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| 1 | Therapeutic temperature modulation is associated with pulmonary complications in patients with severe traumatic brain injury显示文摘AIM: To examine complications associated with the use of therapeutic temperature modulation(mild hypothermia and normothermia) in patients with severe traumatic brain injury(TBI). METHODS: One hundred and fourteen charts were reviewed. Inclusion criteria were: severe TBI with Glasgow Coma Scale(GCS) < 9, intensive care unit(ICU) stay > 24 h and non-penetrating TBI. Patients were divided into two cohorts: the treatment group received therapeutic temperature modulation(TTM) with continuous surface cooling and indwelling bladder temperature probes. The control group received standard treatment with intermittent acetaminophen for fever. Information regarding complications during the time in the ICU was collected as follows: Pneumonia was identified using a combination of clinical and laboratory data. Pulmonary embolism, pneumothorax and deep venous thrombosis were identified based onimaging results. Cardiac arrhythmias and renal failure were extracted from the clinical documentation. acute respiratory distress syndrome and acute lung injury were determined based on chest imaging and arterial blood gas results. A logistic regression was conducted to predict hospital mortality and a multiple regression was used to assess number and type of clinical complications. RESULTS: One hundred and fourteen patients were included in the analysis(mean age = 41.4, SD = 19.1, 93 males), admitted to the Jackson Memorial Hospital Neuroscience ICU and Ryder Trauma Center(mean GCS = 4.67, range 3-9), were identified and included in the analysis. Method of injury included motor vehicle accident(n = 29), motor cycle crash(n = 220), blunt head trauma(n = 212), fall(n = 229), pedestrian hit by car(n = 216), and gunshot wound to the head(n = 27). Ethnicity was primarily Caucasian(n = 260), as well as Hispanic(n = 227) and African American(n = 223); four patients had unknown ethnicity. Patients received either TTM(43) or standard therapy(71). Within the TTM group eight patients were treated with normothermia after TBI and 35 patients were treated with hypothermia. A logistic regression predicting in hospital mortality with age, GCS, and TM demonstrated that GCS(Beta = 0.572, P < 0.01) and age(Beta =-0.029) but not temperature modulation(Beta = 0.797, ns) were significant predictors of in-hospital mortality [χ2(3) = 22.27, P < 0.01] A multiple regression predicting number of complications demonstrated that receiving TTM was the main contributor and was associated with a higher number of pulmonary complications(t =-3.425, P = 0.001). CONCLUSION: Exposure to TTM is associated with an increase in pulmonary complications. These findings support more attention to these complications in studies of TTM in TBI patients. | Kristine H O’Phelan Amedeo Merenda Katherine G Denny Kassandra E Zaila Cynthia Gonzalez | 2015 | World Journal of Critical Care Medicine2015，4，4： | 18 |
| 2 | Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders显示文摘Inappropriate T cell responses in the central nervous system(CNS)affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include,but are not limited to,multiple sclerosis,amyotrophic lateral sclerosis,Alzheimer’s disease and Parkinson’s disease.On the one hand immune responses can exacerbate neurotoxic responses;while on the other hand,they can lead to neuroprotective outcomes.The temporal and spatial mechanisms by which these immune responses occur and are regulated in the setting of active disease have gained significant recent attention.Spatially,immune responses that affect neurodegeneration may occur within or outside the CNS.Migration of antigen-specific CD4+T cells from the periphery to the CNS and consequent immune cell interactions with resident glial cells affect neuroinflammation and neuronal survival.The destructive or protective mechanisms of these interactions are linked to the relative numerical and functional dominance of effector or regulatory T cells.Temporally,immune responses at disease onset or during progression may exhibit a differential balance of immune responses in the periphery and within the CNS.Immune responses with predominate T cell subtypes may differentially manifest migratory,regulatory and effector functions when triggered by endogenous misfolded and aggregated proteins and cell-specific stimuli.The final result is altered glial and neuronal behaviors that influence the disease course.Thus,discovery of neurodestructive and neuroprotective immune mechanisms will permit potential new therapeutic pathways that affect neuronal survival and slow disease progression. | Kristi M Anderson Katherine E Olson Katherine A Estes Ken Flanagan Howard E Gendelman R Lee Mosley | 2014 | Translational Neurodegeneration2014，3，1： | 8 |
