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| 1 | PROTAC-induced BTK degradation as a novel therapy for mutated BTK C481S induced ibrutinib-resistant B-cell malignancies显示文摘 | Yonghui Sun Xingwang Zhao Ning Ding Hongying Gao Yue Wu Yiqing Yang Meng Zhao Jinseok Hwang Yuqin Song Wanli Liu Yu Rao | 2018 | Cell Research2018，28，7： | 29 |
| 2 | Characterizing the dynamics of soil organic carbon in grasslands on the Qinghai-Tibetan Plateau显示文摘Carbon dynamics of grasslands on the Qinghai-Tibetan Plateau may play an important role in regional and global carbon cycles. The CENTURY model (Version 4.5) is used to examine temporal and spatial variations of soil organic carbon (SOC) in grasslands on the Plateau for the period from 1960 to 2002. The model successfully simulates the dynamics of aboveground carbon and soil surface SOC at the soil depth of 0-20 cm and the simulated results agree well to the measurements. Examination of SOC for eight typical grasslands shows different patterns of temporal variation in different ecosystems in 1960-2002. The extent of temporal variation increases with the increase of SOC of ecosystem. SOC increases first and decreases quickly then during the period from 1990 to 2000. Spatially, SOC density obtained for the equilibrium condition declines gradually from the southeast to the northwest on the plateau and showed a high heterogeneity in the eastern plateau. The results suggest that (i) SOC den-sity in the alpine grasslands shows remarkable response to climate change during the 42 years, and (ii) the net carbon exchange rate between the alpine grassland ecosystems and the atmosphere increases from 1990 to 2000 as compared with that before 1990. | ZHANG YongQiang TANG YanHong JIANG Jie YANG YongHui | 2007 | Science China Earth Sciences2007，50，1： | 25 |
| 3 | The oasis expansion and eco-environment change over the last 50 years in Manas River Valley, Xinjiang显示文摘The oasis expansion and economic development of the Manas River Valley is one of the most successful examples in Xinjiang. In this paper, the oasis spatial distribution pattern and dynamic change were examined using imageries of Landsat MSS, TM and ETM, land use and topographic maps in six different periods (such as 1949, 1962, 1976, 1989, 1999 and 2001) over the last 50 years in the valley. The oasis expansion process could be divided into two stages according to the annual rate of oasis area increase, the fast oasization stage (from 1949 to 1976) when the oasis area ex-panded from 156.385 km2 in 1949 to 3,639.491 km2 in 1976 because of rapidly increased population and quickly enlarged farmland area; and the urbanization stage (from 1976 to 2001) when the ex-pansion ratio of farmland slowed down, and the urbanization process quickened, the total oasis area reached 5042.440 km2 in 2001. With the continuous expansion of oasis and farmland, a large quantity of river water was drawn into irrigation ditch and plain lakes, so only a small quantity of river water could flow into lakes, as a result, the Manas Lake dried up, salization and basification problems happened in the low-lying oasis region. The natural swamp around the lake was shrunk greatly and biodiversity decreased significantly. The driving force analysis reveals that human activities, such as reclamation and population growth, played a major role in the oasis expansion and ecological dete-rioration in the Manas River Valley. So further efforts should be made to improve the efficiency of water resource utility and adjust layout of the regional agricultural and animal husbandry to keep the sustainable development of oasis economic belt of the northern slope of Tianshan Mts. | CHENG Weiming ZHOU Chenghu LIU Haijiang ZHANG Yang JIANG Yan ZHANG Yichi YAO Yonghui | 2006 | Science China Earth Sciences2006，49，2： | 24 |
