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| 1 | Phytochemistry,pharmacology,and clinical trials of Morus alba显示文摘The present review is aimed at providing a comprehensive summary on the botany,utility,phytochemistry,pharmacology,and clinical trials of Morus alba(mulberry or sang shu).The mulberry foliage has remained the primary food for silkworms for centuries.Its leaves have also been used as animal feed for livestock and its fruits have been made into a variety of food products.With flavonoids as major constituents,mulberry leaves possess various biological activities,including antioxidant,antimicrobial,skin-whitening,cytotoxic,anti-diabetic,glucosidase inhibition,anti-hyperlipidemic,anti-atherosclerotic,anti-obesity,cardioprotective,and cognitive enhancement activities.Rich in anthocyanins and alkaloids,mulberry fruits have pharmacological properties,such as antioxidant,anti-diabetic,anti-atherosclerotic,anti-obesity,and hepatoprotective activities.The root bark of mulberry,containing flavonoids,alkaloids and stilbenoids,has antimicrobial,skin-whitening,cytotoxic,anti-inflammatory,and anti-hyperlipidemic properties.Other pharmacological properties of M.alba include anti-platelet,anxiolytic,anti-asthmatic,anthelmintic,antidepressant,cardioprotective,and immunomodulatory activities.Clinical trials on the efficiency of M.alba extracts in reducing blood glucose and cholesterol levels and enhancing cognitive ability have been conducted.The phytochemistry and pharmacology of the different parts of the mulberry tree confer its traditional and current uses as fodder,food,cosmetics,and medicine.Overall,M.alba is a multi-functional plant with promising medicinal properties. | Eric Wei-Chiang CHAN Phui-Yan LYE Siu-Kuin WONG | 2016 | Chinese Journal of Natural Medicines2016，14，1： | 40 |
| 2 | Ursolic acid: An overview on its cytotoxic activities against breast and colorectal cancer cells显示文摘Ursolic acid(UA) is a pentacyclic triterpene of the ursane type. As a common chemical constituent among species of the family Lamiaceae, UA possesses a broad spectrum of pharmacological properties. This overview focuses on the anticancer properties of UA against breast cancer(BC) and colorectal cancer(CRC)that are most common among women and men, respectively. In vitro studies have shown that UA inhibited the growth of BC and CRC cell lines through various molecular targets and signaling pathways.There are several in vivo studies on the cytotoxic activity of UA against BC and CRC. UA also inhibits the growth of other types of cancer. Studies on structural modifications of UA have shown that the –OH groups at C3 and at C28 are critical factors influencing the cytotoxic activity of UA and its derivatives.Some needs for future research are suggested. Sources of information were from ScienceDirect, Google Scholar and PubMed. | Eric Wei Chiang Chan Chu Yong Soon Joash Ban Lee Tan Siu Kuin Wong Yew Woh Hui | 2019 | Journal of Integrative Medicine2019，17，3： | 11 |
| 3 | 腹腔镜下止血设备新进展显示文摘目的为提高血管闭合性能、手术效果和临床结局,市场上研发了许多新式的血管闭合系统。在微创手术中,爆破压、横向热扩散、闭合率和故障率是选择器备并获得最理想手术效果的重要考虑参数。本文详细介绍多种新式止血设备的物理学原理和基本运行机制,并回顾相关文献评价各个设备的优缺点。 | Eric Lee WS Felix Wong 黄倩 应小燕 | 2011 | 中国微创外科杂志2011，11，5： | 6 |
| 4 | 通过腹腔镜子宫切除术(LH)和改良小切口经腹子宫切除术(MAH)切除巨大子宫的回顾性分析--子宫切除术手术路径的再评价显示文摘腹腔镜子宫切除术(laparoscopic hysterectomy,LH)自1989年引入临床,已经成为除了传统的经腹子宫切除术(abdominal hysterectomy,AH)的广泛的可以接受的另一种选择。一些随机对照试验表明LH与AH相比有它的优点,如恢复快、疼痛轻、住院时间短、近期生活质量高,而AH的优点在于手术时间短,若腹腔镜手术失败可作为一个后备的手术方案。通过对盆腔解剖有很好的了解而充分的术前评估,加之技术的成熟,作者(Felix Wong)用改良的小切口经腹子宫切除术(modified mini-laparotomy approach for abdominal hysterectomy,MAH)处理巨大子宫,体会在处理有潜在较复杂的病例中MAH可能更加适宜,如非常大的子宫平滑肌瘤或子宫重量超过500 g,尤其是当LH很难操作时或LH可能导致不适当的并发症时。在2006~2008年的回顾性分析中,MAH手术具有时间短、手术后止痛剂的使用少、术后感染率低的优点,尽管与LH相比,在做巨大子宫切除术时,MAH仍存在术中出血稍增加、手术后住院时间平均延长1.5 d的缺点。MAH伤口更小,疼痛更轻。本文显示MAH治疗增大的子宫的操作技术可以安全完成,不伴有任何器官损伤,手术时间更短。因此,在行巨大子宫切除术时,MAH可以作为一种备选的手术方法。 | Felix Wong Eric Lee 应小燕(翻译) | 2011 | 中国微创外科杂志2011，11，4： | 6 |
