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| 1 | 在 esophagogastroduodenoscopy 使用 lidocaine 的实用性与 propofol 表现在镇静下面显示文摘 AIM:To determine whether topical lidocaine benefits esophagogastroduoduenoscopy(EGD) by decreasing propofol dose necessary for sedation or procedurerelated complications.METHODS:The study was designed as a prospective,single centre,double blind,randomised clinical trial and was conducted in 2012 between January and May(NCT01489891).Consecutive patients undergoing EGD were randomly assigned to receive supplemental topical lidocaine(L;50 mg in an excipient solution which was applied as a spray to the oropharynx) or placebo(P;taste excipients solution without active substance,similarly delivered) prior to the standard propofol sedation procedure.The propofol was administered as a bolus intravenous(iv) dose,with patients in the L and P groups receiving initial doses based on the patient’s American Society of Anaesthesiologists(ASA) classification(ASAⅠ-Ⅱ:0.50-0.60 mg/kg;ASA Ⅲ-Ⅳ:0.25-0.35 mg/kg),followed by 10-20 mg iv dose every 30-60 s at the anaesthetist’s discretion.Vital signs,anthropometric measurements,amount of propofol administered,sedation level reached,examination time,and the subjective assessments of the endoscopist’s and anaesthetist’s satisfaction(based upon a four point Likert scale) were recorded.All statistical tests were performed by the Stata statistical software suite(Release 11,2009;StataCorp,LP,College Station,TX,United States).RESULTS:No significant differences were found between the groups treated with lidocaine or placebo in terms of total propofol dose(310.7 ± 139.2 mg/kg per minute vs 280.1 ± 87.7 mg/kg per minute,P = 0.15) or intraprocedural propofol dose(135.3 ± 151.7 mg/kg per minute vs 122.7 ± 96.5 mg/kg per minute,P = 0.58).Only when the L and P groups were analysed with the particular subgroups of female,< 65-year-old,and lower anaesthetic risk level(ASA Ⅰ-Ⅱ) was a statistically significant difference found(L:336.5 ± 141.2 mg/kg per minute vs P:284.6 ± 91.2 mg/kg per minute,P = 0.03) for greater total propofol requirements).The total incidence of complications was also similar between the two groups,with the L group showing a complication rate of 32.2%(95%CI:21.6-45.0) and the P group showing a complication rate of 26.7%(95%CI:17.0-39.0).In addition,the use of lidocaine had no effect on the anaesthetist’s or endoscopist’s satisfaction with the procedure.Thus,the endoscopist’s satisfaction Likert assessments were equally distributed among the L and P groups:unsatisfactory,[L:6.8%(95%CI:2.2-15.5) vs P:0%(95%CI:0-4.8);neutral,L:10.1%(95%CI:4.2-19.9) vs P:15%(95%CI:7.6-25.7)];satisfactory,[L:25.4%(95%CI:10-29.6) vs P:18.3%(95%CI:15.5-37.6);and very satisfactory,L:57.6%(95%CI:54-77.7) vs P:66.6%(95%CI:44.8-69.7)].Likewise,the anaesthetist’s satisfaction Likert assessments regarding the ease of maintaining a patient at an optimum sedation level without agitation or modification of the projected sedation protocol were not affected by the application of lidocaine,as evidenced by the lack of significant differences between the scores for the placebo group:unsatisfactory,L:5.8%(95%CI:1.3-13.2) vs P:0%(95%CI:0-4.8);neutral,L:16.9%(95%CI:8.9-28.4) vs P:16.7%(95%CI:8.8-27.7);satisfactory,L:15.2%(95%CI:7.7-26.1) vs P:20.3%(95%CI:11.3-31.6);and very satisfactory,L:62.7%(95%CI:49.9-74.3) vs P:63.3%(95%CI:50.6-74.7).CONCLUSION:Topical pharyngeal anaesthesia is safe in EGD but does not reduce the necessary dose of propofol or improve the anaesthetist’s or endoscopist’s satisfaction with the procedure. | Felipe de la Morena Cecilio Santander Carlos Esteban Beatriz de Cuenca Juan Antonio García Javier Sánchez Ricardo Moreno | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，5： | 3 |
| 2 | Paclobutrazol and Its Use in Fruit Production:A Review显示文摘There are documentary records referring to paclobutrazol(PBZ)as a growth bioregulator that inhibits the gibberellin synthesis and its application increases yields in fruit and vegetable crop productions.Its agronomic management includes it as an emerging technology to reduce vigour,promote flower induction and flower development in fruit trees with increased economic returns.Its use is banned in some countries because of concerns about residues that can cause harmful effects on the environment.Therefore,the aim of this article was to collect,analyse and summarise relevant information on the use of PBZ in fruit tree production and its possible risks to the environment.The results obtained indicated that the application of PBZ can be effective in solving some problems related to flowering if it is applied in the right amount and at the right time.However,it is necessary to elucidate the physiological processes with which it is associated and its response to be taken into account to increase yield.PBZ is currently used in fruit trees such as mango,lime,apple and guava,increasing their productivity.However,some studies have shown its residual effect on the environment.Therefore,PBZ is a viable strategy,because it presents a series of advantages in the production of fruit trees.However,it is vital to generate protocols that seek its regulation with a rational and sustainable approach. | Laura Raquel Orozco-Meléndez Ofelia Adriana Hernández-Rodríguez Oscar Cruz-Álvarez Loreto Robles-Hernández Graciela Dolores Avila-Quezada Esteban Sánchez Chavez DamiánAarón Porras-Flores Dámaris Leopoldina Ojeda-Barrios | 2022 | Phyton-International Journal of Experimental Botany2022，91，1： | 2 |