| 4 | Changing patterns and survival improvements of young breast cancer in China and SEER database, 1999-2017显示文摘Objective: Breast cancer in young females was usually considered more aggressive and requires aggressive therapy. We investigated whether early detection and improved treatments changed the patterns of characteristics,management and outcomes of young breast cancer patients over time.Methods: Females under 40 years of age diagnosed with breast cancer during the periods 1999-2017 and1999-2015 were identified in the Fudan University Shanghai Cancer Center(FUSCC) and the population-based Surveillance, Epidemiology, and End Results(SEER) registry, respectively. Clinicopathologic characteristics and treatment information were collected. Patients diagnosed before 2013 were followed up.Results: The proportions of young breast cancer patients were 15.0% and 5.3% in the FUSCC and SEER cohorts, respectively. In the FUSCC cohort, there was a significant increase in the proportion of ductal carcinoma in situ(DCIS)(from 8.8% to 16.9%;P<0.0001) and it remained stable in SEER cohort. The proportion of T1-stage tumors increased dramatically in the FUSCC cohort(from 35.3% to 41.9%;P=0.008), whereas it decreased in SEER cohort(from 42.4% to 33.0%;P<0.0001). The percentage of estrogen receptor(ER)-positive cancers was consistently increased in both the invasive ductal carcinoma(IDC) and DCIS patients in the two cohorts. Breastconserving surgery and immediate implant reconstruction after mastectomy both exhibited increased use over time in the FUSCC cohort. Both the FUSCC and SEER cohorts showed a significantly better prognosis in the recent time period.Conclusions: With the increased early-stage and ER-positive diseases in young patients as well as better systemic treatment strategies, improved survival has been observed in recent years. There has been a substantial deescalation in surgical therapies in young breast cancer patients. | Rong Guo Jing Si Jingyan Xue Yonghui Su Miao Mo Benlong Yang Qi Zhang Weiru Chi Yayun Chi Jiong Wu | 2019 | Chinese Journal of Cancer Research2019，31，4： | 24 |
| 5 | A review of the estimation of downward surface shortwave radiation based on satellite data:Methods, progress and problems显示文摘The estimation of downward surface shortwave radiation(DSSR)is important for the Earth’s energy budget and climate change studies.This review was organised from the perspectives of satellite sensors,algorithms and future trends,retrospects and summaries of the satellite-based retrieval methods of DSSR that have been developed over the past 10 years.The shortwave radiation reaching the Earth’s surface is affected by both atmospheric and land surface parameters.In recent years,studies have given detailed considerations to the factors which affect DSSR.It is important to improve the retrieval accuracy of cloud microphysical parameters and aerosols and to reduce the uncertainties caused by complex topographies and high-albedo surfaces(such as snow-covered areas)on DSSR estimation.This review classified DSSR retrieval methods into four categories:empirical,parameterisation,look-up table and machine-learning methods,and evaluated their advantages,disadvantages and accuracy.Further efforts are needed to improve the calculation accuracy of atmospheric parameters such as cloud,haze,water vapor and other land surface parameters such as albedo of complex terrain and bright surface,organically combine machine learning and other methods,use the new-generation geostationary satellite and polar orbit satellite data to produce highresolution DSSR products,and promote the application of radiation products in hydrological and climate models. | Husi LETU Jiancheng SHI Ming LI Tianxing WANG Huazhe SHANG Yonghui LEI Dabin JI Jianguang WEN Kun YANG Liangfu CHEN | 2020 | Science China Earth Sciences2020，63，6： | 8 |
