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| 1 | Effects of 5-HT2B, 5-HT3 and 5-HT4 receptor antagonists on gastrointestinal motor activity in dogs显示文摘AIM:To study the effects of 5-hydroxytryptamine(5-HT)receptor antagonists on normal colonic motor activity in conscious dogs.METHODS:Colonic motor activity was recorded using a strain gauge force transducer in 5 dogs before and after 5-HT2B,5-HT3 and 5-HT4 receptor antagonist administration.The force transducers were implanted on the serosal surfaces of the gastric antrum,terminal ileum,ileocecal sphincter and colon.Test materials or vehicle alone was administered as an intravenous bolus injection during a quiescent period of the whole colon in the interdigestive state.The effects of these receptor antagonists on normal gastrointestinal motor activity were analyzed.RESULTS:5-HT2B,5-HT3 and 5-HT4 receptor antagonists had no contractile effect on the fasting canine terminal ileum.The 5-HT3 and 5-HT4 receptor antagonists inhibited phaseⅢof the interdigestive motor complex of the antrum and significantly inhibited colonic motor activity.In the proximal colon,the inhibitory effect was dose dependent.Dose dependency,however,was not observed in the distal colon.The 5-HT2B receptor antagonist had no contractile effect on normal colonic motor activity.CONCLUSION:The 5-HT3 and 5-HT4 receptor antagonists inhibited normal colonic motor activity.The5-HT2B receptor antagonist had no contractile effect on normal colonic motor activity. | Hiroki Morita Erito Mochiki Nobuyuki Takahashi Kiyoshi Kawamura Akira Watanabe Toshinaga Sutou Atsushi Ogawa Mitsuhiro Yanai Kyoichi Ogata Takaaki Fujii Tetsuro Ohno Souichi Tsutsumi Takayuki Asao Hiroyuki Kuwano | 2013 | World Journal of Gastroenterology2013，19，39： | 9 |
| 2 | Neoatherosclerosis:Coronary stents seal atherosclerotic lesions but result in making a new problem of atherosclerosis显示文摘Chronic inflammation of the native vessel wall with infiltration of lipid-laden foamy macrophages through impaired endothelium results in atherosclerosis. Percutaneous coronary intervention, including metallic stent implantation, is now widely utilized for the treatment of atherosclerotic lesions of the coronary artery. Baremetal stents and the subsequently developed drugeluting stents seal the atherosclerosis and resolve lumen stenosis or obstruction of the epicardial coronary artery and myocardial ischemia. After stent implantation, neointima proliferates within the stented segment. Chronic inflammation caused by a foreign body reaction to the implanted stent and subsequent neovascularization, which is characterized by the continuous recruitment of macrophages into the vessel, result in the transformation of the usual neointima into an atheromatous neointima. Neointima with an atherosclerotic appearance, such as that caused by thin-cap fibroatheromas, is now recognized as neoatherosclerosis, which can sometimes cause in-stent restenosis and acute thrombotic occlusion originating from the stent segment following disruption of the atheroma. Neoatherosclerosis is emerging as a new coronary stent-associated problem that has not yet been resolved. In this review article, we will discuss possible mechanisms, clinical challenges, and the future outlook of neoatherosclerosis. | Hidenori Komiyama Masamichi Takano Noritake Hata Yoshihiko Seino Wataru Shimizu Kyoichi Mizuno | 2015 | World Journal of Cardiology2015，7，11： | 7 |
| 3 | GENERALIZED LANDSCAPE THEORY:AGENT-BASED APPROACH TO ALLIANCE FORMATIONS IN CIVIL AVIATION INDUSTRY显示文摘The purpose of this paper is to generalize Landscape theory proposed by R. Axelrod and, then, to apply it to the civil aviation industry for simulating alliance formations in it. Landscape theory provides a well-known agent-based simulation model for analyzing alliance (or coalition) formation process. When a set N of agents or autonomous decision makers is given, the theory assumes that each agent tries to make a coalition in such a way that the resulting alliance minimizes its frustration. The theory is essentially based on two premises. One is that a propensity is symmetric, i.e., the propensity of agent i toward j is exactly the same as that of j toward i for any agents i and j in N. The other is that the number of alliances