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| 1 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 2 | Gut-brain connection: The neuroprotective effects of the anti-diabetic drug liraglutide显示文摘Long-acting glucagon-like peptide-1(GLP-1) analogues marketed for type 2 diabetes(T2D) treatment have been showing positive and protective effects in several different tissues, including pancreas, heart or even brain. This gut secreted hormone plays a potent insulinotropic activity and an important role in maintaining glucose homeostasis. Furthermore, growing evidences suggest the occurrence of several commonalities between T2 D and neurodegenerative diseases, insulin resistance being pointed as a main cause for cognitive decline and increased risk to develop dementia. In this regard, it has also been suggested that stimulation of brain insulin signaling may have a protective role against cognitive deficits. As GLP-1 receptors(GLP-1R) are expressed throughout the central nervous system and GLP-1 may cross the blood-brain-barrier, an emerging hypothesis suggests that they may be promising therapeutic targets against brain dysfunctional insulin signaling-related pathologies. Importantly, GLP-1 actions depend not only on the direct effect mediated by its receptor activation, but also on the gut-brain axis involving an exchange of signals between both tissues via the vagal nerve, thereby regulating numerous physiological functions(e.g., energy homeostasis, glucose-dependent insulin secretion, as well as appetite and weight control). Amongst the incretin/GLP-1 mimetics class of anti-T2 D drugs with an increasingly described neuroprotective potential, the already marketed liraglutide emerged as a GLP-1R agonist highly resistant to dipeptidyl peptidase-4 degradation(thereby having an increased half-life) and whose systemic GLP-1R activity is comparable to that of native GLP-1. Importantly, several preclinical studies showed anti-apoptotic, anti-inflammatory, anti-oxidant and neuroprotective effects of liraglutide against T2 D, stroke and Alzheimer disease(AD), whereas several clinical trials, demonstrated some surprising benefits of liraglutide on weight loss, microglia inhibition, behavior and cognition, and in AD biomarkers. Herein, we discuss the GLP-1 action through the gut-brain axis, the hormone's regulation of some autonomic functions and liraglutide's neuroprotective potential. | Emanuel Monteiro Candeias Inês Carolina Sebastio Susana Maria Cardoso Sónia Catarina Correia Cristina Isabel Carvalho Ana Isabel Plácido Maria Sancha Santos Catarina Resende Oliveira Paula Isabel Moreira Ana Isabel Duarte | 2015 | World Journal of Diabetes2015，6，6： | 9 |
| 3 | A genetic etiology for a DiGeorge syndrome:comistent deletions and mi-crodeletions of 22q11显示文摘 | Driscoll D A Budarf M L Emanuel B S | 1992 | The American Journal of Human Genetics1992，50，： | 1 |
| 4 | Chronic rhinosinusitis:allergy and sinus computed tomography relationships显示文摘 | Emanuel I A shah S B | 2000 | Otolaryngol Head Neck Surg2000，123，6： | 1 |
| 5 | A search of the missing carbon sink:a model of terrestrial biospheric response to landuse change and atmospheric CO2显示文摘 | King A W Emanuel W R Wullschleger S D and Post W M | 1995 | Tellus1995，47，： | 1 |
| 6 | Apoptosis induced in hepatoblastoma HepG2 cells by the proteasome inhibitor MG132 is associated with hydrogen peroxide production, expression of Bcl-XS and activation of caspase-3 显示文摘 | Emanuele S Calvaruso G Lauricella M Giuliano M Bellavia GD Anneo A | 2002 | Int J Oncol2002，21，4： | 1 |
| 7 | Use of a digital infrared pupillometer to assess patient suitability for refractive surgery显示文摘 | Emanuel S Christa L Taylor | 2002 | J Cataract Refract Surg2002，28，8： | 1 |
| 8 | Effects of a polymer-coated urea product on nitrogen metabolism in lactating Holstein dairy cattle显示文摘 | GALO E EMANUELE S M SNIFFEN C J | 2003 | Journal of Dairy Science2003，86，： | 1 |
| 9 | Effects of a new multielement buffer on production,ruminal environment,and blood minerals of lactating dairy cow显示文摘 | Emanuele S M Ventura M | 1988 | J Dairy Sci1988，71，： | 1 |
| 10 | Long AT-rich palindromes and the constitutional t(11 ;22)breakpoint显示文摘 | Kurahashi H Emanuel B S | 2001 | Hum Mol Genet2001，10，23： | 1 |
| 11 | Effect o f microbial inoculants on quality of alfalfa hay baled at high moisture and cattle performance显示文摘 | Emanuele S M H or ton G M J Aldw in J | 1992 | J Dairy Sci1992，75，： | 1 |
| 12 | A Multifrequency Algorithm for the Retrieval of Soil Moisture on A Large Scale Using Microwave Data from SMMR and SSM/I Satellites显示文摘 | Paloscia S Giovanni Macelloni Emanuele Santi | 2001 | IEEE Transactions on Geoscience and Remote Sensing2001，39，： | 1 |
| 13 | On large scale circulations in convecting atmospheres 显示文摘 | Emanuel K A Neelin J D Bretherton C S | 1994 | Q J R Meteorol Soc1994，120，519： | 1 |
| 14 | JNK and AP-1 mediate apoptosis induced by bortezornib in HepG2 cells via FasL/easpase-8 and mitochondri- a-dependent pathways 显示文摘 | Lauricella M Emanuelle S D Anneo A | 2006 | Apoptosis2006，11，4： | 1 |
| 15 | Physical exercise prevents and mitigates non-alcoholic steatohepatitis-induced liver mitochondrial structural and bioenergetics impairments显示文摘 | Inês O. Gon?alves Emanuel Passos Silvia Rocha-Rodrigues Cátia V. Diogo Joan R. Torrella David Rizo Ginés Viscor Estela Santos-Alves Inês Marques-Aleixo Paulo J. Oliveira António Ascens?o José Magalh?es | 2014 | Mitochondrion2014，，： | 1 |
| 16 | The influence of feeding chelated trace minerals on dairy cattle performance and colostrum quality显示文摘 | Formigoni A S Emanuele C Sniffen | 2009 | J Anim Sci2009，87，2： | 1 |
| 17 | Polyester polyol-based polyurethane adhesive:effect oftreatment on rubber surface显示文摘 | DESAI S D EMANUEL A L SINHA V | 2003 | Journal of polymer research2003，10，3： | 1 |
| 18 | A hardware platform for research in hel- icopter UAV control 显示文摘 | Emanuel S Lewis L F | 2009 | Journal of Intelligent and Robotic Systems2009，54，13： | 1 |
| 19 | Polyester Polyol-Based Polyurethane Adhesive:Effect of Treatment on Rubber Surface显示文摘 | Desai S D Emanuel A L Sinha V K | 2003 | Journal of Polymer Research2003，10，3： | 1 |
| 20 | A DNA probe combination for improved detection of MLL/11q23 breakpoints by doublecolor interphase-FISH in acute leukemias显示文摘 | von Bergh A Emanuel B von Zelderen-Bhola S | 2000 | Genes Chromosomes Cancer2000，28，1： | 1 |
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