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| 1 | Dasatinib inhibits proliferation of liver cancer cells,but activation of Akt/mTOR compromises dasatinib as a cancer drug显示文摘Dasatinib is a multi-target protein tyrosine kinase inhibitor.Due to its potent inhibition of Src,Abl,the platelet-derived growth factor receptor(PDGFR)family kinases,and other oncogenic kinases,it has been investigated as a targeted therapy for a broad spectrum of cancer types.However,its efficacy has not been significantly extended beyond leukemia.The mechanism of resistance to dasatinib in a wide array of cancers is not clear.In the present study,we investigated the effect of dasatinib on hepatocellular carcinoma cell growth and explored the underlying mechanisms.Our results showed that dasatinib potently inhibited the proliferation of SNU-449 cells,but not that of other cell lines,such as SK-Hep-1,even though it inhibited the phosphorylation of Src on both negative and positive regulation sites in all these cells.Dasatinib activated the phosphoinositide-dependent protein kinase1(PDK1)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR)signaling pathway in SK-Hep-1 cells,but not in SNU-449 cells.Blocking the Akt/mTOR signaling pathway strongly promoted the efficacy of dasatinib in SK-Hep-1 cells.In SNU-449 cells,dasatinib promoted apoptosis and the cleavage of caspase-3 and caspase-7,induced cell cycle arrest in the G1 phase,and inhibited the expression of Cyclin-dependent kinase(CDK4)/6/CyclinD1 complex.These findings demonstrate that dasatinib exerts its anti-proliferative effect on hepatocellular cell proliferation by blocking the Src family kinases;however,it causes Akt activation,which compromises dasatinib as an anti-cancer drug. | Chang Liu Xiaoxia Zhu Yuqi Jia Fenqing Chi Keru Qin Jinhong Pei Chan Zhang Xiuli Mu Hongwei Zhang Xiushan Dong Jun Xu Baofeng Yu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，7： | 2 |
| 2 | Mapping and assessing of urban impervious areas using multiple endmember spectral mixture analysis: A case study in the city of Tampa, Florida显示文摘 | Weng Fenqing Pu Ruiliang | 2013 | Geocarto International2013，28，7： | 1 |
| 3 | Shifts of dust source regions over central Asia and the Tibetan Plateau: Connections with the Arctic oscillation and the westerly jet显示文摘 | Yongxiang Han Xiaomin Fang Shichang Kang Huijun Wang Fenqing Kang | 2007 | Atmospheric Environment2007，，10： | 1 |
| 4 | Hand hygiene quality management of medical staff 显示文摘 | HanYueling Shi Fenqing Hu Shufang | 2009 | Chinese Journal ''of Disinfection2009，，2： | 1 |
| 5 | Endoscopic ligation and resecion for the treatment of small EUS-suspected gastric GI stromal tumors 显示文摘 | Huanq W H Fenq C L Lai H C | 2010 | Gastrointest Endoscopy2010，71，6： | 1 |
| 6 | Processescontrolling the geochemical composition of the South ChinaSea sediments during the last climatic cycle 显示文摘 | SUN YOUBIN WU FENQ STEVEN C | 2008 | ChemicalGeology2008，257，： | 1 |
| 7 | Studies of the role for NSP4 in the pathogenesis of homologous murine rotavirus diarrhea显示文摘 | Angel J Tang B Fenq N | 1998 | J Infect Dis1998，177，2： | 1 |
| 8 | The ultimate strength of doubler plate reinforced Y-joints under compression loading显示文摘It is common practice in the offshore industry to solve the punching shear problem due to compression by using doubler plate. The finite-element method is a useful tool for studying this problem. The aim of this paper is to study the static strength of doubler plate reinforced Y-joints subjected to compression loading. The finite-element method is adopted in numerical parametric studies. The individual influences of the geometric parameters βand τd (doubler plate to chord wall thickness ratio) and ld/d1(dubler plate length to brace diameter ratio) on the ultimate strength are made clear. The results show the size of plate may have important effects on the strength of reinforced joints. It is found that the ultimate strength of Y-joints reinforced with appropriately proportioned doubler plates can be greatly improved nearly up tothree times to un-reinforced Y-joints. | FENQ Qi TAN Jia-hua | 2005 | Journal of Marine Science and Application2005，4，2： | 1 |
| 9 | Roles of Mycobacterium smegmatis D-alanine:D-alanine ligase and D-alanine racemase in the mechanisms of action of and resistance to the peptidoglycan inhibitor D-cycloserine显示文摘 | Fenq Z Barletta RG | 2003 | Antimicrob Agents Chemother2003，47，1： | 1 |
| 10 | The effect of PA-MSHA during operation on immunity in patients with gastric cancer 显示文摘 | ZHENCX FENQ XUQ etal | 2012 | 中华普通外科杂志2012，27，5： | 1 |
| 11 | Endoscopic ligation and resection for the treatment of small EUS--suspected gastric GI stromal tumor 显示文摘 | Huanq WH Fenq CL Lai HC | 2010 | Gastrointest Endoscopy2010，71，6： | 1 |
| 12 | A Retrospective Cohort Analysis of the Efficacy of Adjuvant Radiotherapy after Primary Surgical Resection in Patients with Adrenocortical Carcinoma 显示文摘 | HABRA MA EIAZ S FENQ L | 2013 | J Clin Endocrinol Metab2013，98，1： | 1 |
| 13 | Studies of the role for NSP4 in the pathogenesis of homologous murine rotavirus diarrhea显示文摘 | Angel J Tang B Fenq N et a1 | 1998 | J Infet Dis1998，177，2： | 1 |
| 14 | Endoscopic ligation and resection for the treatment of small EUS-suspected gastric G1 stromal tumors显示文摘 | Huanq WH Fenq CL Lai HC | 2010 | Gastro Intest Endoscopy2010，71，6： | 1 |
| 15 | Effect of continuous versus multiple intermittent light exposures on rat retina显示文摘 | Fenq Lih Lee Dao Yi Yu Mark O. M. Tso | 1990 | Current Eye Research1990，，1： | 1 |
| 16 | NF-kappa B activation mediates doxorubicin-induced cell death in N-type neuroblastoma ceils 显示文摘 | Bian X McAllister-Lucas LM Shao F Schumacher KR Fenq Z Porter AG | 2001 | J Biol Chem2001，276，48： | 1 |
| 17 | Toxicity of copper and zinc in seeding of Mung Bean and inducing accumulation of polyamine显示文摘 | Zhenguo Shen Fenqing Zhang | 1998 | Journal of Plant Nutrition1998，21，6： | 1 |
| 18 | Hysteroscopc tubal Catheterization and hydrotubation for treatment of some tubal inFertilite显示文摘 | Fenq ZC Huang YL Sun JF | 1988 | Contracep fertilite-seualite1988，16，3： | 1 |
| 19 | Prevalence,characterizationand clonal analysis of Escherichia coli O157:non-H7 serotypes that carryeae alleles显示文摘 | Fenq PC Keys C Lacher D | 2010 | FEMS Microbiol Lett2010，308，1： | 1 |
| 20 | Boron Isotopic Composition of Halite from 46-m-long Sediment Core in the Qarhan Salt Lake,Western China显示文摘Previous studies have investigated the boron isotopic composition of salt lake brines in the Qaidam Basin,western China.However,the research on boron isotopic composition of halite is very limited due to halite’s | FAN Qishun MA Yunqi CHENG Huaide MA Haizhou HAN Fenqing | 2014 | Acta Geologica Sinica(English Edition)2014，88，S1： | 0 |
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