| 6 | Micro/nano-structured TiO2 surface with dual-functional antibacterial effects for biomedical applications显示文摘Implant-associated infections are generally difficult to cure owing to the bacterial antibiotic resistance which is attributed to the widespread usage of antibiotics.Given the global threat and increasing influence of antibiotic resistance,there is an urgent demand to explore novel antibacterial strategies other than using antibiotics.Recently,using a certain surface topography to provide a more persistent antibacterial solution attracts more and more attention.However,the clinical application of biomimetic nano-pillar array is not satisfactory,mainly because its antibacterial ability against Gram-positive strain is not good enough.Thus,the pillar array should be equipped with other antibacterial agents to fulfill the bacteriostatic and bactericidal requirements of clinical application.Here,we designed a novel model substrate which was a combination of periodic micro/nano-pillar array and TiO2 for basically understanding the topographical bacteriostatic effects of periodic micro/nano-pillar array and the photocatalytic bactericidal activity of TiO2.Such innovation may potentially exert the synergistic effects by integrating the persistent topographical antibacterial activity and the non-invasive X-ray induced photocatalytic antibacterial property of TiO2 to combat against antibiotic-resistant implant-associated infections.First,to separately verify the topographical antibacterial activity of TiO2 periodic micro/nano-pillar array,we systematically investigated its effects on bacterial adhesion,growth,proliferation,and viability in the dark without involving the photocatalysis of TiO2.The pillar array with sub-micron motif size can significantly inhibit the adhesion,growth,and proliferation of Staphylococcus aureus(S.aureus)and Escherichia coli(E.coli).Such antibacterial ability is mainly attributed to a spatial confinement size-effect and limited contact area availability generated by the special topography of pillar array.Moreover,the pillar array is not lethal to S.aureus and E.coli in 24 h.Then,the X-ray induced photocatalytic antibacterial property of TiO2 periodic micro/nano-pillar array in vitro and in vivo will be systematically studied in a future work.This study could shed light on the direction of surface topography design for future medical implants to combat against antibiotic-resistant implant-associated infections without using antibiotics. | Xiang Ge Chengzu Ren Yonghui Ding Guang Chen Xiong Lu Kefeng Wang Fuzeng Ren Meng Yang Zhuochen Wang Junlan Li Xinxin An Bao Qian Yang Leng | 2019 | Bioactive Materials2019，4，1： | 8 |
| 7 | Folate receptor-mediated boron-10 containing carbon nanoparticles as potential delivery vehicles for boron neutron capture therapy of nonfunctional pituitary adenomas显示文摘Invasive nonfunctional pituitary adenomas(NFPAs) are difficult to completely resect and often develop tumor recurrence after initial surgery.Currently,no medications are clinically effective in the control of NFPA.Although radiation therapy and radiosurgery are useful to prevent tumor regrowth,they are frequently withheld because of severe complications.Boron neutron capture therapy(BNCT) is a binary radiotherapy that selectively and maximally damages tumor cells without harming the surrounding normal tissue.Folate receptor(FR)-targeted boron-10 containing carbon nanoparticles is a novel boron delivery agent that can be selectively taken up by FR-expressing cells via FR-mediated endocytosis.In this study,FR-targeted boron-10 containing carbon nanoparticles were selectively taken up by NFPAs cells expressing FR but not other types of non-FR expressing pituitary adenomas.After incubation with boron-10 containing carbon nanoparticles and following irradiation with thermal neutrons,the cell viability of NFPAs was significantly decreased,while apoptotic cells were simultaneously increased.However,cells administered the same dose of FR-targeted boron-10 containing carbon nanoparticles without neutron irradiation or received the same neutron irradiation alone did not show significant decrease in cell viability or increase in apoptotic cells.The expression of Bcl-2 was down-regulated and the expression of Bax was up-regulated in NFPAs after treatment with FR-mediated BNCT.In conclusion,FR-targeted boron-10 containing carbon nanoparticles may be an ideal delivery system of boron to NFPAs cells for BNCT.Furthermore,our study also provides a novel insight into therapeutic strategies for invasive NFPA refractory to conventional therapy,while exploring these new applications of BNCT for tumors,especially benign tumors. | DAI CongXin CAI Feng HWANG Kuo Chu ZHOU YongMao ZHANG ZiZhu LIU XiaoHai MA SiHai YANG YaKun YAO Yong FENG Ming BAO XinJie LI GuiLin WEI JunJi JIAO YongHui WEI ZhenQing MA WenBin WANG RenZhi | 2013 | Science China(Life Sciences)2013，56，2： | 8 |