| 3 | High-resolution microendoscopy for esophageal cancer screening in China: A cost-effectiveness analysis显示文摘AIM:To study the cost-effectiveness of high-resolution microendoscopy(HRME)in an esophageal squamous cell carcinoma(ESCC)screening program in China.METHODS:A decision analytic Markov model of ESCC was developed.Separate model analyses were conducted for cohorts consisting of an averagerisk population or a high-risk population in China.Hypothetical 50-year-old individuals were followed until age 80 or death.We compared three different strategies for both cohorts:(1)no screening;(2)standard endoscopic screening with Lugol’s iodine staining;and(3)endoscopic screening with Lugol’s iodine staining and an HRME.Model parameters were estimated from the literature as well as from GLOBOCAN,the Cancer Incidence and Mortality Worldwide cancer database.Health states in the model included non-neoplasia,mild dysplasia,moderate dysplasia,high-grade dysplasia,intramucosal carcinoma,operable cancer,inoperable cancer,and death.Separate ESCC incidence transition rates were generated for the average-risk and high-risk populations.Costs in Chinese currency were converted to international dollars(I$)and were adjusted to 2012dollars using the Consumer Price Index.RESULTS:The main outcome measurements for this study were quality-adjusted life years(QALYs)and incremental cost-effectiveness ratio(ICER).For the average-risk population,the HRME screening strategy produced 0.043 more QALYs than the no screening strategy at an additional cost of I$646,resulting in an ICER of I$11808 per QALY gained.Standard endoscopic screening was weakly dominated.Among the high-risk population,when the HRME screening strategy was compared with the standard screening strategy,the ICER was I$8173 per QALY.For both the high-risk and average-risk screening populations,the HRME screening strategy appeared to be the most cost-effective strategy,producing ICERs below the willingness-topay threshold,I$23500 per QALY.One-way sensitivity analysis showed that,for the average-risk population,higher specificity of Lugol’s iodine(>40%)and lower specificity of HRME(<70%)could make Lugol’s iodine screening cost-effective.For the high-risk population,the results of the model were not substantially affected by varying the follow-up rate after Lugol’s iodine screening,Lugol’s iodine test characteristics(sensitivity and specificity),or HRME specificity.CONCLUSION:The incorporation of HRME into an ESCC screening program could be cost-effective in China.Larger studies of HRME performance are needed to confirm these findings. | Chin Hur Sung Eun Choi Chung Yin Kong Gui-Qi Wang Hong Xu Alexandros D Polydorides Li-Yan Xue Katherine E Perzan Angela C Tramontano Rebecca R Richards-Kortum Sharmila Anandasabapathy | 2015 | World Journal of Gastroenterology2015，21，18： | 8 |
| 4 | Hzf and hCAS/CSEIL: making the right choice in p53-mediated tumour suppression显示文摘 | Katherine E Ewings Kevin M Ryan | 2007 | Cell Research2007，17，10： | 2 |
| 5 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 6 | Medications as a Potential Source of Exposure to Phthalates in the U.S. Population显示文摘 | Hernández-Díaz Sonia Mitchell Allen A Kelley Katherine E Calafat Antonia M Hauser Russ | 2009 | Environmental Health Perspectives2009，，2： | 2 |
| 7 | Respiratory syncytial virus infection results in airway hyperresponsiveness and enhanced airway sensitiztion to allergen 显示文摘 | Sehwarze J Hamelmarm E Katherine L | 1997 | J Clin Invest1997，100，1： | 1 |
| 8 | Management Strategies for Herpes Zoster and Postherpetic Neuralgia显示文摘 | Galluzzi DO | 2007 | J Am Osteopath Assoc2007，1073，： | 1 |
| 9 | Uncertainty and variability in risk from trophic transfer of contaminants in dredged sediments 显示文摘 | IGOR L KATHERINE E DMITRIY B | 2001 | The Science of the Total Environment2001，274，3： | 1 |
| 10 | Do Consumers Expect Companies to be Socially Responsibility? The Impact of Corporate Social Responsibility on Buying Behavior显示文摘 | Lois A Mohr Deborah J Webb Katherine E Harris | 2001 | The Jour- nal of Consumer Affairs2001，，35： | 1 |
| 11 | Regulatory role of SGTI in early R Gene-Mediated plant defenses显示文摘 | Mark J Paul M Katherine K Bart J Jonathan D G Jane E | 2002 | Science2002，295，15： | 1 |
| 12 | Do Consumers Expect Companies to be Socially Responsibility? The Impact of Corporate Social Responsibility on Buying Behavior显示文摘 | Lois A Mohr Deborah J Webb Katherine E Harris | 2001 | The Jour- nal of Consumer Affairs2001，，35： | 1 |
| 13 | Risk factors for morbidity and mortality after colectomy for colon ca- ncer显示文摘 | Walter E Iamgo Katherine S Virgo Frank E Johnson | 2000 | Dis Colon & Rectum2000，43，1： | 1 |
| 14 | A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome显示文摘 | Mark E Curran Igor Splawski Katherine W Timothy G.Michael Vincen Eric D Green Mark T Keating | 1995 | Cell1995，，： | 1 |
| 15 | Determination of para-synephrine and meta-synephrine positional isomers in bitter orange-containing dietary supplements by LC/UV and LC/MS/MS显示文摘 | Jose Santana Katherine E Sharpless Bryant C Nelson | 2008 | Food Chemistry2008，109，： | 1 |
| 16 | Impact of electron acceptor availability on the anaerobic oxidation of methane in coastal freshwater and brackish wetland sediments显示文摘 | Segarra Katherine E A Comerford C Slaughter J | 2013 | Geochimica et Cosmochimica Acta2013，115，： | 1 |
| 17 | A Reexamination of Socially Responsible Consumption and Its Measurement 显示文摘 | Deborah J Webb Lois A Mohr Katherine E Harris | 2008 | Journal of Business Research2008，61，2： | 1 |
| 18 | Hepatotoxicity in an African antiretroviral therapy cohort: the effect of tuberculosis and hepatitis B显示文摘 | Christopher J Hoffmann Salome Charalambous Chloe L Thio Desmond J Martin Lindiwe Pemba Katherine L Fielding Gavin J Churchyard Richard E Chaisson Alison D Grant | 2007 | AIDS2007，，10： | 1 |
| 19 | The epidemiology of threatened preterm labor :A prospective cohort study显示文摘 | Melissal Mcpheeters William C Miller Katherine E Hartmann | 2005 | Am J Obstet Gynecol2005，192，： | 1 |
| 20 | Causes of pneumonia epizootics among bighorn sheep,western United States,2008-2010显示文摘 | Thomas E B Margaret A H Katherine B | 2012 | Emerg Infect Dis2012，18，3： | 1 |
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