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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | High-salt diet induces Helicobacter pylori colonization in epithelial hyperplasia and parietal cell loss, and enhances helicobacter pylori colonization in C57BL/6 mice显示文摘 | Fox J G Dangler C A Taylor N S | 1999 | Cancer Res1999，59，9： | 1 |
| 3 | Prediction of ruminal volatile fatty acids and pH within the net carbohydrate and protein system显示文摘 | Pitt R E Van KesselJ S Fox D G | 1996 | J Anita Sci1996，74，： | 1 |
| 4 | Prospective study ofhealth care utilisation and respiratory morbidity due to RSVinfection in prematurely born infants 显示文摘 | Broughton S Roberts A Fox G | 2005 | Thorax2005，60，12： | 1 |
| 5 | Nonlinear electrical properties of lead-lanthanum-titanate thin fill deposited by multi-ion-beam reactive sputtering 显示文摘 | Fox G R Krupanidhi S B | 1993 | J Appl Phys1993，74，： | 1 |
| 6 | En- hanced innate type 2 immune response in peripheral blood from patients with asthma显示文摘 | BARTEMES K R KEPHART G M FOX S J | 2014 | J Allergy Clin Immunol2014，134，3： | 1 |
| 7 | Prediction of ruminal volatile fatty acids and pH within thd net carbohydrate and protein system显示文摘 | Pitt R E Van Kessel J S Fox D G Pell A N Barry M C Van Soest P J | 1996 | Journal of Animal Science1996，74，： | 1 |
| 8 | Quantification of reg- ulatory T ceils enables the identification of high-risk breast cancer patients and those at risk of late relapse 显示文摘 | Bates G J Fox S B Han C | 2006 | J Clin Oncol2006，24，34： | 1 |
| 9 | Phosphorus require- ments of soybean and cowpea as affected by mode of N nutri- tion显示文摘 | Cassman K G Whitney A S Fox R L | 1981 | Agronomy Journal1981，73，1： | 1 |
| 10 | Influence of molecular weight and degree ofcrosslinking on the specific volume and glass temperature of poly-mers显示文摘 | Fox T G Loshaek S | 1955 | Journal of Polymer Science1955，15，： | 1 |
| 11 | Assessment of glo- merular charge selectivity in man by differential clearance of isoamylases 显示文摘 | Fox J G Quin J D O'reilly D S | 1993 | Clinical Science1993，84，4： | 1 |
| 12 | The micmstructure and mechanical properties of two navy HSLA-100 steels in plate form 显示文摘 | Fox A G Mikalae S Vassilaros M G | 1992 | Speieh Symposium Proceedings1992，10，： | 1 |
| 13 | Reactions of the diiron enzyme stearoyl-acyl carrier protein desaturase显示文摘 | Fox B G Lyle K S Rogge C E | 2004 | Acc Chem Res2004，37，7： | 1 |
| 14 | Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans显示文摘 | Rhee Eugene P Cheng Susan Larson Martin G Walford Geoffrey A Lewis Gregory D McCabe Elizabeth Yang Elaine Farrell Laurie Fox Caroline S O’Donnell Christopher J Carr Steven A Vasan Ramachandran S Florez Jose C Clish Clary B Wang Thomas J Ger | 2011 | Journal of Clinical Investigation2011，，4： | 1 |
| 15 | The role of glutamate dehydrogenase in plant nitrogen metabolism 显示文摘 | Robinson S A Slade A P Fox G G | 1991 | Plant Physiol1991，95，2： | 1 |
| 16 | Association of oxidative stress, insulin resistance, and diabetes risk phenotypes: the Framingham Offspring Study 显示文摘 | MEIGS J B LARSON M G FOX C S | 2007 | Diabetes Care2007，30，10： | 1 |
| 17 | Predic- ting amino acid adequacy of diets fed to Holstein steers 显示文摘 | AINSLIE S J FOX D G PERRY T C | 1993 | Journal of Animal Science1993，71，： | 1 |
| 18 | Design, syn- thesis and preliminary pharmacological evaluation of N-alkyl 3-aminoglutarimides as broad-spectrum chemo- kine inhibitors in vitro and anti-inflammatory agents in vivo 显示文摘 | Fox D J Reckless J Warren S G | 2002 | Journal of Medicinal Chemistry2002，45，2： | 1 |
| 19 | Nonlinear Electrical Properties of Lead-lanthanum-titanate Thin Fill Deposited by Multi-ion-beam Reactive Sputtering J Appl显示文摘 | Fox G R Krupanidhi S B | 1993 | Phys1993，74，3： | 1 |
| 20 | Transoral Incisionless Fundoplication: 2-year Results from the Prospective Multicenter U.S. Study显示文摘 | Bell Reginald C W Barnes William E Carter Bart J Sewell Robert W Mavrelis Peter G Ihde Glenn M Hoddinott Kevin M Fox Mark A Freeman Katherine D Gunsberger Tanja Hausmann Mark G Dargis David Gill Brian DaCosta Wilson Erik Trad Karim S | 2014 | The American Surgeon2014，，11： | 1 |
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