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| 1 | Relationship between adipose tissue dysfunction, vitamin D deficiency and the pathogenesis of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide.Its pathogenesis is complex and not yet fully understood.Over the years many studies have proposed various pathophysiological hypotheses,among which the currently most widely accepted is the'multiple parallel hits'theory.According to this model,lipid accumulation in the hepatocytes and insulin resistance increase the vulnerability of the liver to many factors that act in a coordinated and cooperative manner to promote hepatic injury,inflammation and fibrosis.Among these factors,adipose tissue dysfunction and subsequent chronic low grade inflammation play a crucial role.Recent studies have shown that vitamin D exerts an immune-regulating action on adipose tissue,and the growing wealth of epidemiological data is demonstrating that hypovitaminosis D is associated with both obesity and NAFLD.Furthermore,given the strong association between these conditions,current findings suggest that vitamin D may be involved in the relationship between adipose tissue dysfunction and NAFLD.The purpose of this review is to provide an overview of recent advances in the pathogenesis of NAFLD in relation to adipose tissue dysfunction,and in the pathophysiology linking vitamin D deficiency with NAFLD and adiposity,together with an overview of the evidence available on the clinical utility of vitamin D supplementation in cases of NAFLD. | Flavia A Cimini Ilaria Barchetta Simone Carotti Laura Bertoccini Marco G Baroni Umberto Vespasiani-Gentilucci Maria-Gisella Cavallo Sergio Morini | 2017 | World Journal of Gastroenterology2017，23，19： | 9 |
| 2 | Therapeutic and prophylactic thalidomide in TNBS-induced colitis: Synergistic effects on TNF-α, IL-12 and VEGF production显示文摘AIM: To evaluated the therapeutic and prophylactic effect of thalidomide on 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. Thalidomide has been reported to downregulate the expression of tumor necrosis factor a (TNF-α), IL-12, and vascular endothelial growth factor (VEGF), hallmarks of intestinal inflammation in Crohn's disease (CD). METHODS: Male Wistar rats were divided in five groups of ten animals each. Four groups received a rectal infusion of TNBS in ethanol. The first group was sacrificed 7 d after colitis induction. The second and third groups received either thalidomide or placebo by gavage and were sacrificed at 14 d. The fourth group received thalidomide 6 h before TNBS administration, and was sacrificed 7 d after induction. The fifth group acted as the control group and colitis was not induced. Histological inflammatory scores of the colon were performed and lamina propria CD4+ T cells, macrophages, and VEGF+ cells were detected by immunohistochemistry. TNF-a and IL-12 were quantified in the supernatant of organ cultures by ELISA. RESULTS: Significant reduction in the inflammatory score and in the percentage of VEGF+ cells was observed in the group treated with thalidomide compared with animals not treated with thalidomide. Both TNF-αand IL-12 levels were significantly reduced among TNBS induced colitis animals treated with thalidomide compared with animals that did not receive thalidomide. TNF-αlevels were also significantly reduced among the animals receiving thalidomide prophylaxis compared with untreated animals with TNBS-induced colitis. Intestinal levels of TNF-αand IL-12 were significantly correlated with the inflammatory score and the number of VEGF+ cells. CONCLUSION: Thalidomide significantly attenuates TNBS-induced colitis by inhibiting the intestinal production of TNF-α, IL-12, and VEGF. This effect may support the use of thalidomide as an alternate approach in selected patients with CD. | Ana Teresa Carvalho Heitor Souza Antonio Jose Carneiro Morgana Castelo-Branco Kalil Madi Alberto Schanaider Flavia Silva Fernando Antonio Pereira Júnior Márcia G Pereira Cláudio Tortori Ilana Dines Jane Carvalho Eduardo Rocha Celeste Elia | 2007 | World Journal of Gastroenterology2007，13，15： | 6 |
