|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effects of 5-HT2B, 5-HT3 and 5-HT4 receptor antagonists on gastrointestinal motor activity in dogs显示文摘AIM:To study the effects of 5-hydroxytryptamine(5-HT)receptor antagonists on normal colonic motor activity in conscious dogs.METHODS:Colonic motor activity was recorded using a strain gauge force transducer in 5 dogs before and after 5-HT2B,5-HT3 and 5-HT4 receptor antagonist administration.The force transducers were implanted on the serosal surfaces of the gastric antrum,terminal ileum,ileocecal sphincter and colon.Test materials or vehicle alone was administered as an intravenous bolus injection during a quiescent period of the whole colon in the interdigestive state.The effects of these receptor antagonists on normal gastrointestinal motor activity were analyzed.RESULTS:5-HT2B,5-HT3 and 5-HT4 receptor antagonists had no contractile effect on the fasting canine terminal ileum.The 5-HT3 and 5-HT4 receptor antagonists inhibited phaseⅢof the interdigestive motor complex of the antrum and significantly inhibited colonic motor activity.In the proximal colon,the inhibitory effect was dose dependent.Dose dependency,however,was not observed in the distal colon.The 5-HT2B receptor antagonist had no contractile effect on normal colonic motor activity.CONCLUSION:The 5-HT3 and 5-HT4 receptor antagonists inhibited normal colonic motor activity.The5-HT2B receptor antagonist had no contractile effect on normal colonic motor activity. | Hiroki Morita Erito Mochiki Nobuyuki Takahashi Kiyoshi Kawamura Akira Watanabe Toshinaga Sutou Atsushi Ogawa Mitsuhiro Yanai Kyoichi Ogata Takaaki Fujii Tetsuro Ohno Souichi Tsutsumi Takayuki Asao Hiroyuki Kuwano | 2013 | World Journal of Gastroenterology2013，19，39： | 9 |
| 2 | Nuclear heat shock protein 110 expression is associated with poor prognosis and hyperthermo-chemotherapy resistance in gastric cancer patients with peritoneal metastasis显示文摘AIM To investigate the significance of heat shock protein 110(HSP110) in gastric cancer(GC) patients with peritoneal metastasis undergoing hyperthermochemotherapy.METHODS Primary GC patients(n = 14) with peritoneal metastasis or positive peritoneal lavage cytology who underwent distal or total gastrectomy between April 2000 and December 2011 were enrolled in this study. The patients underwent postoperative intraperitoneal hyperthermo-chemotherapy using a Thermotron RF-8 heating device two weeks after surgery. We analyzed nuclear HSP110 expression in surgically resected tumors using immunohistochemistry. Additionally, the effect of HSP110 suppression on hyptherthermochemosensitivity was assessed in vitro in the MKN45 GC cell line using the HSP inhibitor KNK437. RESULTS HSP110 immnohistochemical staining in 14 GC patients showed that five(35.7%) samples belonged to the low expression group, and nine(64.3%) samples belonged to the high expression group. Progression-free survival was significantly shorter in the HSP110 high-expression group than in the low-expression group(P = 0.0313). However, no significant relationships were identified between HSP110 expression and the clinicopathological characteristics of patients. Furthermore, high HSP110 expression was not an independent prognostic factor in GC patients with peritoneal metastasis(P = 0.0625). HSP110 expression in MKN45 cells was suppressed by KNK437 at the hyperthermic temperature of 43 ℃ in vitro. Comparison of MKN45 cell proliferation in the presence and absence