|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A pilot study of the modulation of sirtuins on arylamine N-acetyltransferase 1 and 2 enzymatic activity显示文摘Arylamine N-acetyltransferase(NAT; E.C. 2.3.1.5) enzymes are responsible for the biotransformation of several arylamine and hydrazine drugs by acetylation. In this process, the acetyl group transferred to the acceptor substrate produces NAT deacetylation and, in consequence, it is susceptible of degradation. Sirtuins are protein deacetylases, dependent on nicotine adenine dinucleotide,which perform post-translational modifications on cytosolic proteins. To explore possible sirtuin participation in the enzymatic activity of arylamine NATs, the expression levels of NAT1, NAT2,SIRT1 and SIRT6 in peripheral blood mononuclear cells(PBMC) from healthy subjects were examined by flow cytometry and Western blot. The in situ activity of the sirtuins on NAT enzymatic activity was analyzed by HPLC, in the presence or absence of an agonist(resveratrol) and inhibitor(nicotinamide) of sirtuins. We detected a higher percentage of positive cells for NAT2 in comparison with NAT1, and higher numbers of SIRT1t cells compared to SIRT6 in lymphocytes. In situ NAT2 activity in the presence of NAM inhibitors was higher than in the presence of its substrate, but not in the presence ofresveratrol. In contrast, the activity of NAT1 was not affected by sirtuins. These results showed that NAT2 activity might be modified by sirtuins. | Eneida Turiján-Espinoza Rául Alejandro Salazar-González Edith Elena Uresti-Rivera Gloria Estela Hernández-Hernández Montserrat Ortega-Juárez Rosa Milán Diana Portales-Pérez | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 7 |
| 2 | Hepatic ischemic preconditioning increases portal vein flow in experimental liver ischemia reperfusion injury显示文摘BACKGROUND: Ischemic preconditioning(IPC) has been shown to decrease liver injury and to increase hepatic microvascular perfusion after liver ischemia reperfusion. This study aimed to evaluate the effects of IPC on hemodynamics of the portal venous system. METHODS: Thirty-two rats were randomized into two groups: IPC group and control group. The rats of the IPC group underwent IPC by 10 minutes of liver ischemia followed by 10 minutes of reperfusion before liver ischemia, and the rats of the control group were subjected to 60 minutes of partial liver ischemia. Non-ischemic lobes were resected immediately after reperfusion. The animals were studied at 4 hours and 12 hours after reperfusion. Mean arterial pressure, heart rate, portal vein flow and pressure were analyzed. Blood was collected for the determination of the levels of aspartate aminotransferase, alanine aminotransferase, calcium, lactate, pH, bicarbonate, and base excess. RESULTS: IPC increased the mean portal vein flow at 4 hours and 12 hours after reperfusion. IPC recovered 78% of the meanportal vein flow at 12 hours after reperfusion. IPC decreased the levels of aspartate aminotransferase, alanine aminotransferase and lactate, and increased the levels of ionized calcium, bicarbonate and base excess at 12 hours after reperfusion. CONCLUSIONS: This study demonstrated that IPC increases portal vein flow and enhances hepatoprotective effects in liver ischemia reperfusion. The better recovery of portal vein flow after IPC may be correlated with the lower levels of transaminases and with the better metabolic profile. | Estela RR Figueira Joel A Rocha-Filho Mauro Nakatani Marcelo FS Buto Eduardo R Tatebe Vitor O Andre Ivan Cecconello Luiz AC D'Albuquerque | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，1： | 6 |
| 3 | Effects of a dust deposition event on coastal marine microbial abundance and activity, bacterial community structure and ecosystem function 显示文摘 | Itziar L Thomas L Estela R | 2010 | Journal of Plankton Research2010，32，4： | 1 |
