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| 1 | Effect of TGF-131 antisense oligodeoxynucleotide on renal function in chronic renal failure rats显示文摘目的:学习是调查转变生长因素( TGF )贝它 1 反的有效性的礼品的目的在改善察觉到 oligodeoxynucleotides ( ODN )在有 导致puromycin 的长期的肾衰竭( CRF )的老鼠的败坏的肾功能 .Methods :盐,嘌呤霉素,puromycin+TGF贝它 1 反感觉 ODN 或 puromycin+scrambled ODN 予被以单方地 nephrecto-mized 老鼠。肾的血液动力学、分泌的大小在经历了外科的 procedure.Results 的使麻木的老鼠被拿:在 CRF 老鼠,在肾的血流( RBF )有显著减小,这被观察, glomerular 率( GFR ),严重蛋白尿,并且几乎6褶层在控制老鼠作为与那相比增加了钠( FE Na^+)的部分排泄(所有 P < 0.05 )。在 CRF 老鼠,有 1 反察觉到的 TGF 贝它的处理,然而并非爬的 ODN,显著地稀释了 RBF, GFR,和蛋白尿的减小并且显著地阻止了 FE Na^+ 的增加,这进一步被观察(所有 P < 0.05 ) 。另外,在 CRF 的肾的肥大组织(P < 0.05 对非肾的失败控制) 是有 TGF-1 反感觉 ODN 的显著地稀释的术后疗法(P < 0.05 ) 。焦点的部分肾小球硬化症在未经治疗、爬的对待 ODN 的 CRF 组仅仅是明显的。这研究的有趣的观察在 CRF 老鼠是那,尽管有显著 attenuating 和TGF贝它的预防效果败坏的肾的功能上的 1 反感觉 ODN ,反感觉处理没在TGF贝它的肾的表示引起任何显著变化 1 在蛋白质 level.Conclusion :一起,获得的数据建议 1 反感觉 ODN 拥有的那TGF贝它在 导致puromycin 的长期的肾衰竭的有益的效果并且在形态学的恶化和处于这个病理学的状态的损害肾的功能部分地依赖于TGF贝它的行动 1 在肾以内。 | Law Chung HIONG Kiew Lik VOON Nor Azizan ABDULLAH Munavvar A SATTAR Nazarina Abdul RAHMAN Abdul Hye KHAN4, Edward James JOHNS | 2008 | Acta Pharmacologica Sinica2008，29，4： | 7 |
| 2 | Sofosbuvir and Ribavirin Prevent Recurrence of HCV Infection after Liver Transplantation: An Open-Label Study显示文摘 | Michael P. Curry Xavier Forns Raymond T. Chung Norah A. Terrault Robert Brown Jonathan M. Fenkel Fredric Gordon Jacqueline O’Leary Alexander Kuo Thomas Schiano Gregory Everson Eugene Schiff Alex Befeler Edward Gane Sammy Saab John G. McHutchison G. Mani S | 2014 | Gastroenterology2014，，： | 3 |
| 3 | Fusing moving average model and stationary wavelet decomposition for automatic incident detection:case study of Tokyo Expressway显示文摘Traffic congestion is a growing problem in urban areas all over the world.The transport sector has been in full swing event study on intelligent transportation system for automatic detection.The functionality of automatic incident detection on expressways is a primary objective of advanced traffic management system.In order to save lives and prevent secondary incidents,accurate and prompt incident detection is necessary.This paper presents a methodology that integrates moving average(MA)model with stationary wavelet decomposition for automatic incident detection,in which parameters of layer coefficient are extracted from the difference between the upstream and downstream occupancy.Unlike other wavelet-based method presented before,firsdy it smooths the raw data with MA model.Then it uses stationary wavelet to decompose,which can achieve accurate reconstruction of the signal,and does not shift the signal transfer coefficients.Thus,it can detect the incidents more accurately.The threshold to trigger incident alarm is also adjusted according to normal traffic condition with congestion.The methodology is validated with real data from Tokyo Expressway ultrasonic sensors.Experimental results show that it is accurate and effective,and that it can differentiate traffic accident from other condition such as recurring traffic congestion. | Qinghua Liu Edward Chung Liujia Zhai | 2014 | Journal of Traffic and Transportation Engineering(English Edition)2014，1，6： | 2 |