of KNK437 at 43 ℃, revealed that proliferation was significantly decreased when HSP110 was inhibited by KNK437. Additionally, HSP110 suppression via HSP inhibitor treatment increased cellular sensitivity to hyperthermo-chemotherapy in vitro.CONCLUSION The expression of nuclear HSP110 in GC patients might be a new marker of chemosensitivity and a therapeutic target for patients who are tolerant to existing hyperthermo-chemotherapies. | Akiharu Kimura Kyoichi Ogata Bolag Altan Takehiko Yokobori Erito Mochiki Mitsuhiro Yanai Norimichi Kogure Toru Yanoma Masaki Suzuki Tuya Bai Hiroyuki Kuwano | 2017 | World Journal of Gastroenterology2017，23，42： | 5 |
| 3 | Evaluation of 18F-2-deoxy-2-fluoro-d-glucose Positron Emission Tomography for Gastric Cancer显示文摘 | Erito Mochiki Hiroyuki Kuwano Hiroyuki Katoh Takayuki Asao Noboru Oriuchi Keigo Endo | 2004 | World Journal of Surgery2004，，3： | 2 |
| 4 | Laparoscopically assisted total gastrectomy with lymph node dissection for upper and middle gastric cancer显示文摘 | Erito Mochiki Yoshitaka Toyomasu Kyouichi Ogata Hiroyuki Andoh Tetsuro Ohno Ryusuke Aihara Takayuki Asao Hiroyuki Kuwano | 2008 | Surgical Endoscopy2008，，9： | 2 |
| 5 | Relationship between clinicopathological features and mucin phenotypes of advanced gastric adenocarcinoma显示文摘AIM: To investigate a relationship between the clinicopathological features and mucin phenotypes in advanced gastric adenocarcinoma (AGA). METHODS: Immunohistochemical staining was performed to determine the mucin phenotypes in 38 patients with differentiated adenocarcinomas (DACs), 9 with signet-ring cell carcinomas (SIGs), and 48 with other diffuse-type adenocarcinomas (non-SIGs) of AGA. The mucin phenotypes were classified into 4 types: gastric (G), gastrointestinal (GI), intestinal, and unclassified. RESULTS: The G-related mucin phenotypes were highly expressed in all the histological subtypes of AGA. The expression of the GI phenotype in SIG patients was lower than that in DAC patients (P = 0.02), and this phenotype was observed in 56% of the non-SIG patients in the intramucosal layer. Among non-SIG cases, the expression of the GI phenotype was significantly higherin patients with extended adenocarcinomas and those with positive rates of lymph node metastasis. There was no difference between the expressions of the G and other GI phenotypes factors. Among DAC and non-SIG patients, there were no differences between the survival rates of the corresponding patient groups. CONCLUSION: The GI phenotype might possess more invasive characteristics than the G phenotype in nonSIG. Neither of the phenotypes indicated a poor prognosis of DAC and non-SIG. | Fumiaki Toki Atsushi Takahashi Ryusuke Aihara Kyoichi Ogata Hiroyuki Ando Tetsuro Ohno Erito Mochiki Hiroyuki Kuwano | 2010 | World Journal of Gastroenterology2010，16，22： | 2 |
| 6 | Feasibility study of post- operative intraperitoneal hyperthermochemotherapy by radiofre quency capacitive heating system for advanced gastric cancer with peritoneal seeding显示文摘 | Erito M Mariko S Hideyuki S | 2007 | Int J Hyperthermia2007，23，6： | 1 |
| 7 | Laparoscopically assisted total gastrectomy with lymph node dissection for upper and middle gastric cancer显示文摘 | Erito Mochiki Yoshitaka Toyomasu Kyouichi Ogata Hiroyuki Andoh Tetsuro Ohno Ryusuke Aihara Takayuki Asao Hiroyuki Kuwano | 2008 | Surgical Endoscopy2008，，9： | 1 |