is restricted to two, i.e., at any moment N is partitioned into two parties. Though the two basic premises underpin the theory and make the model simple and operational, they do not always reflect alliance formation processes in a realistic way. A generalized Landscape theory that this paper proposes removes them and allows asymmetric propensity and existence of alliances of any number. Since the premises are essential for the model, the generalization requires a drastic reconstruction of the whole idea of the theory. Finally, we analyze a real alliance formation process in the civil aviation industry. This analysis provides interesting insights about the industry as well as some validation of our generalized Landscape theory. | Kyoichi Kijima (Graduate School of Decision Science and Technology, Tokyo Institute of Technology Ookayama, 152-8552, Japan) | 2001 | Journal of Systems Science & Complexity2001，14，2： | 5 |
| 4 | Familial pancreatic cancer: Concept, management and issues显示文摘Familial pancreatic cancer (FPC) is broadly defined as two first-degree-relatives with pancreatic cancer (PC) and accounts for 4%-10% of PC. Several genetic syndromes, including Peutz-Jeghers syndrome, hereditary pancreatitis, hereditary breast-ovarian cancer syndrome(HBOC), Lynch syndrome, and familial adenomatous polyposis (FAP), also have increased risks of PC, but the narrowest definition of FPC excludes these known syndromes. When compared with other familial tumors, proven genetic alterations are limited to a small proportion (<20%) and the familial aggregation is usually modest. However, an ethnic deviation (Ashkenazi Jewish>Caucasian) and a younger onset are common also in FPC. In European countries, 'anticipation' is reported in FPC families, as with other hereditary syndromes; a trend toward younger age and worse prognosis is recognized in the late years. The resected pancreases of FPC kindred often show multiple pancreatic intraepithelial neoplasia (Pan IN) foci, with various K-ras mutations, similar to colorectal polyposis seen in the FAP patients. As with HBOC patients, a patient who is a BRCA mutation carrier with unresectable pancreatic cancer (accounting for 0%-19% of FPC patients) demonstrated better outcome following platinum and Poly (ADP-ribose) polymerase inhibitor treatment. Western countries have established FPC registries since the 1990 s and several surveillance projects for highrisk individuals are now ongoing to detect early PCs. Improvement in lifestyle habits, including non-smoking, is recommended for individuals at risk. In Japan, the FPC study group was initiated in 2013 and the Japanese FPC registry was established in 2014 by the Japan Pancreas Society. | Hiroyuki Matsubayashi Kyoichi Takaori Chigusa Morizane Hiroyuki Maguchi Masamichi Mizuma Hideaki Takahashi Keita Wada Hiroko Hosoi Shinichi Yachida Masami Suzuki Risa Usui Toru Furukawa Junji Furuse Takamitsu Sato Makoto Ueno Yoshimi Kiyozumi Susumu Hijioka Nobumasa Mizuno Takeshi Terashima Masaki Mizumoto Yuzo Kodama Masako Torishima Takahisa Kawaguchi Reiko Ashida Masayuki Kitano Keiji Hanada Masayuki Furukawa Ken Kawabe Yoshiyuki Majima Toru Shimosegawa | 2017 | World Journal of Gastroenterology2017，23，6： | 5 |
| 5 | Nuclear heat shock protein 110 expression is associated with poor prognosis and hyperthermo-chemotherapy resistance in gastric cancer patients with peritoneal metastasis显示文摘AIM To investigate the significance of heat shock protein 110(HSP110) in gastric cancer(GC) patients with peritoneal metastasis undergoing hyperthermochemotherapy.METHODS Primary GC patients(n = 14) with peritoneal metastasis or positive peritoneal lavage cytology who underwent distal or total gastrectomy between April 2000 and December 2011 were enrolled in this study. The patients underwent postoperative intraperitoneal hyperthermo-chemotherapy using a Thermotron RF-8 heating device two weeks after surgery. We analyzed nuclear HSP110 expression in surgically resected tumors using immunohistochemistry. Additionally, the effect of HSP110 suppression on hyptherthermochemosensitivity was assessed in vitro in the MKN45 GC cell line using the HSP inhibitor KNK437. RESULTS HSP110 immnohistochemical staining in 14 GC patients showed that five(35.7%) samples belonged to