| 8 | Seasonal variation of snow microbial community structure in the East Rongbuk glacier, Mt. Everest显示文摘The bacterial diversity and abundance in the snow of East Rongbuk glacier, Mt. Everest were examined through 16S rRNA gene clone library and flow cytometry approaches. In total, 35 16S rRNA gene sequences were obtained, which belong to α, β, γ-Proteobacteria, Actinobacteria, Firmicutes, CFB, Cyanobacteria, Eukaryotic chloroplast, and TM7 candidate phylum respectively. γ-Proteobacteria was the dominant bacterial group in this region, while the genera Acinetobacter and Leclercia were domi- nant on the genus level. The community structure varied seasonally. The bacterial abundance in sum- mer snow was higher than that in winter. Moreover, the snow bacterial community structures in both seasons were diverse, with not only common species but season-specific species. The common species most likely originated from the Tibet Plateau. Bacteria in summer snow are affiliated with marine environ- ment, whereas bacteria in winter snow are closely related to more diverse environments and show the feature of resistance to cold. Seasonal variations of abundance and bacterial diversity were most proba- bly due to the seasonal characteristics of climate and atmospheric circulation in Mt. Everest. | LIU Yongqin YAO Tandong KANG Shichang JIAO Nianzhi ZENG Yonghui SHI Yang LUO Tingwei JING Zhefang HUANG Shijun | 2006 | Chinese Science Bulletin2006，51，12： | 7 |
| 9 | Genome-wide identification of Gossypium INDETERMINATE DOMAIN genes and their expression profiles in ovule development and abiotic stress responses显示文摘Background:INDETERMINATE DOMAIN(IDD)transcription factors form one of the largest and most conserved gene families in plant kingdom and play important roles in various processes of plant growth and development,such as flower induction in term of flowering control.Till date,systematic and functional analysis of IDD genes remained infancy in cotton.Results:In this study,we identified total of 162 IDD genes from eight different plant species including 65 IDD genes in Gossypium hirsutum.Phylogenetic analysis divided IDDs genes into seven well distinct groups.The gene structures and conserved motifs of GhIDD genes depicted highly conserved exon-intron and protein motif distribution patterns.Gene duplication analysis revealed that among 142 orthologous gene pairs,54 pairs have been derived by segmental duplication events and four pairs by tandem duplication events.Further,Ka/Ks values of most of orthologous/paralogous gene pairs were less than one suggested the purifying selection pressure during evolution.Spatiotemporal expression pattern by qRT-PCR revealed that most of the investigated GhIDD genes showed higher transcript levels in ovule of seven days post anthesis,and upregulated response under the treatments of multiple abiotic stresses.Conclusions:Evolutionary analysis revealed that IDD gene family was highly conserved in plant during the rapid phase of evolution.Whole genome duplication,segmental as well as tandem duplication significantly contributed to the expansion of IDD gene family in upland cotton.Some distinct genes evolved into special subfamily and indicated potential role in the allotetraploidy Gossypium hisutum evolution and development High transcript levels of GhIDD genes in ovules illustrated their potential roles in seed and fiber development Further,upregulated responses of GhIDD genes under the treatments of various abiotic stresses suggested them as important genetic regulators to improve stress resistance in cotton breeding. | ALI Faiza QANMBER Ghulam LI Yonghui MA Shuya LU Lili YANG Zuoren WANG Zhi LI Fuguang | 2019 | Journal of Cotton Research2019，2，1： | 5 |
