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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 3 | Chronic proliferative hepatitis in A / J Cr mice associated with persistent Helicobacter hepaticus infection: a model of Helicobacter-induced carcinogenesis 显示文摘 | Fox J G Li X Yan L | 1996 | Infect Immun1996，64，5： | 1 |
| 4 | HIV replication in IL-2-stimulated peripheral blood mononuclear cells is driven in an autocrine/paracrine manner by endogenous cytokines显示文摘 | Kinter AL Poli G Fox L | 1995 | J Immunol1995，154，5： | 1 |
| 5 | Persistent hepatitis and enterocolitis in germfree mice infected with Helicobacter hepaticus 显示文摘 | Fox J G Yan L Shames B | 1996 | Infect Immun1996，64，9： | 1 |
| 6 | Methanogens: reevaluation of a unique biological group显示文摘 | BALCH W E FOX G E MAGRUM L J | 1979 | Microbiological Reviews1979，43，2： | 1 |
| 7 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 8 | Spontaneous deletion of the methicillin resistance determinant,mecA,partially compensates for the fitness cost associated with high-level vancomycin resistance in Staphylococcus aureus显示文摘 | Noto M J Fox P M Archer G L | 2008 | Anti micro Agents Chemother2008，52，4： | 1 |
| 9 | Methanogens:reevaluation of a unique biological group显示文摘 | Balch W E Fox G E Magrum L J | 1979 | Microbiol Rev1979，43，2： | 1 |
| 10 | Red-pigmented micrococci:a basis for taxonomy显示文摘 | Brooks B W Murray R G Johnson J L Stackebrandt E Woese C R Fox G E | | 0，，： | 1 |
| 11 | The microsurgieal approach to intracranial an-eurysms显示文摘 | Yasargil M G Fox J L | 1975 | Surg Neurol1975，3，1： | 1 |
| 12 | Phosphorus require- ments of soybean and cowpea as affected by mode of N nutri- tion显示文摘 | Cassman K G Whitney A S Fox R L | 1981 | Agronomy Journal1981，73，1： | 1 |
| 13 | Conservation of Primary Structure in 16S Ribosomal RNA显示文摘 | WOESE C R FOX G E ZABLEN L | 1975 | Nature1975，254，： | 1 |
| 14 | A mechanistic model for predicting the nutrient requirements and feed biological values for sheep显示文摘 | Cannas A Tedeschi L O Fox D G | 2004 | Journal of Animal Science2004，82，： | 1 |
| 15 | Long-termtreatment of ghrelin stimulates feeding,fat deposition,and alters the GH/IGF-I axis in the tilapia, Oreochro-mis mossambicus显示文摘 | RILEY L G FOX B K KAIYA H | 2005 | General and Comparative Endo-crinology2005，142，12： | 1 |
| 16 | Parent-Professional Partnership in Behavioral Support:A Qualitative Analysis of One Family’s Experience显示文摘 | Fox L Vaughn J Dunlap G Bucy M | 1997 | The Journal of the Association for Persons with Severe Handicaps1997，，4： | 1 |
| 17 | Gene expression profiling of bovine macrophages in response to Escherichia coli O157:H7 lipopolysacch-aride显示文摘 | Chitko-McKown C G Fox J M Miller L C | 2004 | Dev Comp Immun2004，28，6： | 1 |
| 18 | Predictors of major bleeding in acute coronary syndromes: the Global Registry of Acute Coronary Events (GRACE)显示文摘 | Moscucci M Fox K A Cannon C P Klein W López-Sendón J Montalescot G | 2003 | Eur Heart J2003，24，： | 1 |
| 19 | Absenceof effects of short-term fasting on plasma ghrelin andbrain expression of ghrelin receptors in the tilapia,Oreochromis mossambicus 显示文摘 | RILEY L G FOX B K BREVES J P | 2008 | Zoological Science2008，25，8： | 1 |
| 20 | Microstructure and defects of wurtzite structure thin films显示文摘 | SAGALOWICZ L FOX G R DUBOIS M A | 1999 | Journal of the European Ceramic Society1999，19，67： | 1 |
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