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| 1 | Acupotomy versus sodium hyaluronate for treatment of knee osteoarthritis in rabbits显示文摘OBJECTIVE: To investigate the possible advantages of acupotomy over sodium hyaluronate injection for the treatment of knee osteoarthritis(KOA).METHODS: Twenty rabbits were divided randomly into four groups(n = 5 in each): a control group,model group, acupotomy group, and sodium hyaluronate injection group. The model, acupotomy,and sodium hyaluronate groups underwent anterior cruciate ligament transection plus partial medial meniscectomy. Sodium hyaluronate injection and acupotomy were administered to the respective groups from weeks 5 to 8, and samples of the tibial plateau and medial condyle of the femur were collected in week 9. Vascular endothelial growth factor(VEGF) expression was assessed in cartilage and subchondral bone by immunohistochemical staining.RESULTS: Articular cartilage degeneration was less pronounced in the acupotomy compared with the model and sodium hyaluronate groups. VEGF expression levels in cartilage and subchondral bone were increased in the model group compared with the control group(P < 0.01), and acupotomy had a more pronounced therapeutic effect than sodium hyaluronate injection(P < 0.01).CONCLUSION: Acupotomy and sodium hyaluronate injection may both reduce degeneration in the cartilage and subchondral bone in KOA based on the results from a rabbit model, but acupotomy improved the histopathology and reduced the VEGF content more effectively than sodium hyaluronate injection, probably by reducing venous stasis and intraosseous pressure. Acupotomy may improve KOA by lowering VEGF. | Ding Yu Yuan Xueling Wang Yongcheng Wang Aiyuan Shi Xian Wang Lu Daniela Litscher Ingrid Gaischek Irmgard Th.Lippe Gerhard Litscher | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 8 |
| 2 | Combined incisional ropivacaine infiltration and pulmonary recruitment manoeuvre for postoperative pain relief after diagnostic hysteroscopy and laparoscopy显示文摘 | Liu Huili Ma Caihong Zhang Xiaoqing Yu Chen Yang Yan Song Xueling Tang Yi Guo Xiangyang | 2014 | Chinese Medical Journal2014，，5： | 3 |
| 3 | A Critical Role of Activin A in Maturation of Mouse Peritoneal Macrophages in vitro and in vivo显示文摘Activin A,转变生长因素贝它(TGF-) 的一个多功能的因素总科,被 microglia 和巨噬细胞主要生产,并且它的反煽动性并且支持 inflammatory 活动是与巨噬细胞功能有关的两个。然而,在 vivo 的剩余的巨噬细胞上的 activin A 的直接效果仍然保持不清楚。在现在的学习,结果显示出那 activin A 不仅不增加了并且 IL-1 版本,而且在 vitro 并且在 vivo 的鼠标腹巨噬细胞的支持的吞噬细胞的能力,而它没影响 MHC 我和 MHC II 表示。而且,我们显著地发现那 activin A upregulated CD14 和 CD68 的表情,成熟巨噬细胞的标记,在在 vitro 并且在 vivo 的巨噬细胞的表面上。这些数据建议 activin A 能在 vitro 并且在 vivo 导致主要巨噬细胞成熟,但是不能经由调整涉及抗原的表示的 MHC 分子的表示触发获得的有免疫力的反应。 | Yinan Wang Xueling Cui Guixiang Tai Jingyan Ge Nan Li Fangfang Chen Fang Yu Zhonghui Liu | 2009 | Cellular & Molecular Immunology2009，6，5： | 2 |
| 4 | Development and Application of Four Typical Rapid Prototy-ping Technologies 显示文摘 | YANG Xueling WANG Di YU Dongman | 2012 | Applied Mechanics and Materials2012，160，： | 1 |
| 5 | Effect of mechanically damaged starch on wheat flour, noodle and steamed bread making quality显示文摘 | Chong Liu Limin Li Jing Hong Xueling Zheng Ke Bian Yu Sun Jie Zhang | 2014 | Int J Food Sci Technol2014，，1： | 1 |
| 6 | Stability of loess high-fill slope based on monitored soil moisture changes显示文摘This paper aims to assess the influence of moisture content changes during rainfall on the stability of loess high-fill slopes by taking a loess high-fill slope in Lanzhou City as an example.First,according to the moisture content monitoring data collected from a slope online monitoring system,direct shear tests were performed on soil samples of different moisture content to determine the relationship between the shear strength parameters and moisture content.Next,a coupled hydro-mechanical model with soil shear strength related to moisture content was established and used to analyze 16 working conditions with various rainfall intensities and durations for two cases:shear strength parameters from the site exploration report and those from this study.Finally,the results from the two cases were compared regarding the changes in stresses and displacements after rainfall infiltration to analyze the influence of moisture content on the stability of loess high-fill slopes.The conclusions are as follows:(1)Segmental relationship equations of cohesion and angle of internal friction were established for loess with various moisture content.(2)Under the conditions of different rainfall intensities,significant differences were observed in the trends of slope stress and displacement changes.(3)The slope displacement occurred in the shallow soil layer within about 12.5 m from the slope top,and the plastic strain concentrated in the soil layer within about 6 m from the slope top.(4)The results of slope stability analyses based on moisture content monitoring data are more in line with the observed. | XueLing Yong Yu Zhang YunLong Hou BingBing Han Ning An Hui Zhang Ying Ma | 2023 | Research in Cold and Arid Regions2023，15，4： | 0 |
