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| 1 | The willow genome and divergent evolution from poplar after the common genome duplication显示文摘 | Xiaogang Dai Quanjun Hu Qingle Cai Kai Feng Ning Ye Gerald A Tuskan Richard Milne Yingnan Chen Zhibing Wan Zefu Wang Wenchun Luo Kun Wang Dongshi Wan Mingxiu Wang Jun Wang Jianquan Liu Tongming Yin | 2014 | Cell Research2014，24，10： | 28 |
| 2 | The Deep-Time Digital Earth program:data-driven discovery in geosciences显示文摘Current barriers hindering data-driven discoveries in deep-time Earth(DE)include:substantial volumes of DE data are not digitized;many DE databases do not adhere to FAIR(findable,accessible,interoperable and reusable)principles;we lack a systematic knowledge graph for DE;existing DE databases are geographically heterogeneous;a significant fraction of DE data is not in open-access formats;tailored tools are needed.These challenges motivate the Deep-Time Digital Earth(DDE)program initiated by the International Union of Geological Sciences and developed in cooperation with national geological surveys,professional associations,academic institutions and scientists around the world.DDE’s mission is to build on previous research to develop a systematic DE knowledge graph,a FAIR data infrastructure that links existing databases and makes dark data visible,and tailored tools for DE data,which are universally accessible.DDE aims to harmonize DE data,share global geoscience knowledge and facilitate data-driven discovery in the understanding of Earth’s evolution. | Chengshan Wang Robert MHazen Qiuming Cheng Michael HStephenson Chenghu Zhou Peter Fox Shu-zhong Shen Roland Oberhansli Zengqian Hou Xiaogang Ma Zhiqiang Feng Junxuan Fan Chao Ma Xiumian Hu Bin Luo Juanle Wang Craig M.Schiffries | 2021 | National Science Review2021，8，9： | 14 |
| 3 | COVID-19 Super Spreading Event Amongst Elderly Individuals—Jilin Province,China,January 2021显示文摘Summary What is already known on this topic?Clusters of COVID-19 cases often happened in small settings(e.g.,families,offices,school,or workplaces)that facilitate person-to-person virus transmission,especially from a common exposure.What is added by this report?On January 10 and 11,2021,an individual gave three product promotional lectures in Tonghua City. | Laishun Yao Mingyu Luo Tiewu Jia Xingang Zhang Zhulin Hou Feng Gao Xin Wang Xiaogang Wu Weihua Cheng Guoqian Li Jing Lu Bing Zhao Tao Li Enfu Chen Dapeng Yin Biao Huang | 2021 | China CDC weekly2021，3，10： | 13 |
| 4 | Plausible cloth animation using dynamic bending model显示文摘Simulating the mechanical behavior of a cloth is a very challenging and important problem in computer animation. The models of bending in most existing cloth simulation approaches are taking the assumption that the cloth is little deformed from a plate shape. Therefore, based on the thin-plate theory, these bending models do not consider the condition that the current shape of the cloth under large deformations cannot be regarded as the approximation to that before deformation, which leads to an unreal static bending. [This paper introduces a dynamic bending model which is appropriate to describe large out-plane deformations such as cloth buckling and bending, and develops a compact implementation of the new model on spring-mass systems. Experimental results show that wrinkles and folds generated using this technique in cloth simulation, can appear and vanish in a more natural way than other approaches.] | Chuan Zhou Xiaogang Jin Charlie C.L. Wang Jieqing Feng | 2008 | Progress in Natural Science:Materials International2008，18，7： | 8 |