| 8 | Gastrointestinal Recovery and Outcome after Laparoscopy-assisted versus Conventional Open Distal Gastrectomy for Early Gastric Cancer显示文摘 | Erito Mochiki Toshihiro Nakabayashi Hitoshi Kamimura Norihiro Haga Takayuki Asao Hiroyuki Kuwano | 2002 | World Journal of Surgery2002，，9： | 1 |
| 9 | Feasibility study of postoperative intraperitoneal hyperthermochemotherapy by radiofrequency capacitive heating system for advanced gastric cancer with peritoneal seeding显示文摘 | Erito M Mariko $ Hideuki S et aI | 2007 | lnt J Hypertherm ia2007，23，6： | 1 |
| 10 | Laparoscopically assisted total gastrectomy with lymph node dissection for upper and middle gastric cancer显示文摘 | Erito Mochiki Yoshitaka Toyomasu Kyouichi Ogata Hiroyuki Andoh Tetsuro Ohno Ryusuke Aihara Takayuki Asao Hiroyuki Kuwano | 2008 | Surgical Endoscopy2008，，9： | 1 |
| 11 | Pyloric motility after pylorus-preserving gastrectomy with or without the pyloric branch of the vagus nerve显示文摘 | Toshihiro Nakabayashi M.D. Erito Mochiki M.D. Moises Garcia M.D. Norihiro Haga M.D. Tomoaki Suzuki M.D. Takayuki Asao M.D. Hiroyuki Kuwano M.D | 2002 | World Journal of Surgery2002，，5： | 1 |
| 12 | Laparoscopic surgery update for gastrointestinal malignancy显示文摘 | Takayuki Asao Hiroyuki Kuwano Erito Mochiki | 2004 | Journal of Gastroenterology2004，，4： | 1 |
| 13 | Scheduling a multi-product pipeline network显示文摘 | FILHO Erito Marques de Souza BAHIENSE Laura FILHO Virgilio Jose Martins Ferreira | 2013 | Computers & Chemical Engineering2013，，53： | 1 |
| 14 | Gastrointestinal Recovery and Outcome after Laparoscopy-assisted versus Conventional Open Distal Gastrectomy for Early Gastric Cancer显示文摘 | Erito Mochiki Toshihiro Nakabayashi Hitoshi Kamimura Norihiro Haga Takayuki Asao Hiroyuki Kuwano | 2002 | World Journal of Surgery2002，，9： | 1 |
| 15 | The benefits of laparoscopically assisted distal gastrectomy for obese patients显示文摘 | Tetsuro Ohno Erito Mochiki Hiroyuki Ando Atsushi Ogawa Mitsuhiro Yanai Yoshitaka Toyomasu Kyoichi Ogata Ryuusuke Aihara Takayuki Asao Hiroyuki Kuwano | 2010 | Surgical Endoscopy2010，，11： | 1 |
| 16 | 18F-Fluorodeoxyglucose Positron Emission Tomography: Useful Technique for Predicting Malignant Potential of Gastrointestinal Stromal Tumors显示文摘 | Yoichi Kamiyama MD Ryuusuke Aihara MD PhD Toshihiro Nakabayashi MD PhD Erito Mochiki MD PhD Takayuki Asao MD PhD Hiroyuki Kuwano MD PhD Nobuo Oriuchi MD PhD Keigo Endo MD PhD | 2005 | World Journal of Surgery2005，，11： | 1 |
| 17 | Scheduling a multi-product pipeline network 显示文摘 | Erito Marques de Souza Filho Laura Bahiense irgilio Jos6 Martins Ferreira Filho | 2013 | Computers and Chemical Engineering2013，53，： | 1 |
| 18 | Postoperative functional evaluation of jejunal interposition with or without a pouch after a total gastrectomy for gastric cancer显示文摘 | Erito Mochiki Yoichi Kamiyama Ryusuke Aihara Toshihiro Nakabayashi Hitoshi Kamimura Takayuki Asao Hiroyuki Kuwano | 2004 | The American Journal of Surgery2004，，6： | 1 |
| 19 | Sentinel lymph node mapping with technetium-99m colloidal rhenium sulfide in patients with gastric carcinoma显示文摘 | Erito Mochiki Hiroyuki Kuwano Youichi Kamiyama Ryusuke Aihara Toshihiro Nakabayashi Hiroyuki Katoh Takayuki Asao Noboru Oriuchi Keigo Endo | 2006 | The American Journal of Surgery2006，，4： | 1 |
| 20 | Sudden bilateral sensorineural hearing loss as the presenting symptom of meningeal carcinomatosis of gastric cancer: Report of a case显示文摘 | Tetsuro Ohno Yozo Yokoyama Ryuusuke Aihara Erito Mochiki Takayuki Asao Hiroyuki Kuwano | 2010 | Surgery Today2010，，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员