| 7 | An Early Cretaceous gold mineralization event in the Triassic West Qinling orogen revealed from U-Pb titanite dating of the Ma'anqiao gold deposit显示文摘The West Qinling orogen in central China,formed from continental collision between the North China and Yangtze cratons in the Late Triassic,hosts numerous gold deposits with a total Au endowment of about 2000 t.Most deposits were emplaced at ca.250-195 Ma and are genetically associated with the Triassic orogenesis.Here in situ U-Pb titanite dating with laser ablation inductively coupled plasma mass spectrometry indicates the Ma’anqiao gold deposit in the northern portion of this orogen has a distinctive age and under a contrasting tectonic regime.This structurally controlled gold deposit is hosted in Late Ordovician to Early Silurian sub-greenschist facies metasedimentary rocks.The gold mineralization is hosted in quartz-pyritepyrrhotite veins and pyrite-pyrrhotite disseminations in hydrothermally altered rocks,which are crosscut by K-feldspar-calcitechlorite±pyrite veins.Titanite,present both in the disseminated sulfide ores and later veins,was used for in situ U-Pb dating.Titanite from three disseminated sulfide ore samples with Th and U averaging 27.46 and 39.31 ppm(1 ppm=1μg g^(-1)),respectively,yielded lower-intercept ages of 121.1±3.1 to 120.7±3.5 Ma(2σ)in the Tera-Wasserburg diagram.Titanite from three later vein samples with much lower Th and U concentrations averaging 2.74 and 16.21 ppm,respectively,yielded overlapping ages of 120.8±3.2 to 120.3±5.8 Ma(2σ).These new titanite U-Pb ages tightly constrain the formation of the Ma’anqiao gold deposit at ca.121-120 Ma and,when combined with independent geological data,indicate it is not related to the Triassic Qinling orogeny.Rather,its formation is attributed to lithospheric thinning and destruction of the North China craton during the Late Jurassic to Early Cretaceous which has generated numerous gold deposits along the southern margin of this craton.This catastrophic event caused extensive magmatism in large areas of the North Qinling terrane and northern edge of the West Qinling orogen immediately to the south of the North China craton.The heat flux and elevated geothermal gradients associated with this magmatism could have induced prograde metamorphism of the Paleozoic sedimentary infrastructure in and beneath these areas with the derived fluids ascending along pre-existing crustal-scale regional structures to form the Ma’anqiao gold deposit.We suggest that areas in the North Qinling terrane that have been affected by the Late Mesozoic magmatism are potential targets for future exploration of the decratonization-related gold deposits.Additionally,this study highlights the use of titanite U-Pb dating as a robust geochronometer for metasedimentary rock-hosted gold deposits in Phanerozoic orogens,which has previously not been utilized. | Chongguo HE Jianwei LI Daniel J.KONTAK Xiaoye JIN Yafei WU Hao HU Bo ZU Xueling YU Shaorui ZHAO Shiguang DU Yunlong ZHU Huan TAO | 2023 | Science China Earth Sciences2023，66，2： | 0 |
| 8 | Highly Efficient Self-Trapped Bluish White-Light Emission from[Pb4Cl5]3+Nodes in a Moisture-Tolerant Metal–Organic Framework显示文摘Highly luminescent zero-dimensional(0D)metal halide clusters attract widespread attention owing to strong exciton confinement and populated self-trapped states but often exhibit narrow emission and are susceptible to hydrolysis.Herein,we demonstrate a moisture-resistant metal–organic framework(MOF)consisting of cationic 0D[Pb_(4)Cl_(5)]^(3+)nodes bridged by adamantanetetracarboxylate.Upon near-UV excitation,the material emits intrinsic broadband bluish white-light emission with high external quantum efficiency of 35%and a color rendering index of 76.Unlike organoammonium cations in lead perovskites,the Pb-carboxylate coordination affords the MOF to be chemically stable and photostable in high humidity.The photoemitter exhibits undiminished photoemissions under ambient conditions[∼60%relative humidity(RH)]upon continuous UV irradiation(143 mW/cm^(2),365 nm)for 7 days.The insertion of[Na_(4)Cl]^(3+)moieties will connect 0D units into two-dimensional(2D)metal halide layers to limit structural strain and decrease the quantum efficiency from 35%to 15%,confirming the key importance of 0D units for efficient emission. | Jinlin Yin Yuan Yu Xueling Song Yilin Jiang Honghan Fei | 2022 | CCS Chemistry2022，4，2： | 0 |