| 3 | Gastric cancer in young people under 30 years of age: worse prognosis, or delay in diagnosis?显示文摘 | Horacio N López-Basave Diaz Romero C Alejandro Padilla Rosciano Melchor Ruan J Silvio A. ?amendys-Silva Vela Sarmiento I Ruiz Molina JM Calderillo Ruiz G Flavia Morales-Vásquez Abelardo Meneses Garcia Angel Herrera-Gomez | 2013 | Cancer Management and Research (default)2013，，： | 2 |
| 4 | The Rai ( She C) adaptor protein regulates the neuronal stress response and protects against cerebral ischemia显示文摘 | Flavia T Cinara E Alberto G | 2004 | Proc Natl Acad Sci U S A2004，101，15： | 1 |
| 5 | Urinary 11-dehydro thromboxane B 2 levels in type 2 diabetic patients before and during aspirin intake显示文摘 | Lillian Harboe Gon?alves Luci Maria Sant'Ana Dusse Ana Paula Fernandes Karina Braga Gomes Mirelle Oliveira Sóter Michelle Teodoro Alves Kathryna Fontana Rodrigues Fernanda Rocha Freitas Flavia Komatsuzaki Marinez Oliveira Sousa Adriana Aparecida Bosco Gér | 2011 | Clinica Chimica Acta2011，，15： | 1 |
| 6 | Manganese and iron oxides as combustioncatalysts of volatile organic compounds显示文摘 | Flavia G Bibiana P Luis E | 2009 | Applied Catalysis B:Environmental2009，92，： | 1 |
| 7 | Evaluation of an adsorptionelution method for detection of astrovirus and norovirus in environmental waters显示文摘 | Matvias V Flavia G Fumian T | 2009 | J Virol Methods2009，156，2009： | 1 |
| 8 | Global health 2035: a world converging within a generation显示文摘 | Dean T Jamison Lawrence H Summers George Alleyne Kenneth J Arrow Seth Berkley Agnes Binagwaho Flavia Bustreo David Evans Richard G A Feachem Julio Frenk Gargee Ghosh Sue J Goldie Yan Guo Sanjeev Gupta Richard Horton Margaret E Kruk Adel Mahmoud Linah K Mo | 2013 | 2013 (9908)2013，，9908： | 1 |
| 9 | A versatile splitless injection GC-FID method for the determination of mineral oil paraffins in vegetable oils and dried fruit显示文摘 | DENNIS F ALBERTO P FLAVIA G | 2010 | Food Control2010，21，8： | 1 |
| 10 | Effects of Different Immunolabeling Techniques on the Detection of Small-cell Lung Cancer Cells in Bone Marrow显示文摘 | Felice P Flavia P | 1999 | J Histochem Cytochem1999，47，8： | 1 |
| 11 | Use of double bulk cur- rent injection for susceptibility testing of avionics显示文摘 | Flavia G Giordano S Filippo M | 2008 | IEEE Transactions on Electromagnetic Compatibility2008，50，3： | 1 |
| 12 | A Comparative Study of Diesel Analysis by FTIR,FTNIR and FT-Raman Spectroscopy Using PLS and Arti-ficial Neural Network Analysis显示文摘 | Vianney O S J Flavia C C O Daniella G L | 2005 | Analytica Chimica Acta2005，547，2： | 1 |
| 13 | Moire topography: Characteristics and clinical application显示文摘 | Flavia' P Jonas L G Thais R | 2010 | Gait & Posture2010，32，： | 1 |
| 14 | Evaluation of an adsorptionelution method for detection of astrovirus and norovirus in environmental waters显示文摘 | Matias V Flavia G Tulio F | 2009 | J Virol Methods2009，156，1： | 1 |
| 15 | EZH2 mutational status pre- dicts poor survival in myelofibrosis 显示文摘 | Paola G Flavia B Joannah S | 2011 | Blood2011，118，19： | 1 |
| 16 | Chemoenzymatic deacyl- ation of ramoplanin显示文摘 | Raffaella G Flavia M Enzio R | 2012 | Bioorgan Med Chem Lett2012，22，16： | 1 |
| 17 | Use of double bulk current injec- tion for susceptibility testing of avionics显示文摘 | Flavia G Giordano S Filippo M | 2008 | IEEE Transactions on Electromagnetic Compatibility2008，50，3： | 1 |
| 18 | Circuit modeling of injection probes for bulk current injection显示文摘 | Flavia G Filippo M Sergio A P | 2007 | IEEE Transactions on E lectro Magnetic Compatibility2007，49，3： | 1 |
| 19 | Evaluation of an adsorptio-nelution method for detection of astro virus and norovirus in environ-mental waters显示文摘 | Matvias V Flavia G Fumian T | 2009 | J Virol Methods2009，156，12： | 1 |
| 20 | Hepatitis B virus genetic diversity in Argentina: Dissimilargenotype distribution in two different geographical regions;description of hepatitis B surface antigen variants显示文摘 | Flavia G Pineiro y Leone | 2008 | Journal of Clinical Virology2008，42，3： | 1 |
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