| 5 | Casticin from Vitex species: a short review on its anticancer and anti-inflammatory properties显示文摘This short review provides an update of the anticancer and anti-inflammatory properties of casticin from Vitex species. Casticin is a polymethylflavone with three rings, an orthocatechol moiety, a double bond,two hydroxyl groups and four methoxyl groups. Casticin has been isolated from various tissues of plants in the Vitex genus: fruits and leaves of V. trifolia, aerial parts and seeds of V. agnus-castus and leaves of V.negundo. Studies have reported the antiproliferative and apoptotic activities of casticin from Vitex species.The compound is effective against many cancer cell lines via different molecular mechanisms. Studies have also affirmed the anti-inflammatory properties of casticin, with several molecular mechanisms identified. Other pharmacological properties include anti-asthmatic, tracheospasmolytic, analgesic, antihyperprolactinemia, immunomodulatory, opioidergic, oestrogenic, anti-angiogenic, antiglioma, lung injury protection, rheumatoid arthritis amelioration and liver fibrosis attenuation activities. Clinical trials and commercial use of the casticin-rich fruit extract of V. agnus-castus among women with premenstrual syndrome were briefly discussed. | Eric Wei Chiang Chan Siu Kuin Wong Hung Tuck Chan | 2018 | Journal of Integrative Medicine2018，16，3： | 6 |
| 6 | 中草药对良性前列腺增生的疗效及安个性:随机对照试验的系统回顾显示文摘中草药经常被用于治疗良性前列腺增生,但其疗效及安全性仍有待证实。为了比较单用中草药和中药与西药联合治疗良性前列腺增生的疗效及副作用,两位独立的评审员在主要的电子数据库中检索了单用中草药或中草药与西药联用与安慰剂或单用西药之间比较的随机对照试验,于动检索了相关期刊和灰色文献。评估的结果包括泌尿系统症状、尿动力学检测、小草药的效果优于西药。中草药的副作用发生需要有大型的质量更高的随机对照试验。 | Chun Ho Ma Wai Ling Lin Sing Leung Lui Xun-Yuan Cai Vivian Taam Wong Kun-Yuan Cai Eric Zie Zhang-Jin Zhang | 2013 | Asian Journal of Andrology2013，15，4： | 6 |
| 7 | Recurrent ectopic pancreatitis of the jejunum and mesentery over a 30-year period显示文摘BACKGROUND:Ectopic pancreas is defined as pancreatic tissue found outside its usual anatomical position,with no ductal or vascular communication with the native pancreas. We describe a case of ectopic pancreas of the small bowel and mesentery causing recurrent episodes of pancreatitis, initially suspected on computed tomography(CT)and magnetic resonance cholangiopancreatography(MRCP),and confirmed on histological review of the resection. METHODS:A 67-year-old woman presented with clinical symptoms and biochemical evidence of pancreatitis.She had similar episodes over the past 30 years with unrevealing investigations,and was concluded to have idiopathic pancreatitis. She underwent CT and MRCP,with findings suggestive of ectopic pancreas,a diagnosis confirmed on histology of the resection. RESULTS:MRCP identified a mass in the proximal small bowel mesentery isointense to the native pancreas,with a small duct draining into a proximal jejunal loop.The resected specimen consisted of normal parenchyma with lobulated acinar tissue with scattered islets of Langerhans,an occasional ductular structure,and admixed areas of adipose tissue.The patient remained asymptomatic with normal biochemistry six months post-operatively. CONCLUSION:In an individual with abdominal pain,elevated serum amylase/lipase,but imaging findings of a normal native pancreas,ectopic pancreatitis should be considered,and can be evaluated by CT and MRCP. | John CT Wong Charlotte Robinson Edward C Jones Alison Harris Charles Zwirewich Robert Wakefield Richard K Simons Eric M Yoshida | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，2： | 4 |
| 8 | An empirical study on constraint optimization techniques for test generation显示文摘Constraint solving is a frequent, but expensive operation with symbolic execution to generate tests for a program. To improve the efficiency of test generation using constraint solving, four optimization techniques are usually applied to existing constraint solvers, which are constraint independence, constraint set simplification, constraint caching, and expression rewriting. In this paper, we conducted an empirical study, using these four constraint optimization techniques in a well known test generation tool KLEE with 77 GNU Coreutils applications, to systematically investigate how these optimization techniques affect the efficiency of test generation. The experimental results show that these constraint optimization techniques as well as their combinations cannot improve the efficiency of test generation significantly for ALL-SIZED programs. Moreover, we studied the constraint optimization techniques with respect to two static metrics, lines of code(LOC) and cyclomatic complexity(CC), of programs. The experimental results show that the 'constraint set simplification' technique can improve the efficiency of test generation significantly for the programs with high LOC and CC values. The'constraint caching' optimization technique can improve the efficiency of test generation significantly for the programs with low LOC and CC values. Finally, we propose four hybrid optimization strategies and practical guidelines based on different static metrics. | Zhiyi ZHANG Zhenyu CHEN Ruizhi GAO Eric WONG Baowen XU | 2017 | Science China(Information Sciences)2017，60，1： | 3 |