| 5 | Photocatalytic degradation of trace-level of Microcystin-LR by nano-film of titanium dioxide显示文摘Microcystins, a group of hepatotoxin produced by cyanobacteria in eutrophic freshwater, have proven unreliable to be removed by conven-tional treatments. In this study, the photocatalytic degradation experiments of Microcystin-LR were conducted using nano-TiO2 thin film, prepared by sol- gel and dip-coating method, with low UVA intensity irradiation. Analysis results from SPE (solid-phase extraction) combined with HPLC method showed that Microcystin-LR whose initial concentration (μg/L) around that occurs naturally was easily to be re-moved by photocatalytic system. The degradation efficiency of toxin was influenced by the pH condi-tions, initial concentration and UV intensity. The maximum initial rate of photocatalytic degradation occurred at pH 4 and over 95% of 20 μg/L Micro-cystin-LR was decomposed within 120 min under 400μW/cm2 UV illumination. The kinetic equations and parameters revealed that degradation reaction of trace level MC-LR, which was depicted by Langmuir- Hinshelwood kinetics model, was in accordance with pseudo first order kinetics process in appearance well. Under the condition of pH=6.7, irradiation inten-sity=400 μW/cm2 and initial concentration=20 μg/L, the corresponding pseudo-first-order rate constant k and half-life were determined to be 0.0157 min?1 and 44 min, respectively. During the range of 200―1000 μW/cm2, the degradation rate increases with incident intensity to the 0.82 power and the corresponding apparent quantum yield (Φapp) was found to be 5.19× 10-8 g/J approximately. | FENG Xiaogang RONG Fei FU Degang YUAN Chunwei HU Yan | 2006 | Chinese Science Bulletin2006，51，10： | 8 |
| 6 | Electrochemically and DNA-triggered cell release from ferrocene/β-cyclodextrin and aptamer modified dual- functionalized graphene substrate显示文摘这里,我们报导 dual-functionalized 基于在 -cyclodextrin 之间的超分子的相互作用触发癌症房间版本的电气化学的底层(临床的试用 II aptamer AS1411 functionalized graphene 上的 -CD) 和 Fc 站台。一方面,主人客人相互作用能电气化学地是可逆的控制了认识到癌症房间捕获 / 释放,和 1-adamantylamine 绑定能进一步由和 CD 的竞争相互作用放大这个表面变化。在另一方面, AS1411 aptamer 和它的互补 DNA (cDNA ) 能也为房间粘附被用作一个可切换的锚。我们的工作给一个例子为没有标签, multi-functionalized 在修改表面也提供的 graphene 上为房间 catch-and-release 基于 aptamer 和 -CD/graphene-modified 表面和这个多方法触发了房间版本他们的潜在的生物医学的申请。 | Lingyan Feng Wen Li Jinsong Ren Xiaogang Qu | 2015 | Nano Research2015，8，3： | 3 |
| 7 | Poor outcomes of immunoglobulin D multiple myeloma patients in the era of novel agents:a single-center experience显示文摘Dear Editor, Multiple myeloma (MM) is a disease characterized by the clonal expansion of malignant plasma cells in the marrow, leading to anemia, hypercalcemia, bone lesion, and renal dysfunction [1]. Immunoglobulin D (IgD) myeloma is a rare subtype of MM, accounting for approximately 1% to 2% of all MM patients [2]. It occurs at a young age, often accom-panied with a high disease burden and short median sur-vival (18-21 months) [3, 4]. Several studies have suggested that in patients with IgD subtype, the outcomes of those who have had undergone autologous stem cell transplanta-tion (ASCT) were superior than those treated with chemo-therapy alone [5, 6]. However, these have been debatable as other reports have displayed opposite results [7, 8]. | Qian Zhao Feng Li Ping Song Xiaogang Zhou Zhiming An Jiangang Mei Jingjing Shao Hanqing Li Xuli Wang Xing Guo Yongping Zhai | 2019 | Cancer Communications2019，39，1： | 3 |
| 8 | Homocysteine aggravates cerebral hemorrhage in rats: Correlation with oxygen-free radical production and cell apoptosis in tissue surrounding hematoma显示文摘BACKGROUND:Previous studies have demonstrated that homocysteine is an independent risk factor for ischemic stroke,as determined by detection of apoptosis and oxygen-free radical scavengers following cerebral ischemia.However,the mechanisms of homocysteine remain unclear.Several reports have addressed the effects of homocysteine on ischemic stroke.OBJECTIVE:To analyze the effects of homocysteine on apoptosis,intracellular superoxide dismutase(SOD) activity,and malondialdehyde content in tissue surrounding hematoma in rats with cerebral hemorrhage,and to determine the action pathway of malondialdehyde following cerebral hemorrhage.DESIGN,TIME AND SETTING:The randomized,controlled,animal experiment was performed at the Laboratory of Molecular Biology,Hospital Affiliated to Luzhou Medical College,China from April 2007 to April 2008.MATERIALS:In situ apoptosis detection kit(Roche,Mannheim,Germany),SOD detection kit and malondialdehyde detection kit(Nanjing Jiancheng Bioengineering Institute,China),and homocysteine(Sigma,St Louis,MO,USA) were used in the present study.METHODS:A total of 75 Sprague Dawley rats were equally and randomly assigned to sham surgery,model,and homocysteine groups.Autologous blood was