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| 1 | Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis显示文摘AIM:To evaluate the impact of metadoxine(MTD) on the 3- and 6-mo survival of patients with severe alcoholic hepatitis(AH).METHODS:This study was an open-label clinical trial,performed at the'Hospital General de México,Dr.Eduardo Liceaga'.We randomized 135 patients who met the criteria for severe AH into the following groups:35 patients received prednisone(PDN)40 mg/d,35patients received PDN+MTD 500 mg three times daily,33 patients received pentoxifylline(PTX)400 mg three times daily,and 32 patients received PTX+MTD 500 mg three times daily.The duration of the treatment for all of the groups was 30 d.RESULTS:In the groups treated with the MTD,thesurvival rate was higher at 3 mo(PTX+MTD 59.4%vs PTX 33.3%,P=0.04;PDN+MTD 68.6%vs PDN20%,P=0.0001)and at 6 mo(PTX+MTD 50%vs PTX18.2%,P=0.01;PDN+MTD 48.6%vs PDN 20%,P=0.003)than in the groups not treated with MTD.A relapse in alcohol intake was the primary independent factor predicting mortality at 6 mo.The patients receiving MTD maintained greater abstinence than those who did not receive it(74.5%vs 59.4%,P=0.02).CONCLUSION:MTD improves the 3-and 6-mo survival rates in patients with severe AH.Alcohol abstinence is a key factor for survival in these patients.The patients who received the combination therapy with MTD were more likely to maintain abstinence than those who received monotherapy with either PDN or PTX. | Fátima Higuera-de la Tijera Alfredo I Servín-Caamano Aurora E Serralde-Zúniga Javier Cruz-Herrera Eduardo Pérez-Torres Juan M Abdo-Francis Francisco Salas-Gordillo JoséL Pérez-Hernández | 2015 | World Journal of Gastroenterology2015，21，16： | 8 |
| 2 | 14-day triple, 5-day concomitant, and 10-day sequential therapies for Helicobacter pylori infection in seven Latin American sites: a randomised trial显示文摘 | E Robert Greenberg Garnet L Anderson Douglas R Morgan Javier Torres William D Chey Luis Eduardo Bravo Ricardo L Dominguez Catterina Ferreccio Rolando Herrero Eduardo C Lazcano-Ponce María Mercedes Meza-Montenegro Rodolfo Pe?a Edgar M Pe?a Eduardo Salazar- | 2011 | The Lancet2011，，9790： | 2 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | Detrimental effects of tropisetron on permanent ischemie stroke in the rat 显示文摘 | Eduardo C J Eduardo M Bernd L F | 2008 | BMC Neuroscience2008，9，6： | 1 |
| 5 | Filtration of gases at high pressures:Permeation behavior of fiber-based media used for natural gascleaning显示文摘 | INNOCENTINIA Murilo D M TANABEB Eduardo H AGUIARBMonica L | 2012 | Chemical Engineering Science2012，74，： | 1 |
| 6 | Randomized trial of non-invasive ventilation combined with exercise training in patients with chronic hypercapnic failure due to Chronic Obstructive Pulmonary Disease显示文摘 | Eduardo Márquez-Martín Francisco Ortega Ruiz Pilar Cejudo Ramos Jose Luis López-Campos Borja Valencia Azcona Emilia Barrot Cortés | 2014 | Respiratory Medicine2014，，： | 1 |
| 7 | Asymptomatic dogs are highly competent to transmit Leishmania ( Leishmania ) infantum chagasi to the natural vector显示文摘 | Márcia Dalastra Laurenti Claudio Nazaretian Rossi Vania Lúcia Ribeiro da Matta Thaise Yumie Tomokane Carlos Eduardo Pereira Corbett Nágila Francinete Costa Secundino Paulo Filemon Paulocci Pimenta Mary Marcondes | 2013 | Veterinary Parasitology2013，，： | 1 |
| 8 | Experiments on virulence dose and portals of entry for Aeromonas hydrophila in walking catfish显示文摘 | GILDA D L LAWRENCE J A EDUARDO M L | 1996 | J Aquat Anita Health1996，8，4： | 1 |
| 9 | Myocardial infarction area quantification using high-resolution SPECT images in rats显示文摘 | Luciano F L Jorge M Eduardo E V | 2013 | Arq Bras Cardiol2013，101，1： | 1 |
| 10 | Simultaneous Extraction and Determination of Anionic Surfactants in Waters and Sediments 显示文摘 | PABLO A L ABELARDO G P EDUARDO G M | 2006 | J Chromatogr A2006，1114，2： | 1 |
| 11 | Photocatalytic/ HzO2 treatment of oilfield produced waters显示文摘 | Eduardo Bessa Sant Anna G L Dezotti M | 2001 | Applied Ca talysis B: Environmental2001，，29： | 1 |
| 12 | Newcastle dis ease:Evolution of genotypes and the related diagnostic challenges显示文摘 | Patti J M Eduardo L D Claudio L A | 2010 | Infect Genet Evol2010，10，： | 1 |
| 13 | Effect of light cycles(night/day)on CO2 fixation and biomass production by microalgae in photobioreactors显示文摘 | Eduardo J L Carlos H G S Lucy M C F L | | 0，，01： | 1 |
| 14 | Seismic history analy- sis of asymmetric buildings with soil-structure inter- action显示文摘 | Lin J L Tsai K C Eduardo M | 2009 | Journal of Structural Engineering2009，135，2： | 1 |
| 15 | Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18显示文摘 | Nidhi K Wenbin L Eduardo M | 2013 | Nat Biotechnol2013，31，1： | 1 |
| 16 | Photocatalytic/H2O2 Treatment of Oilfield Produced Waters显示文摘 | Eduardo Bessa Sant Anna G L Dezotti M | | 0，，： | 1 |
| 17 | A review of bioohars ' potential role in the remediation,revegeta-tion and restoration of contaminated soils 显示文摘 | Luke B Eduardo M J Jose L G Eva H Brett R Tom S | 2011 | Environmental Pollution2011，，159： | 1 |
| 18 | Experi- mental fuel cell performance analysis under different operating conditions and bipolar plate designs 显示文摘 | Alfredo I Miguel M Eduardo L | 2010 | International Journal of Hydrogen Energy2010，35，11： | 1 |
| 19 | Controlling the emotional state of an embodied conversational agent with a dynamic probabilistic fuzzy rules based system显示文摘 | EDUARDO M E VICTOR L JUAN L C | | 0，，06： | 1 |
| 20 | Extrahepatic right hepatic duct diverticulum: a rare entity显示文摘BACKGROUND:Douglas described choledochal cysts in 1852 and Todani proposed an anatomy-based classification in 1977. The classification is the most extensively used,but does not include some rare variations.We present a case of hepatic duct diverticulum,one of the variations,and discuss its diagnosis and treatment. METHODS:A 57-year-old woman presented with upper abdominal pain and discomfort associated with nausea and vomiting.She was finally diagnosed with cholelithiasis and right hepatic duct diverticulum. RESULT:The patient underwent resection of the hepatic duct diverticulum and cholecystectomy,and was asymptomatic 26 months after surgery. CONCLUSIONS:Hepatic duct diverticulum is a rare form of choledochal cyst,not included in Todani's classification. Todani's classification including this and other uncommon variations of choledochal cysts must be reviewed.The best diagnostic imaging methods and treatment for choledochal cysts must be defined. | Eduardo SM Fernandes Raquel L Bernardo Moacir M Fernandes Rogério MC Araújo Renato Sebbe Asterio Monte JoséF Coelho Antonio AP Souza Joaquim Ribeiro Filho | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，2： | 1 |
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