| 9 | Phenolic constituents from the root bark of Morus alba with emphasis on morusin and its anti-cancer properties显示文摘The root bark of Morus alba L. or white mulberry is widely used as traditional medicine in China, Japan and Korea. Major classes and types of phenolic compounds isolated from the root bark are flavonoids(kuwanons, morusin, cyclomorusin and sanggenons), benzofurans(moracins and mulberrofurans), and stilbenoids(mulberrosides). Some of the flavonoids and benzofurans are products of Diel-Alder type adducts. Other classes of compounds include triterpenes, phenolic acids and coumarins. Morusin, a prenylated flavonoid, was first isolated from the root bark of M. alba, and later from the leaf, stem bark and twig of the plant. The potent anti-cancer properties of morusin have attracted much attention with research on-going and new findings being published. The compound inhibits angiogenesis, tumour progression and tumour migration, and triggers apoptosis, cell cycle arrest and autophagy in colorectal, cervical, prostate, breast, hepatoma, pancreatic, glioblastoma, gastric, ovarian and lung cancer cell lines. The anti-cancer activities of morusin are executed via various molecular targets and signalling pathways. It is anticipated that on-going in vitro studies will progress gradually to in vivo studies using animal models before efforts towards drug development can be initiated for clinical trials. | Eric Wei Chiang Chan Siu Kuin Wong Tomomi Inoue Hung Tuck Chan | 2019 | Journal of Chinese Pharmaceutical Sciences2019，28，2： | 3 |
| 10 | Characterization of the Intestinal Cancer Stem Cell Marker CD166 in the Human and Mouse Gastrointestinal Tract显示文摘 | Trevor G. Levin Anne E. Powell Paige S. Davies Alain D. Silk Adria D. Dismuke Eric C. Anderson John R. Swain Melissa H. Wong | 2010 | Gastroenterology2010，，： | 2 |
| 11 | Alpinia zerumbet, a ginger plant with a multitude of medicinal properties: An update on its research findings显示文摘In this review, the botany and uses of Alpinia zerumbet(yan shan jiang) are described, and the current knowledge of its phytochemistry, pharmacological properties, and clinical trials is summarized. An important ginger crop in East Asia, A. zerumbet has many uses, both medicinal and non-medicinal. Leaves are used to produce essential oils and herbal teas. Rhizomes are consumed as spices, and stem fibers are made into paper, fabrics, and handicrafts. In Brazil, tea from A. zerumbet leaves is believed to have hypotensive, diuretic, and anti-ulcerogenic properties. This species possesses many medicinal properties due to its chemical constituents, including flavonoids, phenolic acids, phenylpropanoids, kava pyrones, sterols, and terpenoids. Extracts of A. zerumbet display antioxidant, antimicrobial, insecticidal, anthelmintic, tyrosinase and melanogenesis inhibitory, anti-atherogenic, anti-aging, anti-glycation, integrase and neuraminidase inhibitory, lifespan prolongation, hair growth promotion, anticancer, antidepressant, anxiolytic, anti-obesity, analgesic, anti-inflammatory, hypolipidemic, anti-ulcerogenic, anti-platelet, osteoblastic, osteogenic, thrombolytic, and cardiac arrhythmogenic activities. Essential oils of A. zerumbet leaves have antimicrobial, larvicidal, antinociceptive, hypotensive, vasorelaxant, myorelaxant, antispasmodic, antidepressant, anxiolytic, anti-neuraminidase, anti-atherogenic, anti-aging, anti-melanogenic, anti-tyrosinase, cytoprotective, cardiodepressive, antipsychotic, analgesic, anti-inflammatory, and tissue healing activities. Clinical trials conducted in Brazil showed that extracts of A. zerumbet have hypotensive and diuretic effects whereas topical application of the essential oil has positive therapeutic effects on patients with fibromyalgia. Spanning two continents of Asia and South America, A. zerumbet is truly a multi-purpose ginger plant with promising medicinal properties. | Eric Wei Chiang Chan Siu Kuin Wong Hung Tuck Chan | 2017 | Journal of Chinese Pharmaceutical Sciences2017，26，11： | 2 |
