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| 1 | High performance liquid chromatographic separation of eight drugs collected in Chinese Pharmacopoeia 2010 on amylose ramification chiral stationary phase显示文摘The enantiomers separation of ei ght pharmaceutical racemates collected in Chinese Pharmacopoeia 2010(Ch.P2010),including nitrendipine,felodipine,omeprazole,praziquantel,sulpiride,clenbuterol hydrochloride,verapamil hydrochloride and chlorphenamine maleate,was performed on chiral stationary phase of amylose ramification by high performance liquid chromatography(HPLC)on Chiralpak AD-H column and Chiralpak AS-H column with the mobile phase consisted of isopropanol and n-hexane.The detection wavelength and the flow rate were set at 254 nm and 0.7 mL/min,respectively.The effects of proportion of organic additives,alcohol displacer and temperature on the separation were investigated.The results indicated that eight chiral drugs were separated on chiral stationary phase of amylase ramification in normal phase chroma tographic system.The chromatographic retention and resolution of enantiomers were adjusted by factors,including the changes of the concentration of alcohol displacer in mobile phase,organic alkaline modifier and column temperature.It was shown that the resolution was improved with reducing concentration of alcohol displacer.When the concentration of organic alkaline modifier was 0.2%,the resolution and the peak shape were fairly good.Most racemates mentioned above had the best resolution at column temperature of 25℃.The best temperature should be kept unchanged in the process of separation so as to obtain stable separation results. | Yan Wang Ying Zhou Chao Ma Beibei Yang Ru Feng Yiying Zhang Jie Fu Wenjing Chen Yupeng Sun Jingyi Ma Qiming Zhang Yulin Deng Yukui Zhang Wenyi He | 2012 | Acta Pharmaceutica Sinica B2012，2，5： | 3 |
| 2 | 显示文摘 | YUAN Lijuan ZHANG Qinghe FENG Yukui | 2006 | J Chromatogr: A2006，1121，1： | 1 |
| 3 | The hydrogenmigration in cryogenic tubes of superconductive accelerator with gas source显示文摘Background In superconductive linear accelerator,the performance and stability can be impacted by gas adsorbed on cryogenic surfaces adversely.The cryogenic devices usually work at 4.2 K or 1.9 K and are refrigerated by normal or super fluid liquid helium,respectively.Purpose The purpose of this paper is to study the character of gas migration in cryogenic tubes.Method Adsorption coefficient for hydrogen at 4.2 K is measured by experimental study.Then,a gas migration model is established based on the experimental results to depict the hydrogen migration process in cryogenic tubes.Results The experimental results and model analysis indicated that at cryogenic temperature(4.2 K),adsorption coefficient for hydrogen is very close to 1,which is several orders higher than the adsorption coefficient at room temperature,resulting in a unique pressure distribution pattern in cryogenic tubes when compared with the pressure distribution in room temperature tubes.Conclusions At 4.2 K or 1.9 K,the gas migration process is obviously different from the process at room temperature and is significantly affected by the gas adsorption on the cryogenic surfaces.The model established in this article can be applied not only to hydrogen migration in cryogenic tubes but also to other gas migration in tubes with high adsorption coefficient. | Chuanfei Hu Feng Bai Wanhong Guo Yukui Yin Yugang Zhao Junhui Zhang | 2019 | Radiation Detection Technology and Methods2019，3，2： | 0 |
| 4 | 6-31 Progress of Cryogenic System in 2014显示文摘During the year of 2014, the work of cryogenic group was mainly focused on operation of refrigerator system,test of TCM1, design and machining of HCM6. At the end of 2014 refrigerator system has achieved closed-loopoperation and recycle of helium gas, which did great contribution to superconducting cavity and superconductingmagnet test. Since the refrigerator was put into use(Fig. 1), it has operated continuously and reliably for more than5 110 h, reached helium lique ed capacity 270 L/h at 850 W. | Zhang Junhui Guo Xiaohong Jin Tao Zhao Yugang Niu Xiaofei Wan Yuqin Su Hailin Han Yanning Yang Yonghui Bai Feng Jiang Ziyun Hu Chuanfei Zhang Peng Guo Wanhong Yin Yukui Liu Zuohui Hu Yongping Wang Xianjin | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 