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| 1 | Colonic ulcerations may predict steroid-refractory course in patients with ipilimumab-mediated enterocolitis显示文摘AIM To investigate management of patients who develop ipilimumab-mediated enterocolitis, including association of endoscopic findings with steroid-refractory symptoms and utility of infliximab as second-line therapy.METHODS We retrospectively reviewed all patients at our centerwith metastatic melanoma who were treated with ipilimumab between March 2011 and May 2014. All patients received a standard regimen of intravenous ipilimumab 3 mg/kg every 3 wk for four doses or until therapy was stopped due to toxicity or disease progression. Basic demographic and clinical data were collected on all patients. For patients who developed grade 2 or worse diarrhea(increase of 4 bowel movements per day), additional data were collected regarding details of gastrointestinal symptoms, endoscopic findings and treatment course. Descriptive statistics were used.RESULTS A total of 114 patients were treated with ipilimumab during the study period and all were included. Sixteen patients(14%) developed ≥ grade 2 diarrhea. All patients were treated with high-dose corticosteroids(1-2 mg/kg prednisone daily or equivalent). Nine of 16 patients(56%) had ongoing diarrhea despite highdose steroids. Steroid-refractory patients received one dose of intravenous infliximab at 5 mg/kg, and all but one had brisk resolution of diarrhea. Fourteen of the patients underwent either colonoscopy or sigmoidoscopy with variable endoscopic findings, ranging from mild erythema to colonic ulcers. Among 8 patients with ulcers demonstrated by sigmoidoscopy or colonoscopy, 7 patients(88%) developed steroidrefractory symptoms requiring infliximab. With a median follow-up of 264 d, no major adverse events associated with prednisone or infliximab were reported.CONCLUSION In patients with ipilimumab-mediated enterocolitis, the presence of colonic ulcers on endoscopy was associated with a steroid-refractory course. | Animesh Jain Evan J Lipson William H Sharfman Steven R Brant Mark G Lazarev | 2017 | World Journal of Gastroenterology2017，23，11： | 8 |
| 2 | Pancreatitis: Preventing catastrophic haemorrhage显示文摘Pancreatitis represents nearly 3% of acute admissions to general surgery in United Kingdom hospitals and has a mortality of around 1%-7% which increases to around 10%-18% in patients with severe pancreatitis. Patients at greatest risk were those identified to have infected pancreatic necrosis and/or organ failure. This review seeks to highlight the potential vascular complications associated with pancreatitis that despite being relatively uncommon are associated with mortality in the region of 34%-52%. We examine the current evidence base to determine the most appropriate method by which to image and treat pseudo-aneurysms that arise as the result of acute and chronic inflammation of pancreas. We identify how early recognition of the presence of a pseudo-aneurysm can facilitate expedited care in an expert centre of a complex pathology that may require angiographic, percutaneous, endoscopic or surgical intervention to prevent catastrophic haemorrhage. | Richard PT Evans Moustafa Mabrouk Mourad Gunraj Pall Simon G Fisher Simon R Bramhall | 2017 | World Journal of Gastroenterology2017，23，30： | 6 |
| 3 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) - Update 2008显示文摘 | M Claudon D Cosgrove T Albrecht L Bolondi M Bosio F Calliada J.-M Correas K Darge C Dietrich M D’Onofrio D Evans C Filice L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani S Meairs C Nols?e F Piscaglia P Ricci G Seidel B Skjoldbye L Solbia | 2008 | Ultraschall in Med2008，，01： | 4 |
| 4 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) - Update 2008显示文摘 | M Claudon D Cosgrove T Albrecht L Bolondi M Bosio F Calliada J.-M Correas K Darge C Dietrich M D'Onofrio D Evans C Filice L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani S Meairs C Nols?e F Piscaglia P Ricci G Seidel B Skjoldbye L Solbia | 2008 | Ultraschall in Med2008，，01： | 3 |
| 5 | Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial显示文摘 | John Burn Anne-Marie Gerdes Finlay Macrae Jukka-Pekka Mecklin Gabriela Moeslein Sylviane Olschwang Diane Eccles D Gareth Evans Eamonn R Maher Lucio Bertario Marie-Luise Bisgaard Malcolm G Dunlop Judy WC Ho Shirley V Hodgson Annika Lindblom Jan Lubinski Pa | 2011 | The Lancet2011，，9809： | 3 |
| 6 | Polycrystalline silicon strain sensors 显示文摘 | French P J Evans A G R | 1985 | Sensors and Actuators A1985，7，： | 2 |
| 7 | Novel MMC Microstructure with Tailored Distribution of the Reinforcing Phase 显示文摘 | Peng H X Fan Z Evans J R G | 2001 | Journal of Microscopy2001，201，： | 1 |
| 8 | Stress and decohesion of oxide scales显示文摘 | EVANS A G CANNON R M | 1989 | Materials Science Forum1989，43，3： | 1 |
| 9 | Mycorrhizal colonization of crested wheatgrass as influenced by grazing显示文摘 | Bethlenfalvay G J Evans R A Lesperance A L | 1985 | Agronomy Journal1985，77，： | 1 |
| 10 | The BPR Scope Concept in Leveraging Improved Supply Chain Performance显示文摘 | D Berry G N Evans R Mason-Jones | 1999 | Business Process Management Journal Bradford1999，5，3： | 1 |
| 11 | Influence of sulfur on the adhesion of the Ni/Al2O3 interface显示文摘 | ZHANG W SMITH J R WANG X G EVANS A G | 2003 | Physical Review B2003，67，24： | 1 |
| 12 | Review: fabrication of engineering ceramics by injection molding (II): techniques 显示文摘 | EDIRSINHGE M J EVANS J R G | 1986 | Int J High Technol Ceram1986，，2： | 1 |
| 13 | A multipath data association tracker for over-the-horizon radar显示文摘 | G W Pulford R J Evans | 1998 | IEEE Transactions on Aerospace and Electronic Systems1998，34，4： | 1 |
| 14 | Degradation of polyolefin blends used for ceramic injection molding 显示文摘 | WRIGHT J K EVANS J R G EDIRISINGHE M G | 1989 | J Am Ceram Soc1989，72，10： | 1 |
| 15 | Mechanisms controlling the durability of thermal barrier coatings显示文摘 | EVANS A G MUMM D R HUTCHINSON J W MEIER G H Pettit F S | 2001 | Progress in Materials Science2001，46，5： | 1 |
| 16 | A model for crack initiation in elastic/plastic: indentation fields 显示文摘 | LAWN B R EVANS A G | 1977 | Journal of Materials Science1977，12，： | 1 |
| 17 | Permanent-magnet Linear Actuator for Static and Reciprocating Short-stroke Electromechanical Systems显示文摘 | Evans S A Smith I R Kettleborough J G | 2001 | IEEE/ASME Transactions on Mechatronics2001，6，1： | 1 |
| 18 | First principles assessment of metal/oxide interface adhesion显示文摘 | JIANG Y SMITH J R EVANS A G | 2008 | Applied Physics Letters2008，92，14： | 1 |
| 19 | Relativistically correct hole-boring and ion acceleration by circularly polarized laser pulses显示文摘 | A P L Robinson P Gibbon M Zepf S Kar R G Evans C Bellei | 2009 | Plasma Physics and Controlled Fusion2009，，2： | 1 |
| 20 | Analytical toxicology:guidelines for sample collection postmortem显示文摘 | Flanagan R J Connally G Evans J M | 2005 | Toxicol Rev2005，24，1： | 1 |
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