| 10 | Biological applications of copper-containing materials显示文摘Copper is an indispensable trace metal element in the human body,which is mainly absorbed in the stomach and small intestine and excreted into the bile.Copper is an important component and catalytic agent of many enzymes and proteins in the body,so it can influence human health through multiple mechanisms.Based on the biological functions and benefits of copper,an increasing number of researchers in the field of biomaterials have focused on developing novel copper-containing biomaterials,which exhibit unique properties in protecting the cardiovascular system,promoting bone fracture healing,and exerting antibacterial effects.Copper can also be used in promoting incisional wounds healing,killing cancer cells,Positron Emission Tomography(PET)imaging,radioimmunological tracing and radiotherapy of cancer.In the present review,the biological functions of copper in the human body are presented,along with an overview of recent progress in our understanding of the biological applications and development of copper-containing materials.Furthermore,this review also provides the prospective on the challenges of those novel biomaterials for future clinical applications. | Peng Wang Yonghui Yuan Ke Xu Hongshan Zhong Yinghui Yang Shiyu Jin Ke Yang Xun Qi | 2021 | Bioactive Materials2021，6，4： | 5 |
| 11 | Recyclable Fenton-like catalyst based on zeolite Y supported ultrafine,highly-dispersed Fe_2O_3 nanoparticles for removal of organics under mild conditions显示文摘A versatile wet impregnation method was employed to conveniently and controllably deposit Fe_2O_3 nanoparticles on zeolites including commercial Y, mordenite and ZSM-5 with the similar framework Si/Al ratios and crystal sizes, respectively. The ultrafine Fe_2O_3 nanoparticles in size of 5 nm can be highly dispersed on zeolite Y matrix due to its much better wettability than ZSM-5 and mordenite. By using the obtained Fe_2O_3/zeolite composite as the heterogeneous Fenton-like catalysts, the degradation of phenol as a model reaction was systematically investigated, including the zeolite supports, particle size and dispersion of Fe_2O_3, and reaction conditions of H_2O_2 concentration, temperature, and pH value. The catalyst based on zeolite Y with Fe loading of 9% exhibited the best phenol degradation efficiency (> 90%)in neutral pH within 2 h. Its high catalytic activity in Fenton reaction can be attributed to the bifunctional properties of strong surface BrФnsted acidity and high reactivity of octahedral Fe^(3+) in the highlydispersed ultrafine Fe_2O_3 nanoparticles in size of 5 nm, which were the primary active centers to quickly decompose H_2O_2 into hydroxyl radicals. Since phenol degradation can be performed under mild conditions of ambient temperature (283-323 K) and a wide pH range (4.0-7.0), the catalysts can be easily recovered for recyclable use with stable degradation activity, which own the immense potential in deep treatment of organic pollutants in industrial wastewater. | Xuanyu Yang Xiaowei Cheng Ahmed A.Elzatahry Jinyang Chen Abdulaziz Alghamdi Yonghui Deng | 2019 | Chinese Chemical Letters2019，30，2： | 4 |
| 12 | Differential protein expression in spinal cord tissue of a rabbit model of spinal cordischemia/reperfusion injury显示文摘New Zealand rabbits were randomly divided into an ischemia group(occlusion of the abdominal aorta for 60 minutes),an ischemia-reperfusion group(occlusion of the abdominal aorta for 60 minutes followed by 48 hours of reperfusion) and a sham-surgery group.Two-dimensional gel electrophoresis detected 49 differentially expressed proteins in spinal cord tissue from the ischemia and ischemia/reperfusion groups and 23 of them were identified by mass spectrometry.In the ischemia group,the expression of eight proteins was up regulated,and that of the remaining four proteins was down regulated.In the ischemia/reperfusion group,the expression of four proteins was up regulated,and that of two proteins was down regulated.In the sham-surgery group,only one protein was detected.In the ischemia and ischemia/reperfusion groups,four proteins overlapped between groups with the same differential expression,including three that were up regulated and one down regulated.These proteins were related to energy metabolism,cell defense,inflammatory mechanism and cell signaling. | Qi Gao Yonghui Liang Xiaoyu Yang Guifeng Liu Xiaoxue Li Benqing Zhu Jian Liu Maoguang Yang Weiwei Xia Jian Dong Jianhang Jiao | 2012 | Neural Regeneration Research2012，7，20： | 4 |