| 3 | Urinary neutrophil gelatinase-associated lipocalin as biomarker in the differential diagnosis of impairment of kidney function in cirrhosis显示文摘 | Claudia Fagundes Marie-No?lle Pépin Mónica Guevara Rogelio Barreto Gregori Casals Elsa Solà Gustavo Pereira Ezequiel Rodríguez Elisabet Garcia Verónica Prado Esteban Poch Wladimiro Jiménez Javier Fernández Vicente Arroyo Pere Ginès | 2012 | Journal of Hepatology2012，，2： | 2 |
| 4 | Chronic model of tympanic perforation in rats with mitomycin C and dexamethasone显示文摘A rat model of chronic tympanic membrane perforation was developed to be used in the search of new materials for the sealing of these perforations. A longitudinal study was carried out in rats subjected to incisional myr-ingotomy followed by the application of mitomycin C alone or with dexamethasone. Rats were checked at days 3, 7,1 0,1 4 and weekly thereafter until perforation closure, for up to 6 months. The addition of dexamethasone is a key component in order to obtain a chronic opening. Myringotomies treated w ith saline had a mean healing time of 8.5 days. At 8 weeks, between 62.5% and 77.7% of tympanic membranes treated w ith mitomycin C and dexamethasone remained perforated and at 6 months this number fell to 21.4%. This technique is able to maintain most tympanic membrane perforations patent for at least 8 weeks. This rat model is adequate for its use in preclinical or translational research. | Tomás Esteban Noemí M.Atucha Jose María Moraleda Joaquín Garcia-Esta? Carmen L.Insausti Javier Moraleda-Deleyto | 2019 | Journal of Otology2019，14，1： | 2 |
| 5 | High-resolution melting analysis for rapid screening of BRCA1 and BRCA2 Spanish mutations 显示文摘 | De Juan I Esteban E Palanca S | 2009 | Breast Cancer Res Treat2009，115，2： | 1 |
| 6 | MicroRNAs miR-30b,miR-30d,and miR-494 regulate human endometrial receptivity显示文摘 | Altm(a)e S Martinez-Conejero JA Esteban FJ | | 0，，03： | 1 |
| 7 | Fatty acid composition of five candidate aquaculture species in Central Philippines 显示文摘 | Ogata Hiroshi Y Emata Amil C Garibay Esteban S | 2004 | Aquacultre2004，236，： | 1 |
| 8 | A High Index of Suspicion: The Key to an Early Diagnosis of Wilson’s Disease in Childhood显示文摘 | Icíar Sánchez-Albisua Teresa Garde Loreto Hierro Carmen Camarena Esteban Frauca Angela de la Vega María Carmen Díaz Javier Larrauri Paloma Jara | 1999 | Journal of Pediatric Gastroenterology & Nutrition1999，，2： | 1 |
| 9 | The role of antibiotic prophylaxis on wound infection after mesh hernia repair under local anesthesia on an ambulatory basis显示文摘 | Angel Celdrán Octavio Frieyro Juan C. Pinta José L. Souto Jaime Esteban José M. Rubio José F. Se?arís | 2004 | Hernia2004，，1： | 1 |
| 10 | Changes in the etiology, incidence and prognosis of acute lower respiratory track infections in human immunodeficiency virus patients显示文摘 | Rafael Perelló Ona Escoda Silvia Camón òscar Miró Marta Casta?eda Asunción Moreno Maria ángeles Marcos Verónica Perea Natalia Alcolea Miquel Sánchez Josep Maria Gatell Esteban Martínez | 2014 | Enfermedades Infecciosas y Microbiologia Clinica2014，，： | 1 |
| 11 | Paleoclimatic controls on sedimentation diagenesis and reservoir quality: lessons from Miocene carbonates显示文摘 | SUN S Q ESTEBAN M | 1994 | AAPG Bulletin1994，78，： | 1 |
| 12 | Antimicrobial residues in animal waste and water resources proximal to large-scale swine and poultry feeding operations显示文摘 | Campagnolo E R Johnson K R Karpati A Rubin C S Kolpin D W Meyer M T Esteban J E Currier R W Smith K Thu K M McGeehin M | | 0，，： | 1 |
| 13 | The changing epidemiology of hepatitis C virus infection in Europe 显示文摘 | Esteban J I Sauleda S Quer J | 2008 | J Hepatol2008，48，14： | 1 |
| 14 | Activity of weekly irinotecan(CPT-11)in patients with advanced non-small cell lung cancer pretreated with platinum and taxanes显示文摘 | Sánchez R Esteban E Palacio I | 2003 | Invest New Drugs2003，21，4： | 1 |
| 15 | The changing epidemiology of hepatitis C virus infection in Europe显示文摘 | Esteban JI Sauleda S Quer J | | 0，，1： | 1 |
| 16 | Why Off- shore Wind Energy?显示文摘 | ESTEBAN M D DIEZ J J LOPEZ J S | 2011 | Renewable Energy2011，36，2： | 1 |
| 17 | Role of rinin-angioten system in vascular disease显示文摘 | Ruiz-Ortega M Lorenzo O Ruperez M Esteban V Suzuki Y Mezzano S | 2001 | Hypertension2001，38，： | 1 |
| 18 | Effect of orally administered L tryptophan on serotonin,melatonin,and the innate immune response in the rat显示文摘 | Esteban S C Nicolaus A Garmundi R E | 2004 | Molecular and Cellular Biochemistry2004，267，： | 1 |
| 19 | Hydrogen production from glycerol on Ni/Al 2 O 3 cata-lyst显示文摘 | Sánchez Esteban A D’Angelo Miguel A Comelli Raúl A | 2010 | International Journal of Hydrogen Energy2010，35，： | 1 |
| 20 | Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons显示文摘 | Shi S Hayashi Y Esteban J A Malinow R | 2001 | Cell2001，105，3： | 1 |
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