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| 1 | Colon cancer-associated B2 Escherichia coli colonize gut mucosa and promote cell proliferation显示文摘AIM:To provide further insight into the characterization of mucosa-associated Escherichia coli(E.coli)isolated from the colonic mucosa of cancer patients.METHODS:Phylogroups and the presence of cyclomodulin-encoding genes of mucosa-associated E.coli from colon cancer and diverticulosis specimens weredetermined by PCR.Adhesion and invasion experiments were performed with I-407 intestinal epithelial cells using gentamicin protection assay.Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6)expression in T84 intestinal epithelial cells was measured by enzyme-linked immunosorbent assay and by Western Blot.Gut colonization,inflammation and procarcinogenic potential were assessed in a chronic infection model using CEABAC10 transgenic mice.Cell proliferation was analyzed by real-time mRNA quantification of PCNA and immunohistochemistry staining of Ki67.RESULTS:Analysis of mucosa-associated E.coli from colon cancer and diverticulosis specimens showed that whatever the origin of the E.coli strains,86%of cyclomodulin-positive E.coli belonged to B2 phylogroup and most harbored polyketide synthase(pks)island,which encodes colibactin,and/or cytotoxic necrotizing factor(cnf)genes.In vitro assays using I-407 intestinal epithelial cells revealed that mucosa-associated B2 E.coli strains were poorly adherent and invasive.However,mucosa-associated B2 E.coli similarly to Crohn’s disease-associated E.coli are able to induce CEACAM6expression in T84 intestinal epithelial cells.In addition,in vivo experiments using a chronic infection model of CEACAM6 expressing mice showed that B2 E.coli strain11G5 isolated from colon cancer is able to highly persist in the gut,and to induce colon inflammation,epithelial damages and cell proliferation.CONCLUSION:In conclusion,these data bring new insights into the ability of E.coli isolated from patients with colon cancer to establish persistent colonization,exacerbate inflammation and trigger carcinogenesis. | Jennifer Raisch Emmanuel Buc Mathilde Bonnet Pierre Sauvanet Emilie Vazeille Amélie de Vallée Pierre Déchelotte Claude Darcha Denis Pezet Richard Bonnet Marie-Agnès Bringer Arlette Darfeuille-Michaud | 2014 | World Journal of Gastroenterology2014，20，21： | 12 |
| 2 | Differential radiometers using Fabry-Perot interferometric technique for remote sensing of greenhouse gases显示文摘 | E M Georgieva W S Heaps Emily L Wilson | 2008 | IEEE Transactions on Geoscienceand Remote sensing2008，46，10： | 1 |
| 3 | Energy expenditure and body composition of chronically maintained decerebrate rats in the fed and fasted condition显示文摘 | RUTH B S H HARRIS E W K EMILY W K | 2006 | Endocrinology2006，147，： | 1 |
| 4 | Cardiogenic shock complicating acute myocardial infarction—etiologies, management and outcome: a report from the SHOCK Trial Registry显示文摘 | Judith S Hochman Christopher E Buller Lynn A Sleeper Jean Boland Vladimir Dzavik Timothy A Sanborn Emilie Godfrey Harvey D White John Lim Thierry LeJemtel | 2000 | Journal of the American College of Cardiology2000，，3： | 1 |
| 5 | Understanding, managing, and minimizing urban impacts on surface water nitrogen loading 显示文摘 | Emily S Bernhardt Lawrence E Band Christopher J Walsh | 2008 | Annals of the New York Academy of Sciences2008，1134，1： | 1 |
| 6 | The dynamic exchange of dissolved or- ganic matter percolating through six diverse soils显示文摘 | EMILY E S DAVID E R | 2014 | Soil Biology and Biochemistry2014，69，1： | 1 |
| 7 | Syner- gistic, aditive and antagonistic mutagenic responses to binary mixtures of benzo(a) pyrene and benz(e) pyrene as detected by strains TA98 and TA100 in the 'salmonella/microsome assay 显示文摘 | Bruce S H ass Emily E Brooks Karen E Schumann | 1981 | Environmental and Molecular Mutagenesis1981，3，2： | 1 |
| 8 | Update: Interim Guidelines for Health Care Providers Caring for Pregnant Women and Women of Reproductive Age with Possible Zika Virus Exposure - United States, 2016显示文摘 | Titilope Oduyebo Emily E Petersen Sonja A Rasmussen Paul S Mead Dana Meaney-Delman Christina M Renquist Sascha R Ellington Marc Fischer J Erin Staples Ann M Powers Julie Villanueva Romeo R Galang Ada Dieke Jorge L Mu?oz Margaret A Honein Denise J Jamieson | 2016 | MMWR. Morbidity and Mortality Weekly Report2016，，： | 1 |
