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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Parallcl ization of the Scatter Search for the p median Problem 显示文摘 | FELIX G L BELEN M B JOSE A M P | 2003 | Parallel Computing2003，29，5： | 1 |
| 3 | Applying RCM in larger scale systems:A case study with railway networks显示文摘 | JESUS C JOSE M P FELIX G C | 2003 | Reliability Engineering and System Safety2003，，82： | 1 |
| 4 | TACS:A Trust Model for P2P Networks显示文摘 | Felix G M Gregorio M P Antonio F G S | 2009 | Wireless Personal Communications2009，51，1： | 1 |
| 5 | Patients with mild to moderate body dysmorphic disorder may benefit from rhinoplasty 显示文摘 | Felix G A A de Brito M J A Nahas F X | 2014 | Journal of Plastic Reconstructive & Aesthetic Surgery2014，67，5： | 1 |
| 6 | Dexmedetomidine/ketamine for diagnostic cardiac catheterization in a child with idiopathic pulmonary hypertension 显示文摘 | MUNRO H M FELIX D E NYKANEN D G | 2009 | Clin Anesth2009，21，6： | 1 |
| 7 | When do firms support environ- mental agreements?显示文摘 | Ana E A Felix M G | 2012 | Journal of Regulatory Econo- mics2012，41，3： | 1 |
| 8 | Determination of oxyte-tracycline in tomatoes by HPLC using fluorescence detection显示文摘 | Patricia P M Susanne R Felix G R | 2008 | Food Chemistry2008，109，1： | 1 |
| 9 | The SJR indicator: a new indi- cator of journals ' scientific prestige 显示文摘 | Borja G Vicente P Felix M | 2009 | Arxiv2009，，： | 1 |
| 10 | Mitochondrial Ca2+ homeostasis in human NADH:ubiquinone oxidoreductase deficiency显示文摘 | PETER H G M FEDERIC A V FELIX D | 2008 | Cell Calcium2008，44，1： | 1 |
| 11 | Specific perception of subnanomolar concentrations of chitin fragments by tomato cells: Induction of extracellular alkalinization changes in protein phosphorylation and establishment of a refractory state显示文摘 | Felix G Regenass M Boller T | 1993 | Plant J1993，4，2： | 1 |
| 12 | TAGS:a trustmodel for P2P networks显示文摘 | FELIX G M GREGORIO M P ANTONIO F G S | 2009 | Wireless Personal Communications2009，51，1： | 1 |
| 13 | META-TACS:atrust model demonstration of robustness through a genetic algorithm显示文摘 | FELIX G M GREGORIO M P JAVIER G M | 2011 | Intelligent Automation & Soft Computing2011，17，1： | 1 |
| 14 | Laser radar observations of atmospheric potassium 显示文摘 | Felix F Keenliside W Kent G Sandford M C W | 1973 | Nature1973，246，： | 1 |
| 15 | Dexmedetomidine for diag- nostic cardiac catheterization in a child with idiopathic pulmonary hypertension显示文摘 | Munro H M Felix D E Nykanen D G | 2009 | J Clin Anesth2009，21，6： | 1 |
| 16 | The protein phosphatase inhibitor calyculin A mimicselicitor action in plant cells and induces rapid hyperphosphorylation of specific proteins as revealed by pulse labeling with[33P]phosphate显示文摘 | Felix G Regenass M Spanu P | | 0，，： | 1 |
| 17 | Modulation of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 on human coronary smooth muscle cells by cytokines显示文摘 | Braun M Pietsch P Felix SB Baumann G | 1995 | J Mol Cell Cardiol1995，27，12： | 1 |
| 18 | Iron:an essential cofactor for the conversion of laminocyclopropane-1-carboxylic acid to ethylene显示文摘 | BOUZAYEN M FELIX G LATCHE A PED JC BOLLER T | 1991 | Planta1991，，184： | 1 |
| 19 | Effects of platelet-activating factor on intracellular Ca2+ concentration and contractility in isolated cardiomyocytes显示文摘 | Pietsch P Hunger T Braun M Roediger A Baumann G Felix SB | 1998 | J Cardiovasc Pharmacol1998，31，5： | 1 |
| 20 | Specific perception of subnanomolar concentrations of chitin fragements by tomato cells:induction of extracellular alkalinization,changes in protein phosphorylation,and establishment of a refractory state显示文摘 | Felix G Regenass M Boller T | 1993 | Plant J1993，4，： | 1 |
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