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| 1 | From NAFLD to MAFLD:a“redefining”moment for fatty liver disease显示文摘The term non-alcoholic fatty liver disease(NAFLD)was coined in 1980 to characterize a disease similar to alcoholic fatty liver disease that developed in patients without a history of excessive alcohol intake.[1]Morphologically,NAFLD is characterized by excess fatty infiltration of the liver in the absence of known causes of liver disease(eg,alcohol,autoimmune liver disease,viral hepatitis,etc).The clinical manifestations of NAFLD(both hepatic and extrahepatic)depend on the outcome of complex interactions between its primary drivers including poor lifestyle habits and diet,a dysfunctional microbiota,genetic predisposition,and environmental cues that result in metabolic dysfunction and liver disease.However,bringing all patients with their markedly different clinical courses under the NAFLD umbrella belies its complexity and implies a homogeneous disease state that then negatively impacts clinical management and a deeper understanding of pathogenesis.With advances in current knowledge on the spectrum of fatty liver diseases,it is apparent that the fourdecade-old outdated term NAFLD can no longer serve to usefully describe a highly heterogeneous disease.The disease as we understand it today not only impacts patients who consume alcohol and those who do not,but also potentially impacts all patients with any form of liver disease,by acting as a disease modifier.[2] | Kenneth IZheng Jian-Gao Fan Jun-Ping Shi Vincent Wai-Sun Wong Mohammed Eslam Jacob George Ming-Hua Zheng | 2020 | Chinese Medical Journal2020，，19： | 14 |
| 2 | Solvent extraction and separation of light rare earth elements (La, Pr and Nd) in the presence of lactic acid as a complexing agent by Cyanex 272 in kerosene and the effect of citric acid,acetic acid and Titriplex Ⅲ as auxiliary agents显示文摘At present, the use of rare earth elements(REEs) has become an inevitable necessity in many modern industries. In general, liquid extraction is the best commercial method for extracting REEs due to its ability to control high volumes of liquids with electrical load. With the aim of improving a separation technology that would be superior to the existing extraction systems, the extraction behaviors of La(Ⅲ),Pr(Ⅲ), and Nd(Ⅲ) from an HCI medium with Cyanex 272 in the presence of the complexing agent lactic acid(HLac) and auxiliary agents citric acid(H_3 Cit), acetic acid(HAc), and Titriplex Ⅲ have been reported.The effect of pH and lactic acid concentration has been examined. The use of lactic acid as a complexing agent leading to a high extraction of REEs with Cyanex 272 at pH = 5 was compared with systems without lactic acid. The results show that the use of acetic acid along with lactic acid leads to an increase in the extraction percentage of LREEs. While use of citric acid and Titriplex Ⅲ reduces the extraction percentage of LREEs. Finally, the presence of Titriplex Ⅲ together with lactic acid could lead to an increase in the separation factor of Pr and Nd. | Eslam Kashi Razieh Habibpour Hesamoddin Gorzin Armin Maleki | 2018 | Journal of Rare Earths2018，36，3： | 12 |
| 3 | Effect of welding parameters on the heat-affected zone of AISI409 ferritic stainless steel显示文摘One of the main problems during the welding of ferritic stainless steels is severe grain growth within the heat-affected zone(HAZ).In the present study,the microstructural characteristics of tungsten inert gas(TIG) welded AISI409 ferritic stainless steel were investigated by electron backscattered diffraction(EBSD),and the effects of welding parameters on the grain size,local misorientation,and low-angle grain boundaries were studied.A 3-D finite element model(FEM) was developed to predict the effects of welding parameters on the holding time of the HAZ above the critical temperature of grain growth.It is found that the base metal is not fully recrystallized.During the welding,complete recrystallization is followed by severe grain growth.A decrease in the number of low-angle grain boundaries is observed within the HAZ.FEM results show that the final state of residual strains is caused by competition between welding plastic strains and their release by recrystallization.Still,the decisive factor for grain growth is heat input. | Eslam Ranjbarnodeh Stefanie Hanke Sabine Weiss Alfons Fischer | 2012 | International Journal of Minerals,Metallurgy and Materials2012，19，10： | 6 |
