK cells(pNKs and cNKs).1,2,3 It is generally believed that uterine NKs are recruited from the peripheral blood and are further educated to develop a decidual NK cell(dNK)-like phenotype in the microenvironment at the maternal-fetal interface.4 However,the defined mechanisms involved in this education remain unclear. | Xueling Jin Liyuan Cui Weijie Zhao Xinyi Li Lu Liu Yanhong Li Qiang Fu Dajin Li Min Yu Meirong Du | 2021 | Cellular & Molecular Immunology2021，18，6： | 0 |
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