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| 1 | DNA and histone methylation in gastric carcinogenesis显示文摘Epigenetic alterations contribute significantly to the development and progression of gastric cancer,one of the leading causes of cancer death worldwide.Epigenetics refers to the number of modifications of the chromatin structure that affect gene expression without altering the primary sequence of DNA,and these changes lead to transcriptional activation or silencing of the gene.Over the years,the study of epigenetic processes has increased,and novel therapeutic approaches that target DNA methylation and histone modifications have emerged.A greater understanding of epigenetics and the therapeutic potential of manipulating these processes is necessary for gastric cancer treatment.Here,we review recent research on the effects of aberrant DNA and histone methylation on the onset and progression of gastric tumors and the development of compounds that target enzymes that regulate the epigenome. | Danielle Queiroz Calcagno Carolina Oliveira Gigek Elizabeth Suchi Chen Rommel Rodriguez Burbano Marília de Arruda Cardoso Smith | 2013 | World Journal of Gastroenterology2013，19，8： | 14 |
| 2 | Interrelationship between chromosome 8 aneuploidy,C-MYC amplification and increased expression in individuals from northern Brazil with gastric adenocarcinoma显示文摘AIM: To investigate chromosome 8 numerical aberra- tions, C-MYC oncogene alterations and its expression in gastric cancer and to correlate these findings with histo- pathological characteristics of gastric tumors. METHODS: Specimens were collected surgically from seven patients with gastric adenocarcinomas. Immu- nostaining for C-MYC and dual-color fluorescence in situ hybridization (FISH) for C-MYC gene and chromosome 8 centromere were performed. RESULTS: All the cases showed chromosome 8 aneu- ploidy and C-MYC amplification, in both the diffuse and intestinal histopathological types of Lauren. No significant difference (P < 0.05) was observed between the level ofchromosome 8 ploidy and the site, stage or histological type of the adenocarcinomas. C-MYC high amplification, like homogeneously stained regions (HSRs) and double minutes (DMs), was observed only in the intestinal-type. Structural rearrangement of C-MYC, like translocation, was observed only in the diffuse type. Regarding C-MYC gene, a significant difference (P < 0.05) was observed between the two histological types. The C-MYC protein was expressed in all the studied cases. In the intestinal- type the C-MYC immunoreactivity was localized only in the nucleus and in the diffuse type in the nucleus and cytoplasm. CONCLUSION: Distinct patterns of alterations between intestinal and diffuse types of gastric tumors support the hypothesis that these types follow different genetic path- ways. | Danielle Queiroz Calcagno Mariana Ferreira Leal Aline Damaceno Seabra Andre Salim Khayat Elizabeth Suchi Chen Samia Demachki Paulo Pimentel Assumpcao Mario Henrique Girao Faria Silvia Helena Barem Rabenhorst Márcia Valéria Pitombeira Ferreira Marília de Arruda Cardoso Smith Rommel Rodríguez Burbano | 2006 | World Journal of Gastroenterology2006，12，38： | 9 |
| 3 | Acute myeloid leukemia is characterized by Wnt pathway inhibitor promoter hypermethylation显示文摘 | Elizabeth A. Griffiths Steven D. Gore Craig Hooker Michael A. McDevitt Judith E. Karp B. Douglas Smith Helai P. Mohammad Ying Ye James G. Herman Hetty E. Carraway | 2010 | Leukemia & Lymphoma2010，，9： | 3 |
| 4 | Acetylation: a novel method for modulation of the immune response following trauma/hemorrhage and inflammatory second hit in animals and humans显示文摘 | Elizabeth A. Sailhamer Yongqing Li Eleanor J. Smith Fahad Shuja Christian Shults Baoling Liu Chad Soupir Marc deMoya George Velmahos Hasan B. Alam | 2008 | Surgery2008，，2： | 2 |
