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| 1 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 2 | Bevacizumab plus oxaliplatin-based chemotherapy as adjuvant treatment for colon cancer (AVANT): a phase 3 randomised controlled trial显示文摘 | Aimery de Gramont Eric Van Cutsem Hans-Joachim Schmoll Josep Tabernero Stephen Clarke Malcolm J Moore David Cunningham Thomas H Cartwright J Randolph Hecht Fernando Rivera Seock-Ah Im Gy?rgy Bodoky Ramon Salazar Frédérique Maindrault-Goebel Einat Shacham- | 2012 | Lancet Oncology2012，，12： | 3 |
| 3 | Enhanced caveolin-1 expression in smooth muscle cells: Possible prelude to neointima formation显示文摘AIM: To study the genesis of neointima formation in pulmonary hypertension(PH), we investigated the role of caveolin-1 and related proteins. METHODS: Male Sprague Dawley rats were given monocrotaline(M, 40 mg/kg) or subjected to hypobaric hypoxia(H) to induce PH. Another group was given M and subjected to H to accelerate the disease process(M + H). Right ventricular systolic pressure, right ventricular hypertrophy, lung histology for medial hypertrophy and the presence of neointimal lesions were examined at 2 and 4 wk. The expression of caveolin-1 and its regulatory protein peroxisome proliferator-activated receptor(PPAR) γ, caveolin-2, proliferative and antiapoptotic factors(PY-STAT3, p-Erk, Bcl-x L), endothelial nitric oxide synthase(e NOS) and heat shock protein(HSP) 90 in the lungs were analyzed, and the results from M + H group were compared with the controls, M and H groups. Double immunofluorescence technique was used to identify the localization of caveolin-1 in pulmonary arteries in rat lungs and in human PH lung tissue. RESULTS: In the M + H group, PH was more severe compared with M or H group. In the 4 wk M+H group, several arteries with reduced caveolin-1 expression in endothelial layer coupled with an increased expression in smooth muscle cells(SMC), exhibited neointimal lesions. Neointima was present only in the arteries exhibiting enhanced caveolin-1 expression in SMC. Lung tissue obtained from patients with PH also revealed neointimal lesions only in the arteries exhibiting endothelial caveolin-1 loss accompanied by an increased caveolin-1 expression in SMC. Reduction in e NOS and HSP90 expression was present in the M groups(2 and 4 wk), but not in the M + H groups. In both M groups and in the M + H group at 2 wk, endothelial caveolin-1 loss was accompanied by an increase in PPARγ expression. In the M + H group at 4 wk, increase in caveolin-1 expression was accompanied by a reduction in the PPARγ expression. In the H group, there was neither a loss of endothelial caveolin-1, eNOS or HSP 90, nor an increase in SMC caveolin-1 expression; or any alteration in PPARγ expression. Proliferative pathways were activated in all experimental groups. CONCLUSION: Enhanced caveolin-1 expression in SMC follows extensive endothelial caveolin-1 loss with subsequent neointima formation. Increased caveolin-1 expression in SMC, thus, may be a prelude to neointima formation. | Jing Huang John H Wolk Michael H Gewitz James E Loyd James West Eric D Austin Rajamma Mathew | 2015 | World Journal of Cardiology2015，7，10： | 2 |
| 4 | Differential relations between general cognitive ability and interest-vocation fit 显示文摘 | CHARLIE L R ERIC D H | 2004 | Journal of Occupational and Organizational Psychology2004，，77： | 1 |
| 5 | Wavelets for computer graphics : A primer, Part2 显示文摘 | Eric J Stollnitz Tony D DeRose David H Salesin | 1995 | IEEE Computer Graphics and Applications1995，15，4： | 1 |
| 6 | Deposition mechanisms of thermal barrier coatings in the solution precursou plas ma spray process显示文摘 | Xie L D Ma X Q Eric H | 2004 | Surface and Coatings Technology2004，，： | 1 |
| 7 | Coordinated charging of plug-in hybrid electric vehicles to minimize distribution system losses显示文摘 | ERIC S MOHAMMAD M H JAMES MAC PHERSON S D | 2011 | IEEETransOilSmartGrid2011，2，1： | 1 |
| 8 | Social lifecycle costs of cars with alternative fuels/engines显示文摘 | Joan M O Robert H W Eric D L | 2004 | Energy Policy2004，，32： | 1 |
| 9 | Effect of ENSO and MJO on Western North Pacific tropical cyclones显示文摘 | ADAM H Sobel ERIC D Maloney | 2000 | Geophysical research letters2000，27，12： | 1 |
| 10 | Nickel and cobalt sorption on anaerobic granular sludges:kinetic and equilibrium studies显示文摘 | Hullebusch Eric D V Zandvoort M H Lens P N L | 2004 | Journal of Chemical Technology and Biotechnology2004，79，： | 1 |
| 11 | Overexpression of miR-10a and miR-375 and downregulation of YAP1 in medullary thyroid carcinoma显示文摘 | Jena H Eric D Anna T | 2013 | Experimental and Molecular Pathology2013，95，1： | 1 |
| 12 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 1 |
| 13 | Above and below-the-elbow plaster casts for distal forearm fractures in children显示文摘 | ERIC R KEN Y H ANNE D | 2006 | J Bone Joint Surg (Am)2006，88，： | 1 |
| 14 | Wavelets for computer graphics:A primer(part 2)显示文摘 | Eric J Stollnitz Tony D DeRose David H Salesin | 1995 | IEEE Computer Graphics and Applications1995，15，3： | 1 |
| 15 | Single-electron spectroscopy in a coupled triple-dot system: Role of interdot electron-electron interactions 显示文摘 | S-R Eric Yang Macdonald A H Johnson M D | 1993 | Phys Rev Lett1993，，71： | 1 |
| 16 | Surgical strategies for coexisting glaucoma and cataract显示文摘 | David S Friedman Henry D Jampel Lisa H Lubomski John H Kempen Harry Quigley Nathan Congdon Hani Levkovitch-Verbin Karen A Robinson Eric B Bass | 2002 | Ophthalmology2002，，： | 1 |
| 17 | Increased osteoblast apoptosis in apert craniosynostosis:Role of Protein Kinase C and Interleukin-1显示文摘 | Eric H Philippe D | 2001 | Am J Pathol2001，158，5： | 1 |
| 18 | Nudge your customers toward better choices 显示文摘 | Goldstein D G Eric J J Andreas H | 2008 | Harvard Business Review2008，86，12： | 1 |
| 19 | Manipulation and mobilization the cervical spine显示文摘 | ERIC L H PETER D A ALAN H A | 1996 | Spine1996，21，： | 1 |
| 20 | Interpreting discor- dant indirect and multiple treatment comparison meta- analyses:an evaluation of direct acting antivirals for chronic hepatitis C infection显示文摘 | Eric D Kristian T Samantha H | 2013 | Clinical Epidemiology2013，5，5： | 1 |
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