| 12 | Acute sensorineural hearing loss associated with peginterferon and ribavirin combination therapy during hepatitis C treatment: Outcome after resumption of therapy显示文摘Peginterferon and ribavirin combination therapy for the treatment of hepatitis C virus (HCV) is well known to be associated with significant adverse effects. Sensorineural hearing loss, that in most cases is unilateral, has been reported as a consequence of therapy with both non-pegylated and pegylated interferon (pegIFN) but is not a well-known adverse effect. We report a 45-year-old Caucasian woman who developed acute sensorineural hearing loss 2 mo after starting therapy with pegIFN-α 2b and ribavirin for the treatment of chronic HCV, genotype 1a. She did not report the hearing loss to the hepatitis clinic until L mo,later whereupon therapy was promptly discontinued.Although her serum alanine aminotransferase (ALT)normalized and her HCV-RNA became undetectable after 12 wk of pegIFN and ribavirin therapy, after discontinuation,her HCV-RNA became detectable with significant elevations of serum ALT. Four months after initial discontinuation,the patient re-commenced pegIFN and ribavirin combination therapy. After 44 of 48 wk of therapy, the patient's liver biochemistry has normalized and the HCV-RNA is undetectable. She has not developed worsening of her hearing loss and hearing on the left-side is unaffected.Both patients and physicians should be aware that sensorineural hearing loss may occur with pegIFN therapy.Our experience suggests that re-institution of therapy is not always associated with further hearing impairment. | Victor K Wong Cindy Cheong-Lee Jo-Ann E Ford Eric M Yoshida | 2005 | World Journal of Gastroenterology2005，11，34： | 2 |
| 13 | Phytochemistry and pharmacology of ornamental gingers,Hedychium coronarium and Alpinia purpurata:a review显示文摘In this review, the phytochemistry and pharmacology of two ornamental gingers, Hedychium coronarium(butterfl y ginger) and Alpinia purpurata(red ginger), are updated, and their botany and uses are described. Flowers of H. coronarium are large, showy, white, yellow or white with a yellow centre and highly fragrant. Infl orescences of A. purpurata are erect spikes with attractive red or pink bracts. Phytochemical investigations on the rhizomes of H. coronarium generated research interest globally. This resulted in the isolation of 53 labdane-type diterpenes, with little work done on the leaves and fl owers. Pharmacological properties of H. coronarium included antioxidant, antibacterial, antifungal, cytotoxic, chemopreventive, anti-allergic, larvicidal, anthelminthic, analgesic, anti-infl ammatory, anti-urolithiatic, anti-angiogenic, neuropharmacological, fi brinogenolytic, coagulant and hepatoprotective activities. On the contrary, little is known on the phytochemistry of A. purpurata with pharmacological properties of antioxidant, antibacterial, larvicidal, cytotoxic and vasodilator activities reported in the leaves and rhizomes. There is much disparity in terms of research effort within and between these two ornamental gingers. | Eric Wei Chiang Chan Siu Kuin Wong | 2015 | Journal of Integrative Medicine2015，13，6： | 2 |
| 14 | Characterization of Hepatitis C Virus Resistance from a Multiple-Dose Clinical Trial of the Novel NS5A Inhibitor GS-5885显示文摘 | Kelly A. Wong Angela Worth Ross Martin Evguenia Svarovskaia Diana M. Brainard Eric Lawitz Michael D. Miller Hongmei Mo | 2013 | Antimicrobial Agents and Chemotherapy2013，，12： | 2 |