| 13 | The progress on antifouling organic coating: From biocide to biomimetic surface显示文摘The advancement in material science and engineering technology has led to the development of antifouling(AF) coatings which are cheaper, durable, less toxic, and safe to the environment. The use of AF coatings containing tributyltin compounds was prohibited at the beginning of 2003, this necessitated the development of environmentally friendly coatings. The fouling release coating(FRC) lacks biocides and has low surface energy, low elastic modulus with smooth surface properties, hence a better release effect to fouling organisms. Several functional coatings have been recently developed based on fouling release(FR) technology to combat the effects of biofouling. Here, we provide a brief overview of innovative technologies and recent developments based on FRCs, including silicone, modified fluorinated polymer,cross-linked coatings, amphiphilic copolymer coating, hydrogel coatings, and biomimetic coatings. We also highlight the key issues and shortcomings of innovative technologies based on FRCs. This may give new insights into the future development of marine AF coatings. | Xu Han Jianhua Wu Xianhui Zhang Junyou Shi Jiaxin Wei Yang Yang Bo Wu Yonghui Feng | 2021 | Journal of Materials Science & Technology2021，，2： | 2 |
| 14 | Profiling human protein degradome delineates cellular responses to proteasomal inhibition and reveals a feedback mechanism in regulating proteasome homeostasis显示文摘在蛋白质周转(蛋白质 degradome ) 的全球变化组成对内在或外来的刺激的细胞的回答的中央部分。然而,介绍蛋白质 degradome 仍然保持技术上挑战性。最近, proteasome 的抑制,例如由使用 bortezomib (BTZ ) ,为对待多重骨髓瘤和其它人恶意,但是药行动和肿瘤药抵抗还有待于被完成的为 BTZ 的机制的系统的理解作为主要化学疗法的策略出现了。这里,我们开发了并且适用 dual-fluorescence-based 蛋白质周转试金(ProTA ) 到份量上在导致 BTZ 的 proteasomal 抑制之上在人的蛋白质 degradome 介绍全球变化。ProTA 和随后的网络分析描出在 BTZ 化疗的 BTZ 行动和肿瘤药抵抗的潜在的分子的基础。最后,把 BTZ 的使用与指向识别 ProTA 的关键基因的药相结合或在 BTZ 行动的小径在多重骨髓瘤房间减少了 BTZ 抵抗。显著地, BTZ 稳定 proteasome 子单元 PSMC1 和 proteasome 集会因素 PSMD10,建议为调整 proteasome 动态平衡的以前下面欣赏的机制。因此, ProTA 是为介绍人的蛋白质 degradome 阐明的一个新奇工具药行动和抵抗的潜在的机制,它可能便于指向 proteostasis 对待人的混乱的治疗学的开发。 | Tao Yu Yonghui Tao Meiqiang Yang Peng Chen Xiaobo Gao Yanbo Zhang Tao Zhang Zi Chen Jian Hou Yan Zhang Kangcheng Ruan Hongyan Wang Ronggui Hu | 2014 | Cell Research2014，24，10： | 2 |
| 15 | Shifting from homogeneous to heterogeneous surfaces in estimating terrestrial evapotranspiration: Review and perspectives显示文摘Terrestrial evapotranspiration(ET)is a crucial link between Earth’s water cycle and the surface energy budget.Accurate measurement and estimation remain a major challenge in geophysical,biological,and environmental studies.Pioneering work,represented by Dalton and Penman,and the development of theories and experiments on turbulent exchange in the atmospheric boundary layer(ABL),laid the foundation for mainstream methodologies in ET estimation.Since the 1990s,eddy covariance(EC)systems and satellite remote sensing have been widely applied from cold to tropical and from arid to humid regions.They cover water surfaces,wetlands,forests,croplands,grasslands,barelands,and urban areas,offering an exceptional number of reports on diverse ET processes.Surface nocturnal ET,hysteresis between ET and environmental forces,turbulence intermittency,island effects on heterogeneous surfaces,and phase transition between underlying surfaces are examples of reported new phenomena,posing theoretical and practical challenges to mainstream ET methodologies.Additionally,based on non-conventional theories,new methods have emerged,such as maximum entropy production and nonparametric approaches.Furthermore,high-frequency on-site observation and aerospace remote sensing technology in combination form multi-scale observations across