| 9 | Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma显示文摘Detailed characterizations of genomic alterations have not identified subtype-specific vulnerabilities in adult gliomas. Mapping gliomas into developmental programs may uncover new vulnerabilities that are not strictly related to genomic alterations. After identifying conserved gene modules co-expressed with EGFR or PDGFRA (EM or PM), we recently proposed an EM/PM classification scheme for adult gliomas in a histological subtype- and grade-independent manner. By using cohorts of bulk samples, paired primary and recurrent samples, multi-region samples from the same glioma, single-cell RNA-seq samples, and clinical samples, we here demonstrate the temporal and spatial stability of the EM and PM subtypes. The EM and PM subtypes, which progress in a subtype-specific mode, are robustly maintained in paired longitudinal samples. Elevated activities of cell proliferation, genomic instability and microenvironment, rather than subtype switching, mark recurrent gliomas. Within individual gliomas, the EM/PM subtype was preserved across regions and single cells. Malignant cells in the EM and PM gliomas were correlated to neural stem cell and oligodendrocyte progenitor cell compartment, respectively. Thus, while genetic makeup may change during progression and/or within different tumor areas, adult gliomas evolve within a neurodevelopmental framework of the EM and PM molecular subtypes. The dysregulated developmental pathways embedded in these molecular subtypes may contain subtype-specific vulnerabilities. | Jing Feng Zheng Zhao Yanfei Wei Zhaoshi Bao Wei Zhang Fan Wu Guanzhang Li Zhiyan Sun Yanli Tan Jiuyi Li Yunqiu Zhang Zejun Duan Xueling Qi Kai Yu Zhengmin Cong Junjie Yang Yaxin Wang Yingyu Sun Fuchou Tang Xiaodong Su Chuan Fang Tao Jiang Xiaolong Fan | 2023 | Frontiers of Medicine2023，17，2： | 0 |
| 10 | Overexpression of ACE2 ameliorates Aβ-induced blood–brain barrier damage and angiogenesis by inhibiting NF-κB/VEGF/VEGFR2 pathway显示文摘Background:Pathological angiogenesis and blood–brain barrier damage may play an important role in Alzheimer's disease(AD).ACE2 is mainly expressed on the surface of endothelial cells in brain.Recent studies have shown that the expression of ACE2 in AD is reduced,but its role in AD is still unclear.Method:We induced AD damage in endothelial cells using Aβ25-35 and overexpressed ACE2 in bEend.3 cells through lentiviral transfection.We detected the effect of Aβ25-35 on cell viability using the CCK-8 assay and examined the effect of overexpressing ACE2 on angiogenesis using an angiogenesis assay.We used western blot and cell immunofluorescence to detect changes in the expression of the VEGF/VEGFR2 pathway,tight junction protein,and NF-κB pathway.Results:Aβ25-35 treatment significantly decreased the expression of ACE2 and reduced cell viability.ACE2 overexpression(1)reduced the number of branches and junctions in tube formation,(2)inhibited the activation of the VEGF/VEGFR2 pathway induced by Aβ25-35,(3)increased the expression of TJPs,including ZO-1 and claudin-5,and(4)restored Aβ25-35-induced activation of the NF-κB pathway.Conclusion:Overexpression of ACE2 can improve pathological angiogenesis and blood–brain barrier damage in AD models in vitro by inhibiting NF-κB/VEGF/VEGFR2 pathway activity.ACE2 may therefore represent a therapeutic target for endothelial cell dysfunction in AD. | Xueling Zhang Yu Zhang Ling Zhang Chuan Qin | 2023 | Animal Models and Experimental Medicine2023，6，3： | 0 |
| 11 | Discussion on Construction and Mechanism of Practice Bases for Professional Degree Postgraduates Based on the Integration of Production and Education in Local Universities显示文摘Under the background of emerging agricultural education,practice bases are an important place to train profession talented person that match social needs,so it is very important to build stable and long-term practice bases.At present,the main problems in the construction of practice bases for postgraduates in local colleges and universities are mainly focusing on construction and neglecting management,imperfect cooperation mechanism and lack of teaching management effectively.It is of great significance to build a long-term management mechanism to ensure the education quality of practice bases.Therefore,constructing the mode of'double integration and double promotion of production and education'with practice bases as the carrier and realizing the organic combination of industrial needs and postgraduate projects is an important idea for local colleges and universities to train professional degree postgraduates to'know agriculture,love agriculture,strengthen agriculture and promote agriculture',and it also provides a reference for the mechanism construction of postgraduate bases. | Dabing XIANG Yu FAN Xueling YE Changying LIU Liangzhen JIANG Yan WAN Yuehua WANG Yanxia SUN | 2023 | Agricultural Biotechnology2023，12，5： | 0 |