5 | 6-32 Design and Operation of Cryogenic Vertical Testing System for Superconducting Cavity显示文摘The superconducting accelerating segment in injectorⅡof Accelerator Driven Sub-critical System(ADS) uses superconductingcavities whose frequency are 162.5 MHz. The vertical performance of superconducting cavity devicesmust be tested at liquid helium temperature(2, 4.2 K) before being assembled in cryostat. To meet the runninggoal of the 0 25 MeV linac system, it is necessary to build a set of cryogenic testing system for superconductingcavity, which is used to test the performance of the superconducting cavity and whether cavity meet the designgoal. | Bai Feng Su Hailin Zhang Junhui Guo Xiaohong Hu Chuanfei Niu Xiaofei Zhang Peng Zhao Yugang Yin Yukui Guo Wanhong Liu Zuohui Wang Xianjin Hu Yongping | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 6 | Pressure controllable aptamers picking strategy by targets competition显示文摘Selection of aptamers with high affinity and good specificity requires multiple rounds of alternating steps of separation and PCR amplification.Herein,we proposed a novel high-efficiency aptamers picking strategy:One-round pressure controllable selection(OPCS).OPCS integrates four types of screening superiority,high-efficiency separation,one-round selection and PCR amplification,synchronous negative selection and targets competition.The controllable screening pressure can be achieved through two approaches,balanced competition by the regulation of protein concentration,and dominant competition by introducing a predatory protein with high concentration.In OPCS process,two proteins were co-incubated with one ssDNA library,and each protein bound its favorable sequences specifically and formed protein-ss D NA complex re spectively.Meanwhile,one protein could supply/sufferthe picking pressure of affinity and specificity to/from another,which eliminated weakly bound or unbound sequences for each other.Two complexes could be separated and collected conveniently,and aptamers for two proteins obtained synchronously with high affinity and good specificity.This strategy not only provides a more effective way for aptamers selection,but shows great potential in other ligands or drugs selection. | Ge Yang Chao Zhu Liping Zhao Linsen Li Yuanyu Huang Yukui Zhang Feng Qu | 2021 | Chinese Chemical Letters2021，32，1： | 0 |
| 7 | Additive-Controlled Kinetic Trapping of Quadruple Platinum(Ⅱ)Stacks with Emergent Photothermal Behaviors显示文摘Molecular chaperones are widely employed as additives in nature to trap proteins in the kinetic state,which inspire the development of kinetically trapped artificial supramolecular systems.Till now,such additive-controlled approaches have enabled the stabilization of extended supramolecular structures in the kinetically trapped state,while discrete assemblies with sufficient kinetic persistence are scarce.In this study,a Pt(Ⅱ)-based discrete supramolecular system has been constructed by taking advantage of Cu+-bridged ions as chaperone-like additives. | Zongchun Gao Yukui Tian Hung-Kai Hsu Yifei Han Yi-Tsu Chan Feng Wang | 2021 | CCS Chemistry2021，3，10： | 0 |
| 8 | 2K Cryogenic System Upgrade for CiADS and HIAF Superconducting Cavity Test显示文摘For the purpose of better performance,running stability and efficiency of CiADS and HIAF Superconducting Proton linac system,2K superfluid helium will be adopted for superconducting cavity cooling due to its specific properties,such as high thermal conductivity,low viscosity. | Zhang Junhui Niu Xiaofei Bai Feng Zhang Peng Zhao Yugang Yang Yonghui Yin Yukui Guo Wanhong Hu Jianjun Wang Xianjin | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 9 | 2017年低温系恒温器系统显示文摘ADS Injector-II linear accelerator is mainly composed of ECR ion source,LEBT,RFQ,MEBT,a superconducting accelerating segment and HEBT.The superconducting accelerating segment is composed of two HWR010 cavity cryomodules,a taper cavity cryomodule and a spoke cavity cryomodule(CM1+CM2+CM3+CM4),which has accelerated the proton beam to 25 MeV in Jun.2017. | Zhang Junhui Guo Xiaohong Bai Feng Wan Yuqin Hu Chuanfei Niu Xiaofei Zhang Peng Zhao Yugang Yin Yukui Guo Wanhong Hu Jianjun Wang Xianjin Han Yanning | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
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