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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans显示文摘 | Fox D S Cruz M C Sia R A L | 2001 | Molecular Microbiology2001，39，： | 1 |
| 3 | The serine/ threonine kinase Pim-2 is a transcriptionally regulated apopotot-ic inhibitor显示文摘 | FOX C J HAMMERMAN P S CINALLI R M | 2003 | Genes Dev2003，17，15： | 1 |
| 4 | Molecular dynamics simulations of a supercooled monatomic liquid and glass显示文摘 | Fox J R Andersen H C | | 0，，18： | 1 |
| 5 | Strategies for reducing foundry emissions 显示文摘 | Fox J R Adamovits M Henry C | 2002 | American Foundry Society Transactions2002，110，： | 1 |
| 6 | The Psychology self-perception profile:Development and preliminary validation显示文摘 | Fox K R Corbin C B | 1989 | Journal of Sport and Exercise Psychology1989，11，： | 1 |
| 7 | Determination of the in situ forces in the human posterior cruciate ligament using robotic technology 显示文摘 | Fox R J Harner C D Sakane M | 1998 | American Journal of Sports and Medicine1998，26，： | 1 |
| 8 | Potential clinical rele-vance of Eph receptors and ephrin ligands expressed in prostate carcinoma cell lines显示文摘 | FOX B P TABONE C KANDPAL R P | | 0，，04： | 1 |
| 9 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 10 | Phylogenetic structure of the prokaryotic domain,the primary kingdoms显示文摘 | Woese C R and Fox G E | 1977 | Proceeding of the National Academy of Science USA1977，74，11： | 1 |
| 11 | A comparison of stable strontium and 32p as traces for estimating alfalfa root activity 显示文摘 | Fox R L Lipps R C | 1964 | Plant and Soil1964，30，： | 1 |
| 12 | G protein - coupled receptors in Anopheles gambiae显示文摘 | HILL C A FOX A N PlqqS R J | 2002 | Science2002，298，5591： | 1 |
| 13 | Red-pigmented micrococci:a basis for taxonomy显示文摘 | Brooks B W Murray R G Johnson J L Stackebrandt E Woese C R Fox G E | | 0，，： | 1 |
| 14 | Antisense inhibition of basic fibroblast growth factor induces apoptosis in vascular smooth muscle cells 显示文摘 | FOX J C SHANLEY J R | 1996 | JBiolChem1996，271，12： | 1 |
| 15 | Application of the Cornell net carbohydrate and protein model for cattle consuming forage 显示文摘 | Fox D G Barry M C Pitt R E | 1995 | Journal of Animal Science1995，73，： | 1 |
| 16 | Utility of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) to distinguish between congestive heart failure and non-cardiac causes of acute dyspnea in cats显示文摘 | Fox P R Oyama M A Reynolds C | | 0，，1： | 1 |
| 17 | Thyroid hormone resistance and pregnancy显示文摘 | Kane S Fox R Close C | 2003 | BJOG2003，110，： | 1 |
| 18 | Prediction of ruminal volatile fatty acids and pH within thd net carbohydrate and protein system显示文摘 | Pitt R E Van Kessel J S Fox D G Pell A N Barry M C Van Soest P J | 1996 | Journal of Animal Science1996，74，： | 1 |
| 19 | Relationship of endothe- lial cell proliferation to tumor vascularity in human breast cancer 显示文摘 | Fox S B Garter K C Bicknell R | 1993 | Cancer Res1993，53，18： | 1 |
| 20 | Pa rental atrial fibrillation as a risk factor for atrial fibril lation in offspring显示文摘 | FOX C X PARISE H DAGOSTINO R S | 2004 | JAMA2004，291，： | 1 |
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