| 5 | A Pooled Analysis of Advanced Colorectal Neoplasia Diagnoses After Colonoscopic Polypectomy显示文摘 | María Elena Martínez John A. Baron David A. Lieberman Arthur Schatzkin Elaine Lanza Sidney J. Winawer Ann G. Zauber Ruiyun Jiang Dennis J. Ahnen John H. Bond Timothy R. Church Douglas J. Robertson Stephanie A. Smith–Warner Elizabeth T. Jacobs David S. Alb | 2009 | Gastroenterology2009，，3： | 2 |
| 6 | Cardiovascular Magnetic Resonance, Fibrosis, and Prognosis in Dilated Cardiomyopathy显示文摘 | Ravi G. Assomull Sanjay K. Prasad Jonathan Lyne Gillian Smith Elizabeth D. Burman Mohammed Khan Mary N. Sheppard Philip A. Poole-Wilson Dudley J. Pennell | 2006 | Journal of the American College of Cardiology2006，，： | 2 |
| 7 | XCMS:Processing Mass Spectrometry Data for Metabolite Profiling Using Nonlinear Peak Alignment,Matching and Identification显示文摘 | Colin A Smith Elizabeth J Want Grace O'Maille | 2006 | Analytical Chemistry2006，78，3： | 1 |
| 8 | Wages, employment and economic shocks: Evidence from Indonesia显示文摘 | James P. Smith Duncan Thomas Elizabeth Frankenberg Kathleen Beegle Graciela Teruel | 2002 | Journal of Population Economics2002，，1： | 1 |
| 9 | Prediction of cochlear implant performance by genetic mutation: The spiral ganglion hypothesis显示文摘 | Robert W. Eppsteiner A. Eliot Shearer Michael S. Hildebrand Adam P. DeLuca Haihong Ji Camille C. Dunn Elizabeth A. Black-Ziegelbein Thomas L. Casavant Terry A. Braun Todd E. Scheetz Steven E. Scherer Marlan R. Hansen Bruce J. Gantz Richard J.H. Smith | 2012 | Hearing Research (-)2012，，1： | 1 |
| 10 | Witnessing Brown: Pursuit of an equity agenda in American education显示文摘 | ANNE SMITH ELIZABETH B KOZLESKI | 2005 | Remedial and Special Education2005，26，910： | 1 |
| 11 | Preclinical toxicity of a geldanamycin analog, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG), in rats and dogs: potential clinical relevance显示文摘 | Elizabeth R. Glaze Amy L. Lambert Adaline C. Smith John G. Page William D. Johnson David L. McCormick Alan P. Brown Barry S. Levine Joseph M. Covey Merrill J. Egorin Julie L. Eiseman Julianne L. Holleran Edward A. Sausville Joseph E. Tomaszewski | 2005 | Cancer Chemotherapy and Pharmacology2005，，6： | 1 |
| 12 | Using an Atlantis model of the southern Benguela to explore the response of ecosystem indicators for fisheries management显示文摘 | Smith Michael D Fhlton Elizabeth A Day Robert W | 2005 | Environmental Modelling & Software2005，69，： | 1 |
| 13 | A study of the prevention arid management of pressure sores显示文摘 | Elizabeth P Tolmie Lorraine N Smith | 2002 | Olinical Effectiveness in Nursing2002，6，34： | 1 |
| 14 | The role of tacit and explicit knowledge in the workplace显示文摘 | Elizabeth A. Smith | 2001 | Journal of Knowledge Management2001，，4： | 1 |
| 15 | A Comparison of levobupivacaine 0.5% and racemic bupivacaine 0.5% for extradural anesthesia for caesarean section显示文摘 | Kathryne A Faccenda Alison M Simpson Duncan J Henderson Drew Smith Elizabeth M McGrady Lachlan M.M Morrison | 2003 | Regional Anesthesia and Pain Medicine2003，，5： | 1 |
| 16 | The phylogeny of echinoderm classes based on mitochondrial gene arrangements显示文摘 | Michael J. Smith Allan Arndt Sharon Gorski Elizabeth Fajber | 1993 | Journal of Molecular Evolution1993，，6： | 1 |
| 17 | Ethics and target marketing= the role of product harm and consumer vulnerability显示文摘 | Smith N C Elizabeth C M | 1997 | Journal of Marketing1997，，3： | 1 |
| 18 | Behavioral foundations of reciprocity : experimental economics and evolutionary psychology显示文摘 | Hoffman Elizabeth Kevin McCabe and Vernon Smith | 1998 | Economic Inquiry1998，，36： | 1 |
| 19 | Delay in disclosure of childhood rape: results from a national survey显示文摘 | Daniel W Smith Elizabeth J Letourneau Benjamin E Saunders Dean G Kilpatrick Heidi S Resnick Connie L Best | 2000 | Child Abuse & Neglect2000，，2： | 1 |
| 20 | Aqueous Shunts in Glaucoma显示文摘 | Don S. Minckler Brian A. Francis Elizabeth A. Hodapp Henry D. Jampel Shan C. Lin John R. Samples Scott D. Smith Kuldev Singh | 2008 | Ophthalmology2008，，6： | 1 |
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