| 15 | Factors associated with 5-year survival of combined hepatocellular and cholangiocarcinoma显示文摘BACKGROUND Combined hepatocellular and cholangiocarcinoma(HCC/CC)is a rare primary hepatic malignancy which carries a poor prognosis due to its aggressive nature.Few centers have enough cases to draw definitive conclusions and there is limited understanding of prognosis.Given the rarity of HCC/CC,an analysis of large national cancer database was needed to obtain larger number of HCC/CC cases.AIM To identify associated factors for 5-year survival of HCC/CC.METHODS We conducted a retrospective study of The Surveillance,Epidemiology,and End Results(SEER)database obtained from SEER*Stat 8.3.6 software.Previously defined histology code 8180 for the International Classification of Disease for Oncology,3rd edition was used to identify HCC/CC cases from 2004 to 2015.We collected demographics,American Joint Committee on Cancer(AJCC)stage,treatment,tumor size,and survival data.These data were converted to categorical variables.The Shapiro-Wilk normality test was used to assess normal distribution.Mann-Whitney U test was used to compare continuous variables without normal distribution,and t-test was used to compare continuous variables with a normal distribution.The Kaplan-Meier survival curve analyzed 5-year survival.Univariate and multivariate logistic regression model was used to analyze factors associated with 5-year survival.Multivariate Cox proportional hazard regression was done on 5-year survival.We defined P<0.05 was statistically significant.RESULTS We identified 497 patients with the following characteristics:Mean age 62.4 years(SD:11.3),149(30.0%)were female,racial distribution was:276(55.5%)white,53(10.7%)black,84(16.9%)Asian and Pacific Islander(API),77(15.5%)Hispanic,and 7(1.4%)others or unknown.Stage I/II disease occurred in 41.5%and tumor size<50 mm was seen in 35.6%of patients.Twenty-four(4.8%)received locoregional therapy(LRT),119(23.9%)underwent resection,and 50(10.1%)underwent liver transplantation.The overall median survival was 6 mo[Interquartile range(IQR):1-22].After multivariate logistic regression,tumor size<50 mm[Odds ratios(OR):2.415,P=0.05],resection(OR:12.849,P<0.01),and transplant(OR:27.129,P<0.01)showed significance for 5-year survival.Age>60,sex,race,AJCC stages,metastasis,and LRT were not significant.However,API vs white showed significant OR of 2.793(CI:1.120-6.967).Cox proportional hazard regression showed AJCC stages,tumor size<50 mm,LRT,resection,and transplant showed significant hazard ratio.CONCLUSION HCC/CC patients with tumor size<50 mm,resection,and transplant were associated with an increase in 5-year survival.API showed advantageous OR and hazard ratios over white,black. | Tomoki Sempokuya Eric A Wien Robert J Pattison Jihyun Ma Linda L Wong | 2020 | World Journal of Hepatology2020，12，11： | 2 |
| 16 | Relief of Profound Feedback Inhibition of Mitogenic Signaling by RAF Inhibitors Attenuates Their Activity in BRAFV600E Melanomas显示文摘 | Piro Lito Christine A. Pratilas Eric W. Joseph Madhavi Tadi Ensar Halilovic Matthew Zubrowski Alan Huang Wai Lin Wong Margaret K. Callahan Taha Merghoub Jedd D. Wolchok Elisa de Stanchina Sarat Chandarlapaty Poulikos I. Poulikakos James A. Fagin Neal Rose | 2012 | Cancer Cell2012，，5： | 1 |
| 17 | Political Control and Performance in China's Listed Firms显示文摘 | Chang Eric C Sonia M.L Wong | | 0，，32： | 1 |
| 18 | Monitoring mode II fracture behaviour of composite laminates using embedded fiber-optic sensors显示文摘 | Hang-Yin Ling Kin-Tak Lau Zhongqing Su Eric Tsun-Tat Wong | 2006 | Composites Part B2006，，4： | 1 |
| 19 | Vitamin D Deficiency Is Associated with Depletion of Circulating Endothelial Progenitor Cells and Endothelial Dysfunction in Patients with Type 2 Diabetes显示文摘 | Yuen-Fung Yiu Yap-Hang Chan Kai-Hang Yiu Chung-Wah Siu Sheung-Wai Li Lai-Yung Wong Stephen W. L. Lee Sidney Tam Eric W. K. Wong Bernard M. Y. Cheung Hung-Fat Tse | 2011 | The Journal of Clinical Endocrinology & Metabolism2011，，5： | 1 |
| 20 | Intensity-Modulated Radiotherapy in the Treatment of Oropharyngeal Cancer: An Update of the Memorial Sloan-Kettering Cancer Center Experience显示文摘 | Jeremy Setton Nicola Caria Jonathan Romanyshyn Lawrence Koutcher Suzanne L. Wolden Michael J. Zelefsky Nicholas Rowan Eric J. Sherman Matthew G. Fury David G. Pfister Richard J. Wong Jatin P. Shah Dennis H. Kraus Weiji Shi Zhigang Zhang Karen D. Schupak D | 2012 | International Journal of Radiation Oncology, Biology, Physics2012，，： | 1 |
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