| 4 | Effects of heavy metals on microbial activity of water and sediment communities 显示文摘 | Cristina R M Mercedes G E Estela B D | 1999 | Water Air&Soil Pollution1999，15，2： | 1 |
| 5 | Sequential fractionation and plant availability of heavy metals as affected by sewage sludge applications to soil显示文摘 | Canet Pomares R F Estela M | 1998 | Communications in Soil Science and Plant Analysis1998，29，56： | 1 |
| 6 | Molecular and insecticidal characterization of a Cry1I protein toxic to insects of the families Noctuidae,Tortricidae,Plutellidae and Chrysomelidae显示文摘 | Escudero I R Estela A Porcar M | 2006 | Applied and Environmental Microbiology2006，72，7： | 1 |
| 7 | Software applied to oral implantology: Update 显示文摘 | Serrano M R Estela S A Diago M P | 2008 | Med Oral Patol Oral Cir Bucal2008，13，10： | 1 |
| 8 | Sequential fractionation and plant availability of heavy metals as affected by sewage sludge applications to soil显示文摘 | CANET POMARES R F ESTELA M | 1998 | Communications in Soil Science and Plant Analysis1998，29，56： | 1 |
| 9 | Molecular and insecticidal characterization of a CrylI protein toxic to insects of the families Noctuidae, Tortricidae, Plute- llidae and Chrysomelidae显示文摘 | Escudem I R Estela A Porcar M | 2006 | Applied and Environmen- tal Microbiology2006，72，7： | 1 |
| 10 | Water imbibing capacity of soy protein isolate:influence of protein denaturation显示文摘 | Delia A S Jorge R W Estela L A | 2001 | Journal of Agricultural and Food Chemistry2001，39，： | 1 |
| 11 | Genetic polymorphisms in transforming growth factor beta-1 (TGFB1) and childhood asthma and atopy显示文摘 | Huiling Li Isabelle Romieu Hao Wu Juan-Jose Sienra-Monge Matiana Ramírez-Aguilar Blanca Estela Río-Navarro Irma Carmen Lara-Sánchez Emily O. Kistner H?kon K. Gjessing Stephanie J. London | 2007 | Human Genetics2007，，5： | 1 |
| 12 | Electrophoretic solubility and functional properties of commercial soy protein isolates 显示文摘 | Arrese Estela L Sorgentini Delia A Wagner Jorge R | 1991 | J Agric Food Chem1991，39，： | 1 |
| 13 | Cores of convex and strictly convex games显示文摘 | Julio G D Estela S R | 2008 | Games and Economic Behavior2008，62，： | 1 |
| 14 | Erosion in Mediterranean landscapes:Changes and future challenges显示文摘 | Josd M G Estela N R Noemi L R | 2013 | Geomorphology2013，，198： | 1 |
| 15 | 2010,Effects of a dust deposition event on coastal marine microbial abundance and activity, bacterial community structure and ecosystem function 显示文摘 | LEKUNBERRI I THOMAS L ESTELA R | 2010 | Journal of Plankton Research2010，32，4： | 1 |
| 16 | Molecular and insec ticidal characterization of a CrylI protein toxic to insects of the families Noctuidae, Tortricidae, Plutellidae, and Chrysomeli- dae显示文摘 | Escudero I R Estela A Porcar M | 2006 | Appl Environ Microbiol2006，72，7： | 1 |
| 17 | Physiological traits associated with mass selection for improved yield in a maize population显示文摘 | Jorge I Sarqu??s Hector Gonzalez Estela Sánchez de Jiménez James R Dunlap | 1998 | Field Crops Research1998，，3： | 1 |
| 18 | Effects of ailatoxin B1 and fumonisin B1 on blood biochemical parameters in broilers 显示文摘 | Eliana N C T Estela K Ledoux D R et 01 | 2010 | Toxins2010，2，4： | 1 |
| 19 | A new heparin fragment decreases liver ischemia-reperfusion injury显示文摘To the Editor:Ischemia-reperfusion injury following surgery and transplantation can lead to irreversible multiorgan failure.Intracellular calcium overload is associated to cellular death during ischemiareperfusion.A recently discovered heparin fragment (HF),trisulfated disaccharide (TD),that acts on sodium-calcium exchanger(NCX) decreasing intracellular Ca^(2+),showed effectiveness on protecting hepatocytes from ischemia-reperfusion injury [1]. | Enio R Vasques Estela RR Figueira Joel A Rocha-Filho Cinthia Lanchotte Jorge LS Ximenes Helena B Nader Ivarne LS Tersariol Marcelo A Lima Tiago Rodrigues JoséEM Cunha Eleazar Chaib Luiz AC D’Albuquerque Flávio HF Galvão | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员