| 4 | Endoscopic advances in the management of non-variceal upper gastrointestinal bleeding:A review显示文摘Upper gastrointestinal bleeding is defined as the bleeding originating from the esophagus to the ligament of Treitz and further classified into variceal and nonvariceal gastrointestinal bleeding.Non-variceal upper gastrointestinal bleeding remains a common clinical problem globally.It is associated with high mortality,morbidity,and cost of the health care system.Despite the continuous improvement of therapeutic endoscopy,the 30-d readmission rate secondary to rebleeding and associated mortality is an ongoing issue.Available Food and Drug Administration approved traditional or conventional therapeutic endoscopic modalities includes epinephrine injection,argon plasma coagulation,heater probe,and placement of through the scope clip,which can be used alone or in combination to decrease the risk of rebleeding.Recently,more attention has been paid to the novel advanced endoscopic devices for primary treatment of the bleeding lesion and as a secondary measure when conventional therapies fail to achieve hemostasis.This review highlights emerging endoscopic modalities used in the management of non-variceal upper gastrointestinal related bleeding such as over-the-scope clip,Coagrasper,hemostatic sprays,radiofrequency ablation,cryotherapy,endoscopic suturing devices,and endoscopic ultrasound-guided angiotherapy.In this review article,we will also discuss the technical aspects of the common procedures,outcomes in terms of safety and efficacy,and their advantages and limitations in the setting of non-variceal upper gastrointestinal bleeding. | Maliha Naseer Karissa Lambert Ahmed Hamed Eslam Ali | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，1： | 6 |
| 5 | Macrophages in metabolic associated fatty liver disease显示文摘Metabolic associated fatty liver disease(MAFLD),formerly named non-alcoholic fatty liver disease is the most common liver disorder in many countries.The inflammatory subtype termed steatohepatitis is a driver of disease progression to cirrhosis,hepatocellular carcinoma,liver transplantation,and death,but also to extrahepatic complications including cardiovascular disease,diabetes and chronic kidney disease.The plasticity of macrophages in response to various environmental cues and the fact that they can orchestrate cross talk between different cellular players during disease development and progression render them an ideal target for drug development.This report reviews recent advances in our understanding of macrophage biology during the entire spectrum of MAFLD including steatosis,inflammation,fibrosis,and hepatocellular carcinoma,as well as for the extra-hepatic manifestations of MAFLD.We discuss the underlying molecular mechanisms of macrophage activation and polarization as well as cross talk with other cell types such as hepatocytes,hepatic stellate cells,and adipose tissue.We conclude with a discussion on the potential translational implications and challenges for macrophage based therapeutics for MAFLD. | Jawaher Alharthi Olivier Latchoumanin Jacob George Mohammed Eslam | 2020 | World Journal of Gastroenterology2020，26，16： | 5 |
| 6 | Biomarkers of Metabolic(Dysfunction)-associated Fatty Liver Disease:An Update显示文摘The prevalence of metabolic(dysfunction)-associated fatty liver disease(MAFLD)is rapidly increasing and affects up to two billion individuals globally,and this has also resulted in increased risks for cirrhosis,hepatocellular carcinoma,and liver transplants.In addition,it has also been linked to extrahepatic consequences,such as cardiovascular disease,diabetes,and various types of cancers.However,only a small proportion of patients with MAFLD develop these complications.Therefore,the identification of high-risk patients is paramount.Liver fibrosis is the major determinant in developing these complications.Although,liver biopsy is still considered the gold standard for the assessment of patients with MAFLD.Because of its invasive nature,among many other limitations,the search for noninvasive biomarkers for MAFLD remains an area of intensive research.In this review,we provide an update on the current and future biomarkers of MAFLD,including a discussion of the associated genetics,epigenetics,microbiota,and metabolomics.We also touch on the next wave of multiomic-based biomarkers. | Jawaher Alharthi Mohammed Eslam | 2022 | Journal of Clinical and Translational Hepatology2022，10，1： | 3 |