the low expression group, and nine(64.3%) samples belonged to the high expression group. Progression-free survival was significantly shorter in the HSP110 high-expression group than in the low-expression group(P = 0.0313). However, no significant relationships were identified between HSP110 expression and the clinicopathological characteristics of patients. Furthermore, high HSP110 expression was not an independent prognostic factor in GC patients with peritoneal metastasis(P = 0.0625). HSP110 expression in MKN45 cells was suppressed by KNK437 at the hyperthermic temperature of 43 ℃ in vitro. Comparison of MKN45 cell proliferation in the presence and absence of KNK437 at 43 ℃, revealed that proliferation was significantly decreased when HSP110 was inhibited by KNK437. Additionally, HSP110 suppression via HSP inhibitor treatment increased cellular sensitivity to hyperthermo-chemotherapy in vitro.CONCLUSION The expression of nuclear HSP110 in GC patients might be a new marker of chemosensitivity and a therapeutic target for patients who are tolerant to existing hyperthermo-chemotherapies. | Akiharu Kimura Kyoichi Ogata Bolag Altan Takehiko Yokobori Erito Mochiki Mitsuhiro Yanai Norimichi Kogure Toru Yanoma Masaki Suzuki Tuya Bai Hiroyuki Kuwano | 2017 | World Journal of Gastroenterology2017，23，42： | 5 |
| 6 | Vulnerable atherosclerotic plaque features:findings from coronary imaging显示文摘Pathological studies have suggested that features of vulnerable atherosclerotic plaques likely to progress and lead to acute cardiovascular events have specific characteristics.Given the progress of intravascular coronary imaging technology,some large prospective studies have detected features of vulnerable atherosclerotic plaques using these imaging modalities.However,the rate of cardiovascular events,such as acute coronary syndrome,has been found to be considerably reduced in the limited follow-up period available in the statin era.Additionally,not all disrupted plaques lead to thrombus formation with clinical presentation.If sub-occlusive or occlusive thrombus formation does not occur,a thrombus on a disrupted plaque will organize without any symptoms,forming a'healed plaque'.Although vulnerable plaque detection using intracoronary imaging is focused on'thin-cap fibroatheroma'leading to plaque rupture,superficial plaque erosion is increasingly recognized;however,the underlying mechanism of thrombus formation on eroded plaques is not well understood.One of intravascular imaging,optical coherence tomography(OCT)has the highest image resolution and has enabled detailed characterization of the plaque in vivo.Here,we reviewed the status and limitations of intravascular imaging in terms of detecting vulnerable plaque through mainly OCT studies.We suggested that vulnerable plaque should be reconsidered in terms of eroded plaque and healed plaque and that both plaque and circulating blood should be assessed in greater detail accordingly. | Osamu Kurihara Masamichi Takano Yasushi Miyauchi Kyoichi Mizuno Wataru Shimizu | 2021 | Journal of Geriatric Cardiology2021，18，7： | 5 |
| 7 | Effects of anti-hypertensive drugs on esophageal body contraction显示文摘AIM:To clarify the effects of anti-hypertensive drugs on esophageal contraction and determine their possi-ble relationship with gastro-esophageal reflux disease.METHODS:Thirteen healthy male volunteers were enrolled. Esophageal body peristaltic contractions and lower esophageal sphincter (LES) pressure were measured using high resolution manometry. All subjects were randomly examined on four separate occasions following administrations of nifedipine,losartan,and atenolol,as well as without any drug administration.RESULTS:Peristaltic contractions by the esophageal body were separated into three segments by two troughs. The peak peristaltic pressures in the mid and lower segments of the esophageal body under atenolol administration were signifi cantly higher than those without medication in a supine position. On the other hand,peristaltic pressures under nifedipine administration were lower than those observed without drug ad-ministration. Losartan did not change esophageal body peristalsis. Atenolol elevated LES pressure and slowed peristaltic wave transition,while the effects of nifedip-ine were the opposite. CONCLUSION:Among the anti-hypertensive drugs tested,atenolol enhanced esophageal motor activity,which was in contrast to nifedipine. | Koichi Yoshida Kenji Furuta Kyoichi Adachi Shunji Ohara Terumi Morita Takashi Tanimura Shuji Nakata Masaharu Miki Kenji Koshino Yoshikazu Kinoshita | 2010 | World Journal of Gastroenterology2010，16，8： | 4 |