| 12 | HPLC Fingerprint Combined with Chemometrics and Network Pharmacology for Q-Markers Prediction Analysis of Saposhnikovia divaricata显示文摘Saposhnikovia divaricata(SD)has high medicinal and edible value,but relatively little research has been done on its qual-ity markers(Q-markers).To further clarify the Q-markers of SD with their corresponding pharmacodynamic targets.In this experiment,14 batches of SD were identified and screened for Q-marker candidate components using a combination of HPLC fingerprint with similarity analysis,principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis.Then,network pharmacology was used to predict Q-markers and core targets.The results showed that 5-O-methylvisammioside,cimifugin,and prim-O-glucosylcimifugin could be used as Q-markers of SD;while,MAPK1,MAPK3,PIK3CA,JUN,and MAPK8 were the core targets of SD for drug efficacy.To further evaluate the bind-ing efficiency of Q-markers,molecular docking of the main active ingredients of SD to the core targets was performed.The results showed that the compounds bind well to their targets,and binding energies were all less than-5 kcal/mol.The Q-markers obtained from the screening were closely related to the core target genes,which could achieve therapeutic effects by modulating the relevant signaling pathways.This study offers a reference for the establishment of a set of quality control evaluation system for SD potential Q-markers prediction analysis,and lays the foundation for elucidating the mechanism of actionunderlying itspharmacodynamic substance. | Renguo Zhang Xinjian Liu Tong Wang Jie Yu Mengyuan Wang Jianmin Sun Xueling Yu Na Niu Ligang Chen | 2024 | Journal of Analysis and Testing2024，8，1： | 0 |
| 13 | Understanding the combustion behavior of electric bicycle batteries and unveiling its relationship with fire extinguishing显示文摘In this study,a detailed analysis of the combustion behaviors of the lithium iron phosphate(LFP)and lithium manganese oxide(LMO)batteries used in electric bicycles was conducted.This research included quantitative measurements of the combustion duration,flame height,combustion temperature,heat release rate,and total heat release.The results indicated that LMO batteries exhibited higher combustion temperatures of 600–700°C,flame heights of 70–75 cm,a significantly higher heat release rate of40.1 k W(12 Ah),and a total heat release of 1.04 MJ(12 Ah)compared to LFP batteries with the same capacity.Based on these experimental results,a normalized total heat release(NORTHR)parameter was proposed,demonstrating good universality for batteries with different capacities.Utilizing this parameter,quantitative calculations and optimization of the extinguishing agent dosage were conducted for fires involving these two types of batteries,and the method was validated by extinguishing fires for these two types of battery packs with water-based extinguishing fluids. | Zhanglong Yu Xueling Shen Ran Xu Zheng Wang Zengming Wan Mingyang Chen Yi Cui Yanyan Fang Xiaoli Ma | 2024 | Journal of Energy Chemistry2024，91，4： | 0 |
| 14 | Decidualization-derived cAMP regulates phenotypic and functional conversion of decidual NK cells from CD56dimCD16− NK cells显示文摘In early pregnancy,the decidua is populated by a large number of natural killer cells(NKs),most of which are CD56bright with a strong capacity to secrete cytokines,differing from peripheral and cord blood NK cells(pNKs and cNKs).1,2,3 It is generally believed that uterine NKs are recruited from the peripheral blood and are further educated to develop a decidual NK cell(dNK)-like phenotype in the microenvironment at the maternal-fetal interface.4 However,the defined mechanisms involved in this education remain unclear. | Xueling Jin Liyuan Cui Weijie Zhao Xinyi Li Lu Liu Yanhong Li Qiang Fu Dajin Li Min Yu Meirong Du | 2021 | Cellular & Molecular Immunology2021，18，6： | 0 |
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