| 7 | Small for size syndrome difficult dilemma: Lessons from 10 years single centre experience in living donor liver transplantation显示文摘AIM To analyze the incidence, risk factors, prevention, treatment and outcome of small for size syndrome(SFSS) after living donor liver transplantation(LDLT). METHODS Through-out more than 10 years: During the period from April 2003 to the end of 2013, 174 adult-to-adults LDLT(A-ALDLT) had been performed at National Liver Institute, Menoufiya University, Shibin Elkoom, Egypt. We collected the data of those patients to do this cohort study that is a single-institution retrospective analysis of a prospectively collected database analyzing the incidence, risk factors, prevention, treatment and outcome of SFSS in a period started from the end of 2013 to the end of 2015. The median period of follow-up reached 40.50 m, range(0-144 m). RESULTS SFSS was diagnosed in 20(11.5%) of our recipients. While extra-small graft [small for size graft(SFSG)], portal hypertension, steatosis and left lobe graft were significant predictors of SFSS in univariate analysis(P = 0.00, 0.04, 0.03, and 0.00 respectively); graft size was the only independent predictor of SFSS on multivariate analysis(P = 0.03). On the other hand, there was lower incidence of SFSS in patients with SFSG who underwent splenectomy [4/10(40%) SFSS vs 3/7(42.9%) no SFSS] but without statistical significance, However, there was none significant lower incidence of the syndrome in patients with right lobe(RL) graft when drainage of the right anterior and/or posterior liver sectors by middle hepatic vein, V5, V8, and/or right inferior vein was done [4/10(28.6%) SFSS vs 52/152(34.2%) no SFSS]. The 6-mo, 1-, 3-, 5-, 7-and 10-year survival in patients with SFSS were 30%, 30%, 25%, 25%, 25% and 25% respectively, while, the 6-mo, 1-, 3-, 5-, 7-and 10-year survival in patients without SFSS were 70.1%, 65.6%, 61.7%, 61%, 59.7%, and 59.7% respectively, with statistical significant difference(P = 0.00). CONCLUSION SFSG is the independent and main factor for occurrence of SFSS after A-ALDLT leading to poor outcome. However, the management of this catastrophe depends upon its prevention(i.e., selecting graft with proper size, splenectomy to decrease portal venous inflow, and improving hepatic vein outflow by reconstructing large draining veins of the graft). | Hany Shoreem Emad Hamdy Gad Hosam Soliman Osama Hegazy Sherif Saleh Hazem Zakaria Eslam Ayoub Yasmin Kamel Kalid Abouelella Tarek Ibrahim Ibrahim Marawan | 2017 | World Journal of Hepatology2017，9，21： | 3 |
| 8 | Endoscopic stapedotomy: Merits and demerits显示文摘This work is conducted in Mansoura University Hospitals,Egypt,to show the advantages and disadvantages of endoscopic stapedotomy in comparison to microscopic stapedotomy.The work described has not been published previously nor under consideration for publication elsewhere.The authors declare that there is no conflict of interest.This study is a part of a master degree thesis submitted by Eslam Mahmoud as partial fulfillment for a master degree.Institutional review board approval,Faculty of Medicine-Mansoura University,was obtained for the study(IRB:MS/15.09.49). | Waleed Moneir Ahmed Musaad Abd El-fattah Eslam Mahmoud Mohamed Elshaer | 2018 | Journal of Otology2018，13，3： | 2 |
| 9 | PNPLA 3 rs738409 I748M is associated with steatohepatitis in 434 non‐obese subjects with hepatitis C显示文摘 | S. Petta E. Vanni E. Bugianesi C. Rosso D. Cabibi C. Cammà V. Di Marco M. Eslam S. Grimaudo F. S. Macaluso D. McLeod R. M. Pipitone M. L. Abate A. Smedile J. George A. Craxì | 2015 | Aliment Pharmacol Ther2015，，10： | 2 |