| 4 | Photosynthesis,Metabolite Composition and Anatomical Structure of Oryza sativa and Two Wild Relatives,O.grandiglumis and O.alta显示文摘Photosynthesis, enzyme activities and metabolite pools associated with primary carbon metabolism in leaves were studied in O. grandiglumis and O. alta(wild relatives of rice which produce high biomass) versus O. sativa(a japonica cultivar and a indica-japonica hybrid) to assess their potential for identifying traits which might be utilized to enhance rice productivity. The wild relatives had higher rates of photosynthesis on a fresh weight basis, and higher water use efficiency than the O. sativa lines. There were no striking differences in activities of a number of key enzymes in carbon and nitrogen metabolism between the wild relatives and cultivated rice lines. Along with higher rates of photosynthesis on a fresh weight basis, the leaves of the two wild species had higher nitrate content, higher levels of starch, glucose and fructose, and higher levels of organic acids(malate, succinate and acetate), compared to the O. sativa lines. The results suggested that O. grandiglumis and O. alta have differences in physiology and primary metabolism which might be exploited to improve growth and productivity of cultivated rice. | Jwakyung SUNG Suyeon LEE Jong-Wook CHUNG Gerald EDWARDS Hojin RYU Taewan KIM | 2017 | Rice science2017，24，4： | 2 |
| 5 | Strategies to tackle the challenges of external beam radiotherapy for liver tumors显示文摘Primary and metastatic liver cancer is an increasingly common and difficult to control disease entity.Radiation offers a non-invasive treatment alternative for these patients who often have few options and a poor prognosis.However,the anatomy and aggressiveness of liver cancer poses significant challenges such as accurate localization at simulation and treatment,management of motion and appropriate selection of dose regimen.This article aims to review the options available and provide information for the practical implementation and/or improvement of liver cancer radiation programs within the context of stereotactic body radiotherapy and image-guided radiotherapy guidelines.Specific patient inclusion and exclusion criteria are presented given the significant toxicity found in certain sub-populations treated with radiation.Indeed,certain sub-populations,such as those with tumor thrombosis or those with larger lesions treated with transarterial chemoembolization,have been shown to have significant improvements in outcome with the addition of radiation and merit special consideration.Implementing a liver radiation programrequires three primary challenges to be addressed:(1) immobilization and motion management;(2) localization;and(3) dose regimen and constraint selection.Strategies to deal with motion include simple internal target volume(ITV) expansions,non-gated ITV reduction strategies,breath hold methods,and surrogate marker methods to enable gating or tracking.Localization of the tumor and organs-at-risk are addressed using contrast infusion techniques to take advantage of different normal liver and cancer vascular anatomy,imaging modalities,and margin management.Finally,a dose response has been demonstrated and dose regimens appear to be converging.A more uniform approach to treatment in terms of technique,dose selection and patient selection will allow us to study liver radiation in larger and,hopefully,multicenter randomized studies. | Michael I Lock Jonathan Klein Hans T Chung Joseph M Herman Edward Y Kim William Small Nina A Mayr Simon S Lo | 2017 | World Journal of Hepatology2017，9，14： | 2 |