| 8 | Coronary atherosclerosis is already ongoing in pre-diabetic status: Insight from intravascular imaging modalities显示文摘Diabetes mellitus is a powerful risk factor of coronary artery disease(CAD), leading to death and disability. In recent years, given the accumulating evidence that prediabetes is also related to increasing risk of CAD including cardiovascular events, a new guideline has been proposed for the treatment of blood cholesterolfor primary prevention of cardiovascular events. This guideline recommends aggressive lipid-lowering statin therapy for primary prevention in diabetes and other patients. The ultimate goal of patient management is to inhibit progression of systemic atherosclerosis and prevent fatal cardiovascular events such as acute coronary syndrome(ACS). Because disruption of atherosclerotic coronary plaques is a trigger of ACS, the high-risk atheroma is called a vulnerable plaque. Several types of novel diagnostic imaging technologies have been developed for identifying the characteristics of coronary atherosclerosis before the onset of ACS, especially vulnerable plaques. According to coronary angioscopic evaluation, atherosclerosis severity and plaque vulnerability were more advanced in prediabetic than in nondiabetic patients and comparable to that in diabetic patients. In addition, pharmacological intervention by statin therapy changed plaque color and complexity, and the dynamic changes in plaque features are considered plaque stabilization. In this article, we review the findings of atherosclerosis in prediabetes, detected by intravascular imaging modalities, and the therapeutic implications. | Osamu Kurihara Masamichi Takano Yoshihiko Seino Wataru Shimizu Kyoichi Mizuno | 2015 | World Journal of Diabetes2015，6，1： | 4 |
| 9 | Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study显示文摘 | Toru Furukawa Günter Kl?ppel N. Volkan Adsay Jorge Albores-Saavedra Noriyoshi Fukushima Akira Horii Ralph H. Hruban Yo Kato David S. Klimstra Daniel S. Longnecker Jutta Lüttges G. Johan A. Offerhaus Michio Shimizu Makoto Sunamura Arief Suriawinata Kyoichi | 2005 | Virchows Archiv2005，，5： | 3 |
| 10 | Thick vacuum deposited silicon films suitable for the anode of Li-ion battery显示文摘 | Makiko Uehara Junji Suzuki Kohki Tamura Kyoichi Sekine Tsutomu Takamura | 2005 | Journal of Power Sources2005，，1： | 2 |
| 11 | Esophageal epithelial surface in patients with gastroesophageal reflux disease:An electron microscopic study显示文摘AIM: To investigate the intercellular spaces between the most superficially located esophageal epithelial cells in patients with gastroesophageal reflux disease (GERD). METHODS: Eighteen patients with erosive esophagitis, 10 patients with non-erosive reflux disease (NERD), and 18 normal asymptomatic volunteers were enrolled. Biopsy specimens were obtained from the lower esophageal mucosa without ulcer or erosion. Scanning electron microscopy was employed to investigate the tightness of the superficial cellular attachment. RESULTS: The intercellular space between the most superficially located epithelial cells in patients with erosive esophagitis or NERD was not different from that in asymptomatic healthy individuals. CONCLUSION: Widened luminal intercellular spaces of esophageal superficial epithelium are not responsible for the induction of reflux symptoms in patients with GERD. | Takane Azumi Kyoichi Adachi Kenji Furuta Shuji Nakata Shunji Ohara Kenji Koshino Masaharu Miki Terumi Morita Takashi Tanimura Nobuo Ashizawa Yoshikazu Kinoshita | 2008 | World Journal of Gastroenterology2008，14，37： | 2 |