| 9 | Benthic herbivores are not deterred by brevetoxins produced by the red tide dinoflagellate Karenia Brevis显示文摘 | Erik E S Amanda M C Emily A M | 2009 | J Chem Ecol2009，35，85： | 1 |
| 10 | Immunopathogenesis of asymptomatic chronic HIV Infection: the calm before the storm显示文摘 | Emily S Ford Camille E Puronen Irini Sereti | 2009 | Current Opinion in HIV and AIDS2009，，： | 1 |
| 11 | The ionothermal synthesis of SIZ-6-a layerd aluminophosphate 显示文摘 | Emily R P Paul S W Russell E M | 2006 | Chem Common2006，，： | 1 |
| 12 | The Ontogeny of Career Identities in Adolescence 显示文摘 | Oksana Malanchuk Emily E Messersmith Jacquelynne S Eccles | 2010 | New Directions for Child and AdolescentDevelopment2010，130，： | 1 |
| 13 | Endoscopic sleeve gastroplasty in class Ⅲ obesity:Efficacy, safety, and durability outcomes in 404 consecutive patients显示文摘BACKGROUND Endoscopic sleeve gastroplasty(ESG) is an effective therapy for class Ⅰ-Ⅱ obesity, but there are knowledge gaps in the published literature about its implementation in patients with class Ⅲ obesity [body mass index(BMI) ≥ 40 kg/m2].AIM To evaluate the safety, clinical efficacy, and durability of ESG in adults with class Ⅲ obesity.METHODS This was a retrospective cohort study that used prospectively collected data on adults with BMI ≥ 40 kg/m2who underwent ESG and longitudinal lifestyle counseling at two centers with expertise in endobariatric therapies from May 2018-March 2022. The primary outcome was total body weight loss(TBWL) at 12 mo. Secondary outcomes included changes in TBWL, excess weight loss(EWL) and BMI at various time points up to 36 mo, clinical responder rates at 12 and 24 mo, and comorbidity improvement. Safety outcomes were reported through the study duration. One-way ANOVA test was performed with multiple Tukey pairwise comparisons for TBWL, EWL, and BMI over the study duration.RESULTS 404 consecutive patients(78.5% female, mean age 42.9 years, mean BMI 44.8 ± 4.7 kg/m2) were enrolled. ESGs were performed using an average of 7 sutures, over 42 ± 9 min, and with 100% technical success. TBWL was 20.9 ± 6.2% at 12 mo, 20.5 ± 6.9% at 24 mo, and 20.3 ± 9.5% at 36 mo. EWL was 49.6 ± 15.1% at 12 mo, 49.4 ± 16.7% at 24 mo, and 47.1 ± 23.5% at 36 mo. There was no difference in TBWL at 12, 15, 24, and 36 mo from ESG. TBWL exceeding 10%, 15%, and 20% was achieved by 96.7%, 87.4%, and 55.6% of the cohort at 12 mo, respectively. Of the cohort with the relevant comorbidity at time of ESG, 66.1% had improvement in hypertension, 61.7% had improvement in type Ⅱ diabetes, and 45.1% had improvement in hyperlipidemia over study duration. There was one instance of dehydration requiring hospitalization(0.2% serious adverse event rate).CONCLUSION When combined with longitudinal nutritional support, ESG induces effective and durable weight loss in adults with class Ⅲ obesity, with improvement in comorbidities and an acceptable safety profile. | Daniel Barry Maselli Anna Carolina Hoff Ashley Kucera Emily Weaver Laura Sebring Lori Gooch Kathleen Walton Daniel Lee Taylor Cratty Selena Beal Srikar Nanduri Kendall Rease Christina S Gainey Laura Eaton Brian Coan Christopher E McGowan | 2023 | World Journal of Gastrointestinal Endoscopy2023，15，6： | 0 |
| 14 | Lymphocyte phenotypes in wild-caught rats suggest potential mechanisms underlying increased immune sensitivity in post-industrial environments显示文摘野生的老鼠并且实验室老鼠的免疫系统能作为人的免疫系统的模型被利用在工业化前并且 industrial 以后社会分别地。在这研究,在野生的老鼠的淋巴细胞显型广泛地被描绘,并且结果与我们并且由其它用从实验室老鼠的各种各样的紧张导出的房间获得的那些相比。尽管没期望,规章的 T 房间的生产不在与实验室老鼠相比的野生的老鼠是显然不同的。在另一方面,在标记的表示的差别在补充规定包含了,粘附,发信号并且成熟与实验室老鼠相比在野钩子的老鼠建议增加的补充规定和减少的敏感,并且向 T 房间的成熟之间的复杂差别指。结果潜在地借卓见进过敏症和自体免疫的疾病的 industrial 以后流行病的致病。 | Ashley M Trama Zoie E Holzknecht Anitra D Thomas Kuei-Ying Su Sean M Lee Emily E Foltz Sarah E Perkins Shu S Lin William Parker | 2012 | Cellular & Molecular Immunology2012，9，2： | 0 |
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