| 6 | Indications for Cardiac Resynchronization Therapy显示文摘 | Thomas M. O’Brien Edward J. Schloss Eugene S. Chung | 2013 | Cardiology Clinics2013，，： | 1 |
| 7 | Nanostructured Thermoelectric Materials and High-Efficiency Power-Generation Modules显示文摘 | Timothy P. Hogan Adam Downey Jarrod Short Jonathan D’Angelo Chun-I Wu Eric Quarez John Androulakis Pierre F.P. Poudeu Joseph R. Sootsman Duck-Young Chung Mercouri G. Kanatzidis S.D. Mahanti Edward J. Timm Harold Schock Fei Ren Jason Johnson Eldon D. Case | 2007 | Journal of Electronic Materials2007，，7： | 1 |
| 8 | EARLY RENAL ISCHEMIA, WITH OR WITHOUT REPERFUSION, ACTIVATES NFκB AND INCREASES TNF-α BIOACTIVITY IN THE KIDNEY显示文摘 | KIRSTAN K. DONNAHOO DANIEL R. MELDRUM ROBERT SHENKAR CHUN-SHIANG CHUNG EDWARD ABRAHAM ALDEN H. HARKEN | 2000 | The Journal of Urology2000，，4： | 1 |
| 9 | Passenger Segmentation Using Smart Card Data显示文摘 | Le Minh Kieu Ashish Bhaskar Edward Chung | 2015 | IEEE Transaction on Intelligent Transportation System2015，16，3： | 1 |
| 10 | Renal-coloboma syndrome:report of a novel PAX2 gene mutation显示文摘 | Chung GW Edwards AO Schimmenti LA | 2002 | Am J Ophthalmol2002，134，2： | 1 |
| 11 | SNCA variant associated with Parkinson disease and Plasma alpha-synuclein level显示文摘 | Agarwal MP Chung KA Edward KL | 2010 | Arch Neurol2010，67，11： | 1 |
| 12 | Localon-ramp queue management strategy with mainlinespeed recovery 显示文摘 | JIANG Rui CHUNG Edward LEE Jinwoo | 2012 | Procedia Social and BehavioralSciences2012，43，4： | 1 |
| 13 | Renal-coloboma syndrome: report of a novel PAX2 gene mutation 显示文摘 | Chung GW Edwards AO Schimmenti LA | 2002 | Am J Ophthalmol2002，134，： | 1 |
| 14 | 病态窦房结综合征的近展显示文摘 | Edward K Chung 萧立模 向培斌 | 1982 | 国外医学心血管疾病分册1982，，02： | 1 |
| 15 | Combined laparoseopic and endoscopic approach in patients with eholelithiasis and choledocholithiasis 显示文摘 | Liu CL Edward CS Lai Chung Mau Lo | 2008 | Surgery2008，，19： | 1 |
| 16 | Renal-coloboma syndrome:report of a novel PAX2 gene mutation显示文摘 | Chung GW Edwards AO Schimmenti LA | | 0，，： | 1 |
| 17 | 能量午餐显示文摘在寒冷的冬季,从食物中补充充足的能量是保持身体温暖的首要办法。为什么不尝试从家里打包一份营养丰富又美味的午餐便当呢?这样一来即使繁忙的工作让你无法外出午餐,你也能保持旺盛的精力迎接挑战,当然更不会亏待了自己的胃。 | 米苏 Edward Chung(摄影) | 2006 | 健康之友2006，，1： | 0 |
| 18 | 另一杯补钙牛奶显示文摘当补钙牛奶已经成为例行公事,我们再也不会为浓浓的奶香所打动,另一杯别出心裁的补钙牛奶该登场了。 | 麦唛 Edward Chung(摄影) | 2006 | 健康之友2006，，1： | 0 |
| 19 | 儿童期麻疹后硬化性全脑炎显示文摘2005年1月,一18岁的学生由私人神经科医师转诊到我院,以检查其运动障碍。4个月前,患者开始出现躯体和四肢不自主的单纯性“抽搐舞蹈”;每次抽搐后,必须用手支撑身体以免摔倒。自从症状出现以来,患者的学习成绩越来越差。其病史及家族史无明显异常. | Edward Ho Chung Wong Andrew C Hui Vincent C Mok Howan Leung Rickjason C. Chan Ka S Wong Putrick K Kwan | 2009 | 世界临床医学2009，，5： | 0 |