| 12 | Hierarchical Hypergames and Bayesian Games:A Generalization of the Theoretical Comparison of Hypergames and Bayesian Games Considering Hierarchy of Perceptions显示文摘This paper discusses the relationship of two independently developed models of games with incomplete information,hierarchical hypergames and Bayesian games.It can be considered as a generalization of the previous study on the theoretical comparison of simple hypergames and Bayesian games(Sasaki and Kijima,2012) by taking into account hierarchy of perceptions,i.e.,an agent's perception about the other agents' perceptions,and so on.The authors first introduce the general way of transformation of any hierarchical hypergames into corresponding Bayesian games,which was called as the Bayesian representation of hierarchical hypergames.The authors then show that some equilibrium concepts for hierarchical hypergames can be associated with those for Bayesian games and discuss implications of the results. | SASAKI Yasuo KIJIMA Kyoichi | 2016 | Journal of Systems Science & Complexity2016，29，1： | 2 |
| 13 | Upregulation of TRPC1 in the development of cardiac hypertrophy显示文摘 | Takayoshi Ohba Hiroyuki Watanabe Manabu Murakami Yoichiro Takahashi Kenji Iino Sadao Kuromitsu Yasuo Mori Kyoichi Ono Toshihiko Iijima Hiroshi Ito | 2006 | Journal of Molecular and Cellular Cardiology2006，，3： | 2 |
| 14 | Scheduled infliximab monotherapy to prevent recurrence of Crohn’s disease following ileocolic or ileal resection: A 3‐year prospective randomized open trial显示文摘 | Koji Yoshida Ken Fukunaga Hiroki Ikeuchi Koji Kamikozuru Nobuyuki Hida Yoshio Ohda Yoko Yokoyama Masaki Iimuro Naohisa Takeda Kyoichi Kato Risa Kikuyama Kazuko Nagase Kazutoshi Hori Shiro Nakamura Hiroto Miwa Takayuki Matsumoto | 2011 | Inflamm Bowel Dis2011，，9： | 2 |
| 15 | Relationship between clinicopathological features and mucin phenotypes of advanced gastric adenocarcinoma显示文摘AIM: To investigate a relationship between the clinicopathological features and mucin phenotypes in advanced gastric adenocarcinoma (AGA). METHODS: Immunohistochemical staining was performed to determine the mucin phenotypes in 38 patients with differentiated adenocarcinomas (DACs), 9 with signet-ring cell carcinomas (SIGs), and 48 with other diffuse-type adenocarcinomas (non-SIGs) of AGA. The mucin phenotypes were classified into 4 types: gastric (G), gastrointestinal (GI), intestinal, and unclassified. RESULTS: The G-related mucin phenotypes were highly expressed in all the histological subtypes of AGA. The expression of the GI phenotype in SIG patients was lower than that in DAC patients (P = 0.02), and this phenotype was observed in 56% of the non-SIG patients in the intramucosal layer. Among non-SIG cases, the expression of the GI phenotype was significantly higherin patients with extended adenocarcinomas and those with positive rates of lymph node metastasis. There was no difference between the expressions of the G and other GI phenotypes factors. Among DAC and non-SIG patients, there were no differences between the survival rates of the corresponding patient groups. CONCLUSION: The GI phenotype might possess more invasive characteristics than the G phenotype in nonSIG. Neither of the phenotypes indicated a poor prognosis of DAC and non-SIG. | Fumiaki Toki Atsushi Takahashi Ryusuke Aihara Kyoichi Ogata Hiroyuki Ando Tetsuro Ohno Erito Mochiki Hiroyuki Kuwano | 2010 | World Journal of Gastroenterology2010，16，22： | 2 |
| 16 | Administration of the Rho-kinase inhibitor, fasudil, following nitroglycerin additionally dilates the site of coronary spasm in patients with vasospastic angina显示文摘 | Toshiaki Otsuka Chikao Ibuki Takeshi Suzuki Kensuke Ishii Hiroshi Yoshida Eitaro Kodani Yoshiki Kusama Hirotsugu Atarashi Hiroshi Kishida Teruo Takano Kyoichi Mizuno | 2008 | Coronary Artery Disease2008，，2： | 2 |
| 17 | Soluble lectin-like oxidized LDL receptor-1 (sLOX-1) as a valuable diagnostic marker for rupture of thin-cap fibroatheroma: Verification by optical coherence tomography显示文摘 | Nobuaki Kobayashi Masamichi Takano Noritake Hata Noriaki Kume Masanori Yamamoto Shinya Yokoyama Takuro Shinada Kazunori Tomita Akihiro Shirakabe Toshiaki Otsuka Yoshihiko Seino Kyoichi Mizuno | 2013 | International Journal of Cardiology2013，，： | 2 |
| 18 | 显示文摘 | Kyoichi K Yamaji A | 1976 | J Appl Phys1976，47，1： | 1 |
| 19 | Investigations on cold die forging of a gear utilizing divided flow 显示文摘 | Kazuyonshi Kondo Kyoichi Ohga | 1985 | Bulletin of JSME1985，28，244： | 1 |
| 20 | 显示文摘 | Kyoichi K Akihiko Y | 1976 | 47(1):371-3731976，47，1： | 1 |
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