plant stomata,leaves,plants,canopies,landscapes,and basins.This promotes an insightful understanding of diverse ET processes and synthesizes the common mechanisms of the processes between and across spatial and temporal scales.All the recent achievements in conception,model,and technology serve as the basis for breaking through the known difficulties in ET estimation.We expect that they will provide a rigorous,reliable scientific basis and experimental support to address theoretical arguments of global significance,such as the water-heat-carbon cycle,and solve practical needs of national importance,including agricultural irrigation and food security,precise management of water resources and eco-environmental protection,and regulation of the urban thermal environment and climate change adaptation. | Yuanbo LIU Guoyu QIU Hongsheng ZHANG Yonghui YANG Yinsheng ZHANG Quan WANG Wenzhi ZHAO Li JIA Xibin JI Yujiu XIONG Chunhua YAN Ning MA Shumin HAN Yifan CUI | 2022 | Science China Earth Sciences2022，65，2： | 2 |
| 16 | Recent advance in synthesis and application of heteroatom zeolites显示文摘Incorporation of heteroatoms into the framewo rk of zeolites has become a significant strategy to improve their performance in catalysis and adsorption,because the obtained heteroatom zeolites exhibit quite different properties from the conventional aluminosilicate zeolites in aspects of surface acidity,pore structures,particle size and so on.In this review,the progress on the heteroatom zeolites including their synthesis and application is highlighted.First,the recent advance on the design and synthesis of different heteroatom zeolites is summarized.Special emphasis is placed on the introduction and comparison of three typical methods,including the direct synthesis,post synthesis and improved direct synthesis,for the traditional heteroatom zeolites(such as TS-1,Sn-MFI,Sn-β) and newly-reported heteroatom zeolites(such as W-MFI,Mo-MFI).According to their intrinsic characteristics,the application of heteroatom zeolites in diverse fields,such as production of fine chemicals,air pollution control and biomass conversion is then discussed.Finally,the challenges and perspective on the future development of heteroatom zeolites in low-cost preparation and practical application are proposed. | Tingting Pang Xuanyu Yang Chenyi Yuan Ahmed A.Elzatahry Abdulaziz Alghamdi Xing He Xiaowei Cheng Yonghui Deng | 2021 | Chinese Chemical Letters2021，32，1： | 2 |
| 17 | Osteogenesis stimulation by copper-containing 316L stainless steel via activation of akt cell signaling pathway and Runx2 upregulation显示文摘As a metallic orthopedic implant,316L stainless steel(316L SS)is used extensively for its good resistance to corrosion and mechanical properties.However,it takes a long time to achieve osseointegration between 316L SS and adjacent tissues due to its bio-inert characteristic.Hence,the aim is to improve the bio-adaption of 316L SS.A good approach is to add elements to materials to improve their osteogenic capabilities by the appropriate release of ions.Hence copper-containing 316L stainless steel(316L-Cu SS)was investigated in this work,where Cu is an essential trace element that can stimulates osteogenesis.It was found that 316L-Cu SS was bio-safe and did not affect the proliferation of co-cultured osteoblasts in comparison with 316L SS.It increased cell apoptosis on day 1 but inhibited it on day 3,which cooperates with new bone formation processes.Osteoblasts extend themselves more quickly and in a better manner on the surface of 316L-Cu SS,wheneven more pseudopodia are present.Furthermore,the gene expression of alkaline phosphatase,collagen I and runt-related transcription factor 2(Runx2)in osteoblasts cultured with 316L-Cu SS was significantly enhanced.Runx2 protein expression increased,and osteogenesis was stimulated by 316L-Cu SS via an Akt cell signaling pathway.In conclusion,316L-Cu SS stimulates osteogenesis through activation of the Akt cell signaling pathway and the upregulation of Runx2.Thus,316L-Cu SS is a promising material that may be used in surgical implants to stimulate osteogenesis. | Yonghui Yuan Shujing Jin Xun Qi Xudong Chen Wei Zhang Ke Yang Hongshan Zhong | 2019 | Journal of Materials Science & Technology2019，35，11： | 2 |