| 20 | Connective tissue growth factor differentially binds to members of the cystine knot superfamily and potentiates platelet-derived growth factor-B signaling in rabbit corneal fibroblast cells显示文摘AIM:To study the binding of connective tissue growth factor(CTGF) to cystine knot-containing ligands and how this impacts platelet-derived growth factor(PDGF)-B signaling. METHODS:The binding strengths of CTGF to cystine knot-containing growth factors including vascular en-dothelial growth factor(VEGF)-A,PDGF-B,bone morphogenetic protein(BMP)-4,and transforming growth factor(TGF)-β1 were compared using the LexA-based yeast two-hybrid system. EYG48 reporter strain that carried a wild-type LEU2 gene under the control of Lex A operators and a lac Z reporter plasmid(p80plac Z) containing eight high affinity Lex A binding sites were used in the yeast two-hybrid analysis. Interactions between CTGF and the tested growth factors were evaluated based on growth of transformed yeast cells on selective media and colorimetric detection in a liquid β-galactosidase activity assay. Dissociation constants of CTGF to VEGF-A isoform 165 or PDGF-BB homo-dimer were measured in surface plasma resonance(SPR) analysis. CTGF regulation in PDGF-B presentation to the PDGF receptor β(PDGFRβ) was also quantitatively assessed by the SPR analysis. Combinational effects of CTGF protein and PDGF-BB on activation of PDGFRβ and downstream signaling molecules ERK1/2 and AKT were assessed in rabbit corneal fibroblast cells by Western analysis. RESULTS:In the LexA-based yeast two-hybrid system,cystine knot motifs of tested growth factors were fused to the activation domain of the transcriptional factor GAL4 while CTGF was fused to the DNA binding domain of the bacterial repressor protein Lex A. Yeast cotransformants containing corresponding fusion proteins for CTGF and all four tested cystine knot motifs survived on selective medium containing galactose and raffinose but lacking histidine,tryptophan,and uracil. In liquid β-galactosidase assays,CTGF expressing cells that were co-transformed with the cystine knot of VEGF-A had the highest activity,at 29.88 ± 0.91 fold above controls(P < 0.01). Cells containing the cystine knot of BMP-4 expressed the second most activity,with a 24.77 ± 0.47 fold increase(P < 0.01). Cells that contained the cystine knot of TGF-β1 had a 3.80 ± 0.66 fold increase(P < 0.05) and the ones with the cystine knot of PDGF-B had a 2.64 ± 0.33 fold increase of β-galactosidase activity(P < 0.01). Further SPR analysis showed that the association rate between VEGF-A 165 and CTGF was faster than PDGF-BB and CTGF. The calculated dissociation constant(KD) of CTGF to VEGF165 and PDGF-BB was 1.8 and 43 nmol/L respectively. PDGFBB ligand and PDGFRβ receptor formed a stable complex with a low dissociation constant 1.4 nmol/L. Increasing the concentration of CTGF up to 263.2 nmol/L significantly the ligand/receptor binding. In addition,CTGF potentiated phosphorylation of PDGFRβ and AKT in rabbit corneal fibroblast cells stimulated by PDGFBB in tissue culture condition. In contrast,CTGF did not affect PDGF-B induced phosphorylation of ERK1/2.CONCLUSION:CTGF has a differential binding affinity to VEGF-A,PDGF-B,BMP-4,and TGF-β. Its weak association with PDGF-B may represent a novel mechanism to enhance PDGF-B signaling. | Liya Pi Pei-Yu Chung Sriniwas Sriram Masmudur M Rahman Wen-Yuan Song Edward W Scott Bryon E Petersen Gregory S Schultz | 2015 | World Journal of Biological Chemistry2015，6，4： | 0 |
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