infused into the caudate putamen of rats to establish models of cerebral hemorrhage in model and homocysteine groups.Homocysteine was injected directly into the brain through the skull at the hematoma hemisphere at 30 minutes after model induction in the homocysteine group.MAIN OUTCOME MEASURES:At 6,12,24,and 72 hours,as well as 1 week,post-surgery,neurological deficits were observed in each group.Brain water content was measured using the dry-wet weight method.Cell apoptosis in tissue surrounding the hematoma was detected utilizing terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling(TUNEL).SOD activity and malondialdehyde content in tissue surrounding the hematoma were respectively measured using the xanthine oxidase and thiobarbituric acid methods.RESULTS:Neurological function was similar between model and homocysteine groups following cerebral hemorrhage(P > 0.05).Brain water content was increased at 12 hours post-surgery,peaked at 3 days,and remained unchanged at 7 days in the model group.Brain edema was not significantly aggravated following homocysteine intervention(P > 0.05),but SOD activity significantly decreased and malondialdehyde content significantly increased(P < 0.05).The number of apoptotic cells increased in rats with cerebral hemorrhage at 12 hours(P < 0.05),and numbers peaked at 72 hours following model establishment(P < 0.05).The time of peak value was identical between model and homocysteine groups.Brain water content was negatively associated with SOD activity(rmodel group =-0.448,P < 0.05;rhomocysteine group =-0.612,P < 0.05),but was positively associated with malondialdehyde content(rmodel group = 0.542,P < 0.05;rhomocysteine group = 0.684,P < 0.05) in brain tissues surrounding the hematoma following surgery in model and homocysteine groups.CONCLUSION:Homocysteine aggravates neurological dysfunction and brain edema in rats with cerebral hemorrhage.The mechanisms of action are likely associated with production of oxygen-free radical and cellular apoptosis following cerebral hemorrhage. | Yingying Liu Xinjun Li Chun Wang Chun Chen Ping Liu Qin Feng Duanxiu Liao Xiaogang Li | 2010 | Neural Regeneration Research2010，5，13： | 3 |
| 9 | Detecting Vulnerability on IoT Device Firmware: A Survey显示文摘Internet of things (IoT) devices make up 30%of all network-connected endpoints,introducing vulnerabilities and novel attacks that make many companies as primary targets for cybercriminals.To address this increasing threat surface,every organization deploying IoT devices needs to consider security risks to ensure those devices are secure and trusted.Among all the solutions for security risks,firmware security analysis is essential to fix software bugs,patch vulnerabilities,or add new security features to protect users of those vulnerable devices.However,firmware security analysis has never been an easy job due to the diversity of the execution environment and the close source of firmware.These two distinct features complicate the operations to unpack firmware samples for detailed analysis.They also make it difficult to create visual environments to emulate the running of device firmware.Although researchers have developed many novel methods to overcome various challenges in the past decade,critical barriers impede firmware security analysis in practice.Therefore,this survey is motivated to systematically review and analyze the research challenges and their solutions,considering both breadth and depth.Specifically,based on the analysis perspectives,various methods that perform security analysis on IoT devices are introduced and classified into four categories.The challenges in each category are discussed in detail,and potential solutions are proposed subsequently.We then discuss the flaws of these solutions and provide future directions for this research field.This survey can be utilized by a broad range of readers,including software developers,cyber security researchers,and software security engineers,to better understand firmware security analysis. | Xiaotao Feng Xiaogang Zhu Qing-Long Han Wei Zhou Sheng Wen Yang Xiang | 2023 | IEEE/CAA Journal of Automatica Sinica2023，10，1： | 2 |