| 10 | The cellular metabolic landscape in the tumor milieu regulates the activity of myeloid infiltrates显示文摘Malignant cells upregulate distinct energy metabolism programs that support their proliferation,migration,and adaptation to the stressful tumor microenvironment(TME).Additionally,this exaggerated metabolic activity allows cancer cells to hijack essential nutrients and outcompete neighboring infiltrating immune cells,thereby impairing antitumor immunity.During recent years,there has been great interest in the field to understand the tumor-induced energy metabolism signals that regulate the function of immune cells in individuals with cancer.Accordingly,it is now well accepted that uncovering the mechanisms that instruct the metabolic behavior of cancer cells and tumor-associated immune cells is an indispensable strategy for the development of new approaches to overcome immune suppression in tumors.Thus,in this minireview,we briefly discuss the interaction between particular metabolic signaling pathways and immunosuppressive activity in different subsets of myeloid cells within the TME.Additionally,we illustrate potential central mechanisms controlling the metabolic reprogramming of myeloid cells in response to tumor-derived factors. | Eslam Mohamed Amir A.Al-Khami Paulo C.Rodriguez | 2018 | Cellular & Molecular Immunology2018，15，5： | 2 |
| 11 | Interaction of IFNL3 with insulin resistance,steatosis and lipid metabolism in chronic hepatitis C virus infection显示文摘Metabolic changes are inextricably linked to chronic hepatitis C(CHC).Recently polymorphisms in the IFNL3(IL28B)region have been shown to be strongly associated with spontaneous and treatment induced recovery from hepatitis C virus(HCV)infection.Further,circumstantial evidence suggests a link between IFNL3single nucleotide polymorphisms and lipid metabolism,steatosis and insulin resistance in CHC.The emerging picture suggests that the responder genotypes of IFNL3polymorphisms are associated with a higher serum lipid profile,and less frequent steatosis and insulin resistance.This review analyzes the current data regarding this interaction and its meaning for HCV pathogenesis and disease progression. | Mohammed Eslam David R Booth Jacob George Golo Ahlenstiel | 2013 | World Journal of Gastroenterology2013，19，41： | 2 |
| 12 | The Value of Serum Midkine Level in Diagnosis of Hepatocellular Carcinoma显示文摘 | Karim Y. A. Shaheen Abeer I. Abdel-Mageed Eslam Safwat Ashraf M. AlBreedy Shigeru Marubashi | 2015 | International Journal of Hepatology2015，，： | 1 |
| 13 | Predicting portal hypertension and variceal bleeding using non-invasive measurements of metabolic variables显示文摘 | Eslam M Ampuero J Jover M | 2013 | Ann Hepatol2013，12，4： | 1 |
| 14 | Residual platelet activation through protease-activated receptors(PAR)-1 and -4 in patients on P 2 Y 12 inhibitors 显示文摘 | BADR ESLAM R LANG IM KOPPENSTEINER R | 2013 | Int J Cardiol2013，168，1： | 1 |
| 15 | Evaluation of physiological indices, yield and its com- ponents as screening techniques for water deficit tolerance in oilseed rape cuhivars显示文摘 | ESLAM B P | 2009 | Journal of Agricultural Science and Technology2009，11，： | 1 |
| 16 | Insulin resistance and hepatitis c:an evolving story 显示文摘 | ESLAM M KHATTAB M A HARRISON S A | 2011 | Gut2011，60，8： | 1 |
| 17 | Application of genetic algorithm-support vector ma- chine (GA-SVM) for prediction of BK-channels activity 显示文摘 | Eslam Pourbasheer Siavash Riahi Mohammad Reza Ganjali Par- viz Norouzi | 2009 | Eu- ropean Journal of Medicinal Chemistry2009，44，12： | 1 |
| 18 | A novel virtual machine placement in cloud computing 显示文摘 | Eslam Mohammadi ’ Mohammadbager Karimi Saeed Rasouli Heikalabad | 2011 | Australian Journal of Basic and Applied Sciences2011，5，10： | 1 |
| 19 | Metabolic associated fatty liver disease(MAFLD):a milestone in the history of fatty liver disease显示文摘With the widespread increase in energy intake and physical inactivity,the prevalence of metabolic health is declining.Consequently,metabolic associated fatty liver disease(MAFLD)[formerly known as non-alcoholic fatty liver disease(NAFLD)]has risen in prevalence and present a significant challenge to global health causing considerable morbidity and mortality,particularly when fibrosis is present(1). | Jawaher Alharthi Mohammed Eslam | 2021 | Hepatobiliary Surgery and Nutrition2021，10，5： | 1 |
| 20 | IFNL3 polymorphisms predict response to therapy in chronic hepatitis C genotype 2/3 infection 显示文摘 | Eslam M Leung R Romero-Gomez M | 2014 | J Hepatol2014，61，2： | 1 |
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