| 18 | In Vivo Study on Degradation Behavior and Histologic Response of Pure Magnesium in Muscles显示文摘When an orthopedics device is implanted into bone injury site, it will contact the soft tissue(skeletal muscle, fascia, ligament etc.) except for bone. Magnesium based biodegradable metals are becoming an important research object in orthopedics due to their bioactivity to promote bone healing. In this study,pure Mg rods with and without chemical conversion coating were implanted into the muscle tissue of rabbits. Implants and their surrounding tissues were taken out for weight loss measurement, crosssectional scanning electron microscopy observation, elemental distribution analysis and histological examination. The results showed that the chemical conversion coating would increase the in vivo corrosion resistance of pure Mg and decrease the accumulation of calcium(Ca) and phosphorus(P) elements around the implants. For the bare magnesium implant, both Ca and P contents in the surrounding tissues increased at the initial stage of implantation and then decreased at 12 weeks implantation, while for the magnesium with chemical conversion coating, Ca and P contents in the surrounding tissues decreased with the implantation time, but were not significant. The histological results demonstrated that there was no calcification in the muscle tissue with implantation of magnesium for up to 12 weeks. The chemical conversion coating not only increased the in vivo corrosion resistance of pure Mg, but also avoided the depositions of Ca and P in the surrounding tissues, meaning that pure magnesium should be biosafe when contacting with muscle tissues. | Shanshan Chen Lili Tan Bingchun Zhang Yonghui Xia Ke Xu Ke Yang | 2017 | Journal of Materials Science & Technology2017，33，5： | 2 |
| 19 | Sulfonic acid-functionalized core-shell Fe_(3)O_(4)@carbon microspheres as magnetically recyclable solid acid catalysts显示文摘Green and recyclable solid acid catalysts are in urgent demand as a substitute for conventional liquid mineral acids.In this work,a series of novel sulfonic acid-functionalized core-shell Fe_(3)O_(4)@carbon microspheres(Fe_(3)O_(4)@C-SO_(3)H)have been designed and synthesized as an efficient and recyclable heterogeneous acid catalyst.For the synthesis,core-shell Fe_(3)O_(4)@RF(resorcinol-formaldehyde)microspheres with tunable shell thickness were achieved by interfacial polymerization on magnetic Fe_(3)O_(4)microspheres.After high-temperature carbonization,the microspheres were eventually treated by surface sulfonation,re sulting in Fe_(3)O_(4)@C-x-SO_(3)H(x stands for carbonization temperature)microspheres with abundant surface SO_(3)H groups.The obtained microspheres possess uniform core-shell structure,partially-graphitized carbon skeletons,superparamagnetic property,high magnetization saturation value of 10.6 emu/g,and rich SO_(3)H groups.The surface acid amounts can be adju sted in the range of 0.59-1.04 mmol/g via sulfonation treatment of carbon shells with different graphitization degrees.The magnetic Fe_(3)O_(4)@C-x-SO_(3)H microspheres were utilized as a solid acid catalyst for the acetalization reaction between benzaldehyde and ethylene glycol,demonstrating high selectivity(97%)to benzaldehyde ethylene glycol acetal.More importantly,by applying an external magnetic field,the catalysts can be easily separated from the heterogeneous reaction solutions,which later show well preserved catalytic activity even after 9 cycles,revealing good recyclability and high stability. | Chenyi Yuan Xiqing Wang Xuanyu Yang Abdulaziz AAlghamdi Fahad AAlharthi Xiaowei Cheng Yonghui Deng | 2021 | Chinese Chemical Letters2021，32，6： | 2 |
| 20 | Agricultural water-saving and sustainable groundwater management in ShijiazhuangIrrigation District, North China Plain显示文摘 | Hu Yukun Moiwo JP Yang Yonghui | 2010 | Journal of Hydrology2010，393，34： | 1 |
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