| 10 | High-dimensional immune profiling by mass cytometry revealed immunosuppression and dysfunction of immunity in COVID-19 patients显示文摘The outbreak of coronavirus disease 2019(COVID-19)caused by the new virus SARS-CoV-2 has been announced as a public health emergency of international concern.1–3 The clinical features of patients with COVID-19 range from common fever and cough to other rare symptoms,such as diarrhea and nausea.This disease can progress quickly,and 2–3%of patients die within a short time,which is generally due to multiple organ failure.4–7 Clinically,COVID-19 patients are classified into mild,moderate,severe,and critical cases.5–7 The immune response against SARS-CoV-2 is probably linked to the severity of disease.Recently,Zheng et al.8 showed that elevated levels of T-cell exhaustion and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients;however,a more comprehensive understanding of the pathology of SARS-CoV-2 infection remains to be delineated.Here,we profiled immune cellular components using mass cytometry(CyTOF)to analyze the peripheral blood mononuclear cells(PBMCs)from patients with differences in disease progression by comparing with the PBMCs from healthy donors(HDs). | Wenjing Wang Bin Su Lijun Pang Luxin Qiao Yingmei Feng Yabo Ouyang Xianghua Guo Hongbo Shi Feili Wei Xiaogang Su Jiming Yin Ronghua Jin Dexi Chen | 2020 | Cellular & Molecular Immunology2020，17，6： | 2 |
| 11 | Enhanced production of glycyrrhetic acid 3-O-mono-β-D-glucuronide by fed-batch fermentation using p H and dissolved oxygen as feedback parameters显示文摘Glycyrrhetic acid 3-O-mono-β-D-glucuronide(GAMG), the major functional ingredient in licorice, has widespread applications in food, pharmacy and cosmetics industry. The production of GAMG through Penicillium purpurogenum Li-3 cultivation was for the first time performed through both batch and fed-batch processes in bioreactors. In batch process, under optimal conditions(p H 5.0, temperature 32 °C, agitation speed 100 r·min-1), 3.55 g·L-1GAMG was obtained in a 2.5 L fermentor. To further enhance GAMG production, a fine fed-batch process was developed by using p H and DO as feedback parameters. Starting from 48 h, 100 ml 90 g·L-1substrate Glycyrrhizin(GL) was fed each time when p H increased to above 5.0 and DO was increased to above 80%. This strategy can significantly enhance GAMG production: the achieved GL conversion was 95.34% with GAMG yield of 95.15%, and GAMG concentration was 16.62 g·L-1which was 5 times higher than that of batch. Then, a two-step separation strategy was established to separate GAMG from fermentation broth by crude extraction of 15 ml column packed with D101 resin followed by fine purification with preparative C18 chromatography. The obtained GAMG purity was 95.79%. This study provides a new insight into the industrial bioprocess of high-level GAMG production. | Bo Lu Xiaogang Yang Xudong Feng Chun Li | 2016 | Chinese Journal of Chemical Engineering2016，24，4： | 2 |
| 12 | Use of pervaporation for the separation of phenol from dilute aqueous solutions显示文摘 | Xiaogang Hao Mark Pritzker Xianshe Feng | 2009 | Journal of Membrane Science2009，335，： | 1 |
| 13 | Analysis of short fruiting branch gene and Marker-assisted selection with SNP linked to its trait in upland cotton显示文摘Background: With the rapid development of genomics, many functional genes have been targeted. Molecular marker assisted selection can accelerate the breeding process by linking selection to functional genes.Methods: In a study of upland cotton(Gossypium hirsutum L.), the F_2 segregated population was constructed by crossing X1570(short branches) with Ekangmian-13(long branches) to identify the short fruiting branch gene and marker-assisted selection with SNP(Single Nucleotide Polymorphisms, SNP) linked to its trait.Result: The result demonstrated that linked SSR marker BNL3232 was screened by BSA(Bulked segregant analysis,BSA) method; one SNP locus was found, which was totally separated from the fruiting branches trait in upland cotton.Conclusion: It was verified that this SNP marker could be used for molecular assisted selection of cotton architecture. | ZHANG Youchang FENG Changhui BIE Shu WANG Xiaogang ZHANG Jiaohai XIA Songbo QIN Hongde | 2018 | Journal of Cotton Research2018，1，1： | 1 |
| 14 | Functional isolation,culture and cryopreservation of adult human primary cardiomyocytes显示文摘Cardiovascular diseases are the most common cause of death globally.Accurately modeling cardiac homeostasis,dysfunction,and drug response lies at the heart of cardiac research.Adult human primary cardiomyocytes(hPCMs)are a promising cellular model,but unstable isolation efficiency and quality,rapid cell death in culture,and unknown response to cryopreservation prevent them from becoming a reliable and flexible in vitro cardiac model.Combing the use of a reversible inhibitor of myosinⅡATPase,(-)-blebbistatin(Bleb),and multiple optimization steps of the isolation procedure,we achieved a 2.74-fold increase in cell viability over traditional methods,accompanied by better cellular morphology,minimally perturbed gene expression,intact electrophysiology,and normal neurohormonal signaling.Further optimization of culture conditions established a method that was capable of maintaining optimal cell viability,morphology,and mitochondrial respiration for at least 7 days.Most importantly,we successfully cryopreserved hPCMs,which were structurally,molecularly,and functionally intact after undergoing the freeze-thaw cycle.hPCMs demonstrated greater sensitivity towards a set of cardiotoxic drugs,compared to human-induced pluripotent stem cell-derived cardiomyocytes(hiPSC-CMs).Further dissection of cardiomyocyte drug response at both the population and single-cell transcriptomic level revealed that hPCM responses were more pronouncedly enriched in cardiac function,whereas hiPSC-CMs responses reflected cardiac development.Together,we established a full set of methodologies for the efficient isolation and prolonged maintenance of functional primary adult human cardiomyocytes in vitro,unlocking their potential as a cellular model for cardiovascular research,drug discovery,and safety pharmacology. | Bingying Zhou Xun Shi Xiaoli Tang Quanyi Zhao Le Wang Fang Yao Yongfeng Hou Xianqiang Wang Wei Feng Liqing Wang Xiaogang Sun Li Wang Shengshou Hu | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 1 |
| 15 | Passivity of 316L stainless steel in borate buffer solution studied by Mott–Schottky analysis, atomic absorption spectrometry and X-ray photoelectron spectroscopy显示文摘 | Zhicao Feng Xuequn Cheng Chaofang Dong Lin Xu Xiaogang Li | 2010 | Corrosion Science2010，，11： | 1 |
| 16 | One-step, room temperature, colorimetric detection of mercury (Hg^2+) using DNA/ nanoparticle conjugates显示文摘 | XUE Xuejia WANG Feng LIU Xiaogang | 2008 | Journal of the American Chemical Society2008，130，11： | 1 |
| 17 | Simultaneous phase and size control of upconversion nanocrystals through lanthanide doping显示文摘 | WANG Feng HAN Yu LIU Xiaogang | 2010 | Nature2010，463，： | 1 |
| 18 | Impedance specifica- tions for stable DC distributed power system显示文摘 | FENG XIAOGANG LIU JINJUN LEE F C | 2002 | IEEE Transactions on Power Electronics2002，17，2： | 1 |
| 19 | User-controllable mesh segmentation using shape harmonic signature显示文摘Due to different shape modeling applications, partitioning a given complex 3D mesh model into some patches or meaningful subparts is one of the fundamental problems in digital geometry processing. By using the high-dimensional mean-shift clustering scheme in shape signature space, a new method is proposed which can generate user-specified segmentation results automatically for different applications. The shape signature is composed of mesh geometric attributes and its spectral harmonics. The latter one can reflect mesh frequency spectrum information. The low frequency components are essential for semantics-oriented segmentation, while the high frequency components are important for purely geometry-oriented segmentation. The effects of the proposed method are demonstrated by several examples. | Yongwei Miao Jieqing Feng Jinrong Wang Xiaogang Jin | 2009 | Progress in Natural Science:Materials International2009，19，4： | 1 |
| 20 | Impedance specifications for stable DC distributed power systems显示文摘 | Feng Xiaogang Liu Jinjun Lee F C | 2002 | IEEE Transactions on Power Electronics2002，17，2： | 1 |
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